comparing quantitative trait loci and gene expression data
... The major advantage of a dual approach is that it can identify genes of interest with higher reliability in order to focus further work, which is laborious and expensive. However, comparing QTL and microarray data is not completely straightforward. First, the estimated range of QTL positions is gene ...
... The major advantage of a dual approach is that it can identify genes of interest with higher reliability in order to focus further work, which is laborious and expensive. However, comparing QTL and microarray data is not completely straightforward. First, the estimated range of QTL positions is gene ...
GENE EXPRESSION
... repressor will have to be removed from the operator.The repressor is an allosteric protein; when it binds with one particular molecule, it changes the shape of the protein, which changes its ability to react with a second particular molecule. Here the first molecule is the inducer allolactose and the ...
... repressor will have to be removed from the operator.The repressor is an allosteric protein; when it binds with one particular molecule, it changes the shape of the protein, which changes its ability to react with a second particular molecule. Here the first molecule is the inducer allolactose and the ...
Effects of Repeated Administration of 3,4
... In accordance to our study, Cho et al. (2007) found that oral treatment with MDMA (1.25, 5, 20, 40 mg/kg) or saline for 30 days, dose dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Their results suggest that chronic exposure to MDMA suppress ...
... In accordance to our study, Cho et al. (2007) found that oral treatment with MDMA (1.25, 5, 20, 40 mg/kg) or saline for 30 days, dose dependently induced a decrease in the number of BrdU-positive cells in the male and female dentate gyrus. Their results suggest that chronic exposure to MDMA suppress ...
Chapter 12 Recombinant DNA Technology Key Concepts
... its DNA sequence examined directly. Indeed, it seemed impossible to isolate an individual gene from the genome. Although it is relatively easy to isolate DNA from living tissue, DNA in a test tube looks like a glob of mucus. How could it be possible to isolate a single gene from this tangled mass o ...
... its DNA sequence examined directly. Indeed, it seemed impossible to isolate an individual gene from the genome. Although it is relatively easy to isolate DNA from living tissue, DNA in a test tube looks like a glob of mucus. How could it be possible to isolate a single gene from this tangled mass o ...
Figures and figure supplements
... Figure 2—figure supplement 4. ChIP-seq profiles of H3K4me3 and total histone H3 across high-variance and low-variance genes. (A) Developmental expression profile, from early cleavage to adult, of the highly expressed high-variance genes (n = 1066). Expression levels were measured by CEL-seq and resc ...
... Figure 2—figure supplement 4. ChIP-seq profiles of H3K4me3 and total histone H3 across high-variance and low-variance genes. (A) Developmental expression profile, from early cleavage to adult, of the highly expressed high-variance genes (n = 1066). Expression levels were measured by CEL-seq and resc ...
Regulation of Stage I1 of Sporulation in Bacillus subtilis
... spore formation and on the occurrence of biochemical marker events linked to stage 11. Since then, the nature of some of these mutations has been determined by sequencing experiments (Yudkin, 1987) and shown to be either missense or nonsense. This made it possible to attempt to make a more rational ...
... spore formation and on the occurrence of biochemical marker events linked to stage 11. Since then, the nature of some of these mutations has been determined by sequencing experiments (Yudkin, 1987) and shown to be either missense or nonsense. This made it possible to attempt to make a more rational ...
Regulation of Stage I1 of Sporulation in Bacillus subtilis
... spore formation and on the occurrence of biochemical marker events linked to stage 11. Since then, the nature of some of these mutations has been determined by sequencing experiments (Yudkin, 1987) and shown to be either missense or nonsense. This made it possible to attempt to make a more rational ...
... spore formation and on the occurrence of biochemical marker events linked to stage 11. Since then, the nature of some of these mutations has been determined by sequencing experiments (Yudkin, 1987) and shown to be either missense or nonsense. This made it possible to attempt to make a more rational ...
File - interACT - American College of Toxicology
... Zhejiang University in Hangzhou, China, and received her Ph.D. Degree with honors in University of Kansas Medical Center. Julia currently is an Assistant Professor in Toxicology in the Department of Environmental and Occupational Health Sciences. She is a recipient of the Sheldon D. Murphy Endowed C ...
... Zhejiang University in Hangzhou, China, and received her Ph.D. Degree with honors in University of Kansas Medical Center. Julia currently is an Assistant Professor in Toxicology in the Department of Environmental and Occupational Health Sciences. She is a recipient of the Sheldon D. Murphy Endowed C ...
PDF
... formed as an extension of the ASM (supplementary material Movie 1). Thus, the absence of the BWM in Ci-Hox1-deficient juveniles is likely to be due to disruption of ASM formation, and a primary function of Ci-Hox1 is ASM formation. Because ASM and heart muscle originate from the same blastomeres (Hi ...
... formed as an extension of the ASM (supplementary material Movie 1). Thus, the absence of the BWM in Ci-Hox1-deficient juveniles is likely to be due to disruption of ASM formation, and a primary function of Ci-Hox1 is ASM formation. Because ASM and heart muscle originate from the same blastomeres (Hi ...
Seed-Specific Gene Activation Mediated by the Cre//ox Site
... constructed as follows (Fig. 1B). Before adding ihe Iox2 fragment to each promoter, the NcoI site at the 3’ end of each promoter was deleted so that there would be no translationinitiatirig ATG 5’ to the first lox site. Plasmids containing each promoter were digested with NcoI, treated with S1 nucle ...
... constructed as follows (Fig. 1B). Before adding ihe Iox2 fragment to each promoter, the NcoI site at the 3’ end of each promoter was deleted so that there would be no translationinitiatirig ATG 5’ to the first lox site. Plasmids containing each promoter were digested with NcoI, treated with S1 nucle ...
Expression of the six chromate ion transporter
... The chromate ion transporter (CHR) superfamily comprises transporters that confer chromate resistance by extruding toxic chromate ions from cytoplasm. Burkholderia xenovorans strain LB400 has been reported to encode six CHR homologues in its multireplicon genome. We found that strain LB400 displays ...
... The chromate ion transporter (CHR) superfamily comprises transporters that confer chromate resistance by extruding toxic chromate ions from cytoplasm. Burkholderia xenovorans strain LB400 has been reported to encode six CHR homologues in its multireplicon genome. We found that strain LB400 displays ...
Deletion of a conserved noncoding sequence in Plzf intron leads to
... Polydactyly can be classified according to the position of the supernumerary digits as preaxial or postaxial. Preaxial polydactyly, where the supernumerary digits arise at the anterior margin of the autopod, can be further subdivided according to its dependence on ectopic expression of Sonic hedgehog ...
... Polydactyly can be classified according to the position of the supernumerary digits as preaxial or postaxial. Preaxial polydactyly, where the supernumerary digits arise at the anterior margin of the autopod, can be further subdivided according to its dependence on ectopic expression of Sonic hedgehog ...
Acetylcholine Facilitates Recovery of Episodic Memory after Brain
... of cognitive processes, including episodic memory, which is impaired in Alzheimer’s disease, in which there is a decrease in acetylcholine innervation (for review, see Bartus, 2000). However, systemic administration of acetylcholinesterase inhibitors produces only small acute improvements in memory ...
... of cognitive processes, including episodic memory, which is impaired in Alzheimer’s disease, in which there is a decrease in acetylcholine innervation (for review, see Bartus, 2000). However, systemic administration of acetylcholinesterase inhibitors produces only small acute improvements in memory ...
Structural basis for the inhibition of human alkyladenine Please share
... stable abortive complexes between AAG and damaged DNA. The ⑀C-AAG abortive complex has been shown to inhibit AAG glycosylase activity in vivo in human cells and to result in replication blockage (14), increasing the genotoxicity of ⑀C lesions in vivo. In tissues undergoing chronic inflammation, whic ...
... stable abortive complexes between AAG and damaged DNA. The ⑀C-AAG abortive complex has been shown to inhibit AAG glycosylase activity in vivo in human cells and to result in replication blockage (14), increasing the genotoxicity of ⑀C lesions in vivo. In tissues undergoing chronic inflammation, whic ...
Molecular and morphological analyses of basal forebrain
... The axis of patterning in the rostrobasal telencephalon gives rise to subpallial proliferative zones of the medial ganglionic eminence (MGE), lateral ganglionic eminence (LGE) and the preoptic area (POA) which contribute to nearly all forebrain structures such as the cortex, striatum, hippocampus, ...
... The axis of patterning in the rostrobasal telencephalon gives rise to subpallial proliferative zones of the medial ganglionic eminence (MGE), lateral ganglionic eminence (LGE) and the preoptic area (POA) which contribute to nearly all forebrain structures such as the cortex, striatum, hippocampus, ...
Chapter 21
... Each family of transposons in maize has both autonomous and nonautonomous controlling elements. Autonomous controlling elements code for proteins that enable them to transpose. Nonautonomous controlling elements have mutations that eliminate their capacity to catalyze transposition, but they can tra ...
... Each family of transposons in maize has both autonomous and nonautonomous controlling elements. Autonomous controlling elements code for proteins that enable them to transpose. Nonautonomous controlling elements have mutations that eliminate their capacity to catalyze transposition, but they can tra ...
D2 receptor overexpression in the striatum leads to a deficit in
... type of DA receptors are involved in the change in sensitivity of DA to synaptic transmission in layer V pyramidal neurons in striatal D2R-OE mice, we tested the effects of the D1/D5 agonist SKF-81297 on the evoked IPSC and EPSC trains in both transgenic and control mice. SKF-81297 is a highly D1-se ...
... type of DA receptors are involved in the change in sensitivity of DA to synaptic transmission in layer V pyramidal neurons in striatal D2R-OE mice, we tested the effects of the D1/D5 agonist SKF-81297 on the evoked IPSC and EPSC trains in both transgenic and control mice. SKF-81297 is a highly D1-se ...
Functional Analysis of Genes Implicated in Down Syndrome: 2
... wrote with their left hand; (2) if they used their left hand more frequently for the majority of the six primary handedness items in Annett’s questionnaire; or (3) if they used their left hand more frequently in the majority of an extended 11-item handedness questionnaire. In 4.68% of cases, partici ...
... wrote with their left hand; (2) if they used their left hand more frequently for the majority of the six primary handedness items in Annett’s questionnaire; or (3) if they used their left hand more frequently in the majority of an extended 11-item handedness questionnaire. In 4.68% of cases, partici ...
Robust Prediction of Expression Differences among Human
... sequence variation, the robust nature of the predictions means that the identity and quantitative degree to which genes can be predicted is known in advance. We also present an extension that incorporates heterogeneous types of genomic annotations to differentially weigh the importance of the variou ...
... sequence variation, the robust nature of the predictions means that the identity and quantitative degree to which genes can be predicted is known in advance. We also present an extension that incorporates heterogeneous types of genomic annotations to differentially weigh the importance of the variou ...
Title Modulation of Conditioned Fear, Fear
... Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA A receptor agonist, muscimol, on the expression of con ...
... Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA administration of the GABA A receptor agonist, muscimol, on the expression of con ...
166 - UCSF Physiology - University of California, San Francisco
... et al., 2003). More recent studies have also directly implicated the 1 integrins in hippocampal LTP (Chan et al., 2006; Kramar et al., 2006). In addition, studies in neuronal cultures have shown that the integrins may be involved in mediating the enhancement of excitatory synaptogenesis by astrocyt ...
... et al., 2003). More recent studies have also directly implicated the 1 integrins in hippocampal LTP (Chan et al., 2006; Kramar et al., 2006). In addition, studies in neuronal cultures have shown that the integrins may be involved in mediating the enhancement of excitatory synaptogenesis by astrocyt ...
Strategies for the molecular genetic manipulation and visualization of the... Penicillium marneffei
... To facilitate molecular genetic analysis of gene function in P. marneffei, an important opportunistic pathogen of humans, an efficient DNA-mediated transformation protocol was developed using exogenous DNA and polyethylene glycol-mediated protoplast fusion (Borneman et al. 2001). Spontaneous mutants ...
... To facilitate molecular genetic analysis of gene function in P. marneffei, an important opportunistic pathogen of humans, an efficient DNA-mediated transformation protocol was developed using exogenous DNA and polyethylene glycol-mediated protoplast fusion (Borneman et al. 2001). Spontaneous mutants ...
Sequence of the Tribolium castaneum Homeotic Complex
... Sequence analysis: The previously identified cDNAs were mapped on the BAC sequences by comparing cDNA and genomic sequence. The following GenBank accession numbers correspond to the cDNA sequences used: Tclab, AF231104 and AF230312; mxp, AF187068 and AF187069; Tczen1, X97819; Tczen2, AF452568; TcDfd ...
... Sequence analysis: The previously identified cDNAs were mapped on the BAC sequences by comparing cDNA and genomic sequence. The following GenBank accession numbers correspond to the cDNA sequences used: Tclab, AF231104 and AF230312; mxp, AF187068 and AF187069; Tczen1, X97819; Tczen2, AF452568; TcDfd ...
Inan et al., 2006
... the development and plasticity of thalamocortical afferent clustering into a barrel pattern. We localize PKARII function to postsynaptic processes in barrel cortex and show that postsynaptic PKA targets, but not presynaptic PKA targets, have decreased phosphorylation in pkar2b knock-out (PKARII⫺/⫺ ...
... the development and plasticity of thalamocortical afferent clustering into a barrel pattern. We localize PKARII function to postsynaptic processes in barrel cortex and show that postsynaptic PKA targets, but not presynaptic PKA targets, have decreased phosphorylation in pkar2b knock-out (PKARII⫺/⫺ ...
Functional anatomy of neural circuits regulating fear and extinction
... population of active cells and PSD-95:Venus localized to synaptodendritic compartment (Figs. 1 and 2). mRNA and proteins encoded by immediate early genes such as c-Fos, Arc, or Homer are widely used as markers of neuronal activation in behavioral studies including studies on fear (16). However, they ...
... population of active cells and PSD-95:Venus localized to synaptodendritic compartment (Figs. 1 and 2). mRNA and proteins encoded by immediate early genes such as c-Fos, Arc, or Homer are widely used as markers of neuronal activation in behavioral studies including studies on fear (16). However, they ...