Gene Section LPP (lipoma preferred partner) Atlas of Genetics and Cytogenetics
... by the overlapping "CEPH Mark 1" YAC clones 135H6 and 192B10 (start codon in 135H6, stop codon in 192B10) and is dispersed over at least 400 kb genomic DNA; the LIM domains are encoded by separate exons: LIM 1 is encoded by exon 8, LIM 2 by exon 9, and LIM 3 by exon 10 and part of exon 11. ...
... by the overlapping "CEPH Mark 1" YAC clones 135H6 and 192B10 (start codon in 135H6, stop codon in 192B10) and is dispersed over at least 400 kb genomic DNA; the LIM domains are encoded by separate exons: LIM 1 is encoded by exon 8, LIM 2 by exon 9, and LIM 3 by exon 10 and part of exon 11. ...
Spermatogenesis
... or in any proliferating somatic tissue. This observation is surprising because Wee1p type kinase is widely expressed (A. Golden, personal communication; Lamitina and L'Hernault, 2002) and probably negatively regulates the C. elegans cdc2p ortholog ncc-1 (Boxem et al., 1999); cdc2p (or its orthologs) ...
... or in any proliferating somatic tissue. This observation is surprising because Wee1p type kinase is widely expressed (A. Golden, personal communication; Lamitina and L'Hernault, 2002) and probably negatively regulates the C. elegans cdc2p ortholog ncc-1 (Boxem et al., 1999); cdc2p (or its orthologs) ...
review i article
... conditionally lethal in a host-specific manner. What all these systems have in common is that they kill their host from within (the killer plasmid is initially present in the target cell), unlike colicins, microcins or antibiotics. Whilst most killing genes were identified as such and only operation ...
... conditionally lethal in a host-specific manner. What all these systems have in common is that they kill their host from within (the killer plasmid is initially present in the target cell), unlike colicins, microcins or antibiotics. Whilst most killing genes were identified as such and only operation ...
Gene Section BOP1 (block of proliferation 1) Atlas of Genetics and Cytogenetics
... and polyadenylation specific factor 1, 160kDa; SLC39A4, 8q24.3, solute carrier family 39 (zinc transporter), member 4. Note: The BOP1 gene is a member of the nucleolar PeBoW-complex (PES1, BOP1, WDR12) essential for cell proliferation and maturation of the large ribosomal subunit. On the basis of ex ...
... and polyadenylation specific factor 1, 160kDa; SLC39A4, 8q24.3, solute carrier family 39 (zinc transporter), member 4. Note: The BOP1 gene is a member of the nucleolar PeBoW-complex (PES1, BOP1, WDR12) essential for cell proliferation and maturation of the large ribosomal subunit. On the basis of ex ...
Pea–Fusarium solani Interactions Contributions of a System Toward
... possess high antifungal activity at concentrations ranging from 0.04 to 22 µg/ml (2,3). The defensins are usually lower molecular weight proteins (peptides) possessing high levels of the amino acid cysteine (3). The biological activity of the pea defensins corresponds to that of similar highly conse ...
... possess high antifungal activity at concentrations ranging from 0.04 to 22 µg/ml (2,3). The defensins are usually lower molecular weight proteins (peptides) possessing high levels of the amino acid cysteine (3). The biological activity of the pea defensins corresponds to that of similar highly conse ...
Characterization of the snowy cotyledon 1 mutant of Arabidopsis
... contain undifferentiated proplastids, whose proper function seems necessary for seed germination. In lightgrown sco1 seedlings the greening of cotyledons is severely impaired, whereas the following true leaves develop normally as in wild-type plants. Despite this apparent similarity of chloroplast de ...
... contain undifferentiated proplastids, whose proper function seems necessary for seed germination. In lightgrown sco1 seedlings the greening of cotyledons is severely impaired, whereas the following true leaves develop normally as in wild-type plants. Despite this apparent similarity of chloroplast de ...
Drug Development
... Chris Lipinski’s Rule of Five Lipinski and his Pfizer co-workers looked over a data set of drug candidates and noticed that there were some reasonably clear cutoffs for oral absorption and general cell permeability. They suggested that you need: ...
... Chris Lipinski’s Rule of Five Lipinski and his Pfizer co-workers looked over a data set of drug candidates and noticed that there were some reasonably clear cutoffs for oral absorption and general cell permeability. They suggested that you need: ...
Selected Reaction Monitoring (SRM) to determine protein
... limited numbers of available detectable peptides or when studying a group of closely related proteins, redundant peptides as candidate transitions may in fact be favorable, desirable or simply unavoidable. This likely to be the case, for example, when attempting to measure proteins translated from s ...
... limited numbers of available detectable peptides or when studying a group of closely related proteins, redundant peptides as candidate transitions may in fact be favorable, desirable or simply unavoidable. This likely to be the case, for example, when attempting to measure proteins translated from s ...
The Structure of Human Prions: From Biology to Structural Models
... and protein disulfide isomerases (PDI) [37]. Together, these findings suggest that PrPC organizes its molecular environment by binding adhesion molecules, which in turn recognize oligomannose-bearing membrane proteins. 4. Polymorphisms and Mutations in the PRNP Gene ORF More than 30 mutations in the ...
... and protein disulfide isomerases (PDI) [37]. Together, these findings suggest that PrPC organizes its molecular environment by binding adhesion molecules, which in turn recognize oligomannose-bearing membrane proteins. 4. Polymorphisms and Mutations in the PRNP Gene ORF More than 30 mutations in the ...
Nitric Oxide Signalling in Plants: Cross
... submicromolar NO concentrations were shown to activate RYR1 by S-nitrosylation of a single cysteine (Cys 3635), this reaction occurring only at low (e.g. physiological) pO2 but not ambient pO2 (Sun et al., 2003). This specific S-nitrosylation reverses RYR1 inhibition by Ca2+/Calmodulin (CaM) and may ...
... submicromolar NO concentrations were shown to activate RYR1 by S-nitrosylation of a single cysteine (Cys 3635), this reaction occurring only at low (e.g. physiological) pO2 but not ambient pO2 (Sun et al., 2003). This specific S-nitrosylation reverses RYR1 inhibition by Ca2+/Calmodulin (CaM) and may ...
AtMYB93 is a novel negative regulator of lateral root
... statistical analysis, the null hypothesis that there is no difference in the percentage of roots ...
... statistical analysis, the null hypothesis that there is no difference in the percentage of roots ...
2.3.1. Vector construction - Trace: Tennessee Research and
... Biological interactions occur on multiple length scales, ranging from molecular to population wide interactions. This work describes the study of two specific areas of biological interactions in microbial systems: intracellular protein-protein interactions and cell-to-cell interactions. The implemen ...
... Biological interactions occur on multiple length scales, ranging from molecular to population wide interactions. This work describes the study of two specific areas of biological interactions in microbial systems: intracellular protein-protein interactions and cell-to-cell interactions. The implemen ...
Lecture 16 - Gene Transcription and Translation
... A retrotransposon that actively jumped around in lobed-fin fishes 410 million years ago led to the creation of enhancers and exons for a gene responsible for neurodevelopment, ISL1. ISL1 plays a hugely important role in regulating insulin gene expression, governs motor neuron generation, and helps t ...
... A retrotransposon that actively jumped around in lobed-fin fishes 410 million years ago led to the creation of enhancers and exons for a gene responsible for neurodevelopment, ISL1. ISL1 plays a hugely important role in regulating insulin gene expression, governs motor neuron generation, and helps t ...
Molecule Pages - Berkeley Database Group
... databases will become scientific journals and journals will become databases. Biologists will be greatly empowered, and bioinformatics will continue its long evolution.” ...
... databases will become scientific journals and journals will become databases. Biologists will be greatly empowered, and bioinformatics will continue its long evolution.” ...
Interdependence, Reflexivity, Fidelity, Impedance Matching
... By the time protein folding organizes amino acid side chains into a functional active site, genetic information has been irreversibly transformed. Any molecular machine charged with reversing translation by unfolding, then “reading” the sequence of a protein would require shuttling ...
... By the time protein folding organizes amino acid side chains into a functional active site, genetic information has been irreversibly transformed. Any molecular machine charged with reversing translation by unfolding, then “reading” the sequence of a protein would require shuttling ...
Interdependence, Reflexivity, Fidelity, Impedance Matching
... By the time protein folding organizes amino acid side chains into a functional active site, genetic information has been irreversibly transformed. Any molecular machine charged with reversing translation by unfolding, then “reading” the sequence of a protein would require shuttling ...
... By the time protein folding organizes amino acid side chains into a functional active site, genetic information has been irreversibly transformed. Any molecular machine charged with reversing translation by unfolding, then “reading” the sequence of a protein would require shuttling ...
Chapter 5 Lodish 6E
... titer that was slightly lower than the control transfection. This result indicates that reduction of either p24 mRNA or p25 mRNA (and presumably the proteins encoded by them) only minimally affects the ability of the virus to infect the cells. However, transfection of both siRNA-p24 and siRNA-p25 di ...
... titer that was slightly lower than the control transfection. This result indicates that reduction of either p24 mRNA or p25 mRNA (and presumably the proteins encoded by them) only minimally affects the ability of the virus to infect the cells. However, transfection of both siRNA-p24 and siRNA-p25 di ...
Genomic surveys and expression analysis of bZIP gene family in
... to the castor bean genome (http://castorbean.jcvi.org/ index.php) to obtain unique reads and reads abundance using SOAP2 software (Li et al. 2009). To compare the differential expression of genes among tissues, the expression level of each gene in the different tissues was normalized to the number o ...
... to the castor bean genome (http://castorbean.jcvi.org/ index.php) to obtain unique reads and reads abundance using SOAP2 software (Li et al. 2009). To compare the differential expression of genes among tissues, the expression level of each gene in the different tissues was normalized to the number o ...
Bluetongue virus: dissection of the polymerase complex
... cytoplasm. This requires the efficient co-ordination of a number of enzymes, including helicase, polymerase and RNA capping activities. This review will focus on our current understanding of these catalytic proteins as derived from the use of recombinant proteins, combined with functional assays and ...
... cytoplasm. This requires the efficient co-ordination of a number of enzymes, including helicase, polymerase and RNA capping activities. This review will focus on our current understanding of these catalytic proteins as derived from the use of recombinant proteins, combined with functional assays and ...
Genome-wide analysis of the GRAS gene family in
... was shown to play positive roles in brassinosteroid signaling. The GRAS proteins have diverse and important functions in plant growth and development. DELLA proteins have been shown to be involved in gibberellin signal transduction, acting as negative regulators of plant growth; they include GAI, RG ...
... was shown to play positive roles in brassinosteroid signaling. The GRAS proteins have diverse and important functions in plant growth and development. DELLA proteins have been shown to be involved in gibberellin signal transduction, acting as negative regulators of plant growth; they include GAI, RG ...
PDF Links - Asian-Australasian Journal of Animal Sciences
... Val/Val pattern was less frequent than the Leu/Leu or Leu/Val patterns. The significant superiority of the Leu/Leu genotype over the Val/Val and Leu/Val genotypes was observed for milk, fat and protein yield while the fat percentage was lower because of the higher milk yield. Probably the observed d ...
... Val/Val pattern was less frequent than the Leu/Leu or Leu/Val patterns. The significant superiority of the Leu/Leu genotype over the Val/Val and Leu/Val genotypes was observed for milk, fat and protein yield while the fat percentage was lower because of the higher milk yield. Probably the observed d ...
Zhen jin liprin protein regulates differentiation of presynmaptic termini c elegans nature 1999
... 3, 4 and M.Z. and Y.J., unpublished). SNB-1 is a C. elegans synaptobrevin7, a synaptic-vesicle membrane protein involved in vesicle docking and exocytosis2, and SNB-1::GFP is associated with vesicles3. The unc-25 promoter drives the expression of SNB-1::GFP in the GABAergic DD and VD motorneurons4,8 ...
... 3, 4 and M.Z. and Y.J., unpublished). SNB-1 is a C. elegans synaptobrevin7, a synaptic-vesicle membrane protein involved in vesicle docking and exocytosis2, and SNB-1::GFP is associated with vesicles3. The unc-25 promoter drives the expression of SNB-1::GFP in the GABAergic DD and VD motorneurons4,8 ...
Cell cycle exit during terminal erythroid differentiation is associated
... tissue-specific gene expression program. This program is tightly coordinated with cell cycle exit. Commitment to cell division is regulated by a family of G1 cyclin-dependent protein kinases (CDKs) (reviewed in Morgan1 and Pavletich2). CDKs are regulated by activating proteins, cyclins, (reviewed in ...
... tissue-specific gene expression program. This program is tightly coordinated with cell cycle exit. Commitment to cell division is regulated by a family of G1 cyclin-dependent protein kinases (CDKs) (reviewed in Morgan1 and Pavletich2). CDKs are regulated by activating proteins, cyclins, (reviewed in ...
PLANT CELL WALL PROTEINS
... the pistil, CELP mRNAs gather in stylar cells delimiting the transmitting tissue, and in the ovary, they center in a narrow row of cells lining the placenta that are a continuation from the stylar transmitting tissue to which ovules are attached. The expression pattern of CELP mRNAs in these tissues ...
... the pistil, CELP mRNAs gather in stylar cells delimiting the transmitting tissue, and in the ovary, they center in a narrow row of cells lining the placenta that are a continuation from the stylar transmitting tissue to which ovules are attached. The expression pattern of CELP mRNAs in these tissues ...
Structural Studies on the Dosage Compensation Complex from
... RNA helicaseA (hRHA), which is involved in the loading of small interfering RNAs into RISC (RNA-induced silencing complex) (Robb and Rana, 2007). ...
... RNA helicaseA (hRHA), which is involved in the loading of small interfering RNAs into RISC (RNA-induced silencing complex) (Robb and Rana, 2007). ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.