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DNA, Genes and Chromosomes
DNA, Genes and Chromosomes

... 2. To obtain a merit you need to use pictures of your DNA model in a flow diagram showing the progression from a cell to a gene writing descriptions. 3. A distinction will be achieved if you produce a poster writing a summary about how genes can be shuffled ...
EPIGENETICS Textbook
EPIGENETICS Textbook

... • CpG islands – Found in 5’ promoter areas – NOT methylated on active and silent genes – EXCEPTIONS: • Silencing on X chromosome • When cells differentiate • Pathological processes, e.g., inactivation of tumor suppressor genes in some cancers ...
The Human Genome Project CH 13 Sec 3 notes
The Human Genome Project CH 13 Sec 3 notes

TEK 6C
TEK 6C

... Biology 6C Variation among organisms ...
Microorganisms in Biotechnology
Microorganisms in Biotechnology

... • In the medical field, cultured cells are being used to manufacture products such as: ...
E:Med - uni-freiburg.de
E:Med - uni-freiburg.de

... Martin Vingron’s group • Sequence alignment • Microarray gene analysis • Gene regulation and evolution: – (combinatorial) TF DNA binding prediction – Histone modification  gene expression – Factors affecting mutation rates ...
12.4 Mutations
12.4 Mutations

... ...
Human Genome Video Guide
Human Genome Video Guide

... ________________ within us. 2. The human genome is basically all of our __________________. 3. We are made up of over 110 ________________ cells. 4. DNA has a hidden structure that makes it ideal for ________________. 5. The DNA is shaped like a ________________. 6. Chromosomes are the volumes that ...
Epigenetics
Epigenetics

... This is because not every gene is expressed in each cell. There are many opportunities to turn off and on a certain gene, and to alter its phenotype, such things like… ...
Binary Switches in Gene Expression: The Histone Code
Binary Switches in Gene Expression: The Histone Code

... lies outside of the DNA itself. . This system relies on packaging DNA into a DNA-histone complex called chromatin, which is the physiological substrate of all cellular processes involving the DNA. The dynamic change of the three-dimensional architecture of chromatin makes certain genes more readily ...
Epigenetics - Hospital Melaka Department of Medicine Haematology
Epigenetics - Hospital Melaka Department of Medicine Haematology

... The $3-billion project was formally founded in 1990 by the US Department of Energy and the National Institutes of Health  A 'rough draft' of the genome was finished in 2000, announced jointly by U.S. President Bill Clinton and the British Prime Minister Tony Blair on June 26, ...
Oral cancer is one of the leading cancers around the world and
Oral cancer is one of the leading cancers around the world and

CaNCer aND THe ePIGeNOMe
CaNCer aND THe ePIGeNOMe

... epigenetic modification in cancer, and each tumor type has its own specific pattern. Histone modifications also occur, as does remodeling of chromatin. And disruption of noncoding RNA sequences, the so-called “dark genome,” that code for microRNAs also seems to play a role in how cancer originates a ...
PowerPoint
PowerPoint

... because the transcription complex can’t bind. ...
Regulation and Expression of Aldehyde Dehydrogenase in Normal
Regulation and Expression of Aldehyde Dehydrogenase in Normal

... Aberrant changes of DNA methylation, histone modification and chromatin compartments are commonly associated with the progression of human cancers. Hypermethylation of CpG islands is the most well categorised epigenetic change to occur in tumours. Many CpG islands associated with transcription of a ...
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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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