TEV_v7_BY
... We first predicted 103,798 TEVs (28,951 SINEs, 40,074 LINEs and 34,773 ERVs) among the 17 mouse strains, an order of magnitude higher than previous studies 14,16. We employed two approaches to TEV discovery, SVMerge which combines the results of four methods of structural variation prediction 17, an ...
... We first predicted 103,798 TEVs (28,951 SINEs, 40,074 LINEs and 34,773 ERVs) among the 17 mouse strains, an order of magnitude higher than previous studies 14,16. We employed two approaches to TEV discovery, SVMerge which combines the results of four methods of structural variation prediction 17, an ...
supporting information
... DR2 and D4 MS T-cells [13], one of the H-2d strains, BALB/cPt, is also moderately susceptible to EAE induced by PLP 40-59 [14]; The PLP103-150 contains epitopes that are more frequently recognized in MS [15,16] and shown to be associated with HLA-DRB1*1101 [17] as well as with DR2 [15,16], and two e ...
... DR2 and D4 MS T-cells [13], one of the H-2d strains, BALB/cPt, is also moderately susceptible to EAE induced by PLP 40-59 [14]; The PLP103-150 contains epitopes that are more frequently recognized in MS [15,16] and shown to be associated with HLA-DRB1*1101 [17] as well as with DR2 [15,16], and two e ...
Current Microbiology
... Abstract. The bidirectional, NAD1-dependent hydrogenase from cyanobacteria is encoded by the structural genes hoxFUYH, which have been found to be clustered, though interspersed with different open reading frames (ORFs), in the heterocystous, N2-fixing Anabaena variabilis and in the unicellular Syne ...
... Abstract. The bidirectional, NAD1-dependent hydrogenase from cyanobacteria is encoded by the structural genes hoxFUYH, which have been found to be clustered, though interspersed with different open reading frames (ORFs), in the heterocystous, N2-fixing Anabaena variabilis and in the unicellular Syne ...
The Journal of Neuroscience http://jneurosci.msubmit.net Ana
... showed a similar CA3 apical dendritic remodeling in response to 3 weeks of CRS to that previously described for rats. Haploinsufficient BDNF mice (BDNF+/-) did not show such remodeling, but, even without CRS, they presented shorter and simplified CA3 apical dendritic arbors, like those observed in s ...
... showed a similar CA3 apical dendritic remodeling in response to 3 weeks of CRS to that previously described for rats. Haploinsufficient BDNF mice (BDNF+/-) did not show such remodeling, but, even without CRS, they presented shorter and simplified CA3 apical dendritic arbors, like those observed in s ...
Synaptic plasticity: taming the beast
... which neurons become selective to the linear combination of their inputs with the maximum variance. This is, in some sense, the most interesting and informative combination of inputs to which the neuron can become responsive. Activity manipulations scale both AMPA- and NMDA-receptormediated forms of ...
... which neurons become selective to the linear combination of their inputs with the maximum variance. This is, in some sense, the most interesting and informative combination of inputs to which the neuron can become responsive. Activity manipulations scale both AMPA- and NMDA-receptormediated forms of ...
fragile x dna testing: a guide for physicians and families
... There are two separate approaches to fragile X DNA testing, Southern blot analysis and PCR analysis, described below. They have different advantages. Southern blot analysis is the method of choice for identifying full mutations and large premutations and determining if the gene is methylated while P ...
... There are two separate approaches to fragile X DNA testing, Southern blot analysis and PCR analysis, described below. They have different advantages. Southern blot analysis is the method of choice for identifying full mutations and large premutations and determining if the gene is methylated while P ...
Review Article
... infection; then they will need to obtain nutrients and to multiply while at the same time evading the host defence mechanisms. In some instances, they may need to invade host cells for survival or further dissemination within the host (Finlay & Falkow, 1989). The recognition that bacterial pathogeni ...
... infection; then they will need to obtain nutrients and to multiply while at the same time evading the host defence mechanisms. In some instances, they may need to invade host cells for survival or further dissemination within the host (Finlay & Falkow, 1989). The recognition that bacterial pathogeni ...
The importance of having two X chromosomes - Neuroscience
... by eight months after GDX. This demonstrates that two X chromosomes are associated with enhanced body weight, a finding that could never be determined by comparing ...
... by eight months after GDX. This demonstrates that two X chromosomes are associated with enhanced body weight, a finding that could never be determined by comparing ...
The Tel-PDGFRß fusion gene produces a chronic
... with the transmembrane and tyrosine kinase domains of platelet-derived growth factor receptor  (PDGFR) gene. To investigate the role of this fusion protein in the pathogenesis of CMML, we expressed the Tel-PDGFR fusion cDNA in hematopoietic cells of transgenic mice under the control of the human ...
... with the transmembrane and tyrosine kinase domains of platelet-derived growth factor receptor  (PDGFR) gene. To investigate the role of this fusion protein in the pathogenesis of CMML, we expressed the Tel-PDGFR fusion cDNA in hematopoietic cells of transgenic mice under the control of the human ...
Population Differences in Transcript
... To search for eQTLs that are tied to genes which are coregulated in a given population, a multivariate linear regression was used to model the gene expression of the DSTs of TRs as response variables and the genotypes of SNPs as the predictor variables. The analysis was restricted to i) the 333 TRs ...
... To search for eQTLs that are tied to genes which are coregulated in a given population, a multivariate linear regression was used to model the gene expression of the DSTs of TRs as response variables and the genotypes of SNPs as the predictor variables. The analysis was restricted to i) the 333 TRs ...
J Darnell, KH2 domain I304N RGG G
... Sensory to L7 motor neuron “plastic” synapse Neuron need not be present for synaptogenesis Synaptogenesis is anisomycin sensitive 80-100 mRNAs transported to neuritic region Sensorin—Orphan peptide Expressed in sensory neuron, not in L7 Translational regulation, not dependent on transcription Specif ...
... Sensory to L7 motor neuron “plastic” synapse Neuron need not be present for synaptogenesis Synaptogenesis is anisomycin sensitive 80-100 mRNAs transported to neuritic region Sensorin—Orphan peptide Expressed in sensory neuron, not in L7 Translational regulation, not dependent on transcription Specif ...
Pitx1 and Pitx2 are required for development of hindlimb buds
... knockout embryos that lack ilium, this attachment is through the acetabulum, and in some embryos it is displaced posteriorly to S2 or S3. In a few cases, this posterior displacement was asymmetrical, with greater displacement on the right than left side (Fig. 1D). Taken together, these observations ...
... knockout embryos that lack ilium, this attachment is through the acetabulum, and in some embryos it is displaced posteriorly to S2 or S3. In a few cases, this posterior displacement was asymmetrical, with greater displacement on the right than left side (Fig. 1D). Taken together, these observations ...
Characterization of MeCP2e1 Transgenic Mice
... known to be involved in gene transcription and expression, abnormal epigenetic regulation is thought to be the underlying cause of RTT pathogenesis (1). MeCP2 is a DNA-binding protein that preferentially binds methylated CpG dinucleotide regions of DNA (4, 5). In vitro studies have lent substantial ...
... known to be involved in gene transcription and expression, abnormal epigenetic regulation is thought to be the underlying cause of RTT pathogenesis (1). MeCP2 is a DNA-binding protein that preferentially binds methylated CpG dinucleotide regions of DNA (4, 5). In vitro studies have lent substantial ...
The Arabidopsis RAD51 paralogs RAD51B, RAD51D and XRCC2
... DNA fragments in comet tails (% tail-DNA) were used to estimate the extent of DNA damage. RNA extraction and real-time PCR Three-week-old young plants grown without or with DNA damaging agent at a concentration of 23.5 lg ml 1 (in the same manner as for the phenotypic analyses) were collected and qu ...
... DNA fragments in comet tails (% tail-DNA) were used to estimate the extent of DNA damage. RNA extraction and real-time PCR Three-week-old young plants grown without or with DNA damaging agent at a concentration of 23.5 lg ml 1 (in the same manner as for the phenotypic analyses) were collected and qu ...
Muscle hypertrophy induced by myostatin inhibition
... improvement in histopathology but ultimately exacerbates muscle degeneration; this effect was not observed in dystrophindeficient (mdx) mice, suggesting that accelerated degeneration induced by follistatin transgene expression is specific to mice lacking dysferlin. Dysf−/− mice injected with ACVR2B/Fc ...
... improvement in histopathology but ultimately exacerbates muscle degeneration; this effect was not observed in dystrophindeficient (mdx) mice, suggesting that accelerated degeneration induced by follistatin transgene expression is specific to mice lacking dysferlin. Dysf−/− mice injected with ACVR2B/Fc ...
Rapid Selection of Multiple Gene Integrant for the Production of
... ber of G418 resistance gene copies in the chromosome. But homologous recombination into MOX locus could not support such multiple integration. The multiple integration of a transforming vector was completely dependent on the function of telomeric ARS used in the vector. Therefore, a vector containin ...
... ber of G418 resistance gene copies in the chromosome. But homologous recombination into MOX locus could not support such multiple integration. The multiple integration of a transforming vector was completely dependent on the function of telomeric ARS used in the vector. Therefore, a vector containin ...
Gene Section MLL (myeloid/lymphoid or
... t(X;11)(q13;q23)/ANLL, T-ALL --> MLL/AFX1 t(X;11)(q22;q23)/ANLL --> MLL/Septin2 t(1;11)(p32;q23)/ALL --> MLL/AF1p t(1;11)(q21;q23)/ANLL --> MLL/AF1q t(2;11)(q11;q23)/MDS --> MLL/LAF4 t(3;11)(p21;q23)/t-ANLL --> MLL/AF3p21 t(3;11)(q25;q23)/t-ANLL --> MLL/GMPS ins(5;11)(q31;q13q23)/ALL --> MLL/AF5q31 ...
... t(X;11)(q13;q23)/ANLL, T-ALL --> MLL/AFX1 t(X;11)(q22;q23)/ANLL --> MLL/Septin2 t(1;11)(p32;q23)/ALL --> MLL/AF1p t(1;11)(q21;q23)/ANLL --> MLL/AF1q t(2;11)(q11;q23)/MDS --> MLL/LAF4 t(3;11)(p21;q23)/t-ANLL --> MLL/AF3p21 t(3;11)(q25;q23)/t-ANLL --> MLL/GMPS ins(5;11)(q31;q13q23)/ALL --> MLL/AF5q31 ...
Novel Regulation of Cardiac Metabolism and Homeostasis by the
... heart from embryo to adulthood, their analysis has been limited by the embryonic lethality of AM−/− and RAMP2−/−. For this study, we generated inducible cardiac myocyte-specific RAMP2−/− (C-RAMP2−/−). C-RAMP2−/− exhibited dilated cardiomyopathy-like heart failure with cardiac dilatation and myofibri ...
... heart from embryo to adulthood, their analysis has been limited by the embryonic lethality of AM−/− and RAMP2−/−. For this study, we generated inducible cardiac myocyte-specific RAMP2−/− (C-RAMP2−/−). C-RAMP2−/− exhibited dilated cardiomyopathy-like heart failure with cardiac dilatation and myofibri ...
Forebrain glutamatergic neurons mediate leptin action on
... studies have found an association between low levels of leptin and major depressive disorders.25–27 Of note, a recent study by Lawson et al.28 reported an inverse correlation between leptin levels and the severity of depression symptoms. These correlational studies suggest that leptin signaling may ...
... studies have found an association between low levels of leptin and major depressive disorders.25–27 Of note, a recent study by Lawson et al.28 reported an inverse correlation between leptin levels and the severity of depression symptoms. These correlational studies suggest that leptin signaling may ...
Divergent Evolutionary and Expression Patterns between Lineage
... To identify A. thaliana specific new genes, we selected new genes based on two criteria: first, the gene was not located in any of the syntenic regions between A. thaliana and the rest of three species A. lyrata, C. rubella, B. rapa; second, the gene did not have any reciprocal ortholog in A. lyrata ...
... To identify A. thaliana specific new genes, we selected new genes based on two criteria: first, the gene was not located in any of the syntenic regions between A. thaliana and the rest of three species A. lyrata, C. rubella, B. rapa; second, the gene did not have any reciprocal ortholog in A. lyrata ...
Lab #2
... 2. Tests for significance of difference in means of two distribution but does not test for other differences between distributions. Module 2: Analyzing Gene Lists ...
... 2. Tests for significance of difference in means of two distribution but does not test for other differences between distributions. Module 2: Analyzing Gene Lists ...
The Roles of the Amygdala and the Hippocampus in Fear
... Although most research has examined the processes of the amygdala, considerable evidence has been obtained which indicates that the hippocampus is crucial for the development of emotionally significant fear conditioning in relation to contextual information (Phelps, 2004; Bouton & Moody, 2004; Hobin ...
... Although most research has examined the processes of the amygdala, considerable evidence has been obtained which indicates that the hippocampus is crucial for the development of emotionally significant fear conditioning in relation to contextual information (Phelps, 2004; Bouton & Moody, 2004; Hobin ...
Probing the evolution of appendage specialization by
... low levels of PhUbx-I or PhUbx-II upon heat shock resulted in homeotic transformations toward thoracic identities, including ectopic coxal and tergal plates in the head and antennal-to-leg and Mx2-to-Mxp transformations (Fig. 3E). However, misexpression in transgenic lines that express near wild-typ ...
... low levels of PhUbx-I or PhUbx-II upon heat shock resulted in homeotic transformations toward thoracic identities, including ectopic coxal and tergal plates in the head and antennal-to-leg and Mx2-to-Mxp transformations (Fig. 3E). However, misexpression in transgenic lines that express near wild-typ ...
Real-time Quantification of HER2/neu Gene Amplification by
... throughput that is able to deal with formalin-fixed archieved material, PCR might be the best choice. The PCR approaches published so far have used reference genes which are not localized on chromosome 17. Therefore it is not possible to distinguish whether a small region of the chromosome or the wh ...
... throughput that is able to deal with formalin-fixed archieved material, PCR might be the best choice. The PCR approaches published so far have used reference genes which are not localized on chromosome 17. Therefore it is not possible to distinguish whether a small region of the chromosome or the wh ...
Notch activity induces Nodal expression and mediates the
... 3H). Taken together, our results show that there are two conserved RBPjk recognition sites in the Nodal promoter, and that both sites are required for perinodal expression of Nodal in the mouse embryo. One of the earliest determinants of LR establishment in the chick embryo is the left-sided express ...
... 3H). Taken together, our results show that there are two conserved RBPjk recognition sites in the Nodal promoter, and that both sites are required for perinodal expression of Nodal in the mouse embryo. One of the earliest determinants of LR establishment in the chick embryo is the left-sided express ...