DNA supercoiling factor contributes to dosage
... et al., 2002). The chromosome defect in the mutant strains is likely to be the result of an imbalance caused by acetylation by MOF leading to a more open chromatin state, without ISWI working toward a more condensed chromatin state (Deuring et al., 2000). However, it remains unclear whether the phen ...
... et al., 2002). The chromosome defect in the mutant strains is likely to be the result of an imbalance caused by acetylation by MOF leading to a more open chromatin state, without ISWI working toward a more condensed chromatin state (Deuring et al., 2000). However, it remains unclear whether the phen ...
phenotypic correlations - Watson et al (v91)
... Examples have been documented with respect to fore and hindlimb correlations in mammals (Young et al., 2005) and in primates in particular (Young, et al.. 2010). Characterising how these interactions change over evolutionary time is crucial to understanding the properties of developmental processes ...
... Examples have been documented with respect to fore and hindlimb correlations in mammals (Young et al., 2005) and in primates in particular (Young, et al.. 2010). Characterising how these interactions change over evolutionary time is crucial to understanding the properties of developmental processes ...
CONSERVATION AND DIVERGENCE IN MOLECULAR
... axis formation, the morphogenetic transcription factor Dorsal (a NFκB/rel homologue; 170). Degradation of Cactus allows Dorsal to enter the nucleus (12, 186). Since Toll is activated ventrally, Dorsal protein enters the nucleus at highest concentration ventrally. Immunostaining against Dorsal protei ...
... axis formation, the morphogenetic transcription factor Dorsal (a NFκB/rel homologue; 170). Degradation of Cactus allows Dorsal to enter the nucleus (12, 186). Since Toll is activated ventrally, Dorsal protein enters the nucleus at highest concentration ventrally. Immunostaining against Dorsal protei ...
Transvection and pairing of a Drosophila Hox long noncoding RNA
... mutations break within a region in the ftz-Antp interval where intergenic transcription has been previously observed (Calhoun and Levine 2003). One additional GOF mutation maps distal to this region in the first intron of Antp. Though transcripts from the ftz-Antp interval have been structurally det ...
... mutations break within a region in the ftz-Antp interval where intergenic transcription has been previously observed (Calhoun and Levine 2003). One additional GOF mutation maps distal to this region in the first intron of Antp. Though transcripts from the ftz-Antp interval have been structurally det ...
Section and Senior Editor - HAL
... The histamine (HA) neurons, located in the tuberomamillary nucleus (TM) and adjacent posterior hypothalamus, represent one of the identified populations that projects to the entire brain. These cells discharge tonically during W in the cat and mouse (Sakai et al.,1990; Vanni-Mercier et al.,2003; Tak ...
... The histamine (HA) neurons, located in the tuberomamillary nucleus (TM) and adjacent posterior hypothalamus, represent one of the identified populations that projects to the entire brain. These cells discharge tonically during W in the cat and mouse (Sakai et al.,1990; Vanni-Mercier et al.,2003; Tak ...
[PDF]
... CGG repeat was detected (A.M. Peier and D.L. Nelson, submitted for publication). In these transgenic mice, the integration sites of either transgene or YAC are random, which may indicate that triplet repeat instability requires the cisacting element(s). This is further supported by association studi ...
... CGG repeat was detected (A.M. Peier and D.L. Nelson, submitted for publication). In these transgenic mice, the integration sites of either transgene or YAC are random, which may indicate that triplet repeat instability requires the cisacting element(s). This is further supported by association studi ...
Xdbx inhibits neurogenesis - Development
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...
... Regionalized X-Ngnr1 expression defines domains of early neurogenesis. Are there negative effectors that similarly define neural progenitor domains in the embryo? The homeodomaincontaining gene Xiro3 is expressed at highest levels in neural progenitors and when overexpressed, Xiro3 inhibits neuronal ...
VegT activates Bix4 to specify endodermal
... detected, however, with increased levels of MgCl2 and VegT protein in the binding reaction (not shown). To ask whether VegT activates Bix4 expression through direct interaction with these sites, we made transgenic Xenopus embryos in which the 1.6 kb Bix4 upstream regulatory sequence was used to driv ...
... detected, however, with increased levels of MgCl2 and VegT protein in the binding reaction (not shown). To ask whether VegT activates Bix4 expression through direct interaction with these sites, we made transgenic Xenopus embryos in which the 1.6 kb Bix4 upstream regulatory sequence was used to driv ...
hag expression in Bacillus subtilis is both negatively
... broth to stationary phase OD600 ~2.0) and the bgalactosidase activities were determined (Nicholson & Setlow, 1990). We observed an almost twofold increase in the hag promoter activity in 168scoC : hag9-lacZ (435±15 Miller units) as compared to that in wild-type (225±10 Miller units) (Table 3A), indi ...
... broth to stationary phase OD600 ~2.0) and the bgalactosidase activities were determined (Nicholson & Setlow, 1990). We observed an almost twofold increase in the hag promoter activity in 168scoC : hag9-lacZ (435±15 Miller units) as compared to that in wild-type (225±10 Miller units) (Table 3A), indi ...
Operon review
... Explain how the regulation of eukaryotic genes is different in eukaryotes vs prokaryotes. ...
... Explain how the regulation of eukaryotic genes is different in eukaryotes vs prokaryotes. ...
Chapter 3
... for animals from the third bilaterian clade, the lophotrochozoans. Therefore, we decided to compare genes known to be involved in mesoderm formation in deuterostomes and ecdysozoans with orthologs of those genes in lophotrochozoans, in particular in molluscs. An obvious candidate gene for a comparis ...
... for animals from the third bilaterian clade, the lophotrochozoans. Therefore, we decided to compare genes known to be involved in mesoderm formation in deuterostomes and ecdysozoans with orthologs of those genes in lophotrochozoans, in particular in molluscs. An obvious candidate gene for a comparis ...
Replication timing and transcriptional control: beyond
... at the time of implantation by a mechanism that chooses the late-replicating allele at random. Notably, it is almost always the early-replicating allele that is initially selected to undergo rearrangement, suggesting that replication timing is an early developmental marker for allelic exclusion in t ...
... at the time of implantation by a mechanism that chooses the late-replicating allele at random. Notably, it is almost always the early-replicating allele that is initially selected to undergo rearrangement, suggesting that replication timing is an early developmental marker for allelic exclusion in t ...
ARTICLES - Weizmann Institute of Science
... Eukaryotic genomes are packaged into nucleosome particles that occlude the DNA from interacting with most DNA binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it ...
... Eukaryotic genomes are packaged into nucleosome particles that occlude the DNA from interacting with most DNA binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it ...
Mol Microbiol. Jun 21. [Epub ahead of print]
... To further investigate the role of c-di-GMP in biofilm formation in L. pneumophila, the vector pMMB206-Gent (Hammer and Swanson, 1999; Molofsky and Swanson, 2003) was used to express two diguanylate cyclase proteins in L. pneumophila, Vca0956 (Tischler and Camilli, 2004) and Lpg1057. pMMB206-Gent ha ...
... To further investigate the role of c-di-GMP in biofilm formation in L. pneumophila, the vector pMMB206-Gent (Hammer and Swanson, 1999; Molofsky and Swanson, 2003) was used to express two diguanylate cyclase proteins in L. pneumophila, Vca0956 (Tischler and Camilli, 2004) and Lpg1057. pMMB206-Gent ha ...
MGF 360-17R Missing
... Trunc – 014 [MGF 110-7L/MGF 360-6L Fusion Protein]: This gene is a fusion between the MGF 110-7L ortholog and MGF 360-6L. The carboxy terminus of this fusion is shown as a small box between the 3L and 4L orthologs as the MGF 110 orthologs are outside of the scope of this diagram. The annotated ortho ...
... Trunc – 014 [MGF 110-7L/MGF 360-6L Fusion Protein]: This gene is a fusion between the MGF 110-7L ortholog and MGF 360-6L. The carboxy terminus of this fusion is shown as a small box between the 3L and 4L orthologs as the MGF 110 orthologs are outside of the scope of this diagram. The annotated ortho ...
this PDF file - E-Journal Faculty of Medicine Universitas
... result in increased levels of homocysteine. This may lead to a decrease in DNA methylation at the cellular level and, eventually, neuronal cell damage and death. Methylation is involved in almost all reactions in the body and is very important for the biomolecular reaction processes.8 It is already ...
... result in increased levels of homocysteine. This may lead to a decrease in DNA methylation at the cellular level and, eventually, neuronal cell damage and death. Methylation is involved in almost all reactions in the body and is very important for the biomolecular reaction processes.8 It is already ...
Control of GL2 expression in Arabidopsis leaves and trichomes
... • Because both GL1 and R are required to ectopically activate GL2, it is possible that GL1 and R function as a complex • A construct containing the GL1 gene with a myc epitope as an Nterminal fusion was generated – This same epitope fusion was made to a truncated version of the GL1 protein that expr ...
... • Because both GL1 and R are required to ectopically activate GL2, it is possible that GL1 and R function as a complex • A construct containing the GL1 gene with a myc epitope as an Nterminal fusion was generated – This same epitope fusion was made to a truncated version of the GL1 protein that expr ...
Mc1r - National Center for Case Study Teaching in Science
... It’s most likely that a single founding population with the Arg65Cys mutation colonized the beach habitat and differentiated into the four subspecies. However, it’s also possible that the mutation arose independently in each subspecies. Work in your small groups to consider what additional informat ...
... It’s most likely that a single founding population with the Arg65Cys mutation colonized the beach habitat and differentiated into the four subspecies. However, it’s also possible that the mutation arose independently in each subspecies. Work in your small groups to consider what additional informat ...
Teacher Guide: Gene Expression. By Ann Brokaw.
... This curriculum guide organizes HHMI resources into the following categories: gene expression, RNA, transcription, translation, and post-translational events. The resources include animations, video clips, interactive Click and Learn activities, virtual labs, and lectures specific to the topic. The ...
... This curriculum guide organizes HHMI resources into the following categories: gene expression, RNA, transcription, translation, and post-translational events. The resources include animations, video clips, interactive Click and Learn activities, virtual labs, and lectures specific to the topic. The ...
Hox Genes: Let`s Work Together
... the activity of anteriorly expressed Hox gene even in the case of forced expression of anterior Hox gene using different promoter and only translated regions of the gene (Gonzalez-Reyes and Morata, 1990). This convincingly suggests that posterior Hox proteins also use post-translational mechanisms t ...
... the activity of anteriorly expressed Hox gene even in the case of forced expression of anterior Hox gene using different promoter and only translated regions of the gene (Gonzalez-Reyes and Morata, 1990). This convincingly suggests that posterior Hox proteins also use post-translational mechanisms t ...
Activation of p38 MAPK in the substantia nigra leads to nuclear
... plkBa/lkBa increased 24 h after MPTP, which may be caused by decreased levels of lkBa and not an absolute increase of plkBa. However, phosphorylation state of IjBa was not altered in the striatum (Fig. 2b). Phospho-IjBa levels were normalized to the total IjBa level in each sample to assess NF-jB ac ...
... plkBa/lkBa increased 24 h after MPTP, which may be caused by decreased levels of lkBa and not an absolute increase of plkBa. However, phosphorylation state of IjBa was not altered in the striatum (Fig. 2b). Phospho-IjBa levels were normalized to the total IjBa level in each sample to assess NF-jB ac ...
Comparison of population coherence of place cells in hippocampal
... example, if there are different behavioural contingencies associated with the familiar and altered environments). ‘Pattern separation’ refers to this ability of a network to make the representations of two similar input patterns more dissimilar, thus decreasing the probability of recall errors22–25. ...
... example, if there are different behavioural contingencies associated with the familiar and altered environments). ‘Pattern separation’ refers to this ability of a network to make the representations of two similar input patterns more dissimilar, thus decreasing the probability of recall errors22–25. ...
Characterisation of the katA gene encoding a catalase and evidence
... 3.3. Construction of a KatA-de¢cient S. xylosus mutant A KatA-de¢cient strain of S. xylosus, designated TX350, was constructed by exchanging the 5P-end of katA for an erythromycin resistance gene, ermB (Fig. 1B). By this replacement, the ¢rst 60 codons of katA including the start codon and ribosome- ...
... 3.3. Construction of a KatA-de¢cient S. xylosus mutant A KatA-de¢cient strain of S. xylosus, designated TX350, was constructed by exchanging the 5P-end of katA for an erythromycin resistance gene, ermB (Fig. 1B). By this replacement, the ¢rst 60 codons of katA including the start codon and ribosome- ...
The Mean Between Meme and Gene Comparison
... origin of memes paralleling the creation of eukaryotic cells, which paved the way for multicellular life. However, not only are both stories vague and that of the meme’s pure speculation, but memes appear to have evolved from genes themselves rather than being an analogue. In Dennett’s view, memes i ...
... origin of memes paralleling the creation of eukaryotic cells, which paved the way for multicellular life. However, not only are both stories vague and that of the meme’s pure speculation, but memes appear to have evolved from genes themselves rather than being an analogue. In Dennett’s view, memes i ...