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Download Ab to glomerular basement membrane
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Transcript
Glomerular basement membrane antibodies General Information Diagnostic test for Goodpasture’s syndrome. • Specimen transport: At room temperature • Repeat Frequency • Special precautions Laboratory Information Normal Range Volume and Sample type Method Turnaround time (working days) < 10 units 7ml clotted blood ELISA 7 days Clinical Information • Indications for the test: Rapidly progressive glomerulonephritis. • Factors affecting the test In comparison to biopsy proven cases of GBM disease, ELISA tests for anti-GBM antibodies have been shown to have a clinical diagnosis agreement of 97 percent, a sensitivity of 87 percent and a specificity of 98 percent. A small number of patients with other renal diseases - systemic vasculitis, SLE and mixed connective tissue disease may exhibit borderline titres. Clinical workstation reference: GBM Ab to glomerular basement membrane (GBM) 8
