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Neural and cognitive mechanisms underlying human
... & Eichenbaum, 2002) memories.2 The constellation of deficits found in these studies effectively demonstrates that the hippocampus is involved in binding the diverse aspects of an event over time to create a coherent memory trace. In contrast, damage to the underlying MTL cortical regions is more oft ...
... & Eichenbaum, 2002) memories.2 The constellation of deficits found in these studies effectively demonstrates that the hippocampus is involved in binding the diverse aspects of an event over time to create a coherent memory trace. In contrast, damage to the underlying MTL cortical regions is more oft ...
RNA-guided gene drives can efficiently bias inheritance in wild yeast
... normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whether ADE2 disruptions in red diploids were the result of successful copying of the drive element via HR, we sequenced the 72 haploids derived from dissected cas9+ diploids. All sequenced colonies contain ...
... normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whether ADE2 disruptions in red diploids were the result of successful copying of the drive element via HR, we sequenced the 72 haploids derived from dissected cas9+ diploids. All sequenced colonies contain ...
RNA-guided gene drives can efficiently bias inheritance in wild yeast
... normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whether ADE2 disruptions in red diploids were the result of successful copying of the drive element via HR, we sequenced the 72 haploids derived from dissected cas9+ diploids. All sequenced colonies contain ...
... normal inheritance of the inactivated drive and the wild-type alleles (Fig. 2D). To determine whether ADE2 disruptions in red diploids were the result of successful copying of the drive element via HR, we sequenced the 72 haploids derived from dissected cas9+ diploids. All sequenced colonies contain ...
Marine integrons containing novel integrase genes
... In order to understand the structure and biological significance of integrons and associated gene cassettes in marine polluted sediments, metagenomic DNAs were extracted from sites at Suez and Tokyo Bays. PCR amplicons containing new integrase genes, intI, linked with novel gene cassettes, were reco ...
... In order to understand the structure and biological significance of integrons and associated gene cassettes in marine polluted sediments, metagenomic DNAs were extracted from sites at Suez and Tokyo Bays. PCR amplicons containing new integrase genes, intI, linked with novel gene cassettes, were reco ...
Analysis of acid-induced asr gene promoter of Enterobacteriaceae
... Deletion analysis of asr promoter region upstream the proposed pho box. In order to identify potential cis-regulatory sites in the asr promoter, deletion analysis of the DNA region upstream the –40 position was performed. The consecutive promoter deletions (p∆70, p∆37, p∆20, p∆21, p∆10, p∆4, p∆1 in ...
... Deletion analysis of asr promoter region upstream the proposed pho box. In order to identify potential cis-regulatory sites in the asr promoter, deletion analysis of the DNA region upstream the –40 position was performed. The consecutive promoter deletions (p∆70, p∆37, p∆20, p∆21, p∆10, p∆4, p∆1 in ...
Article Selection Is No More Efficient in Haploid than in Diploid Life
... Faster evolutionary rates (higher dN/dS) in the haploid phase may be either caused by rapid fixation of beneficial mutations or by reduced selective constraints. To distinguish between these two competing hypotheses, we first conducted a direct test using genome-wide polymorphism data available for ...
... Faster evolutionary rates (higher dN/dS) in the haploid phase may be either caused by rapid fixation of beneficial mutations or by reduced selective constraints. To distinguish between these two competing hypotheses, we first conducted a direct test using genome-wide polymorphism data available for ...
Mice 2 NZW)F Genetic Complementation in Female (BXSB ×
... for disease acceleration (16, 17), and double bone marrow chimera experiments using mixtures of Yaa⫹ and Yaa⫺ cells demonstrated selective production of anti-DNA and hypergammaglobulinemia by Yaa⫹ B cells (18). The Ab promoting effect of the Yaa gene was observed not only for self Ags, but also for ...
... for disease acceleration (16, 17), and double bone marrow chimera experiments using mixtures of Yaa⫹ and Yaa⫺ cells demonstrated selective production of anti-DNA and hypergammaglobulinemia by Yaa⫹ B cells (18). The Ab promoting effect of the Yaa gene was observed not only for self Ags, but also for ...
Multiple genetic loci modify risk for retinoblastoma in
... plO7~/~;Rbl+/~ show retinal dysplasia, a potential precursor to retinoblastoma.25 In additional, inactivation of p53 may contribute to retinoblastoma formation in mice, because expression in the retina of the E7 oncogene from human papillomavirus (HPV) type 16 causes retinoblastoma only on a p53~/~ ...
... plO7~/~;Rbl+/~ show retinal dysplasia, a potential precursor to retinoblastoma.25 In additional, inactivation of p53 may contribute to retinoblastoma formation in mice, because expression in the retina of the E7 oncogene from human papillomavirus (HPV) type 16 causes retinoblastoma only on a p53~/~ ...
University of Groningen Methionine
... For RNA isolation the following procedure was performed: the pellet of the harvested cells was resuspended in 400 ml TE buffer (diethylpyrocarbonate) and the resuspended cells were added into RNA-free screw-cap tubes containing 0.5 g glass beads, 50 ml 10 % SDS, 500 ml phenol/chloroform: isoamylalco ...
... For RNA isolation the following procedure was performed: the pellet of the harvested cells was resuspended in 400 ml TE buffer (diethylpyrocarbonate) and the resuspended cells were added into RNA-free screw-cap tubes containing 0.5 g glass beads, 50 ml 10 % SDS, 500 ml phenol/chloroform: isoamylalco ...
- Lab Fabiana Perocchi
... Quantitative estimation of allele-specific expression Accurate estimation of allele-specific expression was achieved by using both specific and common probes, with the intensities of the latter reflecting the total expression of the two alleles (Figure 1B). One main challenge was accounting for off- ...
... Quantitative estimation of allele-specific expression Accurate estimation of allele-specific expression was achieved by using both specific and common probes, with the intensities of the latter reflecting the total expression of the two alleles (Figure 1B). One main challenge was accounting for off- ...
Gene Section ID4 (inhibitor of DNA binding 4, dominant negative helix-loop-helix protein)
... al., 2006). In another study, BRCA1, ER (estrogen receptor), and ID4 were found expressed in breast cancer specimens from patients with invasive carcinomas. Most of the patients who expressed BRCA1 also expressed ER, but were negative for ID4, and vice versa. BRCA1-ER and ID4 are linked in a negativ ...
... al., 2006). In another study, BRCA1, ER (estrogen receptor), and ID4 were found expressed in breast cancer specimens from patients with invasive carcinomas. Most of the patients who expressed BRCA1 also expressed ER, but were negative for ID4, and vice versa. BRCA1-ER and ID4 are linked in a negativ ...
Changing Fear: The Neurocircuitry of Emotion Regulation
... the fear conditioning circuitry has allowed researchers to investigate functional changes that occur during extinction. Research in rats using lesions, pharmacological manipulations, and electrophysiology are providing an increasingly detailed model of the neural circuitry of fear extinction. Recent ...
... the fear conditioning circuitry has allowed researchers to investigate functional changes that occur during extinction. Research in rats using lesions, pharmacological manipulations, and electrophysiology are providing an increasingly detailed model of the neural circuitry of fear extinction. Recent ...
Real time PCR based determination of gene copy numbers in
... Nevertheless, recent studies reported even higher expression rates when the target gene was under the control of deletion variants of the AOX1 promoter [3] or in some cases also with the constitutive glyceraldehyde-3-phosphate dehydrogenase promoter (PGAP) [4]. Depending on the target gene, high cop ...
... Nevertheless, recent studies reported even higher expression rates when the target gene was under the control of deletion variants of the AOX1 promoter [3] or in some cases also with the constitutive glyceraldehyde-3-phosphate dehydrogenase promoter (PGAP) [4]. Depending on the target gene, high cop ...
Inquiry into Life Twelfth Edition
... folds – Prevents formation of a hairpin – This is part of the transcription termination signal which causes attenuation ...
... folds – Prevents formation of a hairpin – This is part of the transcription termination signal which causes attenuation ...
Aus dem Max-Planck-Institut für Psychiatrie
... et al., 2001) up to the recent discussion of a possible role for chromatin organization (Berton and Nestler, 2006). However, by far the most robust and well-studied somatic changes in depression are changes in HPA hormone secretion. Morphologically, an increase in adrenal volume as measured by compu ...
... et al., 2001) up to the recent discussion of a possible role for chromatin organization (Berton and Nestler, 2006). However, by far the most robust and well-studied somatic changes in depression are changes in HPA hormone secretion. Morphologically, an increase in adrenal volume as measured by compu ...
A conserved blueprint for the eye? - treisman lab
... contains a DNA-binding homeodomain and Eya a transcriptional activation domain, and the phenotypes of loss of either gene from the eye appear identical, an attractive hypothesis is that Eya and So are two subunits of a single transcription factor.(12) Similarly, Dac also interacts with Eya in vitro. ...
... contains a DNA-binding homeodomain and Eya a transcriptional activation domain, and the phenotypes of loss of either gene from the eye appear identical, an attractive hypothesis is that Eya and So are two subunits of a single transcription factor.(12) Similarly, Dac also interacts with Eya in vitro. ...
An In Silico Investigation Into the Discovery of Novel Cis
... PAX genes based not only on sequence but on genomic organization. Genes within a given class have intron/exon boundaries and encoding regions in common. Pax3 and Pax7 are closely related paired box family members expressed during early neural and myogenic development and have been implicated in the ...
... PAX genes based not only on sequence but on genomic organization. Genes within a given class have intron/exon boundaries and encoding regions in common. Pax3 and Pax7 are closely related paired box family members expressed during early neural and myogenic development and have been implicated in the ...
Point Mutation in Intron Sequence Causes Altered Carboxyl
... (QIAamp Tissue Kit; Qiagen). Intron 10 was then amplified by PCR with the primers 59-GGTCAGTCCTCAGGCGTACTA-39 (f; 2325–2345) and 59-GTCCAACCCTCACAGTTCT-39 (r; 2655–2637). The cycling conditions were: 94.8° for 2 min 20 sec; 94.8° for 1 min, 58.7° for 1 min, 72° for 2 min 40 sec 3 35; 72° for 12 min. ...
... (QIAamp Tissue Kit; Qiagen). Intron 10 was then amplified by PCR with the primers 59-GGTCAGTCCTCAGGCGTACTA-39 (f; 2325–2345) and 59-GTCCAACCCTCACAGTTCT-39 (r; 2655–2637). The cycling conditions were: 94.8° for 2 min 20 sec; 94.8° for 1 min, 58.7° for 1 min, 72° for 2 min 40 sec 3 35; 72° for 12 min. ...
computational and in vitro studies of persistent activity
... Fig. 2. Excitatory and inhibitory mechanisms in an attractor network model for object working memory. (A) Example of network performance during a trial. The network consists of one pool of inhibitory neurons (upper rasters, labeled I) and six pools of excitatory neurons, five of them selective to di ...
... Fig. 2. Excitatory and inhibitory mechanisms in an attractor network model for object working memory. (A) Example of network performance during a trial. The network consists of one pool of inhibitory neurons (upper rasters, labeled I) and six pools of excitatory neurons, five of them selective to di ...
Pain Genes?: Natural Variation and Transgenic Mutants
... second order spinal cord neurons to innocuous stimuli. Finally, there are conditions in which pain is maladaptive; in these conditions, pain can be considered a disease of the nervous system. For example, after nerve injury, there may be intense, spontaneous pains, and various stimuli can evoke abno ...
... second order spinal cord neurons to innocuous stimuli. Finally, there are conditions in which pain is maladaptive; in these conditions, pain can be considered a disease of the nervous system. For example, after nerve injury, there may be intense, spontaneous pains, and various stimuli can evoke abno ...
Gene Section (Drosophila). Atlas of Genetics and Cytogenetics
... and telomeric (45g21, yellow) of NKX2-5. (See below for map.) The rearrangement may be a simple insertion or, a double translocation whereby chromosome 14 material is first translocated onto the der(5) and then returned by a nonreciprocal copying process to the der(14) accompanied by genomic materia ...
... and telomeric (45g21, yellow) of NKX2-5. (See below for map.) The rearrangement may be a simple insertion or, a double translocation whereby chromosome 14 material is first translocated onto the der(5) and then returned by a nonreciprocal copying process to the der(14) accompanied by genomic materia ...
A NEW ALLELE OF THE lpr LOCUS, lpr"9, THAT COMPLEMENTS
... Allelism of the Mutant Gene with gld, lpr, and Yaa. So far, three mutant genes, gld, lpr, and Yaa, have been reported to be involved in lymphadenopathy with autoimmune disease in mice (1-5). Since the Yaa gene is linked to Y chromosome (1, 4, 5), the new mutant gene is clearly considered to be diffe ...
... Allelism of the Mutant Gene with gld, lpr, and Yaa. So far, three mutant genes, gld, lpr, and Yaa, have been reported to be involved in lymphadenopathy with autoimmune disease in mice (1-5). Since the Yaa gene is linked to Y chromosome (1, 4, 5), the new mutant gene is clearly considered to be diffe ...
MGF 110-13L/14L overlap
... This gene is a fusion between the MGF 110-7L ortholog and MGF 360-6L. The amino terminus of this fusion is not shown since it is outside the scope of this diagram. The annotated ortholog for this gene is: “Truncated MGF 360 protein” which has been shortened to “Trunc”, however the actual ortholog id ...
... This gene is a fusion between the MGF 110-7L ortholog and MGF 360-6L. The amino terminus of this fusion is not shown since it is outside the scope of this diagram. The annotated ortholog for this gene is: “Truncated MGF 360 protein” which has been shortened to “Trunc”, however the actual ortholog id ...
A gene expression atlas of a bicoid-depleted
... two layers of the segmentation network, the gap genes and the pairrule genes. We found that all gap gene cell fates present in the bcddepleted embryo were also present in wild type. For the pair-rule genes, we observed that extensive early overlap of even-skipped (eve) and fushi-tarazu ( ftz) mRNA p ...
... two layers of the segmentation network, the gap genes and the pairrule genes. We found that all gap gene cell fates present in the bcddepleted embryo were also present in wild type. For the pair-rule genes, we observed that extensive early overlap of even-skipped (eve) and fushi-tarazu ( ftz) mRNA p ...
Discovery and characterization of chromatin states for Please share
... The first group of states, states 1–11, all had high enrichment for promoter regions: 40%– 89% of each state was within 2kb of a RefSeq transcription start site (TSS), compared with 2.7% genome-wide (P<10−200, for all states). These states accounted for 59% of all RefSeq TSS while covering only 1.3% ...
... The first group of states, states 1–11, all had high enrichment for promoter regions: 40%– 89% of each state was within 2kb of a RefSeq transcription start site (TSS), compared with 2.7% genome-wide (P<10−200, for all states). These states accounted for 59% of all RefSeq TSS while covering only 1.3% ...