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Profile Documents Logout
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ppt
ppt

... • not stick to one single substance • reserve similar potential substances • complicate generic drugs („me-too“) [Nachahmungspräparate] ...
Treatment of Bronchial Asthma in Japan
Treatment of Bronchial Asthma in Japan

... essential. Their potentially serious side reactions, when used systemically, limit such use to those situations when other measures do not provide sufficient control of symptoms. Repository injectable preparations of steroids such as triamcinolone are available and convenient in some acute cases, as ...
Medication Therapy Management - Pharmacist`s Letter
Medication Therapy Management - Pharmacist`s Letter

... Hundreds of billions of dollars are wasted every year because of the misuse of medications. Pharmacistprovided medication therapy management (MTM) improves patient outcomes and reduces overall health care costs. MTM can describe a broad range of patient-centered services that optimize therapeutic ou ...
Exam One Notes
Exam One Notes

... - Absorbed slowly & completely from GIT, excreted metabolized in urine. - A single weekly dose of 25 mg is enough for suppression. - Relatively non-toxic but high doses may suppress cell growth by inhibiting FA activity. Trimethoprim: - 2,4-Diamino-5-(3,4,5-tri-methoxybenzyl) pyrimidine - Marketed ...
Conscious Sedation
Conscious Sedation

... Identify the SIUH Policy and Procedure that govern this practice Identify “age specific” and “special” considerations in the administration of conscious sedation ...
The Treatment of Hyperkalemia - Georgia Society of Health
The Treatment of Hyperkalemia - Georgia Society of Health

... • I, Dwayne Pierce, have nothing to disclose concerning possible financial or personal relationships with commercial entities (or their competitors) mentioned in this presentation • There will be discussion of off-label uses of certain pharmaceutical agents and the use of agents not yet approved by ...
Teck TalkCEJanENG - Canadian Healthcare Network
Teck TalkCEJanENG - Canadian Healthcare Network

... (opioid) pain relievers, such as codeine and oxycodone, are also effective for pain but do not reduce inflammation due to arthritis. Patients using these medications should be careful since opioids can cause sedation, which can be dangerous for someone who must drive or operate machinery. Glucosamin ...
Volume 1, Number7
Volume 1, Number7

... counter top as the spot the animals had to return to in order to receive the rewarding electrical stimulation - constituted a crude conditioned place preference (CPP) model. He also noted that early operant BSR selfstimulation studies were based on simple operant rate measures and were thus flawed b ...
a review: advances in drug delivery
a review: advances in drug delivery

... performance of the drug but are also expected to offer a host of additional advantages such as ease of administration, increased patient compliance, decreased side effects and cost reduction. While drug delivery plays an important role in enriching drug performance, researchers are concentrating on ...
Gene Pool - manorlakesscience
Gene Pool - manorlakesscience

... It is applied to populations with a simple genetic situation: recessive and dominant alleles controlling a single trait. The frequency of all of the dominant alleles (A) and recessive alleles (a) equals the total genetic complement, and adds up to 1 (or 100%) of the alleles ...
understanding genetic research - Alternating Hemiplegia of
understanding genetic research - Alternating Hemiplegia of

... Cells are the basic building blocks of all living things. The human body is composed of trillions of cells. They provide structure for the body, take in nutrients from food, convert those nutrients into energy, and carry out specialized functions. DNA DNA, or deoxyribonucleic acid, is the hereditary ...
Proton pump inhibitor side effects and drug interactions Much ado
Proton pump inhibitor side effects and drug interactions Much ado

... lunchtime and the PPI before dinner. ...
The Approach To The Patient With An Unknown Overdose – Emerg
The Approach To The Patient With An Unknown Overdose – Emerg

Evaluation of the efficacy and safety of adalimumab therapy in
Evaluation of the efficacy and safety of adalimumab therapy in

... associated with the administration of IFX. The most common are allergic reactions, with varying degrees of severity – from mild like redness of the skin or tachycardia, through serious – up to anaphylactic shock inclusive. Temporarily interruption or slowing infusion, with antihistamines usually cau ...
Emmanuelle Génin, Josué Feingold, Françoise - HAL
Emmanuelle Génin, Josué Feingold, Françoise - HAL

... penetrant mutations that explain all or a very important part of the variability in disease expression. Examples of this type of modifier genes can be found among the genes involved in the splicing machinery (see the recent review of Wang and Cooper (Wang and Cooper 2007)). Under the multifactorial- ...
antidepressants: what they are and how they work
antidepressants: what they are and how they work

... Once the neurotransmitter molecules are released by the presynaptic cell, they migrate across the synapse through a series of chemical and electrical impulses. They are then capable of binding to receptors that are located on the surface of the postsynaptic nerve cell. Receptors are tiny proteins th ...
ACUTE PAIN MANAGEMENT
ACUTE PAIN MANAGEMENT

... are recommended for mild-to-moderate acute pain. NSAIDs relieve pain by inhibiting prostaglandin synthesis. NSAIDs must be used with caution in patients who are at risk for GI bleeding (>60 years old, history of a GI event, or taking medications such as corticosteroids that may cause bleeding).2 The ...
tamoxifen - Cancer Care Ontario
tamoxifen - Cancer Care Ontario

... response.  Serum calcium should be monitored for a few weeks, starting 3-7 days after starting treatment in patients with extensive bony metastatic disease. The risk of endometrial cancer increases following tamoxifen therapy and may be related to the estrogen-like effect of tamoxifen. An increase i ...
Genetic susceptibility to Hodgkin`s lymphoma and to secondary
Genetic susceptibility to Hodgkin`s lymphoma and to secondary

... of developing a second cancer. During the follow-up time (average 7 years, range 1–13 years), 14 new cancers occurred. Multivariate Cox regression analysis revealed that high levels of SCEs [relative risk (RR) 3.9, P = 0.03, 95% CI 1.1–13.7) and age as a continuous variable (RR 1.1, P = 0.03, CI 1–1 ...
apimanu NeurotoSan
apimanu NeurotoSan

... physical and psychological stress, and preventing high altitude sickness. Rhodiola rosea has been categorized as an adaptogen by Russian researchers due to its observed ability to increase resistance to a variety of chemical, biological, and physical stressors. Its claimed benefits include antidepre ...
Clinical study to evaluate the safety and efficacy of Septilin tablets in
Clinical study to evaluate the safety and efficacy of Septilin tablets in

... various combinations of potent antibacterial agents, which are not only expensive but also potentially toxic, producing unwanted adverse effects and hence not safe for frequent long term use. Indiscriminate use of an antibiotic also produces drug-resistance, creating problem for further use in futur ...
Biologically Based Systems
Biologically Based Systems

...  Media reports of dramatic results  Belief that CAM treatments are natural  Patient empowerment  Focus on spiritual and emotional well-being  Therapist providing “touch, talk, time” ...
Anesthetics and adjuvants
Anesthetics and adjuvants

... • Many people would like to believe that regional is “safer” or “better” than GA, but there is no evidence for this in terms of mortality and major morbidity (except in OB?). • So: Tailor anesthesia to individual needs, preferences and clinical situation, and do what you do best! ...
Basic Principles of Heredity Notes AP Biology Mrs. Laux
Basic Principles of Heredity Notes AP Biology Mrs. Laux

... 2. are a result of a mechanism that determines phenotypic expression, no ability of one allele to subdue another at level of DNA 3. does not determine relative abundance of alleles in a population -ex: polydactyly (1/400 births) Pleiotrophy 1. ability of a single gene to have multiple phenotypic eff ...
ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS
ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS

... consequence of disturbance of the microcirculation, prescription of a diuretic is not helpful. The combined pre-capillary and post-capillary action of lercanidipine may reduce the frequency of this side effect. Peripheral oedema may also be reduced by co-administration of an ACE inhibitor or angiote ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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