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Antithrombotic agents: Implications in dentistry ORAL MEDICINE
Antithrombotic agents: Implications in dentistry ORAL MEDICINE

... protein C, protein S, thrombomodulin, plasminogen, or tissue plasminogen activator; an activated protein C resistance (factor V Leiden); dysfibrinogenemia; and homocysteinemia. Most of these disorders have also been reported as acquired conditions. Patients should be considered for laboratory evalua ...
Opiate Overuse: Pain Management Strategies for Care Coordination
Opiate Overuse: Pain Management Strategies for Care Coordination

... • Some people dying from opiate overdose have Substance Use Disorder (SUD) • Many do not have SUD • Which patient is which? • The old plan for treating chronic pain, makes patients worse, not better ...
Anxiety Disorders - University of Florida College of Dentistry
Anxiety Disorders - University of Florida College of Dentistry

... Recent terrorist attacks in the U.S. have affected the mental health status of individuals involved directly in the attacks, as well as others who were far away from the actual scene.14,18-20 In a national survey of 560 adults conducted three to five days after the 2001 attacks on the World Trade Ce ...
2 MB 2017 Addiction Introduction - Northeast Ohio Nurse Practitioners
2 MB 2017 Addiction Introduction - Northeast Ohio Nurse Practitioners

... lost their power to reward  Drug addiction is insidious because it affects the very brain areas that people need to "think straight," apply good judgment, and make good decisions for their lives  The disease of addiction can develop in people despite their best intentions or strength of character ...
Learning Goal B
Learning Goal B

... • He allowed each variety to self-pollinate for several generations to ensure that they were true-breeding (offspring always exhibited the same trait). He called this the P1 (parent) Generation. • He took two of these parent plants with contrasting forms of the same trait and crosspollinated them. • ...
Chromosomes and
Chromosomes and

... • Used to determine the probability that future offspring will be affected by a genetic abnormality or disorder Studying Inheritance in Humans  Genetic studies can reveal __________________________________ or clues to past events • Example: A link between a Y chromosome and Genghis Khan? Defining G ...
Drug Groupings and Workflow Options for the Processing and Review of Concomitant Medication Data
Drug Groupings and Workflow Options for the Processing and Review of Concomitant Medication Data

... The WHO-DD is an international standard for coding of concomitant medications. Within the WHODD each drug is classified according to the ATC system. Moreover the WHO-DD provides the active ingredients/substances for each included drug. For cases where the inherent ATC classification does not identif ...
Pharmacology/Therapeutics II Block II Lectures
Pharmacology/Therapeutics II Block II Lectures

... “snorting” – 10 min; oral – 30 min) 3. Half-life varies from 40-80 min, requiring repeated administration to maintain blood levels 4. Rapidly metabolized by cholinesterases into benzoylecgnonine (inactive compound) monitored in biological fluids (salive, blood, urine, milk), measured in urine test w ...
Oncology KOLS: AN IMPORTANT PIECE OF THE PUZZLE
Oncology KOLS: AN IMPORTANT PIECE OF THE PUZZLE

Slide set - Perelman School of Medicine at the University of
Slide set - Perelman School of Medicine at the University of

... investigation, including research development, testing and evaluation, designed to develop or contribute to generalizable knowledge” •  FDA focuses on whether or not an investigational test article is used – even if the article is used in only one person (“Clinical Investigation”) ...
Bikini Bottom Genetics
Bikini Bottom Genetics

... is written as an upper case letter. The allele that does NOT appear to affect a trait is called the ________________ allele and is written as a lower case letter. 4. When ____________ form, the alleles separate. Each gamete carries one allele for each trait. This is called the _______________ of ___ ...
H2 Blockers
H2 Blockers

... By reducing stomach acid levels, H 2 blockers might interfere with the absorption of iron, zinc, and perhaps other minerals.5–8 Taking mineral supplements that provide the U.S. Dietary Reference Intake (formerly known as the Recommended Dietary Allowance) of these substances should help. ...
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle

... in patients with newly diagnosed MCL historically has been 3 to 4 years (4). First-line treatment regimens include multiagent chemotherapies; however, almost all patients eventually experience a relapse. Bortezomib and lenalidomide were the only FDA-approved treatments for patients with MCL who had ...
TICAGRELOR VERSUS ASPIRIN IN ACUTE STROKE OR
TICAGRELOR VERSUS ASPIRIN IN ACUTE STROKE OR

... Each year, approximately 200 000 to 500 000 patients are diagnosed by a physician as having experienced a Transient Ischemic Attack (TIA) in the United States. An additional 300,000 to 700,000 individuals experience neurological symptoms suggestive of a TIA but never seek medical attention for their ...
introduction to drug discovery
introduction to drug discovery

... today's industry was founded. With antibiotics and psychotrophics, for example, it was possible to produce breakthrough remedies for conditions which were not previously treatable. By contrast, in the 1990s, whilst there are still many serious disease challenges, we must also recognise that acceptab ...
Commonly Abused Drugs
Commonly Abused Drugs

... increase your risk for a variety of problems. For more information on alcohol’s effects on the body, please see the National Institute on Alcohol Abuse and Alcoholism’s related web page describing alcohol’s effects on the body. ...
Newer Weight Loss Medications: Worth the Weight
Newer Weight Loss Medications: Worth the Weight

... hypertension, and coronary artery disease, amongst others.2 Depending on age and race, obesity is associated with a 6 to 20-year decrease in life expectancy and is the second leading cause of preventable death in the United States.3,4 The most recent data from the Centers for Disease Control and Pre ...
HIGHLIGHTS OF PRESCRIBING INFORMATION Clostridium difficile
HIGHLIGHTS OF PRESCRIBING INFORMATION Clostridium difficile

... received high-dose, defined as multiple daily doses, and long-term PPI therapy (a year or longer). Patients should use the lowest dose and shortest duration of PPI therapy appropriate to the conditions being treated. Patients at risk for osteoporosis-related fractures should be managed according to ...
LOCAL ANESTHETICS,IV SEDATION AND PAIN MANAGEMENT
LOCAL ANESTHETICS,IV SEDATION AND PAIN MANAGEMENT

... • Butyrophenones result in significant: ...
Trisomy21Protocol0211 Trisomy 21 Research
Trisomy21Protocol0211 Trisomy 21 Research

... under certain circumstances (such as heart disease), they should only be taken together under the guidance and supervision of a healthcare provider. Ginkgo biloba should not be used by individuals undergoing blood thinning therapy, those with bleeding issues, or individuals undergoing surgery Curcum ...
VISTARIL® (hydroxyzine pamoate) Capsules and Oral
VISTARIL® (hydroxyzine pamoate) Capsules and Oral

The Truth About Cocaine
The Truth About Cocaine

... can kill. This is true of any drug. Only the amount needed to achieve the effect differs. But many drugs have another liability: they directly affect the mind. They can distort the user’s perception of what is happening around him or her. As a result, the person’s actions may be odd, irrational, ina ...
Bioprospecting
Bioprospecting

... 2) LDCs recognize prior user rights 3) LDCs amend patent law to make plants or traditionally medicinal uses thereof patentable locally 4) DCs constrict rights associated with drug patents 5) DCs treat holders of biocultural knowledge as coinventors 6) Physical Exclusion of Bioprospectors 7) National ...
Peptic Ulcer Disease (PUD)
Peptic Ulcer Disease (PUD)

... • Patients at risk of developing serious ulcer-related complications while on NSAIDs should receive prophylactic therapy with misoprostol or a PPI. • Patients with ulcers refractory to treatment should undergo upper endoscopy to confirm a nonhealing ulcer, exclude malignancy, and assess HP status. • ...
Vol. 25, No. 4 Cold Sores - medSask
Vol. 25, No. 4 Cold Sores - medSask

... oral mucosa).1,3 Multiple vesicles are formed and take seven to twenty-one days to heal.3 HSV1 is transmitted through direct human to human contact with lesions, saliva or respiratory droplets.4 Primary infections are associated with the greatest amount of viral shedding.2,4 but transmission is poss ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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