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Xalatan - Pharmaline
Xalatan - Pharmaline

... profile was similar to that in adults and no new adverse events were identified. The short term safety profiles in the different paediatric subsets were also similar. Adverse events seen more frequently in the paediatric population as compared to adults are: nasopharyngitis and pyrexia. 4.9 Overdose ...
Natural History of Schizophrenia
Natural History of Schizophrenia

... monitor with AIMS test ...
Pharmacological and Pharmaceutical Profile of Gliclazide: A Review
Pharmacological and Pharmaceutical Profile of Gliclazide: A Review

... secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action. All may cause hypoglycaemia but this is uncommon and usually indicates excessive dosage. Sulphonylurea-induced hypoglyc ...
chapter 2 - Eastbourne, Hailsham and Seaford CCG
chapter 2 - Eastbourne, Hailsham and Seaford CCG

... fewer adverse effects. Dronedarone is considerably more expensive than standard treatments hence it should only be used in accordance with NICE guidance (see below). NICE Guidance: Dronedarone for the treatment of non-permanent atrial fibrillation (Technology Appraisal 197 Aug 2010) Dronedarone is r ...
Genetics --- introduction
Genetics --- introduction

... 1. Gene A and gene B are linked. A test cross produces 10 AaBb progeny out of a total of 100. The estimated map distance between gene A and B is: a. 10 b. 20 c. 30 d. 40 e. 50 2. For the pedigree, indicate the most probably mode of inheritance for the rare trait. 3. For the pedigree, what is the pro ...
Side effects
Side effects

... CHLORAMPHENICOL side effects. • Newborn infants lack an effective glucuronic acid conjugation mechanism for the degradation and detoxification of chloramphenicol. •Consequently, when infants are given dosages above 50 mg/kg/d, the drug may accumulate, resulting in the gray baby syndrome, with vomit ...
DIABETIC ENTEROPATHY: TWO DIFFICULT PROBLEMS
DIABETIC ENTEROPATHY: TWO DIFFICULT PROBLEMS

... Metaclopramide p Is it worth a trial of metaclopramide in moderate to severe Gastroparesis? ...
Benzodiazepines
Benzodiazepines

... neurotransmission. ...
Depot neuroleptics: Injection sites, techniques and complications
Depot neuroleptics: Injection sites, techniques and complications

Potential of Drug Interactions among Hospitalized Cancer Patients
Potential of Drug Interactions among Hospitalized Cancer Patients

... prevalence of potential DDIs regardless of whether they actually occurred clinically. Also we want to correlate the frequency of DDIs with demographic information of patient and recognize risk factors for these potential DDIs in a hematology-oncology ward of hospitalized patients in a developing cou ...
Handout 25-27 - U of L Class Index
Handout 25-27 - U of L Class Index

... 3.The fully expressed allele is the dominant allele, the other that has no noticeable effect on the organism’s appearance is the recessive allele 4.Males and females contribute equally to the traits in their offspring. Mendel's law of segregation. Mendel's model for monohybrid inheritance. The purpl ...
T  IBD NEW IBD Videos Available
T IBD NEW IBD Videos Available

... to continue in the program. Those who complete the treatment period and have demonstrated benefit will be eligible to enter a placebo-controlled maintenance study of 52 weeks (A3921096). Subjects who complete the treatment period but have not demonstrated benefit will be eligible to enter an open-la ...
Side Effects of Calcium Channel Blockers
Side Effects of Calcium Channel Blockers

... Even though beneficial effects of the latter combination have been reported, administration of verapamil to patients treated with /3-blocking drugs has the potential for causing severe conduction disturbances as well as negative inotropic effects. Additional long-term studies are needed to resolve t ...
Overview of Oral Modified-Release Opioid Products for
Overview of Oral Modified-Release Opioid Products for

... the effect.14 Therefore, these agents do not have a defined maximum dose, and the “ceiling” to analgesic effectiveness is imposed only by ADEs, which also increase with dose.14 Effective opioid blood concentrations are dependent on several factors including a patient’s age, medical condition, and pr ...
PowerPoint Genetic Technology
PowerPoint Genetic Technology

... different DNA sequences from its normal counterpart, genetic tests use labeled DNA probes that can detect and distinguish the complementary base sequences found in the disease-causing alleles. Genetic tests are now available for diagnosing hundreds of disorders. ...
Community/Ambulatory Care Edition December 2008 Vol.7, Issue 12
Community/Ambulatory Care Edition December 2008 Vol.7, Issue 12

... metFORMIN). Just as dangerous, if not more so, is that some health professionals and patients may not recognize that Jantoven is a brand of warfarin, and patients could easily end up taking two warfarin products together. A case was reported to us in which the patient took warfarin prescribed and di ...
Drugs for primary generalized epilepsy
Drugs for primary generalized epilepsy

... Metabolism is primarily hepatic; induces own metabolism, as well as that of other drugs (OCP’s, warfarin, other anticonvulsants particularly problematic). Half-life is 10-20 hours; tid dosing usually satisfactory, although qid sometimes required Several active metabolites, including a 10,11 epoxide, ...
Anti Hyperlipidaemic Agents
Anti Hyperlipidaemic Agents

... 2. ↑excretion of bile acid a. ↑cholesterol secretion b. ↓hepatic cholesterol level c. ↑uptake of LDL from circulation i. ↓plasma LDL ii. ↓plasma cholesterol level d. Compensatory mechanism of the loss of LDL will ↑VLDL and therefore ↑plasma TG level 3. It most be clear that Resins is not effective i ...
outline27993
outline27993

... he or she may appear clinically unaffected. f. Genetic heterogeneity. Different mutations, at the same locus or at different loci, may result in a similar clinical picture. In addition, the conditions may be inherited in different manners (e.g., retinitis pigmentosa may be inherited as an autosomal ...
How predictive is ocular toxicology?
How predictive is ocular toxicology?

... Take home message from Dr Chambers who is a practicing ophthalmologist “If there is any pharmacologic activity due to the drug product, there is also a risk of adverse events from it due to known or unknown pharmacologic activity” “While the events observed in non-human studies may not be duplicate ...
Nucleoside/Nucleotide reverse transcriptase inhibitors
Nucleoside/Nucleotide reverse transcriptase inhibitors

... The most common side effects are: trouble sleeping, abnormal dreams, headache, dizziness, diarrhea, nausea, rash, tiredness, depression, vomiting, and stomach pain. Less common side effects: kidney problems, bone problems (includes bone pain, softening or thinning, which may lead to fractures), chan ...
Elective choices for a Biochemsitry Degree
Elective choices for a Biochemsitry Degree

... case-based course is intended for first year graduate students and focuses on practical issues of how to design, plan and conduct scientific studies through appropriate use of experimental methods and data analysis. Biomed 532 Neurochemistry - An introduction to neurochemistry and neuropharmacolo ...
7 Recognizing and Avoiding Addiction and Drug
7 Recognizing and Avoiding Addiction and Drug

... excessive preoccupation, with the behavior and an overwhelming need to perform it • Loss of control, or the inability to predict reliably whether any isolated occurrence of the behavior will be healthy or damaging • Negative consequences, such as physical damage, legal trouble, financial problems, a ...
Assessment of the safety, tolerability and
Assessment of the safety, tolerability and

anastrozole - Cancer Care Ontario
anastrozole - Cancer Care Ontario

... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare  providers and is to be used for informational purposes only. The information is not intended to cover all possible  uses, directions, precautions, drug interactions or adverse effects ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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