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DEPARTMENT OF BIOLOGICAL SCIENCES (BIOCHEMISTRYPROGRAMME) SCHOOL OF NATURAL AND APPLIED SCIENCES COLLEGE OF SCIENCE & TECHNOLOGY COVENANT UNIVERSITY COURSE COMPACT COURSE CODE: BCH 417 COURSE TITLE: BIOCHEMISTRY OF MACROMOLECULES UNITS: 2 SEMESTER/ SESSION: ALPHA, 2014/2015 COURSE LECTURERS: *Course Coordinator *Dr. S.O. Rotimi and Dr. O.E. Omotosho TIME: See timetable LOCATION: See timetable A. BRIEF OVERVIEW OF COURSE: The course examines the structure and functions of the major macromolecules (carbohydrates, lipids, proteins, nucleic acids) found in living organisms. Emphasis is on the storage and structural polysaccharides, complex lipids, glycoproteins, bacterial cell wall components, nucleic acids, dextrans, ascorbic acids and secondary metabolites such as antibiotics. B. OBJECTIVES/GOALS: At the end of this course, the students should be able to: Describe the different types of macromolecules and their building block molecules. 1 Draw the structures of the major macromolecules: polysaccharides, dextrans, lipids, glycoproteins, lipoproteins, nucleic acids, etc. Describe the structure of secondary metabolites such as antibiotics. Discuss the significance of hybrid molecules, e.g. glycoproteins and lipoproteins Explain the major functions of the different macromolecules. C. METHODS OF LECTURE DELIVERY /TEACHING AIDS Lecture Delivery and Teaching Aids include; Guided instructions Interactive classroom session Transparencies, multimedia Diagrams Laboratory Practicals Tests for complex carbohydrates Tests for cholesterol D. COURSE OUTLINE Module 1 Hierarchical Organization of Life (Dr. S. O. Rotimi) Week 1 Overview of hierarchy of cell structure Week 2 Classes of Macromolecules Module 2 Complex Carbohydrates (Dr. S.O Rotimi) Week 3 Storage Polysaccharides Week 4 Cell wall polysaccharides, glycoproteins and mucopolysaccharides Week 5 Carbohydrate-derived antibiotics Week 6 Dextrans and ascorbic acids Mid-term Test 2 Module 3 Complex Lipids, Membrane and Plant Lipids (Dr. O.E. Omotosho) Week 7 Complex lipids: sterols, cholesterols, steroid hormones Week 8 Lipoproteins, chylomicrons, and blood lipids Week 9 Membrane lipids; structure of biological membranes Week 10 Plant lipids: terpenes, saponins, tannins and flavonoids Module 4 Nucleic Acids and Ribosomes (Dr. O.E. Omotosho) Week 11 Structure and functions of DNA IN prokaryotic and eukaryotic organisms Week 12 Ribosomes: subunits, structures and functions Week 13 Tutorials Week 14 Revision and evaluation. E. TUTORIALS Explain the hierarchical organization of cells Describe the classes of macromolecules Discuss the structure and function of complex carbohydrates Describe structure and function of types of complex lipids F. STRUCTURE OF THE PROGRAMME/ METHOD OF GRADING 1. 2. G. Continuous Assessment 30 Marks (i) Test 1/ Test 2 15 Marks (ii) Mid-Semester Test 15 Marks Semester Examination 70 Marks GROUND RULES AND REGULATIONS The following ground rules and observations shall be observed: 3 Mandatory 75% class attendance. No eating or dozing in the classroom or laboratory. Active participation in all activities. All class assignments must be submitted on time Punctuality to classes must be observed H. TOPICS FOR TERM PAPERS/ ASSIGNMENTS (i) Discuss the hierarchy of cell structure (ii) Explain the roles of the major classes of macromolecules in the determination of cell structure and activities. (iii) Describe the structure and synthesis of principal storage polysaccharides. (iv) Explain the chemical and structural differences between the cell wall polymers of plants, fungi and bacteria. (v) Write short notes on carbohydrate-derived antibiotics and vitamin C. (vi) Discuss the roles of lipids in the structure and function of the cell membrane. (vii) Describe the nature of lipoproteins and other blood lipids in relation to the incidence of arteriosclerosis and heart diseases. (viii) Write elaborately on the structure and functions of major plant lipids. (ix) Outline the molecular and structural differences between DNA and RNA. (x) H. Discuss the structure and functions of the different ribosomal subunits ALIGNMENT WITH UNIVERSITY VISION AND GOALS 4 The pattern of lecture delivery shall be aligned with the vision and goals of Covenant University which is geared towards building a new generation of world leaders that will restore the dignity of mankind. This will be achieved in the following ways Every lecture shall start with a prayer Class sessions shall be interactive and participatory Lectures shall focus on capacity building by citing practical examples and relating topics to industry Students shall be made to strictly adhere to the ground rules and regulations of this course. I. INDUSTRIAL RELEVANCE Knowledge garnered in this course shall be relevant in the medical, food, biotechnology and agricultural industries. J. RECOMMENDED READING 1. Lehninger, A. Principles of Biochemistry (5th edition) 2. Horton H. A. et al. Principles of Biochemistry (4th edition) 3. Stryer, L. Biochemistry (4th edition). 4. Campbell,M.K and Farrell,S.O. Biochemistry (6th Edition) 5. Russell et al. Biology, the dynamic science (ISE). 5