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anastrozole - Cancer Care Ontario
anastrozole - Cancer Care Ontario

... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare  providers and is to be used for informational purposes only. The information is not intended to cover all possible  uses, directions, precautions, drug interactions or adverse effects ...
OTC Drugs in Pregnancy and Lactation
OTC Drugs in Pregnancy and Lactation

... term may cause neonatal codeine addiction. In labour, may cause neonatal respiratory depression. 1 1 study showed ↑ inguinal hernias when used in 1st trimester. No strong link with congenital defects.1 ...
UNIT 6 Targets- Patterns_of_Inheritance
UNIT 6 Targets- Patterns_of_Inheritance

...  I can connect two or more targets together into one cohesive idea or explanation.  I can recall lab/activity concepts, skills, and results from this unit as specific examples of the targets.  I can use the BioThemes to connect the content and labs/activities in a detailed and reflective manner. ...
No Slide Title
No Slide Title

... when the Food and Drug Administration, for no compelling reason, unexpectedly issued a brief, poorly documented statement disputing the therapeutic value of marijuana. The statement was described as a response to numerous inquiries from Capitol Hill, but its likely intent was to buttress a crackdown ...
DFWP Prescription Drug Module 9.2007
DFWP Prescription Drug Module 9.2007

... “How could it be bad if it’s medicine?” “But my doctor told me to take it.” “They’re legal and certainly not as dangerous as street drugs.” ...
FUNDAMENTALS OF GENETICS
FUNDAMENTALS OF GENETICS

... • Gene – DNA sequence that codes for a protein (may lead to a trait) • Allele – different forms of a gene ...
Rescue medication
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... 500,000 cases per year, with 90% of cases occurring in India, Bangladesh, Nepal, Sudan, Kenya, Ethiopia and Brazil [1, 2]. In East Africa, the disease has been known to occur in cyclical epidemics, one of which resulted in over 100,000 deaths in Southern Sudan between 1984-94 [3, 4]. Parasitological ...
(Agonist) of Nuclear Receptor
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... • Better assessment of new concerns regarding risk-benefit ...
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11-3 Exploring Mendelian Genetics
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Pharmacodynamics
Pharmacodynamics

... • Better assessment of new concerns regarding risk-benefit ...
appendix - iii
appendix - iii

... Ninety pediatric patients, aged 4 to 10 years, received intravenously granisetron 40 microg/kg or ramosetron 6 microg/kg (n = 45 each) at the end of surgery. The same standard general anesthetic technique and postoperative analgesia were used throughout. Emetic episodes and safety assessment were pe ...
Current Approaches for ADME Characterization of
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Gene-Environment Interaction
Gene-Environment Interaction

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Painful Peripheral Neuropathy
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... Referral into the Specialist Diabetes Foot Care Service can be made at any point but would typically be recommended if Amitriptyline and / or topical therapies had been unsuccessful. The following services are available to patients: Painful Peripheral Diabetic Neuropathy Education Groups – These are ...
multiple choice questions (MCQs)
multiple choice questions (MCQs)

... That however, does not readily explain the amenorrhea-galactorrhea and extrapyramidal side effects. What provides the explanation or mechanism relates to another rather unique property of amoxapine: one of its metabolites is a strong dopamine receptor antagonist, an action not shared by any of the o ...
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... A. Quinidine prolongs repolarization and the effective refractory period. B. Mexiletine shortens repolarization and decreases the effective refractory period. C. *Propranolol increases Phase 4 depolarization. D. Verapamil shortens the duration of the action potential. E. Amiodarone prolongs repolari ...
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UNSHARED ENVIRONMENTAL INFLUENCES
UNSHARED ENVIRONMENTAL INFLUENCES

... Studies  Environmental influences are indicated if MZ twins and DZ ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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