Interleukin-6 in Sepsis and Capillary Leakage Syndrome - Labor
... alarming the organism and coordinating appropriate defense mechanisms. The resulting ‘‘cytokine storm’’ not only restricts bacterial invasion; it also harms the host by triggering a hemodynamic collapse with a drop in blood pressure, which could lead to death. One of the cytokines released during se ...
... alarming the organism and coordinating appropriate defense mechanisms. The resulting ‘‘cytokine storm’’ not only restricts bacterial invasion; it also harms the host by triggering a hemodynamic collapse with a drop in blood pressure, which could lead to death. One of the cytokines released during se ...
Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules
... between fluorescence increase and growth rate are seen at times far from the aligning point. In particular, it was found that, due to a restructuring of the CCP in the axial direction, the TIRF fluorescence decreases at late stages, even though the CCP grows. It was observed that clathrin and AP-2 are ...
... between fluorescence increase and growth rate are seen at times far from the aligning point. In particular, it was found that, due to a restructuring of the CCP in the axial direction, the TIRF fluorescence decreases at late stages, even though the CCP grows. It was observed that clathrin and AP-2 are ...
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of
... LC3-I defines the LC3-II form that is tightly associated with the autophagosomal membrane (7, 9). The LC3-II form is involved during the late steps of autophagy after the isolation membrane has formed (3). In humans, three LC3 isoforms (LC3A, -B, and -C) and four additional human Atg8 homologues hav ...
... LC3-I defines the LC3-II form that is tightly associated with the autophagosomal membrane (7, 9). The LC3-II form is involved during the late steps of autophagy after the isolation membrane has formed (3). In humans, three LC3 isoforms (LC3A, -B, and -C) and four additional human Atg8 homologues hav ...
Distinguishing between resistance, tolerance and
... This drug-induced tolerance subsequently protects the bacteria from the lethal activity of the antibiotic9. In contrast to resistance and tolerance, which are attributes of whole bacterial populations, ‘persistence’ is the ability of a subpopulation of a clonal bacterial population to survive exposu ...
... This drug-induced tolerance subsequently protects the bacteria from the lethal activity of the antibiotic9. In contrast to resistance and tolerance, which are attributes of whole bacterial populations, ‘persistence’ is the ability of a subpopulation of a clonal bacterial population to survive exposu ...
Abundant Type III Lipid Transfer Proteins in
... the tapetum is secretory in nature, the tapetum LTPs, which are also found in the anther locule, are considered to function to transfer lipid materials from the tapetum to maturing microspores. However, this function has not been defined, even though the pollen exine consists of lipid monomers and so ...
... the tapetum is secretory in nature, the tapetum LTPs, which are also found in the anther locule, are considered to function to transfer lipid materials from the tapetum to maturing microspores. However, this function has not been defined, even though the pollen exine consists of lipid monomers and so ...
Endothelial Barrier Function Adenosine
... Sailaja Narravula,* Paul F. Lennon,* Beatrice U. Mueller,† and Sean P. Colgan2* ...
... Sailaja Narravula,* Paul F. Lennon,* Beatrice U. Mueller,† and Sean P. Colgan2* ...
A B23-interacting sequence as a tool to visualize protein interactions
... (Fankhauser et al., 1991). In this latter case, B23 could serve as a molecular chaperone for Rev (Olson, 2004). In addition, it was also proposed that B23 could play a role in nucleocytoplasmic transport since it can shuttle between the nucleus and the cytoplasm (Borer et al., 1989; Fankhauser et al ...
... (Fankhauser et al., 1991). In this latter case, B23 could serve as a molecular chaperone for Rev (Olson, 2004). In addition, it was also proposed that B23 could play a role in nucleocytoplasmic transport since it can shuttle between the nucleus and the cytoplasm (Borer et al., 1989; Fankhauser et al ...
Escherichia coli Karl Skoog
... The biogenesis of the peptidoglycan layer can be divided into two steps. The first step, synthesis of the peptidoglycan precursor, occurs in the cytoplasm, whereas the second step, polymerization of peptidoglycan precursors to form the peptidoglycan layer, occurs in the periplasm 35. The peptidoglyc ...
... The biogenesis of the peptidoglycan layer can be divided into two steps. The first step, synthesis of the peptidoglycan precursor, occurs in the cytoplasm, whereas the second step, polymerization of peptidoglycan precursors to form the peptidoglycan layer, occurs in the periplasm 35. The peptidoglyc ...
DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE
... into mature mucosal or connective tissue mast cells (with specialized granule contents, etc.) in response to factors released by the local tissue5. The two varieties of mast cells are differentiated by their tissue of residence and can be identified by their differential histological staining proper ...
... into mature mucosal or connective tissue mast cells (with specialized granule contents, etc.) in response to factors released by the local tissue5. The two varieties of mast cells are differentiated by their tissue of residence and can be identified by their differential histological staining proper ...
What Hydra Has to Say About the Role and Origin of Symbiotic
... What Hydra Has to Say About the Role and Origin of Symbiotic Interactions THOMAS C. G. BOSCH* Zoologisches Institut der Christian-Albrechts-Universität zu Kiel, Germany ...
... What Hydra Has to Say About the Role and Origin of Symbiotic Interactions THOMAS C. G. BOSCH* Zoologisches Institut der Christian-Albrechts-Universität zu Kiel, Germany ...
Pattern recognition receptors and control of adaptive immunity
... Two related checkpoints in the adaptive immune response control the magnitude and duration of the response, which should correlate with the extent and persistence of infection, respectively. Unlike the origin of the antigen or the class of pathogen, the magnitude and duration of a response are grade ...
... Two related checkpoints in the adaptive immune response control the magnitude and duration of the response, which should correlate with the extent and persistence of infection, respectively. Unlike the origin of the antigen or the class of pathogen, the magnitude and duration of a response are grade ...
Efficiency and Diversity of Protein Localization by Random Signal Sequences.
... The first approach was used to identify point mutations in signal peptides that impair signal function. Mutations in secreted bacterial proteins that produce a complete block in translocation were isolated (5, 11). For example, in the signal sequence of the maltose-binding protein of Escherichia col ...
... The first approach was used to identify point mutations in signal peptides that impair signal function. Mutations in secreted bacterial proteins that produce a complete block in translocation were isolated (5, 11). For example, in the signal sequence of the maltose-binding protein of Escherichia col ...
Relative Potencies of Individual Polycyclic Aromatic Hydrocarbons to Induce Dioxinlike
... mass-balance studies of Korean sediment and other environmental samples have relied on the relative potencies (REPs) of PAHs reported in the literature. Although such values are useful for comparative purposes and for the development of consensus values for use in risk assessments, they are not idea ...
... mass-balance studies of Korean sediment and other environmental samples have relied on the relative potencies (REPs) of PAHs reported in the literature. Although such values are useful for comparative purposes and for the development of consensus values for use in risk assessments, they are not idea ...
PDF
... (Mr 27-5 x 103, component of band 5 on ID), 32 (Mr 27-5 x 103, component of band 5 on ID), 33 (Mr 25-5 x 103, band 3 on ID) and 34 (Mr 11-5 x 103). By contrast, although several of the major proteins synthesized by the oocyte before maturation become prominent during maturation e.g. polypeptides 14 ...
... (Mr 27-5 x 103, component of band 5 on ID), 32 (Mr 27-5 x 103, component of band 5 on ID), 33 (Mr 25-5 x 103, band 3 on ID) and 34 (Mr 11-5 x 103). By contrast, although several of the major proteins synthesized by the oocyte before maturation become prominent during maturation e.g. polypeptides 14 ...
Modeling the Mechanics of Cell Division: Influence of
... This article was submitted to Biophysics, a section of the journal Frontiers in Physiology Received: 11 January 2017 Accepted: 30 April 2017 Published: 19 May 2017 Citation: Beltrán-Heredia E, Almendro-Vedia VG, Monroy F and Cao FJ (2017) Modeling the Mechanics of Cell Division: Influence of Spontan ...
... This article was submitted to Biophysics, a section of the journal Frontiers in Physiology Received: 11 January 2017 Accepted: 30 April 2017 Published: 19 May 2017 Citation: Beltrán-Heredia E, Almendro-Vedia VG, Monroy F and Cao FJ (2017) Modeling the Mechanics of Cell Division: Influence of Spontan ...
NF-kB as a primary regulator of the stress response
... suggests that MEKK-2 and MEKK-3 are also capable of inducing NF-kB activity (Zhao and Lee, 1999). The exact role of NIK and the MEKKs in IKK activation has been the subject of considerable controversy. A recent report demonstrated via phosphopeptide mapping studies that IKK2 is phosphorylated at Ser ...
... suggests that MEKK-2 and MEKK-3 are also capable of inducing NF-kB activity (Zhao and Lee, 1999). The exact role of NIK and the MEKKs in IKK activation has been the subject of considerable controversy. A recent report demonstrated via phosphopeptide mapping studies that IKK2 is phosphorylated at Ser ...
Improper chromosome synapsis is associated with
... synapsis both in interstitial and terminal chromosome regions, as can be seen by the “bulges”. In Fig. 1A, the white arrow points to one of these bulges, which is too wide for synapsis. The two black arrows both point to asymmetric loops of the SC. Again the lateral elements are too far apart to syn ...
... synapsis both in interstitial and terminal chromosome regions, as can be seen by the “bulges”. In Fig. 1A, the white arrow points to one of these bulges, which is too wide for synapsis. The two black arrows both point to asymmetric loops of the SC. Again the lateral elements are too far apart to syn ...
Requirement of Heavy Neurofilament Subunit in the Development of
... in vivo, rodent NFs appear to be obligate heteropolymers since none of the rat or mouse NF subunits can form filaments when transfected individually into cells lacking an endogenous IF network (Ching and Liem, 1993; Lee et al., 1993). Similar conclusions have also been reached by expressing rat NFs ...
... in vivo, rodent NFs appear to be obligate heteropolymers since none of the rat or mouse NF subunits can form filaments when transfected individually into cells lacking an endogenous IF network (Ching and Liem, 1993; Lee et al., 1993). Similar conclusions have also been reached by expressing rat NFs ...
PDF
... at the early blastula stage (Revilla-i-Domingo et al., 2007; Smith and Davidson, 2008). Overexpression of Pmar1 results in a decrease in the level of hesC transcripts, whereas morpholino (MO) knockdown of HesC leads to the ectopic expression of delta throughout the embryo and to an increase in the l ...
... at the early blastula stage (Revilla-i-Domingo et al., 2007; Smith and Davidson, 2008). Overexpression of Pmar1 results in a decrease in the level of hesC transcripts, whereas morpholino (MO) knockdown of HesC leads to the ectopic expression of delta throughout the embryo and to an increase in the l ...
Transforming growth factor–1 in supernatants from stored red blood
... Consistent with the possible increased risk of postoperative infections in transfusion patients, various studies suggest that transfusions can induce immunomodulatory effects, including transient reduction in the CD4/CD8 T-cell ratio, reduced natural killer function, impaired lymphocyte mitogenic re ...
... Consistent with the possible increased risk of postoperative infections in transfusion patients, various studies suggest that transfusions can induce immunomodulatory effects, including transient reduction in the CD4/CD8 T-cell ratio, reduced natural killer function, impaired lymphocyte mitogenic re ...
Drosophila Xpd Regulates Cdk7 Localization, Mitotic Kinase
... Direct testing of potential cell cycle functions of xpd in the absence of a transcriptional requirement should be possible if we can make young preblastoderm embryos that lack Xpd. During the rapid nuclear divisions of the preblastoderm stage, embryonic transcription is not required for development ...
... Direct testing of potential cell cycle functions of xpd in the absence of a transcriptional requirement should be possible if we can make young preblastoderm embryos that lack Xpd. During the rapid nuclear divisions of the preblastoderm stage, embryonic transcription is not required for development ...
Autoregulation of Actin Synthesis by Physiological
... F-actm ), respectively. This dynamic process is con- . j ™ * · A. ...
... F-actm ), respectively. This dynamic process is con- . j ™ * · A. ...
Mitochondria Buffer Physiological Calcium
... subsequent stimuli were 20 V over this threshold. Cells were stimulated in this manner once every 4 min. After completion of each experiment, the microscope stage was adjusted so that no cells or debris occupied the field of view defined by the diaphragm, and then background light levels were determ ...
... subsequent stimuli were 20 V over this threshold. Cells were stimulated in this manner once every 4 min. After completion of each experiment, the microscope stage was adjusted so that no cells or debris occupied the field of view defined by the diaphragm, and then background light levels were determ ...
Influence of ovarian muscle contraction and oocyte growth on egg
... increases in volume through the end of stage 10 (stage 10b). The nurse cells increase their volumes throughout stages 1 to 10b, primarily through endoreplication of their genomes. By contrast, the oocyte undergoes an independent expansion beginning at stage 8 when it takes up yolk proteins, a proces ...
... increases in volume through the end of stage 10 (stage 10b). The nurse cells increase their volumes throughout stages 1 to 10b, primarily through endoreplication of their genomes. By contrast, the oocyte undergoes an independent expansion beginning at stage 8 when it takes up yolk proteins, a proces ...