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Structure, expression and chromosomal location of the Oct
Structure, expression and chromosomal location of the Oct

... other members of the POU family. After digestion with PstI, a restriction fragment length polymorphism (RFLP) was identified in C57BL/6 (B6) versus AKR and A / J . This allowed use of the congenic chromosomes listed in Fig. 1A (Flaherty et al., 1990). Whereas, the B6.K1 and B6.K3 recombinants place ...
Memory, aging and external memory aids
Memory, aging and external memory aids

... findings suggest that there is some truth to these three functions but the fact that they positively correlate to each other suggests that a given task generally involve all three (Eysenck & Keane, 2010). Eysenck & Keane (2010) note that a function not involved in these three is dual tasking. It ...
Cotranscriptional coupling of splicing factor recruitment and
Cotranscriptional coupling of splicing factor recruitment and

... contrast, camptothecin treatment did not induce association of spli- snRNPs and U2AF65 have been shown to associate with Pol II in a cing factors with the intronless HIST1H2AB gene, which is not variety of mammalian extracts32–35. Moreover, a recent study has a camptothecin target29, providing an im ...
Supertaster
Supertaster

... same as cupcakes! Not only does taste make consuming food more interesting, but it also serves a purpose – it allows humans to determine the relative safety of what they plan to consume. Toxic substances tend to be bitter in taste, so humans tend to avoid this particular flavor – not only do most pe ...
Epigenetics & Chromatin Xist through transcriptional control of Dnmt3a
Epigenetics & Chromatin Xist through transcriptional control of Dnmt3a

... Establishing appropriate X inactivation patterns requires mechanisms that ensure correct regulation of Xist RNA in early development. Specifically Xist expression must occur from only one allele in XX cells and not at all in XY cells. Studies to date indicate that regulation of Xist expression in ra ...
Etude Annotation
Etude Annotation

... score  (525)  than  the  GeneMark  start  at  position  215  (420).  The  start  at  position  83  is  yields   the  longest  possible  gene  as  well.   Gap/Overlap:  Since  it  is  gene  1,  we  can  omit  determining  the  gap ...
Synaptic Pruning in Development: A Novel Account in Neural Terms
Synaptic Pruning in Development: A Novel Account in Neural Terms

... (e.g. 2 weeks for the macaque monkeys [Bourgeois, 1993]). The changes in synaptic density are not a result of changes in total brain volume, but re ect true synaptic elimination [Rakic et al., 1994]. In some cases, synaptic elimination was shown to be correlated with experience-dependent activity [S ...
Regulation of Bacterial Conjugation in Microaerobiosis by
Regulation of Bacterial Conjugation in Microaerobiosis by

... et al. 2005b). Another example involves the leucineresponsive regulatory protein, which is an activator of traJ transcription in pSLT (Camacho and Casadesus 2002) but not in R100 (Starcic-Erjavec et al. 2003). Adaptation to the host lifestyle and adjustment of conjugal transfer to favorable circumst ...
Memory Maintenance in Synapses with Calcium
Memory Maintenance in Synapses with Calcium

... In this case, r evolves towards one of two possible stable fixed points (the minima of U), one at r~0 - the DOWN state -, the other at r~1 - the UP state -, depending on the initial condition. This corresponds to a bistable synapse. 2. For intermediate calcium concentrations (c(t)whd ), the synapse ...
PDF
PDF

... using a mixture of benzbenzoate and benzylalcohol (2:1) after Fig. 1. Enhanced severity of skeletal phenotype as a consequence of a genetic interaction between Sd and Uns. Vertebral columns of day-17.5 fetuses with the following genotypes are shown; (A) + +/+ +, (B) Uns +/+ +, (C) + Sd/+ + and (D) U ...
Fear Models in Animals and Humans
Fear Models in Animals and Humans

... however, if damage is localized to the hippocampus, conditioned fear to the CS is intact, but the animal no longer exhibits fear to the context [33]. Interestingly, unlike amygdala lesions, which impair conditioned fear even if damage occurs long after fear conditioning, the impact of hippocampal da ...
Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have
Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have

... for the whole duration of the associative learning trials, with ad libitum access to water. Mice were weighed each day to monitor weight loss and maintained at no less than 85% of their original body weight. For the associative learning task mice were trained to associate an odor with a food reward. ...
Chapter 14
Chapter 14

... 14.15 Lysogeny Requires Several Events • cII and cIII cause repressor synthesis to be established. – They trigger inhibition of late gene transcription. ...
No Slide Title
No Slide Title

... • Imprinted genes are expressed differently depending on whether they are inherited through the maternal or paternal parent. ...
Glioma heterogeneity and the LAT-1
Glioma heterogeneity and the LAT-1

... Glioma heterogeneity and the L-Amino acid transporter-1 (LAT1): A first step to stratified BPA-based BNCT? ...
Cloning and Expression of Cellulosimicrobium cellulans β
Cloning and Expression of Cellulosimicrobium cellulans β

... for feeding at a later date [7]. Therefore, ensiled forages are the most commonly used feeds for ruminants all over the world [8]. Lactobacillus plantarum and other Lactobacillus species, Enterococcus faecium and Pediococcus species are most common silage inoculant bacteria and one or more of these ...
Neurofilaments and Orthograde Transport Are Reduced in Ventral
Neurofilaments and Orthograde Transport Are Reduced in Ventral

... in the perikarya and proximal axons of spinal cord motoneurons by z180 d of age (data not shown). Immunohistochemical studies performed with NF subunit-specific antibodies (e.g., RMO32 specific for highly phosphorylated NFM, RMO24 specific for highly phosphorylated NFH, and rabbit anti-NFL polyclona ...
Revealing Past Memories: Proactive Interference
Revealing Past Memories: Proactive Interference

... and ISI on radial water maze performance. In experiment 1A, we examined performance at various delay intervals at 6 months (340 – 480 g) and again at 12 months (440 – 610 g) of age. These rats were also used for pilot ketamine experiments in the months between the 6- and 12-month-long delay testing. ...
HCN channels are a novel therapeutic target for cognitive
HCN channels are a novel therapeutic target for cognitive

... Nf19a–/9a– mutant), in which the neuron-specific NF1 exon 9acontaining isoform is deleted. Reverse transcription-quantitative PCR confirmed the total absence of Nf1 exon 9a-containing mRNA in Nf19a–/9a– mice (Figure 1a and Supplementary Figure 1). Consistent with the relatively high abundance of this ...
The Evolution of CONSTANS-Like Gene Families
The Evolution of CONSTANS-Like Gene Families

... The CCT domain probes from OsA (Hd1) and OsB (S12569) each identified two barley genes (four genes in total) in the preliminary screen. CCT domains from the barley genes were then used to test cross hybridization between the clones and, where appropriate, to rescreen the libraries. The CCT domains o ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics

... Hess JL, Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.2001;5(1):11-13. Huret JL. MLL (myeloid/lymphoid or mixed lineage leukemia). Atlas Genet Cytogenet Oncol Haematol.1997;1(2):68-69. This work is licensed under a Creative Commons Attribution-Nonc ...
Identification of novel endogenous antisense transcripts by DNA
Identification of novel endogenous antisense transcripts by DNA

... conserved NATs (antisense of Acaa1b and Aard) by performing Northern and in situ hybridization (ISH) analyses. Whereas human ACAA1 (acetyl-Coenzyme A acyltransferase 1) overlaps with DLEC1 (deleted in lung and esophageal cancer 1) in a tail-to-tail overlapping manner, its orthologous counterpart in ...
Regulation of the S100B gene by α1-adrenergic - AJP
Regulation of the S100B gene by α1-adrenergic - AJP

... including ␣1-adrenergic agonists, angiotensin (ANG) II, peptide growth factors, and mechanical stretch as instigators of the hypertrophic response (4, 30, 35). Some of these, including ␣1-adrenergic agonists, activate the protein kinase C (PKC) signaling pathway (15, 17). Furthermore, in addition to ...
Temperature-dependent expression of virulence genes in fish
Temperature-dependent expression of virulence genes in fish

... 2010; Steinmann and Dersch, 2013). In addition, bacteria also have response mechanisms to drastic changes in temperature. The paradigms of this adaptation are the cold and heat shock response systems under which the bacteria induce a fast response to sudden and extreme temperature shift (Guisbert et ...
Involvement of Pax6 and Otx2 in the forebrain
Involvement of Pax6 and Otx2 in the forebrain

... In this study, we describe the involvement of the homeodomain containing transcription factors Otx2 and Pax6 in ANF gene regulation. Otx2 is known for its specific function as a transcriptional regulator during forebrain and midbrain development in vertebrates (Boncinelli and Morgan, 2001). In all e ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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