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DATA SHEET LANOXIN
DATA SHEET LANOXIN

... Digoxin improves exercise tolerance in patients with impaired left ventricular systolic dysfunction and normal sinus rhythm. This may or may not be associated with an improved haemodynamic profile. In patients receiving diuretics and an ACE inhibitor, or diuretics alone, the withdrawal of digoxin h ...
Cellular Physiology and Biochemistr and Biochemistry
Cellular Physiology and Biochemistr and Biochemistry

... Langendorff hearts provide evidence of drug action under conditions close to in-vivo physiology, but on the other hand are time-consuming and expensive, because only a limited number of drug concentrations can be tested in the heart of one animal. The advantage of isolated cardiomyocytes is that num ...
Atrial fibrillation and risks of cardiovascular disease, renal
Atrial fibrillation and risks of cardiovascular disease, renal

... mortality, with an estimated five million incident cases globally.1  It is increasing in prevalence in both developing and developed countries and is associated with an increased risk of all cause mortality and stroke, as well as higher medical costs and a reduced quality of life.2 3 Although the pr ...
PDF Article
PDF Article

... The partition ratios of amiodarone and desethylamiodarone were similar to those found in surgical patients (9 ,10), but definitely higher than those reported in another comparable study (8) . Our values for desethylamiodarone, but not amiodarone, were higher than those of Escoubet et al. (10), in ag ...
Sudden cardiac death: A nationwide cohort study among the young
Sudden cardiac death: A nationwide cohort study among the young

... Danish death certificates are suitable to identify SD cases because they contain a supplemental information field (see appendix page 50). This field is mandatory in all medico-legal external examinations (external examinations) and contains information describing the circumstances surrounding the de ...
Effects of posture, Valsalva maneuver and respiration on
Effects of posture, Valsalva maneuver and respiration on

... Inspiration prolonged the Rutler cycle interval and expiration shortened it. This ib opposite to the effects of respiration on sinus node rate (Gws arrhythmia) (31). Inspiration increases both the venous return to the hcan and the afterload of the ventricles by reducing the ventricular diastolic pre ...
1 HRV - DANTEST Introduction http://www.dantest.com/ Heart Rate
1 HRV - DANTEST Introduction http://www.dantest.com/ Heart Rate

... balance at the sinoatrial level. It has been used in a variety of clinical situations including diabetic neuropathy, MI, sudden death and CHF. The standard measurements intervening in the analysis of HRV comprise time domain indices, geometric methods and components of the frequency domain. The use ...
Modelling cardiac mechanical properties in three
Modelling cardiac mechanical properties in three

... is a complex problem for which a general theoretical framework has only recently become available (Johnson & Hoger 1995). (e) New directions A common problem with estimating parameters of the strain energy function, whether directly from isolated tissue testing or indirectly from strains measured in ...
Heart Sounds
Heart Sounds

... aware of pounding in her neck. Most episodes last less than 1 minute, but a few have lasted one half hour. During an episode she is lightheaded, but does not have syncope, chest pain, or shortness of breath. Symptoms usually occur without warning at rest. If she breathes slowly and deeply, the episo ...
ACC/AHA/ESC guidelines for the management of patients with
ACC/AHA/ESC guidelines for the management of patients with

... Class IIb: Usefulness/efficacy is less well established by evidence or opinion. Class III: Conditions for which there is evidence and/or general agreement that the procedure or treatment is not useful/effective and in some cases may be harmful. ...
Incidence and mortality risk of congestive heart failure in
Incidence and mortality risk of congestive heart failure in

... estimated using the Kaplan–Meier method and associated confidence intervals (CIs) based on Greenwood’s formula. In addition, we also assessed the cumulative incidence at 1 and 5 years for six subgroups: those with left ventricular systolic function that was (i) preserved (ejection fraction 50%), (ii ...
C:\Users\SSP\Documents\My Web Sites\CINC.ORG\html\2011
C:\Users\SSP\Documents\My Web Sites\CINC.ORG\html\2011

... file:///C|/Users/SSP/Documents/My%20Web%20Sites/CINC.ORG/html/2011/program/mobile.shtml[9/16/2011 11:48:22 AM] ...
serious arrhythmia induced by terfenadine
serious arrhythmia induced by terfenadine

... later she suddenly developed ventricular fibrillation with no pulse or blood pressure. Immediate electrical defibrillation with 200, 300, and 360 Joules with 5 second intervals was given. Standard doses of epinephrine, lidocaine, sodium bicarbonate and a total of eight unsuccessful electroshock atte ...
A New Mitral Valve Repair Strategy for
A New Mitral Valve Repair Strategy for

... to transaortic myectomy (1,2,11). From the very first series, however, septal myectomy - while generally effective - was associated with a small but significant incidence of complications, such as incomplete relief of gradients, persistent mitral valve dysfunction, conduction defects and ventricular ...
Transthoracic Resistance inHuman Defibrillation
Transthoracic Resistance inHuman Defibrillation

... energy dose of 2 J/kg body weight, which would result in an initial shock of 150-200 J for the average adult, a dose shown by others to be effective in most patients.' If the first shock failed to defibrillate, the shock was repeated using a dose of 4 J/kg, then 6 J/kg. This protocol was followed in ...
LATE DEVELOPMENT AND PARTITIONING OF THE HEART
LATE DEVELOPMENT AND PARTITIONING OF THE HEART

eur hj ci 2015 16 233 lang badano
eur hj ci 2015 16 233 lang badano

... Last, cutoff values may be determined by experience-based consensus of expert opinions. An extensive debate arose among the members of the writing group, some of whom felt that providing partition values on the basis of this scientifically less-than-rigorous approach would be a disservice to the ech ...
Effects of Sauna Alone and Postexercise Sauna Baths on Blood
Effects of Sauna Alone and Postexercise Sauna Baths on Blood

... When hypertension diagnosis is confirmed, nonpharmacologic treatments should be instituted as first-line therapy, whenever appropriate, according to North American1 and European2 guidelines. In order to lower blood pressure (BP), but also to control other cardiovascular risk factors, nonpharmacologi ...
Syncope - ACM
Syncope - ACM

... structural heart disease, arrhythmias or ischemia (palpitations or chest pain), or abnormal ECG ...
Chocolate consumption and mortality following a first acute
Chocolate consumption and mortality following a first acute

... total and cardiac mortality respectively. Additional adjustment for hypertension and systolic blood pressure did not attenuate the risk associated with chocolate intake with cardiac mortality. In further analyses, we additionally controlled for markers of infarct severity (Killip class, maximum CK l ...
Management of Stable Ischemic Heart Disease: Summary of a
Management of Stable Ischemic Heart Disease: Summary of a

... or worsening symptoms not consistent with unstable angina and who are incapable of at least moderate physical functioning or have disabling comorbidity (Grade: strong recommendation; moderatequality evidence). Recommendation 46: The organizations recommend that standard exercise ECG testing should ...
Amiodarone-Induced Postrepolarization Refractoriness Suppresses
Amiodarone-Induced Postrepolarization Refractoriness Suppresses

... Main Findings. Chronic amiodarone treatment induced marked PRR (Figs. 3 and 5). Amiodarone-induced PRR prevented the induction of ventricular arrhythmias and furthermore reduced the incidence of ventricular fibrillation in favor of monomorphic ventricular tachycardias (Figs. 3–5). PRR prevented exci ...
Syncope: Diagnosis and Evidence
Syncope: Diagnosis and Evidence

... In patients younger than 65 years, noncardiac causes make up approximately 40% of syncope cases, while 20% may be attributed to cardiac abnormalities. In those aged 65 years or older, cardiac causes comprise up to 40% of cases, while noncardiac causes comprise only 20% [23]. In general, syncope in c ...
Principles of Multi-slice Cardiac CT Imaging
Principles of Multi-slice Cardiac CT Imaging

PDF
PDF

... A 56-year-old male patient with long standing history of essential hypertension on treatment. Sustained type A aortic dissection with severe Aortic regugitation requiring urgent surgery. He had type A aortic dissection repair. He also received a mechanical aortic valve prosthesis three months prior ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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