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Lesson Plan Summary Sheet Teacher: Howerton Subject: Biotech 2 Unit C: Therapeutic Applications May 10 May 11 May 14 How are immune therapies used to treat various diseases? How are protein replacement therapies used to treat various diseases? How are viruses used in gene therapy? How are non-viral delivery methods used in gene therapy? □ What is the body's first line of defense against invasion? What is the lymphatic system? How does the humoral immune system work? How does the cell-mediated immune system work? How do the innate vs the adaptive immunity differ? What are some autoimmune diseases that affect humans? What are some immunodificiencies that affect humans? How do antibodies and antigens react with each other □ □ Begin Webwalk on Immunology Students will view Immunology powerpoint □ □ □ Look up classes of antibodies Anitgen-Antibody Lab Students will use the ELISA kit from Biorad How are ELISA assays used in biotechnology? □ Students will do some internet research to answer the EQs Students will view a powerpoint on Gene Therapy. □ □ □ □ C1: Write a paragraph summary on gene therapy. □ □ □ □ □ □ □ □ □ □ □ □ TPA Interferon Monoclonal antibodies Enzyme replacement therapy Adenovirus Retrovirus Liposome Humoral Immunity Flora Secretion Macrophages Lymphatic System Vaccine Adaptive innate □ □ □ □ □ Antibodies Antigens ELISA Primary secondary C3:Sketch out what happens in both a direct and indirect ELISA C2:Write a summary paragraph that describes what can go wrong in the immune system How is the human body compartmentalized? What are the different types of pharmacological targets? □ □ How does ADMET relate to pharmocokinetics? □ □ May 16 What are the different categories of pharmacological drugs? □ Use the internet to research and create a graphic organizer that summaries the various drugs in each of the categories. May 17 What have you learned about Therapeutic Applications of Biotechnology □ □ Take unit test Turn in all work including summarizing strategies May 15 □ Pharmacology powerpoint Review anatomy of body by placing organs in correct place on large diagram Create a diagram showing enzyme-receptor interaction in the cell Case Studies http://www.biocreations.com/pages/bioani mations.html Gastrointestinal system Cardiovascular system Endocrine system Nervous system Enzymes Receptors Absorption Distribution Metabolism Elimination Toxicity Peripheral nervous system agents Central nervous system agents Anti-inflammatory, analgesic and antihistaminic agents Cardiovascular and renal agents Antiparasitic agents Antibiotics Antineoplastic agents Hormones and immunosuppressants none C4: Explain the ADMET for X-Lax. The explain how drugs work at the cellular level. C5:Which class drug would take if you: Had a headache Had cancer Had strept throat Had Alzeheimer’s disease Had a kidney transplant C6: Write a Reflection on this course. What you liked and how it could be made better.