• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Clinical pharmacology of facilities used at the diseases of
Clinical pharmacology of facilities used at the diseases of

... A. Quinidine prolongs repolarization and the effective refractory period. B. Mexiletine shortens repolarization and decreases the effective refractory period. C. *Propranolol increases Phase 4 depolarization. D. Verapamil shortens the duration of the action potential. E. Amiodarone prolongs repolari ...
PDF file - Via Medica Journals
PDF file - Via Medica Journals

... nonfatal TdP considered a result of dofetilide therapy; both occurred within the first 3 days of therapy. Prolongation of QTc duration accounted for 10 withdrawals, and one SD occurred. Dosage adjustment based on creatinine clearance or QTc prolongation was required in 33% of patients. The SAFIRE-d ...
- American Heart Journal
- American Heart Journal

... risk, given study drug and disease risk profiles. 3. Analysis of any QT interval-related adverse events reported during clinical development. 4. Summary analysis of overall QT risk profile, taking into account all available data. 5. Risk minimization when QT prolongation is a clinically relevant pro ...
GENERAL ANESTHETICS INHALATION ANESTHETICS
GENERAL ANESTHETICS INHALATION ANESTHETICS

... - Produces strong analgesia, similar to morphine - Combined w/ a butyrophenone (Droperidol): Produces neurolept analgesia, and can be used for major surgery w/o any other kinds of drugs - Patches and lollipops available for chronic pain and children’s surgeries, respectively - Related compounds  Su ...
Piperacillin-Tazobactam Toxicity Questions the Need for Pediatric
Piperacillin-Tazobactam Toxicity Questions the Need for Pediatric

... In another study, Peralta and colleagues reported neutropenia in patients treated with piperacillin-tazobactam for bone-related infections. This retrospective study reviewed patients treated for at least 10 days. Thirty-four percent of these patients developed neutropenia, which was apparent after a ...
UNSHARED ENVIRONMENTAL INFLUENCES
UNSHARED ENVIRONMENTAL INFLUENCES

... Studies  Environmental influences are indicated if MZ twins and DZ ...
Document
Document

... Chapter 5 prodrugs ...
File - Ricci Math and Science
File - Ricci Math and Science

... 7. The principles of probability can be used to _______________ the outcomes of ___________ crosses. 8. When you flip a coin, what is the probability that it will come up tails? _________ 9. What principle states that during gamete formation genes for different traits separate without influencing ea ...
Non-opioid - Hospice New Zealand
Non-opioid - Hospice New Zealand

... • anti-emetics and anti-nauseants • anti-epileptics • anti-inflammatory & anti-rheumatics • drugs for functional GI disorders • laxatives • psycholeptics • stomatological preparations Reverence: Palliative Care Services Australia 2014. www.aihw.gov.au ...
ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS
ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITORS

... influence kinin metabolism, dry cough is not seen and angioedema is very rare. Impairment in renal function may arise in patients with bilateral renal artery stenosis, which should be suspected if there is evidence of peripheral vascular disease. Renal failure, reversible on discontinuation of ARB, ...
Heredity - SPS186.org
Heredity - SPS186.org

... blood sample for the presence of abnormalities in specific genes. Genetic testing has become more common in recent years. The symptoms of some genetic disorders and most diseases don’t show up early in life. By knowing someone has the defective gene as early as possible—in some cases, even before bi ...
Cross a homozygous short pea plant with a
Cross a homozygous short pea plant with a

... 7. The principles of probability can be used to _______________ the outcomes of ___________ crosses. 8. When you flip a coin, what is the probability that it will come up tails? _________ 9. What principle states that during gamete formation genes for different traits separate without influencing ea ...
Extended-Release Injectable Parasiticide 5% Sterile
Extended-Release Injectable Parasiticide 5% Sterile



... can be quite subtle, with angioedema sometimes presenting a long time – even years - after the patient commenced these drugs. ACE inhibitor therapy should be discontinued in patients with chronic urticaria. Other drugs which may rarely act as triggers include proton pump inhibitors, codeine and stat ...
Public Safety Substance Abuse Journal by MEDTOX June 2009
Public Safety Substance Abuse Journal by MEDTOX June 2009

... A false-positive screening result, because it is purporting to be positive, automatically triggers a confirmatory process that utilizes a different set of extremely precise scientific instruments to check out the initial result. In this follow-up investigation, specially trained scientists confirm o ...
Anithypertensive_drugs_and_its_classifications
Anithypertensive_drugs_and_its_classifications

...  Block cardiac SA & AV nodes: reduce HR  May produce heart block  Not AB rated as interchangeable/equipotent due to ...
part 2 - GOV.GG
part 2 - GOV.GG

... investigators mean that participants have near-perfect concordance. So the results may demonstrate maximum benefit and minimum harm. Frail elderly people with multiple co-morbidities are rarely if ever included in clinical studies. There is therefore a danger that what is an extremely rare side effe ...
Bi190 Advanced Genetics 2011 Lecture 6 Pathways Genetics to
Bi190 Advanced Genetics 2011 Lecture 6 Pathways Genetics to

... Constructing double mutant strains Double mutant analysis can be used to examine how genes interact. This is because by combining mutations in two different genes, the phenotype you see in the organism carrying mutant alleles of both of these genes is the result of both of these mutant alleles. The ...
Biopharmaceutics / lecture 12 Dr. Aymen Bash Intravenous Infusion
Biopharmaceutics / lecture 12 Dr. Aymen Bash Intravenous Infusion

... (injected all at once) or infused slowly through a vein into the plasma at a constant or zero-order rate. *The main advantage for giving a drug by IV infusion is that IV infusion allows precise control of plasma drug concentrations to fit the individual needs of the patient. *For drugs with a narrow ...
Herbal Supplements - St. Vincent Healthcare
Herbal Supplements - St. Vincent Healthcare

... with certain anesthetics.They are finding certain herbals may prolong the effects of anesthesia. Others may increase the risks of bleeding or raise blood pressure. Some effects may be subtle and less critical, but for anesthesiologists, anticipating a possible reaction is better than reacting to an ...
extemporaneous dosage form for oral liquids
extemporaneous dosage form for oral liquids

... diazepam, lorazepam). This vehicle is especially useful to solubilize drugs with limited water solubility. Patients aged <4 years may accumulate propylene glycol due to decreased metabolism, and those receiving multiple drugs containing this solvent are at high risk of developing central nervous sys ...
JRCALC
JRCALC

... • IV fluids – 250ml boluses • NW Oxygen Guidelines • Obs. & Gynae • Mental Health – future risk table • Burns consensus guidance ...
Slayt 1 - FarmaPatent
Slayt 1 - FarmaPatent

... Hoescht Marion Roussel and Baker Norton Pharmaceuticals have voluntarily discontinued distribution and marketing of all terfenadine-containing antihistamine product lines in the United States. Terfenadine-containing products, such as Seldane and Seldane-D, have been associated with rare, but serious ...
Volume 1, Number7
Volume 1, Number7

... counter top as the spot the animals had to return to in order to receive the rewarding electrical stimulation - constituted a crude conditioned place preference (CPP) model. He also noted that early operant BSR selfstimulation studies were based on simple operant rate measures and were thus flawed b ...
a review: advances in drug delivery
a review: advances in drug delivery

... performance of the drug but are also expected to offer a host of additional advantages such as ease of administration, increased patient compliance, decreased side effects and cost reduction. While drug delivery plays an important role in enriching drug performance, researchers are concentrating on ...
< 1 ... 692 693 694 695 696 697 698 699 700 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2026
  • DMCA
  • Privacy
  • Terms
  • Report