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Central carbon metabolism of Saccharomyces
Central carbon metabolism of Saccharomyces

... In order to recruit proteinogenic amino acids as probes to study central carbon metabolism [1,4], their biosynthetic pathways must be available. When applying this approach to eukaryotic cells, it is necessary to identify which of the cytosolic or mitochondrial pools of Prv, AcCoA or OxAc are used f ...
Rooting the Eukaryotic Tree with Mitochondrial and Bacterial
Rooting the Eukaryotic Tree with Mitochondrial and Bacterial

... the mitochondrial genome and the capacity to generate ATP through oxidative phosphorylation. Nevertheless, most of these amitochondriate species retain numerous mitochondrial proteins in their nuclear genomes, enough to allow their inclusion in mitochondrial protein–based phylogenies—as we will demo ...
A new simple fluorimetric method to assay cytosolic ATP content
A new simple fluorimetric method to assay cytosolic ATP content

... Dipartimento di Scienze Agrarie, degli Alimenti e dell’Ambiente, Università degli Studi di Foggia, Via Napoli 25, 71122 Foggia, Italy; e-mail: [email protected] ...
October 24 AP Biology - John D. O`Bryant School of Math & Science
October 24 AP Biology - John D. O`Bryant School of Math & Science

...  Glycolysis  2 ATP  Kreb’s cycle  2 ATP  Life takes a lot of energy to run, need to extract more energy than 4 ATP! There’s got to be a better way! ...
Oxidation of Carbohydrate
Oxidation of Carbohydrate

... • Glycogen converted back to glucose when needed to make more ATP • Glycogen stores limited (2,500 kcal), must rely on dietary carbohydrate to replenish ...
Plant respiration under low oxygen
Plant respiration under low oxygen

... from photosynthesis in chloroplasts (Atkin et al., 2004). However, for many years the effects of radiation on leaf respiration were studied without considering the effect of temperature. Thus, a study in eucalyptus plants showed that leaf respiration is highly dependent on both radiation and tempera ...
cellular respiration
cellular respiration

... molecules (primarily proteins), is built into the inner membrane of a mitochondrion. • NADH shuttles electrons from food to the “top” of the chain. • At the “bottom”, oxygen captures the electrons and H+ to form water. • The free energy change from “top” to “bottom” is 53 kcal/mole of NADH. • Electr ...
Lec6 Fatty acid oxid..
Lec6 Fatty acid oxid..

... substrates of gluconeogenesis in liver to produce glucose. This glucose could be released into blood and up-taken by brain to be used as source of energy. 3- Liver can degrade the stored glycogen (by glycogenolysis) to produce glucose that is used as source of energy. **** In fasting state, liver sy ...
2.8 Respiration
2.8 Respiration

... 2. The citric acid cycle/ Krebs Cycle (completes the breakdown of glucose) 3. Oxidative phosphorylation (accounts for most of the ATP synthesis) ...
world journal of pharmaceutical research
world journal of pharmaceutical research

... glucose. Cellular respiration or oxidation of hexoses such as glucose or fructose to CO2 and H2O, involves four phases: glycolysis, the prep reaction, the Krebs (citric acid) cycle, and the passage of electrons along the electron transport chain (Figure 3).[1] The theoretical number of ATP equivalen ...
An Introduction to Metabolism and Energetics
An Introduction to Metabolism and Energetics

... • The function of the citric acid cycle is: • To remove hydrogen atoms from organic molecules and transfer them to coenzymes • In the mitochondrion • Pyruvic acid reacts with NAD and coenzyme A (CoA) • Producing 1 CO2, 1 NADH, 1 acetyl-CoA ...
27. GE_7.27 Gluconeo.. - College of Pharmacy at Howard University
27. GE_7.27 Gluconeo.. - College of Pharmacy at Howard University

... o these ~8-6 carbon molecules are used for many structures and functions in the body  Ex: alpha-ketoglutarate is important for the synthesis and maintenance of amino acid pathway; it is a nitrogen shuttle and supplies aminos for biosynth of AA o However, while it is convenient to snatch pre-made mo ...
Chapter 5
Chapter 5

... with most muscles: the lactate is carried by the blood from the muscle cells to the liver, where it can be converted to glucose. Thus, although lactate is formed at high rates when muscles are overworked and become fatigued, it is not directly the cause of muscle fatigue. As oxygen availability cann ...
Figure 7. N-terminus sequence of the predicted
Figure 7. N-terminus sequence of the predicted

... suggested that VDAC1 could function as a redox enzyme [16] although, the mechanism underpinning this function remains to be elucidated. The first evidence of plant VDAC dates back from the sixties of the 20th century when electron microscopy studies on P. aureus mitochondria showed the presence in M ...
03-232 Biochemistry         ... Name:________________________ or the back of the preceding page.  In questions... Instructions:
03-232 Biochemistry ... Name:________________________ or the back of the preceding page. In questions... Instructions:

... Choice A: What is the critical micelle concentration (CMC) and how would it depend on the number of carbons in a fatty acid? Choice B: How does cholesterol affect the properties of membranes and why is this effect important for the function of biological membranes? Choice C: In what way is the funct ...
AP Biology Chapter 9.2016
AP Biology Chapter 9.2016

... phosphorylation. • That energy is used to phosphorylate ADP to ATP. • Chemiosmotic theory describes how that phosphorylation occurs. • The process is analogous to ATP generation in ...
CO 2
CO 2

... 6.9 The citric acid cycle completes the oxidation of organic molecules, generating many NADH and FADH2 molecules • The citric acid cycle • is also called the Krebs cycle (after the GermanBritish researcher Hans Krebs, who worked out much of this pathway in the 1930s) • completes the oxidation of or ...
RACC BIO Cellular respiration
RACC BIO Cellular respiration

... Glycolysis- Occurs In the Cytoplasm of the Cell • Glycolysis harvests energy by oxidizing glucose to pyruvate • Glycolysis ...
Full-Text PDF
Full-Text PDF

... Like peroxisomes, mitochondria are also dynamic organelles that continuously adapt their number, morphology, and function to prevailing environmental conditions [12]. In mammals, these organelles play a central role in many metabolic processes including–among others–adenosine triphosphate (ATP) gene ...
Perspective: emerging evidence for signaling roles of mitochondrial
Perspective: emerging evidence for signaling roles of mitochondrial

... glucose-induced insulin secretion, the rate of pyruvate carboxylation is very high and correlates more strongly with the glucose concentration the ␤-cell is exposed to (and thus with insulin release) than does pyruvate decarboxylation, which produces acetyl-CoA for metabolism in the citric acid cycl ...
Slide 1
Slide 1

... • Some raw materials from food can be incorporated directly into an organism’s molecules • Cells can also make molecules not found in food ...
Chapter 6 How Cells Harvest Chemical Energy
Chapter 6 How Cells Harvest Chemical Energy

... 6.10 Most ATP production occurs by oxidative phosphorylation  Oxidative phosphorylation involves electron transport and chemiosmosis and requires an adequate supply of oxygen – NADH and FADH2 and the inner membrane of the mitochondria are also involved – A H+ ion gradient formed from all of the re ...
Slide 1
Slide 1

... 6.10 Most ATP production occurs by oxidative phosphorylation  Oxidative phosphorylation involves electron transport and chemiosmosis and requires an adequate supply of oxygen – NADH and FADH2 and the inner membrane of the mitochondria are also involved – A H+ ion gradient formed from all of the re ...
ch 6 notes
ch 6 notes

... 6.10 Most ATP production occurs by oxidative phosphorylation  Oxidative phosphorylation involves electron transport and chemiosmosis and requires an adequate supply of oxygen – NADH and FADH2 and the inner membrane of the mitochondria are also involved – A H+ ion gradient formed from all of the re ...
Chapter 10 - Clayton State University
Chapter 10 - Clayton State University

... • Unlike the proteins of the ETS, most of the CoQ is freely mobile in the inner mitochondrial membrane • CoQ is the most abundant electron carriers in the membrane and occupy a central position in the ETS – They serve as a collection point for electrons from the reduced FMN and FAD-linked dehydrogen ...
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Mitochondrion



The mitochondrion (plural mitochondria) is a double membrane-bound organelle found in most eukaryotic cells. The word mitochondrion comes from the Greek μίτος, mitos, i.e. ""thread"", and χονδρίον, chondrion, i.e. ""granule"" or ""grain-like"".Mitochondria range from 0.5 to 1.0 μm in diameter. A considerable variation can be seen in the structure and size of this organelle. Unless specifically stained, they are not visible. These structures are described as ""the powerhouse of the cell"" because they generate most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondria have been implicated in several human diseases, including mitochondrial disorders, cardiac dysfunction, and heart failure. A recent University of California study including ten children diagnosed with severe autism suggests that autism may be correlated with mitochondrial defects as well.Several characteristics make mitochondria unique. The number of mitochondria in a cell can vary widely by organism, tissue, and cell type. For instance, red blood cells have no mitochondria, whereas liver cells can have more than 2000. The organelle is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, the intermembrane space, the inner membrane, and the cristae and matrix. Mitochondrial proteins vary depending on the tissue and the species. In humans, 615 distinct types of protein have been identified from cardiac mitochondria, whereas in rats, 940 proteins have been reported. The mitochondrial proteome is thought to be dynamically regulated. Although most of a cell's DNA is contained in the cell nucleus, the mitochondrion has its own independent genome. Further, its DNA shows substantial similarity to bacterial genomes.
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