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An Aside: X Inactivation in Female Mammals
An Aside: X Inactivation in Female Mammals

... In females, one X chromosome is inactivated (at random) and condenses into a compact Barr body along the inside of the nuclear envelope. Most genes on this X chromosome are not expressed. ...
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Fulltext PDF - Indian Academy of Sciences
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Foundations of Biology
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Genetics and Heredity
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DNA & Heredity
DNA & Heredity

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Cancer epigenetics



Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.
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