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Glucose-6-P to Fructose-6-P
Glucose-6-P to Fructose-6-P

... • First step in glycolysis • Large negative deltaG • Hexokinase is regulated - allosterically inhibited by (product) glucose-6-P • Corresponding reverse reaction (Gluconeogenesis) is catalyzed by a different enzyme (glucose-6phosphatase) • Is it the committed step in glycolysis ? ...
2. Genetic code is degenerate(简并性)
2. Genetic code is degenerate(简并性)

... UAA UAG ...
PowerPoint
PowerPoint

... I. The cells that make up organisms are at constant work producing materials for growth, reproduction, movement, and maintenance of the internal environment. In order for the cells to keep functioning, they must convert substances to make ATP. ...
Fructose-1,6 - LSU School of Medicine
Fructose-1,6 - LSU School of Medicine

... List gluconeogenic precursors List the enzymes and intermediates involved in gluconeogenesis List the irreversible and regulated steps of gluconeogenesis Discuss regulation of gluconeogenesis ...
Lab 7 PPT - Dr Magrann
Lab 7 PPT - Dr Magrann

... as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. • ATP transports chemical energy within cells for metabolism. It is one of the end products of phosphorylation and cellular respiration and used in many cellular processes, including muscle contracti ...
The Process of Cellular Respiration
The Process of Cellular Respiration

... citric acid. One is removed, and then another, releasing 2 molecules of carbon dioxide and leaving a 4-carbon molecule. Why is the Krebs cycle a “cycle”? Because the 4-carbon molecule produced in the last step is the same molecule that accepts the acetyl-CoA in the first step. The molecule needed to ...
Pathophysiology of Skeletal Muscle
Pathophysiology of Skeletal Muscle

... metabolism would allow replenishment of ATP for almost a minute even in the absence of oxygen, but would soon be limited by acidification and accumulation of lactate. In normal circumstances, oxygen is available even during intense efforts, allowing the muscle to run on a mix of anaerobic and aerobi ...
Bio 226: Cell and Molecular Biology
Bio 226: Cell and Molecular Biology

... •Insensitive to Cyanide, Azide or CO •Sensitive to SHAM (salicylhydroxamic acid,) •Also found in fungi, trypanosomes & Plasmodium ...
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases

... DNA. These nDNA-encoded mitochondrial proteins are translated on cytosolic ribosomes and selectively imported into the mitochondrion through various mitochondrial protein import systems. For example, certain proteins destined for the mitochondrial matrix are synthesized with an amino terminal, posit ...
Bioenergetics of Exercise and Training
Bioenergetics of Exercise and Training

... ADP) during the breakdown of glyceraldehyde-3-phosphate (G-3-P) at two specific reactions (as shown in Figure 3, page 7) ...
PYRUVATE OXIDATION, KREBS CYCLE agnes je... 583KB Nov 04
PYRUVATE OXIDATION, KREBS CYCLE agnes je... 583KB Nov 04

... http://drchadedwards.com/244/energy-production-through-the-krebs-cycle/ Freeman, W.H. (2002). The Citric Acid Cycle. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK21163/ Krebs cycle. (n.d.). Retrieved from ...
12_Lecture
12_Lecture

... • The molecules produced by the breakdown are absorbed through the intestinal wall into the bloodstream and transported to different tissues for use by the cells. • In the cells, the hydrolysis products are broken down into a few common metabolites containing two or three carbons. • Metabolites are ...
2. The citric acid cycle
2. The citric acid cycle

... 3. Oxidative Phosphorylation • The process that generates most of the ATP is called oxidative phosphorylation because it is powered by redox reactions • A smaller amount of ATP is formed in glycolysis and the citric acid cycle by substrate-level phosphorylation • Oxidative phosphorylation accounts ...
Nutrient cycles - VBIOLOGY
Nutrient cycles - VBIOLOGY

... coenzyme A to produce acetylcoenzyme A (acetyl CoA).  Another oxidation reaction occurs when NAD+ collects more hydrogen ions. This forms reduced NAD (NADH + H+)  No ATP is produced in this reaction. ...
video slide - Ethical Culture Fieldston School
video slide - Ethical Culture Fieldston School

... • NADH and FADH2 – Donate electrons to the electron transport chain, which powers ATP synthesis via oxidative phosphorylation ...
Chapter 9 - John A. Ferguson Senior High School
Chapter 9 - John A. Ferguson Senior High School

... The electron transport chain passes energetic electrons to O2 in a series of enzymatically controlled steps (instead of one explosive reaction) ...


... Choice B: Compare and contrast the chemical structure of cellulose to glycogen (or starch). What is the normal biochemical role of cellulose and glycogen? Choice A: Linear polymers of modified glucose: -NAM-NAG-NAM-NAG- (4 pts) A peptide chain is attached to the NAM saccharide and this is crosslinke ...
Chapter 9
Chapter 9

... Hans Adolf Krebs – received the Nobel Prize in 1953 for his work on the series of chemical reactions known as the tricarboxylic acid cycle (also called the citric acid cycle, or Krebs cycle). This is the basic system for the essential pathway of oxidation within the cell. Copyright © 2005 Pearson E ...
Prediction of mitochondrial proteins of malaria parasite
Prediction of mitochondrial proteins of malaria parasite

... potential drug targets (Vaidya and Mather 2009; Mather and Vaidya 2008; Vaidya and Mather 2005). Thus prediction of mitochondrial proteins is very important to identify novel potential target and new drugs against malaria. In past, number of methods, including multi-subcellular localization and mito ...
Artifact 1
Artifact 1

... Pyruvate enters the mitochondria by active transport. Once inside the matrix of the  mitochondria pyruvate must be converted into Acetyl‐CoA by pyruvate dehydrogenase  in combination with CoASH and NAD+ to enter the Kreb's Cycle. CO2 and NADH, H+ are  also products of this reaction.  ...
6 PUFA - SENS Research Foundation
6 PUFA - SENS Research Foundation

... •Less capable of hard work or recovery from stress •Cell loss (death) ...
Fatty Acid Metabolism
Fatty Acid Metabolism

... SOLID ...
NADH - Mrs. Yu`s Science Classes
NADH - Mrs. Yu`s Science Classes

... are really important. • So slap yourself in the face, and stretch a little before you start looking at the next few slides ...
Cell Respiration
Cell Respiration

... • Oxidation occurs when an atom or molecule loses an electron. • Reduction occurs when an atom or molecule gains an electron. Redox reactions occur because every electron that is lost by an atom through oxidation is gained by some other atom through reduction. During redox reactions, H+ are often tr ...
Partial Purification and Characterization of the Maize Mitochondrial
Partial Purification and Characterization of the Maize Mitochondrial

... Randall, 1992). This is most likely the result of photorespiratory Gly metabolism that occurs in the leaf mitochondria during photosynthesis. Gly oxidation generates large amounts of NADH to support the necessary mitochondrial ATP production and NH41 to stimulate PDH kinase (Schuller et al., 1993). ...
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Mitochondrion



The mitochondrion (plural mitochondria) is a double membrane-bound organelle found in most eukaryotic cells. The word mitochondrion comes from the Greek μίτος, mitos, i.e. ""thread"", and χονδρίον, chondrion, i.e. ""granule"" or ""grain-like"".Mitochondria range from 0.5 to 1.0 μm in diameter. A considerable variation can be seen in the structure and size of this organelle. Unless specifically stained, they are not visible. These structures are described as ""the powerhouse of the cell"" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders, cardiac dysfunction, and heart failure. A recent University of California study including ten children diagnosed with severe autism suggests that autism may be correlated with mitochondrial defects as well.Several characteristics make mitochondria unique. The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. For instance, red blood cells have no mitochondria, whereas liver cells can have more than 2000. The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix. Mitochondrial proteins vary depending on the tissue and the species. In humans, 615 distinct types of protein have been identified from cardiac mitochondria, whereas in rats, 940 proteins have been reported. The mitochondrial proteome is thought to be dynamically regulated. Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome. Further, its DNA shows substantial similarity to bacterial genomes.
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