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11-2 Genetics and Probability
11-2 Genetics and Probability

... 1. Restriction enzymes are used to cut the DNA into fragments containing genes and repeats 2. The restriction fragments are separated according to size using gel electrophoresis 3. The DNA fragments containing repeats are then labeled using radioactive probes. This labeling produces a series of band ...
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11-2 Genetics and Probability
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Chapter 17 and 19
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DNA- Experiments and People

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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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