Synthesis, in Vitro Anti-Breast Cancer Activity, and Intracellular
... centration of AZT-MP and not AZT-TP.42 However, as mentioned before, the chronic administration of AZT can lead to the loss of thymidine kinase activity, which negates the therapeutic effects of AZT due to the lack of formation of phosphorylated AZT.43 To bypass the monophosphorylation of AZT by thy ...
... centration of AZT-MP and not AZT-TP.42 However, as mentioned before, the chronic administration of AZT can lead to the loss of thymidine kinase activity, which negates the therapeutic effects of AZT due to the lack of formation of phosphorylated AZT.43 To bypass the monophosphorylation of AZT by thy ...
CASK (LIN2) interacts with Cx43 in wounded skin and their
... In vertebrates, connexin proteins assemble into tightly packed gap junctional channels to connect the cytoplasms of adjacent cells via an aqueous-filled channel. Gap junctions allow the passive diffusion of molecules lower than 1000 Da in size such as ions, amino acids, nutrients and secondary messe ...
... In vertebrates, connexin proteins assemble into tightly packed gap junctional channels to connect the cytoplasms of adjacent cells via an aqueous-filled channel. Gap junctions allow the passive diffusion of molecules lower than 1000 Da in size such as ions, amino acids, nutrients and secondary messe ...
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... the Wnt pathway that sharpens the distinction between opposing Wnt and Notch responses, allowing for robust cell-fate decisions. ...
... the Wnt pathway that sharpens the distinction between opposing Wnt and Notch responses, allowing for robust cell-fate decisions. ...
Plasticity in Cell Division Patterns and Auxin
... d Plant Biotechnology Institute, National Research Council of Canada, Saskatoon S7N 0W9, Canada e Molecular and Developmental Genetics, Institute Biology Leiden, Leiden University, 2333 BE Leiden, The Netherlands b Université ...
... d Plant Biotechnology Institute, National Research Council of Canada, Saskatoon S7N 0W9, Canada e Molecular and Developmental Genetics, Institute Biology Leiden, Leiden University, 2333 BE Leiden, The Netherlands b Université ...
Intermediate Filaments Regulate Tissue Size and Stiffness in the
... This progression is similar to that seen in humans with mutations in CP49, in that these individuals are born with clear lenses, but by young adulthood develop opacities that require lens replacement.22,23 Thus, although not required to achieve the differentiated cellular and tissue level phenotypes ...
... This progression is similar to that seen in humans with mutations in CP49, in that these individuals are born with clear lenses, but by young adulthood develop opacities that require lens replacement.22,23 Thus, although not required to achieve the differentiated cellular and tissue level phenotypes ...
antoniadi_et_al._2015.
... is strongest in the procambium and quiescent center (QC), respectively (Kuroha et al., 2009), whereas root expression of CYP735A2 is predominantly in the vasculature (Kiba et al., 2013). Analysis of GUS patterns reveals that CKX4 is expressed in guard cells and root cap, CKX5 in axillary buds, and C ...
... is strongest in the procambium and quiescent center (QC), respectively (Kuroha et al., 2009), whereas root expression of CYP735A2 is predominantly in the vasculature (Kiba et al., 2013). Analysis of GUS patterns reveals that CKX4 is expressed in guard cells and root cap, CKX5 in axillary buds, and C ...
Full Text - Global Science Books
... Both in monocots and in dicots, the primary root (PR) represents the first visible organ that can be recognized at the time of germination. The onset of PR development starts however much earlier during embryogenesis and in Arabidopsis these early developmental stages have been wellstudied (Mayer et ...
... Both in monocots and in dicots, the primary root (PR) represents the first visible organ that can be recognized at the time of germination. The onset of PR development starts however much earlier during embryogenesis and in Arabidopsis these early developmental stages have been wellstudied (Mayer et ...
SirA enforces diploidy by inhibiting the replication
... copies of the -7° locus per nucleoid (Fig. 3B). This number is consistent with the chromosomal content of B. subtilis grown under our conditions, where celldoubling time is ~30 min (Haeusser and Levin, 2008). In support of the idea that SirA inhibits replication initiation, following 60 min of induc ...
... copies of the -7° locus per nucleoid (Fig. 3B). This number is consistent with the chromosomal content of B. subtilis grown under our conditions, where celldoubling time is ~30 min (Haeusser and Levin, 2008). In support of the idea that SirA inhibits replication initiation, following 60 min of induc ...
INVESTIGATION OF THE EFFECTOR ROLE OF
... testing is further performed for correct diagnosis40. Free-living amoeba have been studied as environmental hosts for Shigella. S. sonnei and S. dysenteriae were able to grow and persist inside Acanthamoeba castellanni41,42, whereas S. flexneri was found to kill the amoeba by necrosis43. These obser ...
... testing is further performed for correct diagnosis40. Free-living amoeba have been studied as environmental hosts for Shigella. S. sonnei and S. dysenteriae were able to grow and persist inside Acanthamoeba castellanni41,42, whereas S. flexneri was found to kill the amoeba by necrosis43. These obser ...
Sharing In The Swap Shop - Memes, Groups and Altruism
... sharing behaviour is a form of reciprocal altruism since sharing within a group, by definition, means that those other members may reciprocate in the future (since a group is defined as those with the same memes and hence sharing behaviours). However, in experiments C and D where resources were neve ...
... sharing behaviour is a form of reciprocal altruism since sharing within a group, by definition, means that those other members may reciprocate in the future (since a group is defined as those with the same memes and hence sharing behaviours). However, in experiments C and D where resources were neve ...
Skeletal Muscle
... muscle cell where it can have an affect on the terminal cisternae. We will cover more about this in the unit on the physiology of muscle contraction. The cytosol is the cytoplasm of the muscle cell. The sarcoplasmic reticulum is the endoplasmic reticulum of the muscle cell. There are sac-like region ...
... muscle cell where it can have an affect on the terminal cisternae. We will cover more about this in the unit on the physiology of muscle contraction. The cytosol is the cytoplasm of the muscle cell. The sarcoplasmic reticulum is the endoplasmic reticulum of the muscle cell. There are sac-like region ...
Redistribution of membrane proteins between the Golgi apparatus
... and movement of the ER network (Boevink et al., 1998; Liebe and Quader, 1994; Quader, 1990). Application of ¯uorescent protein technology has started to revolutionise plant cell biology and the study of the secretory pathway is no exception. It is now possible to observe in vivo the dynamic events o ...
... and movement of the ER network (Boevink et al., 1998; Liebe and Quader, 1994; Quader, 1990). Application of ¯uorescent protein technology has started to revolutionise plant cell biology and the study of the secretory pathway is no exception. It is now possible to observe in vivo the dynamic events o ...
The glycocalyx is present as soon as blood flow is initiated and is
... produce the GAGs of the glycocalyx are expressed before the onset of blood flow (Klewer et al., 2006). Lectins are proteins that bind to specific disaccharides in glycosaminoglycan chains (Barker et al., 2004; Florian et al., 2003; Mulivor and Lipowsky, 2004). Lectin binding affinities change during ea ...
... produce the GAGs of the glycocalyx are expressed before the onset of blood flow (Klewer et al., 2006). Lectins are proteins that bind to specific disaccharides in glycosaminoglycan chains (Barker et al., 2004; Florian et al., 2003; Mulivor and Lipowsky, 2004). Lectin binding affinities change during ea ...
Notochord vacuoles are lysosome-related organelles that function in
... a thick extracellular perinotochordal basement membrane, whereas the inner cells form large fluid-filled intracellular vacuoles. The vacuoles occupy the majority of the volume of the inner cells with diameters of up to 40 µm. Notochord vacuoles have been described in nearly every embryonic vertebrat ...
... a thick extracellular perinotochordal basement membrane, whereas the inner cells form large fluid-filled intracellular vacuoles. The vacuoles occupy the majority of the volume of the inner cells with diameters of up to 40 µm. Notochord vacuoles have been described in nearly every embryonic vertebrat ...
Notochord vacuoles are lysosome-related organelles that function in
... a thick extracellular perinotochordal basement membrane, whereas the inner cells form large fluid-filled intracellular vacuoles. The vacuoles occupy the majority of the volume of the inner cells with diameters of up to 40 µm. Notochord vacuoles have been described in nearly every embryonic vertebrat ...
... a thick extracellular perinotochordal basement membrane, whereas the inner cells form large fluid-filled intracellular vacuoles. The vacuoles occupy the majority of the volume of the inner cells with diameters of up to 40 µm. Notochord vacuoles have been described in nearly every embryonic vertebrat ...
A Monoclonal Antibody against a Laminin
... The role of the ECM in the outgrowth and regeneration of peripheral neurites has been the subject of many recent studies in tissue culture (1, 17, 21, 30). When plated on the ECM deposited by a variety of different cultured cell lines, neurons respond rapidly with extensive neurite outgrowth (21). L ...
... The role of the ECM in the outgrowth and regeneration of peripheral neurites has been the subject of many recent studies in tissue culture (1, 17, 21, 30). When plated on the ECM deposited by a variety of different cultured cell lines, neurons respond rapidly with extensive neurite outgrowth (21). L ...
Nicotinamidase modulation of NAD biosynthesis and nicotinamide
... 2007). Nampt mediated reduction in NAM levels is also implicated in mediating Nampt effects (Fulco et al., 2008). However, the relative importance of increases in NAD+ biosynthesis versus decreases in NAM levels to the biological activity of nicotinamidase and Nampt are still not well understood. Fu ...
... 2007). Nampt mediated reduction in NAM levels is also implicated in mediating Nampt effects (Fulco et al., 2008). However, the relative importance of increases in NAD+ biosynthesis versus decreases in NAM levels to the biological activity of nicotinamidase and Nampt are still not well understood. Fu ...
fist: an Arabidopsis mutant with altered cell division planes and
... Control of cell division orientation is thought to be a critical aspect of morphogenesis in plants. Plant cells are glued together by the middle lamella and, thus, are not able to move relative to one another during development. As a consequence, organ and body shape are generated by other cellular ...
... Control of cell division orientation is thought to be a critical aspect of morphogenesis in plants. Plant cells are glued together by the middle lamella and, thus, are not able to move relative to one another during development. As a consequence, organ and body shape are generated by other cellular ...
Characterization of the effects of antiepileptic drugs on bone
... Tecnologia da Saúde do Porto, for all the companionship, joyful spirit and encouraging words. To all those who, in a more or less permanent way, have shown their support, a big thank you. At last, the biggest and most sincere thank you to my dad and sister for helping me accomplish another important ...
... Tecnologia da Saúde do Porto, for all the companionship, joyful spirit and encouraging words. To all those who, in a more or less permanent way, have shown their support, a big thank you. At last, the biggest and most sincere thank you to my dad and sister for helping me accomplish another important ...
Dispersal of Golgi matrix proteins during mitotic Golgi
... and to account for possible variation between cells, a statistical analysis was performed on results from multiple cells for each condition and each cell was chosen solely on the basis of its DNA staining. Also, endogenous markers for matrix and nonmatrix proteins were used to avoid the various prob ...
... and to account for possible variation between cells, a statistical analysis was performed on results from multiple cells for each condition and each cell was chosen solely on the basis of its DNA staining. Also, endogenous markers for matrix and nonmatrix proteins were used to avoid the various prob ...
Modeled Osteopathic Manipulative Treatments: A Review of Their in
... Repetitive and forceful movements, awkward postures, and sustained forces often lead to repetitive motion strain (RMS), a common condition generally correlated to occupationrelated factors such as physical and psychological distress and monotonous work, but which is also correlated to non–work relat ...
... Repetitive and forceful movements, awkward postures, and sustained forces often lead to repetitive motion strain (RMS), a common condition generally correlated to occupationrelated factors such as physical and psychological distress and monotonous work, but which is also correlated to non–work relat ...
Gonadotropin-Releasing Hormone Containing Neurons and
... portion of the caudal projection may originate from cells in the olfactory epithelium and from a small group of cells in the rostral olfactory bulb. A separate reactive fiber bundle is directed toward the hypothalamus from the region of the glomeruli. Using the lectin DBA a different pattern of reac ...
... portion of the caudal projection may originate from cells in the olfactory epithelium and from a small group of cells in the rostral olfactory bulb. A separate reactive fiber bundle is directed toward the hypothalamus from the region of the glomeruli. Using the lectin DBA a different pattern of reac ...
A novel role for microglia in minimizing excitotoxicity | BMC Biology
... NMDA receptors are a subset of glutamate receptors, which can lead to neuronal excitation; too much gluta mate, such as after CNS damage, can promote excessive excitation and become toxic. Treatment of mouse organotypic hippocampal slice cultures with micromolar amounts of NMDA induces neuronal ce ...
... NMDA receptors are a subset of glutamate receptors, which can lead to neuronal excitation; too much gluta mate, such as after CNS damage, can promote excessive excitation and become toxic. Treatment of mouse organotypic hippocampal slice cultures with micromolar amounts of NMDA induces neuronal ce ...
Roles of ATR1 paralogs YMR279c and YOR378w in boron
... 2.3. Determination of intracellular boron concentrations Wild type and ymr279cD cells were grown to logarithmic phase and then splitted into two cultures. One group was treated with 50 mM boric acid whereas the other group remained untreated. After 1 h of incubation at 30 °C, cells were harvested an ...
... 2.3. Determination of intracellular boron concentrations Wild type and ymr279cD cells were grown to logarithmic phase and then splitted into two cultures. One group was treated with 50 mM boric acid whereas the other group remained untreated. After 1 h of incubation at 30 °C, cells were harvested an ...
Role of the OPG/RANK/RANKL triad in calcifications of - HAL
... be mediated by OPG and Mosheimer et al demonstrated that OPG affects monocyte migration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1. OPGinduced activation of monocyte chemotaxis toward different chemokines is due to the interactions of OPG with heparin and c ...
... be mediated by OPG and Mosheimer et al demonstrated that OPG affects monocyte migration and protein kinase C and phosphatidylinositol 3-kinase/Akt activation via syndecan-1. OPGinduced activation of monocyte chemotaxis toward different chemokines is due to the interactions of OPG with heparin and c ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.