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Natural Selection and Evidence to Support Evolution 1A1: Natural Selection is a major mechanisms of evolution (Bozeman 001 Natural Selection) 1A2: Natural selection acts on phenotypic variations in populations (Bozeman 002 Examples of Natural Selection) 1A4: Biological evolution is supported by scientific evidence from many disciplines, including mathematics (Bozeman 004 Evidence for Evolution) 3C1: Changes in genotype can result in changes in phenotype (Bozeman 033 Genotype & Phenotypes) Natural Selection is a major mechanisms of evolution • This concept is review, remember, natural selection was the mechanisms proposed by Charles Darwin to explain how evolution (change over time in organisms) takes place • Key ideas of natural selection: – There is a limited amount of resources – Differential Survival Rate – Those better fit for environment produce more offspring – Over time frequency of favorable trait (allele) increases; less favorable traits decreases Genetic Variation • Recall in order for natural selection to take place some organisms must be better fit for their environment than others • What is the major source of genetic variation? – MUTATIONS!!! (Or Changes in DNA) • DNAmRNAprotein – Proteins make us who and what we are; they are the result of what we see when we look in the mirror and all the processes that take place in our body • A diverse gene pool is important for the survival of a species; ESPECIALLY in a changing environment Think Pair Share • Is there such a think as the “perfect genome” • Justify your answer What impact does mutation have on genotype and phenotype? • Recall genotype = actual genes; phenotype = physical characteristics • Mutations change the DNA (genotype); however a change in the DNA may or may not cause a change in the phenotype. • If the mutation does cause a change in the phenotype the resulting characteristic can be negative, positive, or neutral Think pair share • What determines the fitness of a genotype? • What is fitness? Phenotype Fitness • The interaction between the environment and the phenotype determines fitness • Fitness – the number of offspring an organisms produces (genes passed along to future generations) • Can the environment act on the genotype? Justify your answer Alternative Mechanisms of Evolution • Natural Selection is the main mechanisms; however, there are other events that take place resulting in changes in organism’s physiology: – Genetic drift – Sexual selection – Artificial selection Genetic Drift • Genetic drift: a random event that causes a change in a populations phenotype • Two Main Types: – Bottleneck Effect: a sudden decrease in population size due to a disaster/war/disease – Founders Effect: when a small population is separated from a larger population and creates a new population • Genetic Drift has a significant effect on small populations Sexual Selection • Non-random mating • Mates select based on desired characteristics – This does not necessarily result in increased fitness based on the environment – Ex: Peacocks – female goes after male with larger tails – detrimental when trying to get away from predator Artificial Selection • Breeding of animals for a desired characteristic – Dogs • Genetic Engineering – producing products with desired traits Hardy-Weinberg Equilibrium • In 1908 a British mathematician and German physician independently derived an equation to help determine if a population is evolving – A population is said to be in Hardy-Weinberg Equilibrium if: 1. 2. 3. 4. The population is large There is no migration (emigration or immigration) No new mutations Random mating/no artificial selection – These conditions are rarely met which is why populations are constantly evolving Hardy-Weinberg Equation • p2 +2pq + q2 = 1 – Expected frequency of the homozygous dominant genotype + expected frequency of the heterozygous genotype + expected frequency of the homozygous recessive genotype =1 – AA + Aa + aa = 1 • p represents the dominant allele (remember an allele is only one letter) • q represents the recessive allele • p2, 2pq, and q2 all refer to individual organisms because organisms are diploid (contain two alleles) • We will play with this equation more next week!!! Natural Selection acts on phenotypic variations in populations • Recall the difference between genotype (actual genes) and phenotype (physical trait) • A mutation results in a change in the genotype • Natural selection can only act (select for or against) a physical trait • An environmental change may occur causing a once detrimental (harmful/bad) trait to become beneficial (good/useful) – Historical Example: Peppered moths during industrial revolution Phenotypic Variations are not directed by the environment • A change in the environment does not cause an automatic change in population • Due to variation that already exist in a population a change in the environment is going to cause the more beneficial trait to become more dominant • Changes in physical appearance (phenotype) occur when there is a change in the genotype (mutation) and the environment selects for the phenotype. Human Impact on Variation • Artificial Selection: the process by which humans select for a specific trait they desire in an organism and sexual reproduce those organisms to produce offspring with a desired trait (ex: breeds of dogs/cats/ desired foods) • Many human behaviors decrease the genetic variation of organisms – when variation is loss a population/ecosystem becomes less stable – What types human behaviors decrease diversity? – Why does an ecosystem/population become less stable when variation is lost? Biological evolution is supported by scientific evidence • Information from geographical, geological, physical, chemical and mathematical applications are used to understand evolution • Morphological (how an organisms looks – phenotype) and genetic (genotype) info of existing and extinct organisms add to our understanding of evolution Fossil Dating • Age of rocks where a fossil is found • Rate of decay of isotopes – Carbon-14 Morphological homologies vs. Vestigial structures • Vestigial structures are remnants of functional structures (used to compare structures and provide evidence for evolution) • Morphological homologies represent features that are shared by common ancestry Genetic Similarities • DA nucleotide • Protein sequences • Provides evidence for evolutionary ancestry Evolutionary Models • Used to illustrate and support evolutionary concepts: – Graphical analysis of allele frequencies in a population (Hardy-Weinberg) – Analysis of DNA sequences – Analysis of phylogenetic trees Changes in genotype can result in changes in phenotype • Alterations in a DNA sequence can lead to changes in the type or amount of the protein produced and the consequent phenotype • DNA mutations can be positive, negative, or neutral based on the effect or the lack of effect they have on the resulting nucleic acid or protein and the phenotypes that are confeered by the protein Causes of mutations • Errors in DNA replication • Radiation and reactive chemicals • Errors in mitosis or meiosis can result in changes in phenotype – Changes in chromosome numbers often result in new phenotypes