Effects of phytanic acid on the vitamin E status, lipid composition and
... of myelin destabilization due to incorporation of phytanic acid into its structure [7]. An accumulation of phytanic acid in the retina may, therefore, perturb retinal membrane functions, such as that of the photoreceptor outer membranes or the apical membranes of the retinal pigment epithelium (RPE) ...
... of myelin destabilization due to incorporation of phytanic acid into its structure [7]. An accumulation of phytanic acid in the retina may, therefore, perturb retinal membrane functions, such as that of the photoreceptor outer membranes or the apical membranes of the retinal pigment epithelium (RPE) ...
Cytokinesis defines a spatial landmark for hepatocyte polarization
... divided by the contractile actomyosin ring and partitioned into the daughter cells. This suggestion is further supported by our observation that the circle of tight junctions that surround the mother bile canaliculus was also pulled inwards at the division site (Fig. 3D), presumably by the same cont ...
... divided by the contractile actomyosin ring and partitioned into the daughter cells. This suggestion is further supported by our observation that the circle of tight junctions that surround the mother bile canaliculus was also pulled inwards at the division site (Fig. 3D), presumably by the same cont ...
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... cellulose fibres and many additives for paper production) due to hydrolysis of cellulose stimulates cellulose fibres and many additives for paper production) due to hydrolysis of cellulose stimulates formation of bacterial gum. With formation of this mucilaginous coating, floating bits of cellulose ...
... cellulose fibres and many additives for paper production) due to hydrolysis of cellulose stimulates cellulose fibres and many additives for paper production) due to hydrolysis of cellulose stimulates formation of bacterial gum. With formation of this mucilaginous coating, floating bits of cellulose ...
- Nottingham ePrints
... receptor FGFR2, which triggers a Ras/Erk response that stimulates Cdx2 expression (Lu et al., 2008). Cdx2, together with Eomes and Elf5, have been proposed to be part of a gene regulatory network (GRN) promoting trophoblast fate in the ExE (Ng et al., 2008). Cdx2 also promotes Bmp4 expression (Muroh ...
... receptor FGFR2, which triggers a Ras/Erk response that stimulates Cdx2 expression (Lu et al., 2008). Cdx2, together with Eomes and Elf5, have been proposed to be part of a gene regulatory network (GRN) promoting trophoblast fate in the ExE (Ng et al., 2008). Cdx2 also promotes Bmp4 expression (Muroh ...
Thesis-1972D-H792p
... It should be pointed out that compounds such as penicillin, vancomycin, or D-amino acids which inhibit division activity and cell wall synthesis do not impair DNA synthesis (Grula et al., 1968), Other investigators, (Weidel, Frank, and Martin, 1964) have equated inhibition of cell division, in the p ...
... It should be pointed out that compounds such as penicillin, vancomycin, or D-amino acids which inhibit division activity and cell wall synthesis do not impair DNA synthesis (Grula et al., 1968), Other investigators, (Weidel, Frank, and Martin, 1964) have equated inhibition of cell division, in the p ...
An Auxin Gradient and Maximum in the Arabidopsis
... exogenous IAA was quickly transported down through the root system and metabolized, mainly to 2-oxoindole-3-acetic acid and 2-oxoindole-3-acetyl-b-D-O-glucopyranose. The 2-oxoindole-3-acetic acid was also the major catabolite observed in isolated protoplasts, while IAA conjugates were formed in mino ...
... exogenous IAA was quickly transported down through the root system and metabolized, mainly to 2-oxoindole-3-acetic acid and 2-oxoindole-3-acetyl-b-D-O-glucopyranose. The 2-oxoindole-3-acetic acid was also the major catabolite observed in isolated protoplasts, while IAA conjugates were formed in mino ...
TEAD4 establishes the energy homeostasis essential for blastocoel
... PMEFs were grown to near confluency, and 1 µM MHT or ethanol vehicle was added to fresh medium. Forty-eight hours later, cells were trypsinized and re-plated onto glass coverslips in 6-well dishes at 1×105 cells per well. Twenty-four hours later, cells were assayed for ROS using an Image-iT live ROS ...
... PMEFs were grown to near confluency, and 1 µM MHT or ethanol vehicle was added to fresh medium. Forty-eight hours later, cells were trypsinized and re-plated onto glass coverslips in 6-well dishes at 1×105 cells per well. Twenty-four hours later, cells were assayed for ROS using an Image-iT live ROS ...
articles
... Basement membrane (BM) breakdown is the first recognizable step and is controlled by loss of basally localized RhoA activity and its activator neuroepithelial-transforming-protein-1 (Net1). Failure of RhoA downregulation during EMT leads to BM retention and reduction of its activity in normal epithe ...
... Basement membrane (BM) breakdown is the first recognizable step and is controlled by loss of basally localized RhoA activity and its activator neuroepithelial-transforming-protein-1 (Net1). Failure of RhoA downregulation during EMT leads to BM retention and reduction of its activity in normal epithe ...
The Lyn kinase C-lobe mediates Golgi export of Lyn through
... subjected to proteolytic cleavage followed by MALDI-TOF-MS. The peptide derived from p70 (VLSEAAISASLEK) exhibited 100% identity with the amino acid sequence of human long-chain acyl-CoA synthetase-3 (ACSL3; EC 6.2.1.3). To verify the association of the Lyn C-lobe with ACSL3 in vitro, we expressed N ...
... subjected to proteolytic cleavage followed by MALDI-TOF-MS. The peptide derived from p70 (VLSEAAISASLEK) exhibited 100% identity with the amino acid sequence of human long-chain acyl-CoA synthetase-3 (ACSL3; EC 6.2.1.3). To verify the association of the Lyn C-lobe with ACSL3 in vitro, we expressed N ...
Slow muscle regulates the pattern of trunk neural crest migration in
... Although all vertebrates have a similar body plan, the early cell movements that establish that body plan can differ considerably in different vertebrate subgroups. For example, neural crest cells, a defining feature of vertebrates, migrate from their origin in the region of the dorsal neural tube t ...
... Although all vertebrates have a similar body plan, the early cell movements that establish that body plan can differ considerably in different vertebrate subgroups. For example, neural crest cells, a defining feature of vertebrates, migrate from their origin in the region of the dorsal neural tube t ...
Anti-bacteria and In Vivo Tumor Treatment by Reactive Oxygen
... (1.58 mL), and HOOC-PEG2000-COOH (4.8 g) were dissolved in diphenyl oxide (20 mL). The solution was heated from room temperature to reflux within 15 min after being purged with nitrogen for 2 h. Under mechanical stirring at 400 rpm, the reaction mixture was refluxed for 15 min. After removing the he ...
... (1.58 mL), and HOOC-PEG2000-COOH (4.8 g) were dissolved in diphenyl oxide (20 mL). The solution was heated from room temperature to reflux within 15 min after being purged with nitrogen for 2 h. Under mechanical stirring at 400 rpm, the reaction mixture was refluxed for 15 min. After removing the he ...
Inflammatory injury in myocardial ischaemia
... with the enzyme myeloperoxidase, one of the major constituents of neutrophil granules, to form an enzymesubstrate complex that oxidizes halides, and ...
... with the enzyme myeloperoxidase, one of the major constituents of neutrophil granules, to form an enzymesubstrate complex that oxidizes halides, and ...
Autoantibody Explosion in Systemic Lupus Erythematosus: More
... disease activity, and which clinical findings are associated with the autoantibodies in SLE. Although any SLE patient might simultaneously have a relatively large number of autoantibodies, most of the autoantibodies described in Tables 1 to 10 are not found in most SLE patients. Whereas ANA are foun ...
... disease activity, and which clinical findings are associated with the autoantibodies in SLE. Although any SLE patient might simultaneously have a relatively large number of autoantibodies, most of the autoantibodies described in Tables 1 to 10 are not found in most SLE patients. Whereas ANA are foun ...
Golgi-targeting sequence of p230 - Journal of Cell Science
... secretory pathway. In polarised cells, two distinct vesicle populations are formed in the TGN to transport proteins selectively to the apical or the basolateral membrane (Wandinger-Ness et al., 1990). Recent data indicate that fibroblasts also have at least two distinct pathways from the TGN to the ...
... secretory pathway. In polarised cells, two distinct vesicle populations are formed in the TGN to transport proteins selectively to the apical or the basolateral membrane (Wandinger-Ness et al., 1990). Recent data indicate that fibroblasts also have at least two distinct pathways from the TGN to the ...
Mast Cell-Derived Exosomes Induce Phenotypic and Functional
... DCs of human tonsil tissue in vivo (8), which does not express these molecules. Tolerosomes assembled in and released from the small intestinal epithelial cells are another example of exosomelike structures (9). Tolerosomes isolated from serum shortly after Ag feeding or from in vitro-pulsed intesti ...
... DCs of human tonsil tissue in vivo (8), which does not express these molecules. Tolerosomes assembled in and released from the small intestinal epithelial cells are another example of exosomelike structures (9). Tolerosomes isolated from serum shortly after Ag feeding or from in vitro-pulsed intesti ...
here - The Nebenführ Lab
... Golgi stacks, and the formation of an endoplasmic reticulum (ER)–Golgi hybrid compartment with stacked domains. These secondary effects appear to depend in part on stabilizing intercisternal filaments and include the continued maturation of cis- and medial cisternae into trans-Golgi cisternae, as pr ...
... Golgi stacks, and the formation of an endoplasmic reticulum (ER)–Golgi hybrid compartment with stacked domains. These secondary effects appear to depend in part on stabilizing intercisternal filaments and include the continued maturation of cis- and medial cisternae into trans-Golgi cisternae, as pr ...
Distinct Cellular Expression Pattern of Annexins in Hydra vulgaris
... a highly conserved core domain and distinctive aminoterminal domains of varying size. The homologues of different annexins have been highly conserved between species. To search for new annexins, one of the most sensitive methods available is to screen cell extracts for proteins that exhibit the prop ...
... a highly conserved core domain and distinctive aminoterminal domains of varying size. The homologues of different annexins have been highly conserved between species. To search for new annexins, one of the most sensitive methods available is to screen cell extracts for proteins that exhibit the prop ...
PDF
... related cell behaviors (Veeman et al., 2003; Wang and Nathans, 2007). The molecular basis of morphogenetic behaviors at the notochord boundary are much less well understood, although components of the extracellular matrix and integrins have been implicated in directing both motility and boundary beh ...
... related cell behaviors (Veeman et al., 2003; Wang and Nathans, 2007). The molecular basis of morphogenetic behaviors at the notochord boundary are much less well understood, although components of the extracellular matrix and integrins have been implicated in directing both motility and boundary beh ...
Auxin and other signals on the move in plants Auxins are a class of
... development of the plant itself. Without hormonal regulation and organization, plants would be merely proliferating heaps of similar cells. Auxin employment begins in the embryo of the plant, where directional distribution of auxin ushers in subsequent growth and development of primary growth poles, ...
... development of the plant itself. Without hormonal regulation and organization, plants would be merely proliferating heaps of similar cells. Auxin employment begins in the embryo of the plant, where directional distribution of auxin ushers in subsequent growth and development of primary growth poles, ...
Isolation, engineering, and characterization of intracellular
... aggregation by binding to the htt fragment and inactivating it or preventing its misfolding. Intrabodies may therefore be a useful gene therapy approach to treatment of the disease. However, high expression levels of previously reported intrabodies have been required to obtain even limited reducti ...
... aggregation by binding to the htt fragment and inactivating it or preventing its misfolding. Intrabodies may therefore be a useful gene therapy approach to treatment of the disease. However, high expression levels of previously reported intrabodies have been required to obtain even limited reducti ...
Role of GATA factors in development, differentiation, and
... possessing three germ layers are linked to the evolution of axis formation and bilateral symmetry. In contrast to diploblastic animals, triploblastic bilaterians (with the exception of a few highly reduced forms) have complete digestive tracts with separate mouth and anus. The through-gut system ena ...
... possessing three germ layers are linked to the evolution of axis formation and bilateral symmetry. In contrast to diploblastic animals, triploblastic bilaterians (with the exception of a few highly reduced forms) have complete digestive tracts with separate mouth and anus. The through-gut system ena ...
Morphologic and functional characterization of granulocytes and
... represented transcripts of the same gene, the 2 primer pairs (5⬘CGGTTCTGTGGATTGTCT-3⬘ with 5⬘-CACGACCACCAGGAGCAA3⬘; and 5⬘-GGATTGTCTGCTCCTCAGA-3⬘ with 5⬘-GCCACCGTCACCAGTCTC-3⬘) were used to amplify 125 and 385 nt fragments, respectively, from an adult zebrafish kidney cDNA library (gift of L. Zon, B ...
... represented transcripts of the same gene, the 2 primer pairs (5⬘CGGTTCTGTGGATTGTCT-3⬘ with 5⬘-CACGACCACCAGGAGCAA3⬘; and 5⬘-GGATTGTCTGCTCCTCAGA-3⬘ with 5⬘-GCCACCGTCACCAGTCTC-3⬘) were used to amplify 125 and 385 nt fragments, respectively, from an adult zebrafish kidney cDNA library (gift of L. Zon, B ...
Cytotoxic effect of lomefloxacin in culture of human epidermal
... lomefloxacin acts by inhibiting DNA topoisomerases, of which DNA gyrase and topoisomerase IV are particularly important [28, 40]. Serious adverse phototoxic reactions on melanin containing tissues (e.g., allergy, toxic dermatitis, retinal degeneration) have been described for the use of lomefloxacin ...
... lomefloxacin acts by inhibiting DNA topoisomerases, of which DNA gyrase and topoisomerase IV are particularly important [28, 40]. Serious adverse phototoxic reactions on melanin containing tissues (e.g., allergy, toxic dermatitis, retinal degeneration) have been described for the use of lomefloxacin ...
the different types of wounds
... Look for redness that is “non-blanchable.” Healthy red areas turn white when pressed and released, while damaged areas are non-blanchable and remain red. Gently feel for changes in skin temperature and be suspicious of areas that feel spongy or harder than surrounding tissue. Check patients from hea ...
... Look for redness that is “non-blanchable.” Healthy red areas turn white when pressed and released, while damaged areas are non-blanchable and remain red. Gently feel for changes in skin temperature and be suspicious of areas that feel spongy or harder than surrounding tissue. Check patients from hea ...
Cell adhesion and cell mechanics during zebrafish
... to a vast number of cells which subsequently have to share specialized tasks and build complex structures such as eyes, heart or brain (see Fig. 1.1). But how can cells that originate from a single ancestor control all these processes? Surely, an important aspect are differences in gene expression a ...
... to a vast number of cells which subsequently have to share specialized tasks and build complex structures such as eyes, heart or brain (see Fig. 1.1). But how can cells that originate from a single ancestor control all these processes? Surely, an important aspect are differences in gene expression a ...
Tissue engineering
Tissue engineering is the use of a combination of cells, engineering and materials methods, and suitable biochemical and physicochemical factors to improve or replace biological functions. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field in its own right.While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e., bone, cartilage, blood vessels, bladder, skin, muscle etc.). Often, the tissues involved require certain mechanical and structural properties for proper functioning. The term has also been applied to efforts to perform specific biochemical functions using cells within an artificially-created support system (e.g. an artificial pancreas, or a bio artificial liver). The term regenerative medicine is often used synonymously with tissue engineering, although those involved in regenerative medicine place more emphasis on the use of stem cells or progenitor cells to produce tissues.