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Fundamentals of Human Genetics MCDB 1041 Course website: www.mcdb.colorado.edu/courses/1041/ Text: Human Genetics: Ricki Lewis, 9th or 10th ed Instructor: • Dr. Jenny Knight • [email protected] • Office: Porter B121B • Office hours: W, TH 10-11 AM Learning Assistants: Justin Murray Jesse Van Divier My general goals for you in this class: • Learn the fundamental principles of genetics and how to apply them in understanding real life scenarios and solving problems • Learn how scientists do science • Appreciate the relevance of genetics to your daily lives and futures • Gain/hone skills that will help you succeed in general Course Details: A thorough description of how the course works is online from the Course Information link of the course webpage: www.mcdb.colorado.edu/courses/1041/ Please review it carefully. Course structure in brief: • Class notes and powerpoints: posted on WEB PAGE (NOT D2L) from Syllabus link: click on the class number. • In class participation: bring clicker to class every day and also be prepared to work on things both individually and as a group. Pre-class questions and Homework: see syllabus. All will be available and submitted online using D2L First pre-class assignment is due by 11 AM on Wednesday. Quizzes: 4 quizzes. Each quiz has both an individual component and a group component, more details online. Final Exam: Cumulative! Final Group Project: a chance for you and your group to work creatively on a topic of your choosing, related to biotechnology. More later. My approach to teaching We re in a partnership where I help you learn the material, but you are an active driver of that process. You take advantage of each other as resources. There will be a lot of group work and discussion of ideas. You work actively in each class period to develop an understanding of the material, which will include a lot of problem solving! Boring! Active! Fun! More effective for learning! Groups and group work You will work in groups of 3, or at the most 4 if you don’t have a multiple of 3 at your table. You’ll work together in this group in class, MWF You’ll do group projects together, which will require some out of class time Please split into groups 1. Make a nametag for yourself; keep this in your notebook so you can use it! 2. Introduce yourself to your neighbors 3. Create a list of things related to genetics that are you find interesting and want to learn more about Put your names and table number at the top of your list and hand in! What do you think when you look at these kids? My kids, at Christmas, 2013 Physical traits are determined by • genes • environment We will begin by considering only the genetic components of physical traits; later we’ll talk about the combination Physical traits: some are “single gene traits” physical or measurable output is due to the protein product of a single gene Many physical traits and diseases are the output of multiple genes and the environment, but we will start in this class by considering traits caused by single genes The field of genetics uses a lot of terminology You need to know some of this language in order to learn about genetics Talk with the people around you about these terms: Gene Allele Genotype Phenotype As a group of 3, decide on a good definition for each word, and explain how the terms are related. Then share with the rest of your table and write your definitions on the white board for your table. . Please get out your clickers. If you don’t have one today, it’s ok, but don’t forget to bring them to class every day from now on! Your mom and dad are both free of any genetic diseases, as are you. Is it possible for you to have a sibling with the genetic disease sickle cell anemia? a. Yes b. No Discuss with your neighbor. Why? Sickle cell anemia is a recessive disease. What do the terms dominant and recessive mean? Dominant (“A”): describes a version of a gene that causes a phenotype when present in one copy example: an individual with an AA or Aa genotype both show the dominant phenotype Recessive (“a”): describes a version of a gene that is required in two copies to produce a phenotype example: aa genotype shows the recessive phenotype When a disease (or other phenotype) is recessive, a person can be a carrier of the disease genotype, but not have a disease phenotype Pick the order that best represents relative size, from smallest size to largest size a. b. c. d. e. Gene, DNA, Chromosome DNA, Chromosome, Gene DNA, Gene, Chromosome Chromosome, DNA, Gene Chromosome, Gene, DNA Discuss with your neighbor. A is best answer, but if you were thinking of DNA as a DNA nucleotide (ie, a “base”, like ATGC) then C was a reasonable choice as well What you should do by next time: • Spend some time on the course web page getting to know how the course works, where to find materials, etc. • Go to D2L and figure out how to use it if you don’t already know. Your first assignment is due by Wednesday at 11 AM so don’t delay! • Register your iClicker and bring it to class every day. Note: bringing someone else s clicker to class and double clicking is a violation of the honor code! • Do the reading on the syllabus (before class) and complete any pre-class assignments to prepare for class