PDF
... The developmental origins of both the epithelial and lymphocytic components of the thymus have been sources of controversy within the field. Lymphocytes were proposed to originate either from transformation of epithelium within the rudiment or from immigration from extrathymic sources. In an early e ...
... The developmental origins of both the epithelial and lymphocytic components of the thymus have been sources of controversy within the field. Lymphocytes were proposed to originate either from transformation of epithelium within the rudiment or from immigration from extrathymic sources. In an early e ...
To be or not to be alive: How recent discoveries challenge the
... with phages studied by microbiologists and viruses by cellular biologists (cells being frequently assimilated to eukaryotic cells). The phage/virus paradigm persists because the “eukaryote/prokaryote” dichotomy became itself a paradigm that has remained dominant in cell biology until now (Pace, 2006 ...
... with phages studied by microbiologists and viruses by cellular biologists (cells being frequently assimilated to eukaryotic cells). The phage/virus paradigm persists because the “eukaryote/prokaryote” dichotomy became itself a paradigm that has remained dominant in cell biology until now (Pace, 2006 ...
SKIP controls lysosome positioning using a composite kinesin
... 2014; Vale, 2003; Vale et al., 1985; Verhey and Hammond, 2009b). Kinesin-1 is hijacked by pathogens including vaccinia virus, herpes viruses and HIV-1 during infection, as well as bacteria that replicate inside the cell such as Salmonella (Boucrot et al., 2005; Dodding and Way, 2011; Dumont et al., ...
... 2014; Vale, 2003; Vale et al., 1985; Verhey and Hammond, 2009b). Kinesin-1 is hijacked by pathogens including vaccinia virus, herpes viruses and HIV-1 during infection, as well as bacteria that replicate inside the cell such as Salmonella (Boucrot et al., 2005; Dodding and Way, 2011; Dumont et al., ...
Splice switching efficiency and specificity for oligonucleotides
... boundaries during pre-mRNA splicing [1]. Manipulation of pre-mRNA splicing is one approach to find novel therapies for inherited diseases such as cystic fibrosis [2], βthalassemia [3] and Duchenne’s muscular dystrophy [4]. An application that has gained increasing attention since its initial discove ...
... boundaries during pre-mRNA splicing [1]. Manipulation of pre-mRNA splicing is one approach to find novel therapies for inherited diseases such as cystic fibrosis [2], βthalassemia [3] and Duchenne’s muscular dystrophy [4]. An application that has gained increasing attention since its initial discove ...
Novel Regulators of Vascular Development in Arabidopsis
... Xylem, the water transporting tissue, differentiates from the procambium during primary development, as mentioned above. In the Arabidopsis root, 4–5 cell files of xylem vessels are formed in the central axis of the vascular cylinder (Figure 2). During differentiation, the xylem vessels develop lign ...
... Xylem, the water transporting tissue, differentiates from the procambium during primary development, as mentioned above. In the Arabidopsis root, 4–5 cell files of xylem vessels are formed in the central axis of the vascular cylinder (Figure 2). During differentiation, the xylem vessels develop lign ...
The mating pair stabilization protein, TraN, of the F plasmid is an
... ability. TraN is a hallmark protein of F-type IV secretion systems as demonstrated by BLAST searches of the databases. The C-terminal region is highly conserved and contains five of the six completely conserved cysteines. Mutation of these residues to serine demonstrated their importance in TraN fun ...
... ability. TraN is a hallmark protein of F-type IV secretion systems as demonstrated by BLAST searches of the databases. The C-terminal region is highly conserved and contains five of the six completely conserved cysteines. Mutation of these residues to serine demonstrated their importance in TraN fun ...
Arrested Differentiation of Proplastids into Chloroplasts in
... from the tip to the middle part of the FTL at 6 d. These data suggested that this is the stage where cells are destined to undergo normal chloroplast differentiation or a possible arrest of thylakoid development (feature 1, Fig. 6). Secondly, cells in green sectors form normal chloroplasts, but this ...
... from the tip to the middle part of the FTL at 6 d. These data suggested that this is the stage where cells are destined to undergo normal chloroplast differentiation or a possible arrest of thylakoid development (feature 1, Fig. 6). Secondly, cells in green sectors form normal chloroplasts, but this ...
Wing Surface of Lepidopteran Insects (Butterflies and Moths
... were rarely adjacent; c-b’s, which are alternation units, are repeated in most regions of the scale rows while c-c-b’s and c-b-b’s, which are unalternation units, were rarely observed (Yoshida and Aoki, 1989). The ratio of the number of c-c-b and c-b-b to the total number of c-b, c-c-b, and c-b-b wa ...
... were rarely adjacent; c-b’s, which are alternation units, are repeated in most regions of the scale rows while c-c-b’s and c-b-b’s, which are unalternation units, were rarely observed (Yoshida and Aoki, 1989). The ratio of the number of c-c-b and c-b-b to the total number of c-b, c-c-b, and c-b-b wa ...
OPTIMISATION OF CHO CELL GROWTH AND
... A statistical approach was used to identify important culture components for cell growth and LFN-y production. When the concentration of the resulting positive variables was initially increased in culture, improvements of approximately 40% in both of these parameters were achieved; the glycosylation ...
... A statistical approach was used to identify important culture components for cell growth and LFN-y production. When the concentration of the resulting positive variables was initially increased in culture, improvements of approximately 40% in both of these parameters were achieved; the glycosylation ...
Homeomorphisms between homotopy manifolds and their resolutions
... topological manifold. This is demonstrated by Siebenmann in [10]. He omits the proof in the case where 0M :~0, but this is supplied by Glaser 1,4] in his recent work on homotopy manifolds. (It is unknown at present March, 1970 - whether every triangulated topological manifold is, in fact, a homotopy ...
... topological manifold. This is demonstrated by Siebenmann in [10]. He omits the proof in the case where 0M :~0, but this is supplied by Glaser 1,4] in his recent work on homotopy manifolds. (It is unknown at present March, 1970 - whether every triangulated topological manifold is, in fact, a homotopy ...
Exploring glycoside hydrolase family 5 (GH5) enzymes
... which they usually tightly bind onto the surface of cellulose via hydrogen bonds. Galactoglucomannan, glucomannan, arabinoglucoronoxylan, glucuronoxylan and xyloglucan (XG) are examples of common and abundant plant cell wall hemicelluloses [17]. In primary walls of dicotyledonous plants, XG is the m ...
... which they usually tightly bind onto the surface of cellulose via hydrogen bonds. Galactoglucomannan, glucomannan, arabinoglucoronoxylan, glucuronoxylan and xyloglucan (XG) are examples of common and abundant plant cell wall hemicelluloses [17]. In primary walls of dicotyledonous plants, XG is the m ...
A GH3-like Domain in Reaper Is Required for Mitochondrial
... SMAC, an IAP inhibitory protein that, in its cytoplasmically released form, carries an N-terminal IBM motif (23, 24). Like Reaper, HID, and Grim, SMAC can interfere with IAP-mediated caspase inhibition. However, unlike the fly IBM proteins, SMAC does not appear to be a potent cell killer, consistent ...
... SMAC, an IAP inhibitory protein that, in its cytoplasmically released form, carries an N-terminal IBM motif (23, 24). Like Reaper, HID, and Grim, SMAC can interfere with IAP-mediated caspase inhibition. However, unlike the fly IBM proteins, SMAC does not appear to be a potent cell killer, consistent ...
Bacteriochlorophyll-Synthesizing Budding Bacterium
... Erythrobacter longus. They also differ from members of the Plunctomycetules phenotypically in their synthesis of bacteriochlorophylland possession of a peptidoglycan cell wall. They can be distinguished from E. longus on the basis of their 16s rRNA sequence, the G+C content of their DNA, cellular fa ...
... Erythrobacter longus. They also differ from members of the Plunctomycetules phenotypically in their synthesis of bacteriochlorophylland possession of a peptidoglycan cell wall. They can be distinguished from E. longus on the basis of their 16s rRNA sequence, the G+C content of their DNA, cellular fa ...
Light and Electron Microscopy of the Sheath of a Blue
... portions sloughed off, it stained with Alcian blue and was probably polysaccharide. The sheath formed salt-like complexes with proteins at appropriate low pH values which rendered it visible by phase-contrast microscopy. The composition of the culture medium influenced sheath formation. Electron mic ...
... portions sloughed off, it stained with Alcian blue and was probably polysaccharide. The sheath formed salt-like complexes with proteins at appropriate low pH values which rendered it visible by phase-contrast microscopy. The composition of the culture medium influenced sheath formation. Electron mic ...
Saliva of the Lyme Disease Vector, Lxodes dammini, Blocks
... inoculation but these responses are greatly delayed or are nonexistent in animals infected with similar numbers of spirochetes delivered by infected ticks (12, 13). This suggests that tick saliva modifies the host-specific T and B cell response to the Lyme spirochete. However, the immunological mech ...
... inoculation but these responses are greatly delayed or are nonexistent in animals infected with similar numbers of spirochetes delivered by infected ticks (12, 13). This suggests that tick saliva modifies the host-specific T and B cell response to the Lyme spirochete. However, the immunological mech ...
BTK, THE TYROSINE KINASE AFFECTED IN X-LINKED
... Several PH domains have been found to associate with different phosphoinositides (56-65). It is possible that some PH domains serve as membrane-binding/associating units. Recently, PH domain of human βIΣII spectrin was localized to the plasma membrane in vivo (66). Dbl PH domains may mediate cellula ...
... Several PH domains have been found to associate with different phosphoinositides (56-65). It is possible that some PH domains serve as membrane-binding/associating units. Recently, PH domain of human βIΣII spectrin was localized to the plasma membrane in vivo (66). Dbl PH domains may mediate cellula ...
The Ovule and the Embryo Sac
... The plant life cycle is characterized by the alternation of generations between a diploid sporophyte and a haploid gametophyte. The sporophyte functions to produce spores, which then develop into gametophytes. The differentiated gametophytes in turn produce either the male gametes (sperm) or female ...
... The plant life cycle is characterized by the alternation of generations between a diploid sporophyte and a haploid gametophyte. The sporophyte functions to produce spores, which then develop into gametophytes. The differentiated gametophytes in turn produce either the male gametes (sperm) or female ...
Prions: Infectious Proteins with Genetic Properties
... diseases may be explained by the increased ability of mutant proteins to convert into the pathogenic form. Two models have been suggested to explain rearrangement of the PrPC protein into the PrPSc form. According to the heterodimer model, the prion state is inherent for the monomer of PrP protein ...
... diseases may be explained by the increased ability of mutant proteins to convert into the pathogenic form. Two models have been suggested to explain rearrangement of the PrPC protein into the PrPSc form. According to the heterodimer model, the prion state is inherent for the monomer of PrP protein ...
POS-1 and germ cell specification
... mex-1 appears to play a distinct role from pie-1, because at least some transcription is properly repressed in the germline blastomeres of mex-1 mutants (Guedes and Priess, 1997). PIE1 is a novel, predominantly nuclear, protein of unknown function that is localized to a germline blastomere at each o ...
... mex-1 appears to play a distinct role from pie-1, because at least some transcription is properly repressed in the germline blastomeres of mex-1 mutants (Guedes and Priess, 1997). PIE1 is a novel, predominantly nuclear, protein of unknown function that is localized to a germline blastomere at each o ...
Malva verticillata seed extracts upregulate the Wnt pathway in
... Factors secreted from dermal papilla cells (DPCs) directly influence the surrounding matrix cells either to proliferate and differentiate or to stimulate hair stem cells to initiate a new anagen phase [5]. The Wnt/b-catenin pathway is known to be essential for these biological processes in hair foll ...
... Factors secreted from dermal papilla cells (DPCs) directly influence the surrounding matrix cells either to proliferate and differentiate or to stimulate hair stem cells to initiate a new anagen phase [5]. The Wnt/b-catenin pathway is known to be essential for these biological processes in hair foll ...
High-Molecular-Weight Forms of Tyrosinase and the
... TRP-2 migrated exclusively in a hig h - molecul ar-we ig ht form, as expected from its behavior on mol ecul ar sieve HPLC (Fig 1b, bottom). No TRP-2 was detected in association with th e peak of "free" tyrosinase from HPLC (Fig lb, lOp), Triton X-1 00 was used only in the initial phase of the purifi ...
... TRP-2 migrated exclusively in a hig h - molecul ar-we ig ht form, as expected from its behavior on mol ecul ar sieve HPLC (Fig 1b, bottom). No TRP-2 was detected in association with th e peak of "free" tyrosinase from HPLC (Fig lb, lOp), Triton X-1 00 was used only in the initial phase of the purifi ...
