Ectopic segmentation gene expression and
... Clearly, the integrity and stability of parasegmental domains are critical to the establishment of metamerism. Loss of alternate en stripes leads to loss of alternate metameres. Nevertheless, the double-metameric primordia must regulate to give approximately normal-sized cuticular segments. It has n ...
... Clearly, the integrity and stability of parasegmental domains are critical to the establishment of metamerism. Loss of alternate en stripes leads to loss of alternate metameres. Nevertheless, the double-metameric primordia must regulate to give approximately normal-sized cuticular segments. It has n ...
Dissecting Gene Expression Changes Accompanying a Ploidy
... In any given environment, the fitness of an aneuploid appears to reflect a combination of these general negative impacts of aneuploidy along with any phenotypes associated with the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the ...
... In any given environment, the fitness of an aneuploid appears to reflect a combination of these general negative impacts of aneuploidy along with any phenotypes associated with the particular pattern of chromosome (and hence gene) copy number change. With sufficiently strong selective pressure, the ...
a new mutant gene causing multiple abnormalities in the mouse
... The lowest grade of abnormality seen in the hind feet of Xtj + mice is the presence of a small splint of bone adjacent to the base of Os metatarsale II (Text-fig. 6). This may be present alone in a foot which externally looks quite normal or may be associated with other abnormalities. It may occur a ...
... The lowest grade of abnormality seen in the hind feet of Xtj + mice is the presence of a small splint of bone adjacent to the base of Os metatarsale II (Text-fig. 6). This may be present alone in a foot which externally looks quite normal or may be associated with other abnormalities. It may occur a ...
Melanic Coat Color Variation in Rock Pocket Mice
... transmembrane protein that spans the entire biological membrane, is found on melanocytes and is one of the key proteins involved in melanogenesis. Agouti, the signaling protein that communicates with and coordinates a cell’s (and Mc1r’s) action, either inhibits or allows melanogenesis. When Mc1r is ...
... transmembrane protein that spans the entire biological membrane, is found on melanocytes and is one of the key proteins involved in melanogenesis. Agouti, the signaling protein that communicates with and coordinates a cell’s (and Mc1r’s) action, either inhibits or allows melanogenesis. When Mc1r is ...
Alterations to the remote control of Shh gene expression cause
... The vast majority of the human genome does not encode protein and within the genome are large gene-free tracts called gene deserts. These are of increasing interest to developmental biologists and in contradiction to the use of the phrase ‘gene desert’, these are not necessarily regions devoid of fu ...
... The vast majority of the human genome does not encode protein and within the genome are large gene-free tracts called gene deserts. These are of increasing interest to developmental biologists and in contradiction to the use of the phrase ‘gene desert’, these are not necessarily regions devoid of fu ...
Transgenic approaches for optogenetics Tim Murphy UBC.
... The Tet system provides control over the timing and location of gene expression using two transgenes: a tetracycline-dependent transcription factor (tTA or rtTA) that determines tissue specificity, and a responsive promoter (tetO) that expresses the transgene of interest. But what if you don’t have ...
... The Tet system provides control over the timing and location of gene expression using two transgenes: a tetracycline-dependent transcription factor (tTA or rtTA) that determines tissue specificity, and a responsive promoter (tetO) that expresses the transgene of interest. But what if you don’t have ...
- Stabilis Fitness
... production during exercise. It is important in the induction of mitochondrial biogenesis and also regulates several genes that encode mitochondrial proteins: these include cytochrome C and TFAM. NRF-2 also regulates heme biosynthesis. Polymorphism: The very rare G allele of the NRF-2 gene is associa ...
... production during exercise. It is important in the induction of mitochondrial biogenesis and also regulates several genes that encode mitochondrial proteins: these include cytochrome C and TFAM. NRF-2 also regulates heme biosynthesis. Polymorphism: The very rare G allele of the NRF-2 gene is associa ...
cg12 Expression Is Specifically Linked to Infection of
... symbiotic interaction with Frankia (Franche et al. 1998b; Laplaze et al. 2000a, 2002). In order to monitor the activity of the cg12 promoter during the early stages of Casuarina infection by Frankia, transcriptional fusions of the 5 upstream region with gus and gfp reporter genes were constructed. ...
... symbiotic interaction with Frankia (Franche et al. 1998b; Laplaze et al. 2000a, 2002). In order to monitor the activity of the cg12 promoter during the early stages of Casuarina infection by Frankia, transcriptional fusions of the 5 upstream region with gus and gfp reporter genes were constructed. ...
Distinct functions of two olfactory marker protein genes derived from
... acids and is specifically expressed in olfactory sensory neurons (OSNs), which are distributed in the main olfactory epithelium in various vertebrates [22–24]. Although OMP is used as a specific marker of mature OSNs in vertebrates [25–28], its function has not yet been fully elucidated. OMP-knockou ...
... acids and is specifically expressed in olfactory sensory neurons (OSNs), which are distributed in the main olfactory epithelium in various vertebrates [22–24]. Although OMP is used as a specific marker of mature OSNs in vertebrates [25–28], its function has not yet been fully elucidated. OMP-knockou ...
study
... complex modes of expression we used an additional analysis approach, which is more sensitive to such cases. This analysis uncovered 241 additional genes in nonmammary gland tissues that were clearly not detected in the first approach (see “Methods” and Additional file 10: Table S3, supplementary res ...
... complex modes of expression we used an additional analysis approach, which is more sensitive to such cases. This analysis uncovered 241 additional genes in nonmammary gland tissues that were clearly not detected in the first approach (see “Methods” and Additional file 10: Table S3, supplementary res ...
ficient mice: Distinct effects in Finnish variant late infantile NCL
... Thalamocortical neurodegeneration Lysosomal storage disorder ...
... Thalamocortical neurodegeneration Lysosomal storage disorder ...
Analyzing the Paper
... of both sexes (n = 4–14 per genotype per sex per status per drug) were either left intact or ovariectomized (OVX), via surgical removal (dorsal incision) of both ovaries under isoflurane/oxygen anesthesia. No testing occurred for at least 2 weeks after surgery. Some OVX mice were given chronic estro ...
... of both sexes (n = 4–14 per genotype per sex per status per drug) were either left intact or ovariectomized (OVX), via surgical removal (dorsal incision) of both ovaries under isoflurane/oxygen anesthesia. No testing occurred for at least 2 weeks after surgery. Some OVX mice were given chronic estro ...
Adaptation of Sucrose Metabolism in the Escherichia coli Wild
... addition to Salmonella enterica serovar Typhimurium LT2 revealed that the csc genes are located in a hot spot region for chromosomal rearrangements in enteric bacteria. The comparison further indicated that the csc genes might have been transferred relatively recently to the E. coli wild-type EC3132 ...
... addition to Salmonella enterica serovar Typhimurium LT2 revealed that the csc genes are located in a hot spot region for chromosomal rearrangements in enteric bacteria. The comparison further indicated that the csc genes might have been transferred relatively recently to the E. coli wild-type EC3132 ...
Environmental Microbiology
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
... mechanism of phase variation (van der Woude et al., 1996; Henderson et al., 1999). Methylation of GATC sites in the genome is dependent on deoxyadenosine methylase (dam), which binds to the GATC site and methylates adenosine at the N6 position (Palmer and Marinus, 1994). Normally, methylation provid ...
Widespread expression of the bovine Agouti gene results from at
... (exons 2, 3 and 4). A single 402 bp fragment was amplified from skin samples of each breed and different tissues (brain, heart, kidney, spleen, lung and liver). PCR fragments were purified and subjected to nucleotide sequence analysis to verify that they contain bovine Agouti coding sequences. These ...
... (exons 2, 3 and 4). A single 402 bp fragment was amplified from skin samples of each breed and different tissues (brain, heart, kidney, spleen, lung and liver). PCR fragments were purified and subjected to nucleotide sequence analysis to verify that they contain bovine Agouti coding sequences. These ...
Spike Timing-Dependent Plasticity: From Synapse to Perception
... (13) and midbrain slices (60). The NMDARs are largely blocked by Mg2⫹ at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional ...
... (13) and midbrain slices (60). The NMDARs are largely blocked by Mg2⫹ at hyperpolarized membrane potentials, but the block can be relieved by depolarization (69, 83), leading to the idea that the NMDAR serves as the coincidence detector for pre/post activity. For LTP and LTD induced by conventional ...
Introduction: - Statistical Science
... Figure SF1. This figure compares the empirical null and observed distributions in the Diabetes example for a randomly generated collection of 1000 gene sets (top) and the functional gene sets (S2 database) before and after normalization (i.e., area under positive and negative density distributions e ...
... Figure SF1. This figure compares the empirical null and observed distributions in the Diabetes example for a randomly generated collection of 1000 gene sets (top) and the functional gene sets (S2 database) before and after normalization (i.e., area under positive and negative density distributions e ...
Perception Spike Timing-Dependent Plasticity: From Synapse to
... described by a small number of parameters, and the dependence of synaptic modification on these parameters (e.g., pre/post spike interval) can be easily determined. For neural circuits in vivo, however, spiking in both preand postsynaptic cells is likely to be irregular (98), with occasional high-fr ...
... described by a small number of parameters, and the dependence of synaptic modification on these parameters (e.g., pre/post spike interval) can be easily determined. For neural circuits in vivo, however, spiking in both preand postsynaptic cells is likely to be irregular (98), with occasional high-fr ...
Linköping University Post Print S. aureus treatment plant
... The aim of this study was to determine if the mecA gene, S. aureus and MRSA could be detected in a municipal WWTP, using molecular methods. Furthermore, the study investigated the effects of the wastewater treatment process on mecA gene concentrations and the prevalence of S. aureus and MRSA over ti ...
... The aim of this study was to determine if the mecA gene, S. aureus and MRSA could be detected in a municipal WWTP, using molecular methods. Furthermore, the study investigated the effects of the wastewater treatment process on mecA gene concentrations and the prevalence of S. aureus and MRSA over ti ...
hippocampo–cerebellar theta band phase synchrony in rabbits
... and Wikgren, 2009; Seager et al., 2002). Moreover, blocking hippocampal theta oscillation with, for example, scopolamine injections before eyeblink conditioning retards behavioral learning and virtually abolishes any learningrelated unit responses in the hippocampus (Salvatierra and Berry, 1989). Pr ...
... and Wikgren, 2009; Seager et al., 2002). Moreover, blocking hippocampal theta oscillation with, for example, scopolamine injections before eyeblink conditioning retards behavioral learning and virtually abolishes any learningrelated unit responses in the hippocampus (Salvatierra and Berry, 1989). Pr ...
Athymic Nude Mice
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
... of CD4+ and CD8+ T-cell(s) associated with bright CD3 expression increases with age, at no age are significant numbers of CD4+8+ cells observed, in contrast to intrathymic T-cell maturation. In addition to the frequently observed inversion in the ratio of CD4 to CD8, the CD8 T-cell subpopulation in ...
Leukaemia Section MLL amplification in leukemia Atlas of Genetics and Cytogenetics
... result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the MLL flanking region have been also amplified. FISH and other molecular techniques have identified genes at 11q such as DDX6, GAB2, ETS1, F ...
... result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the MLL flanking region have been also amplified. FISH and other molecular techniques have identified genes at 11q such as DDX6, GAB2, ETS1, F ...
hindlimb - bthsresearch
... • In this way we can express genes ectopically in chick tissue – Like a gain of function mutation in a mouse, but limited to a specific cell population ...
... • In this way we can express genes ectopically in chick tissue – Like a gain of function mutation in a mouse, but limited to a specific cell population ...
A gene complex controlling segmentation in Drosophila
... hemizygotes, suggesting that BX-C genes control mesodermal as well as ectodermal tissues. Gonadal examination of Uab 4 genotypes was prompted by the report of gonadal defects in homozygotes for certain Uab-like mutants of the homologous 'E-Iocus' complex of Bombyx (see review by Tazima 12). Segment ...
... hemizygotes, suggesting that BX-C genes control mesodermal as well as ectodermal tissues. Gonadal examination of Uab 4 genotypes was prompted by the report of gonadal defects in homozygotes for certain Uab-like mutants of the homologous 'E-Iocus' complex of Bombyx (see review by Tazima 12). Segment ...
Dynamic Model of Paclitaxel Biosynthesis Suggests That the Key
... microenvironment disturbance in the early vaccination. And then the expression decreased slightly and the lowest decrease in transcriptional level was observed on day 8 or day 12. The gene expression went up sharply after day 12 when nutrients have been depleted. (Figure 1) ...
... microenvironment disturbance in the early vaccination. And then the expression decreased slightly and the lowest decrease in transcriptional level was observed on day 8 or day 12. The gene expression went up sharply after day 12 when nutrients have been depleted. (Figure 1) ...