Genetic polymorphisms of vein wall remodeling in chronic venous
... PTS, a type of CVD, is an important and frequent chronic complication of deep venous thrombosis (DVT) that develops in 20% to 50% of patients (severe in 5% to 10%) after DVT despite appropriate anticoagulation.12 Risk factors include incomplete DVT symptom resolution, proximal or previous ipsilatera ...
... PTS, a type of CVD, is an important and frequent chronic complication of deep venous thrombosis (DVT) that develops in 20% to 50% of patients (severe in 5% to 10%) after DVT despite appropriate anticoagulation.12 Risk factors include incomplete DVT symptom resolution, proximal or previous ipsilatera ...
Hierarchical Text Categorization and Its Evaluation
... • to try global hierarchical approach with other learning algorithms • to extend the gene annotation training sets with similar documents from Medline • to perform similar task for other organisms • to use gene annotations in gene classification and clustering ...
... • to try global hierarchical approach with other learning algorithms • to extend the gene annotation training sets with similar documents from Medline • to perform similar task for other organisms • to use gene annotations in gene classification and clustering ...
Comparison of Identified TSS Locations to Other
... The two main sources of library bias that can affect the determination of the condition-specificity of the TSSs by applying Shannon entropy to the ESTs are library normalization and library size. While we recognize that a slight normalization bias may remain in each of the individual libraries, we d ...
... The two main sources of library bias that can affect the determination of the condition-specificity of the TSSs by applying Shannon entropy to the ESTs are library normalization and library size. While we recognize that a slight normalization bias may remain in each of the individual libraries, we d ...
Principal Components Analysis
... analysis between different factors. Covariance is always measured between two factors. So with three factors, covariance is measured between factor x and y; y and z, and x and z. When more than 2 factors are involved, covariance values can be placed into a matrix. This is where PCA becomes useful. P ...
... analysis between different factors. Covariance is always measured between two factors. So with three factors, covariance is measured between factor x and y; y and z, and x and z. When more than 2 factors are involved, covariance values can be placed into a matrix. This is where PCA becomes useful. P ...
Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice
... response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transcription factors within a given cell type determines whether the pre ...
... response to GCs. It has been observed that both overexpression of GR and expression of antisense GR mRNA in transgenic mice alters thymocyte survival in vitro and in vivo (9 –11). Furthermore, the relative ratio of GR to other transcription factors within a given cell type determines whether the pre ...
In vitro fertilization (IVF) in mammals: epigenetic and developmental
... exposing female mice to the xenoestrogen Bisphenol A (BPA), meiosis was altered and the rate of aneuploidy increase in these animals. Other studies demonstrated that exposing mice to BPA at the implantation period produced alterations in uterine morphology, estrogen and progesterone receptors and a ...
... exposing female mice to the xenoestrogen Bisphenol A (BPA), meiosis was altered and the rate of aneuploidy increase in these animals. Other studies demonstrated that exposing mice to BPA at the implantation period produced alterations in uterine morphology, estrogen and progesterone receptors and a ...
Genetic Insights Into Comparative Morphology
... al., 1995; Suemori et al., 1995). Consistent results have also been obtained by the retinoic acid-induced respecification of vertebrae, which is roughly associated with the shift of the Hox code in the provertebrae (Kessel and Gruss, 1991; Kessel, 1992). It has been shown recently that multiple disr ...
... al., 1995; Suemori et al., 1995). Consistent results have also been obtained by the retinoic acid-induced respecification of vertebrae, which is roughly associated with the shift of the Hox code in the provertebrae (Kessel and Gruss, 1991; Kessel, 1992). It has been shown recently that multiple disr ...
Identification of lineage-specific zygotic transcripts in early
... this transition from maternal to zygotic control is regulated (Maduro and Rothman, 2002; Newman-Smith and Rothman, 1998). Keen interest has recently centered upon identification of these target genes. However, genetic screens designed to identify these genes have to date been remarkably unsuccessful ...
... this transition from maternal to zygotic control is regulated (Maduro and Rothman, 2002; Newman-Smith and Rothman, 1998). Keen interest has recently centered upon identification of these target genes. However, genetic screens designed to identify these genes have to date been remarkably unsuccessful ...
Molecular genetics of Rett syndrome and clinical
... correlation studies suggest that X chromosome inactivation patterns have a more prominent effect on clinical severity than the type of mutation. When the full range of phenotypes associated with MECP2 mutations is considered, however, the mutation type strongly affects disease severity. MeCP2 is a t ...
... correlation studies suggest that X chromosome inactivation patterns have a more prominent effect on clinical severity than the type of mutation. When the full range of phenotypes associated with MECP2 mutations is considered, however, the mutation type strongly affects disease severity. MeCP2 is a t ...
Transcriptional analysis of the gene for glutamine synthetase II and
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
... Sanger Centre, Hinxton, UK) provides further evidence that S. coelicolor GSI is post-translationally modi®ed by Ntr-like proteins. Fisher and Wray (1989) have shown that glnA is monocistronically transcribed from the same promoter during all phases of growth; the sequence of this promoter is compati ...
Transgenic Models to Study Disorders of Respiratory Control in
... other settings (Nadeau 2001). The modifier genes responsible for this respiratory phenotype variability could perhaps be identified by interstrain comparisons. To date, no such experiment has been reported in newborn mutant mice. ...
... other settings (Nadeau 2001). The modifier genes responsible for this respiratory phenotype variability could perhaps be identified by interstrain comparisons. To date, no such experiment has been reported in newborn mutant mice. ...
Reliable classification of two-class cancer data using evolutionary
... be made to generalize the procedure for any number of classes. In most problems involving identification of gene subsets in bioinformatics, the number of samples available is small when compared to the gene pool size. This aspect makes it difficult to identify which and how many genes are correlated ...
... be made to generalize the procedure for any number of classes. In most problems involving identification of gene subsets in bioinformatics, the number of samples available is small when compared to the gene pool size. This aspect makes it difficult to identify which and how many genes are correlated ...
Gene Section PAX2 (Paired box gene 2) Atlas of Genetics and Cytogenetics
... below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell survival. Prognosis PAX2 is not expressed in normal prost ...
... below). A detailed understanding of the mechanistic contribution mediated by PAX2 has yet to be established. However, inhibition of PAX2 expression in a number of cancer cell lines induces cell death, indicating a role for PAX2 in tumour cell survival. Prognosis PAX2 is not expressed in normal prost ...
Quantitative genetics of gene expression during fruit fly - EMBL-EBI
... Taking advantage of these new possibilities, we performed a high-resolution eQTL study on 80 inbred fruit fly lines from the Drosophila Genetic Reference Panel, which represent naturally occurring genetic variation in a wild population of Drosophila melanogaster. Using a 3′ Tag RNA-sequencing protoc ...
... Taking advantage of these new possibilities, we performed a high-resolution eQTL study on 80 inbred fruit fly lines from the Drosophila Genetic Reference Panel, which represent naturally occurring genetic variation in a wild population of Drosophila melanogaster. Using a 3′ Tag RNA-sequencing protoc ...
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... diverged. In an elegant study, Shaver et al (Shaver et al., 2010) identified the novel computational PRC2-homologs in several unicellular species and showed that E(z)-homolog in unicellular green algae Chlamydomonas reinhardtii is responsible for mono- and di-methylation of lysine 27 on histone H3. ...
... diverged. In an elegant study, Shaver et al (Shaver et al., 2010) identified the novel computational PRC2-homologs in several unicellular species and showed that E(z)-homolog in unicellular green algae Chlamydomonas reinhardtii is responsible for mono- and di-methylation of lysine 27 on histone H3. ...
Hippocampus, 22, 1703-1719
... learning-dependent reductions in the amplitude and duration of calcium-dependent postburst afterhyperpolarizations (AHPs), accompanied by other increases in excitability (i.e., increased firing rate, or reduced spike-frequency accommodation) after trace eyeblink conditioning or spatial learning, wit ...
... learning-dependent reductions in the amplitude and duration of calcium-dependent postburst afterhyperpolarizations (AHPs), accompanied by other increases in excitability (i.e., increased firing rate, or reduced spike-frequency accommodation) after trace eyeblink conditioning or spatial learning, wit ...
BBSI Final Report
... created by this cut will be inserted into pPV72 and the resultant plasmids used to test interference. The exact nature of this mutation will have to be determined using sequencing, though it is suspected that it was introduced during replication in DH5, since the two fragments were only obtainable ...
... created by this cut will be inserted into pPV72 and the resultant plasmids used to test interference. The exact nature of this mutation will have to be determined using sequencing, though it is suspected that it was introduced during replication in DH5, since the two fragments were only obtainable ...
Genomic Survey and Gene Expression Analysis
... The basic leucine (Leu) zipper (bZIP) proteins compose a family of transcriptional regulators present exclusively in eukaryotes. The bZIP proteins characteristically harbor a bZIP domain composed of two structural features: a DNA-binding basic region and the Leu zipper dimerization region. They have ...
... The basic leucine (Leu) zipper (bZIP) proteins compose a family of transcriptional regulators present exclusively in eukaryotes. The bZIP proteins characteristically harbor a bZIP domain composed of two structural features: a DNA-binding basic region and the Leu zipper dimerization region. They have ...
PowerPoint-Präsentation
... al, 2009). The extracytoplasmatic function (ECF) sigma factor AlgU is the key regulator of alginate biosynthesis (Hershberger et al, 1995; Schurr et al, 1993). AlgU governs the general cell envelope stress response to various environmental challenges such as extreme heat-shock (Schurr et al, 1995), ...
... al, 2009). The extracytoplasmatic function (ECF) sigma factor AlgU is the key regulator of alginate biosynthesis (Hershberger et al, 1995; Schurr et al, 1993). AlgU governs the general cell envelope stress response to various environmental challenges such as extreme heat-shock (Schurr et al, 1995), ...
The physics behind the larger scale organization of DNA in eukaryotes
... in the model that start to matter at such small fiber diameters. 2.3. Energetics: elasticity and electrostatics One important property we need to address is the energetics involved in the models. It is usually inferred from experiments that the linker histones are crucial [20, 19]. For example, Rout ...
... in the model that start to matter at such small fiber diameters. 2.3. Energetics: elasticity and electrostatics One important property we need to address is the energetics involved in the models. It is usually inferred from experiments that the linker histones are crucial [20, 19]. For example, Rout ...
New methods for tightly regulated gene expression and
... can be transformed with non-replicating plasmids carrying the complementary recombination site at efficiencies similar to those obtained with self-replicating vectors. We have also constructed a series of hybrid promoters that combine the highly expressed M. barkeri PmcrB promoter with binding sites ...
... can be transformed with non-replicating plasmids carrying the complementary recombination site at efficiencies similar to those obtained with self-replicating vectors. We have also constructed a series of hybrid promoters that combine the highly expressed M. barkeri PmcrB promoter with binding sites ...
Coexpression of Linked Genes in Mammalian
... linked genes would support the adaptive model. However, when protein function is defined by Gene Ontology (GO), a study of Drosophila did not find functional similarity among coexpressed neighboring genes (Spellman and Rubin 2002). In humans, clusters of coexpressed linked genes that belong to the s ...
... linked genes would support the adaptive model. However, when protein function is defined by Gene Ontology (GO), a study of Drosophila did not find functional similarity among coexpressed neighboring genes (Spellman and Rubin 2002). In humans, clusters of coexpressed linked genes that belong to the s ...
Functional tests of enhancer conservation between
... http://dev.biologists.org/supplemental). Worm strains, injections and microscopy Fusion genes were injected according to standard protocols (Mello et al., 1991) into either Bristol N2 or pha-1 (e2123) animals. Enhancercontaining fusion genes were always injected at 50 ng/µl; whenever pha-1 (e2123) w ...
... http://dev.biologists.org/supplemental). Worm strains, injections and microscopy Fusion genes were injected according to standard protocols (Mello et al., 1991) into either Bristol N2 or pha-1 (e2123) animals. Enhancercontaining fusion genes were always injected at 50 ng/µl; whenever pha-1 (e2123) w ...
A novel C. elegans zinc finger transcription factor, lsy
... organism is determined and stabilized by feedback loops composed of gene regulatory factors (Monod and Jacob, 1961). The autoregulation of transcription factors has now indeed been recognized as a major feature of gene differentiation programs (Davidson, 2001; Edlund and Jessell, 1999). We have rece ...
... organism is determined and stabilized by feedback loops composed of gene regulatory factors (Monod and Jacob, 1961). The autoregulation of transcription factors has now indeed been recognized as a major feature of gene differentiation programs (Davidson, 2001; Edlund and Jessell, 1999). We have rece ...
Telomere Shortening and Tumor Formation by Mouse Cells Lacking
... telomerase RNA component (mTR) is required for telomerase activity • telomerase activity is not necessary for embryonic development or fertility • the absence of telomerase has no influence on the growth rates of cultures • Without telomerase, the telomere length decreases from generation to generat ...
... telomerase RNA component (mTR) is required for telomerase activity • telomerase activity is not necessary for embryonic development or fertility • the absence of telomerase has no influence on the growth rates of cultures • Without telomerase, the telomere length decreases from generation to generat ...