Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces
... (23). Therefore, the development of new treatment strategies is still necessary. It has been reported that unregulated and continuous expression of VEGF can lead to angioma formation at the site of injection (24, 25). A high level of circulating VEGF in acute myocardial infarction can induce acute c ...
... (23). Therefore, the development of new treatment strategies is still necessary. It has been reported that unregulated and continuous expression of VEGF can lead to angioma formation at the site of injection (24, 25). A high level of circulating VEGF in acute myocardial infarction can induce acute c ...
P wave
... • > This is followed by a relatively deep S wave, which results from the mean QRS vector traveling through the LV away from the positive electrodes > The intrinsicoid deflection is a term used to represent ventricular activation time or the time required for peak voltage to develop. ...
... • > This is followed by a relatively deep S wave, which results from the mean QRS vector traveling through the LV away from the positive electrodes > The intrinsicoid deflection is a term used to represent ventricular activation time or the time required for peak voltage to develop. ...
The unipolar leads
... leads. This also is described using Einthovens triangle. The two triaxial diagrams can be combined to form a hexaxial diagram which illustrates the angle of orientation of the leads The unipolar precordial leads record voltages from the heart in the horizontal plane by placing electrodes in specific ...
... leads. This also is described using Einthovens triangle. The two triaxial diagrams can be combined to form a hexaxial diagram which illustrates the angle of orientation of the leads The unipolar precordial leads record voltages from the heart in the horizontal plane by placing electrodes in specific ...
Cross-sectional Area of the Proximal Portions of the
... arteries was determined by videoplanimetry in 98 necropsy patients with coronary heart disease and in 46 control subjects who did not have significant coronary narrowing. Significant (p < 0.001) differences were observed in the mean cross-sectional area of each of the three major coronary arteries i ...
... arteries was determined by videoplanimetry in 98 necropsy patients with coronary heart disease and in 46 control subjects who did not have significant coronary narrowing. Significant (p < 0.001) differences were observed in the mean cross-sectional area of each of the three major coronary arteries i ...
ST segment Elevation Myocardial Infarction (STEMI) with Brugada
... Acute MI and its consequences (death, chronic ischemic coronary artery disease, heart failure) are still the number 1 causes of death and of cardiovascular diseases. In this context, patients with STEMI are at the highest risk. The first-line management of STEMI patients often determines if the out ...
... Acute MI and its consequences (death, chronic ischemic coronary artery disease, heart failure) are still the number 1 causes of death and of cardiovascular diseases. In this context, patients with STEMI are at the highest risk. The first-line management of STEMI patients often determines if the out ...
Conduction Defects
... It remains uncertain whether local delay (or block) of the atrial activation can result in notching of the P-wave without an increase in its duration. On the other hand, some normal subjects, with no evidence of heart disease, do have a small notch at the peak of the P-wave, which is probably relate ...
... It remains uncertain whether local delay (or block) of the atrial activation can result in notching of the P-wave without an increase in its duration. On the other hand, some normal subjects, with no evidence of heart disease, do have a small notch at the peak of the P-wave, which is probably relate ...
PPT - Professional Heart Daily
... Recommendations Modified: Surgical AVR is recommended for symptomatic patients with severe AS (Stage D) and symptomatic patients with severe AS (Stage C) who meet an indication for AVR when surgical risk is low or intermediate For patients in whom TAVR or high-risk surgical AVR is being considered, ...
... Recommendations Modified: Surgical AVR is recommended for symptomatic patients with severe AS (Stage D) and symptomatic patients with severe AS (Stage C) who meet an indication for AVR when surgical risk is low or intermediate For patients in whom TAVR or high-risk surgical AVR is being considered, ...
Corticosteroid-Associated Congestive Heart Failure in 12 Cats
... bpm) with a left anterior fascicular block-like conduction pattern and occasional ventricular premature complexes conducted with right bundle-branch block morphology; sinus bradycardia (80 bpm); atrial standstill with regular ventricular depolarizations (160 bpm) conducted with left bundle-branch bl ...
... bpm) with a left anterior fascicular block-like conduction pattern and occasional ventricular premature complexes conducted with right bundle-branch block morphology; sinus bradycardia (80 bpm); atrial standstill with regular ventricular depolarizations (160 bpm) conducted with left bundle-branch bl ...
ECMO – Extra coporeal membrane oxygenation
... [1] Marasco SF. Review of ECMO (extra corporeal membrane oxygenation) support in critically ill adult patients. Heart Lung Circ. 2008; [3] Schmid C. Extracorporeal life support - systems, indications, and limitations. Thorac Cardiovasc Surg. 2009; [4] Sidebotham D. Extracorporeal membrane oxygenatio ...
... [1] Marasco SF. Review of ECMO (extra corporeal membrane oxygenation) support in critically ill adult patients. Heart Lung Circ. 2008; [3] Schmid C. Extracorporeal life support - systems, indications, and limitations. Thorac Cardiovasc Surg. 2009; [4] Sidebotham D. Extracorporeal membrane oxygenatio ...
Wnt signaling in right ventricular remodeling
... Right ventricular hypertrophy and dysfunction are connected to several conditions including pulmonary hypertension (PH), congenital heart disease or valvular disease. However, in the past, the importance of right ventricle (RV) function in health and disease has been often underestimated. In fact, f ...
... Right ventricular hypertrophy and dysfunction are connected to several conditions including pulmonary hypertension (PH), congenital heart disease or valvular disease. However, in the past, the importance of right ventricle (RV) function in health and disease has been often underestimated. In fact, f ...
The Hemodynamic Effect of Intrinsic Conduction During Left
... The explanation of why LV activation should precede RV activation to provide optimal hemodynamic results is speculative. In an animal model, Verbeek et al. (10) showed that endocardial activation should be restored to baseline to obtain optimal effect of pacing therapy after induction of LBBB. In ca ...
... The explanation of why LV activation should precede RV activation to provide optimal hemodynamic results is speculative. In an animal model, Verbeek et al. (10) showed that endocardial activation should be restored to baseline to obtain optimal effect of pacing therapy after induction of LBBB. In ca ...
NIH Public Access
... vasculature (reviewed in [37]). Besides its generation in endothelial cells, nitric oxide can also be generated by various other tissues via the actions of nitric oxide synthetases (NOS). Studies indicate that a primary mechanism of nitric oxide actions is the inhibition of smooth muscle cell contra ...
... vasculature (reviewed in [37]). Besides its generation in endothelial cells, nitric oxide can also be generated by various other tissues via the actions of nitric oxide synthetases (NOS). Studies indicate that a primary mechanism of nitric oxide actions is the inhibition of smooth muscle cell contra ...
Consensus on Hypertrophic Cardiomyopathy.
... Through genetic analysis, it is also possible to identify relatives who are asymptomatic mutation carriers. It is estimated that up to 30% of the relatives may be silent carriers. (56) Through presymptomatic diagnosis, it is possible to plan and optimize a closer echocardiographic follow-up in carri ...
... Through genetic analysis, it is also possible to identify relatives who are asymptomatic mutation carriers. It is estimated that up to 30% of the relatives may be silent carriers. (56) Through presymptomatic diagnosis, it is possible to plan and optimize a closer echocardiographic follow-up in carri ...
Improved Left Ventricular Relaxation During Short
... a higher peak negative dp/dt during outflow tract pacing, indicating more favorable left ventricular relaxation. This benefit could be attributed to shorter intraventricular conduction times during outflow tract pacing, evidenced by shorter QRS complexes. Previous studies20 –22 have shown that index ...
... a higher peak negative dp/dt during outflow tract pacing, indicating more favorable left ventricular relaxation. This benefit could be attributed to shorter intraventricular conduction times during outflow tract pacing, evidenced by shorter QRS complexes. Previous studies20 –22 have shown that index ...
Cheatham Platinum (CP) and Palmaz stents for
... Stents have been used widely during the last 20 years to treat stenotic lesions in patients with congenital heart disease (CHD). Classical indications are stenotic lesions of the aorta, the systemic veins, the pulmonary outflow and the pulmonary arteries1. The recent introduction of the covered sten ...
... Stents have been used widely during the last 20 years to treat stenotic lesions in patients with congenital heart disease (CHD). Classical indications are stenotic lesions of the aorta, the systemic veins, the pulmonary outflow and the pulmonary arteries1. The recent introduction of the covered sten ...
Alteration in the global and regional strains of heart in patients with
... strain analysis allows discrimination between active and passive myocardial tissue movement. By tracking these speckles, strain can be calculated and reveals the dimensional changes (deformation) as a percentage.16 Shortening or contraction is reflected as a negative value and lengthening or relaxat ...
... strain analysis allows discrimination between active and passive myocardial tissue movement. By tracking these speckles, strain can be calculated and reveals the dimensional changes (deformation) as a percentage.16 Shortening or contraction is reflected as a negative value and lengthening or relaxat ...
Guidelines for the Diagnosis, Treatment and Prevention of Pulmonary Thromboembolism and
... therapy is quite important, and new drugs have become available for this purpose. The Working Groups revised the present guidelines, placing emphasis on currently available evidence whenever possible, but it should be noted that the present guidelines include up-to-date information that may be utili ...
... therapy is quite important, and new drugs have become available for this purpose. The Working Groups revised the present guidelines, placing emphasis on currently available evidence whenever possible, but it should be noted that the present guidelines include up-to-date information that may be utili ...
Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in
... Although the role of the immune system in the pathogenesis of myocardial disease has been established for pathogen-driven diseases such as viral myocarditis, research more recently has focused on the cardiac inflammatory response after AMI as a risk factor for adverse remodeling. Peripheral blood mo ...
... Although the role of the immune system in the pathogenesis of myocardial disease has been established for pathogen-driven diseases such as viral myocarditis, research more recently has focused on the cardiac inflammatory response after AMI as a risk factor for adverse remodeling. Peripheral blood mo ...
Demystifying the Pediatric Cardiomyopathies
... diagnostic imaging and metabolic-genetic evaluations have been initiated. This prepathology processing aims to identify a secondary cardiomyopathy, or if excluded, then reveal a primary cardiomyopathy etiology. Clinical strategies for such investigations have been presented for both childhood and ad ...
... diagnostic imaging and metabolic-genetic evaluations have been initiated. This prepathology processing aims to identify a secondary cardiomyopathy, or if excluded, then reveal a primary cardiomyopathy etiology. Clinical strategies for such investigations have been presented for both childhood and ad ...
PowerPoint File - American College of Cardiology
... Recommendations Modified: Surgical AVR is recommended for symptomatic patients with severe AS (Stage D) and symptomatic patients with severe AS (Stage C) who meet an indication for AVR when surgical risk is low or intermediate For patients in whom TAVR or high-risk surgical AVR is being considered, ...
... Recommendations Modified: Surgical AVR is recommended for symptomatic patients with severe AS (Stage D) and symptomatic patients with severe AS (Stage C) who meet an indication for AVR when surgical risk is low or intermediate For patients in whom TAVR or high-risk surgical AVR is being considered, ...
Redefining the Blanking Period After Catheter Ablation for
... recurrence, and thus do not necessarily represent treatment failure.3,4,6 It has, therefore, become common practice to use a periprocedural blanking period, during which recurrences ...
... recurrence, and thus do not necessarily represent treatment failure.3,4,6 It has, therefore, become common practice to use a periprocedural blanking period, during which recurrences ...
Abnormal Myocardial and Coronary Vasculature Development in
... irregular arterial wall). This deficiency was due to decreased myocyte proliferation rather than to increased apoptosis. By Indian ink injection through the left ventricle we found in normoxic hearts regular coronary branching pattern, while in the hypoxic ones there was often only an irregular plexu ...
... irregular arterial wall). This deficiency was due to decreased myocyte proliferation rather than to increased apoptosis. By Indian ink injection through the left ventricle we found in normoxic hearts regular coronary branching pattern, while in the hypoxic ones there was often only an irregular plexu ...
Retrospective Review of the Frequency of ECG Changes in
... ranging from 0.18 for strict criteria to 0.52 for the presence of any ECG change. The likelihood of meeting strict criteria for ECG changes increased with increasing concentrations of serum potassium (P ⫽ 0.0038), and there was a trend toward increased likelihood of new or resolving symmetric T wave ...
... ranging from 0.18 for strict criteria to 0.52 for the presence of any ECG change. The likelihood of meeting strict criteria for ECG changes increased with increasing concentrations of serum potassium (P ⫽ 0.0038), and there was a trend toward increased likelihood of new or resolving symmetric T wave ...
2014 AHA/ACC Guideline for the Management of Patients With
... Aortic Stenosis: Diagnosis and Follow-Up Recommendations TTE is indicated in patients with signs or symptoms of AS or a bicuspid aortic valve for accurate diagnosis of the cause of AS, hemodynamic severity, LV size and systolic function, and for determining prognosis and timing of valve interventio ...
... Aortic Stenosis: Diagnosis and Follow-Up Recommendations TTE is indicated in patients with signs or symptoms of AS or a bicuspid aortic valve for accurate diagnosis of the cause of AS, hemodynamic severity, LV size and systolic function, and for determining prognosis and timing of valve interventio ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.