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Impact of Papillary Muscles Approximation on the Adequacy of Mitral
Impact of Papillary Muscles Approximation on the Adequacy of Mitral

... class was noted in all three groups. Postoperative hemodynamic data in overall survivors showed a significant improvement of EF (from 19±7 to 32±9%) , LVEDVI (from 189±74 to 132±41 mL/m2), and LVDd (from 73±8 to 65±6 mm) (p<0.001 vs. preoperative EF, LVDd, and LVEDVI. Data from those with preoperati ...
Guidelines for Deactivating Implantable cardioverter defibrillators
Guidelines for Deactivating Implantable cardioverter defibrillators

... end of life experience less distressing. It does not require a further procedure after death. Procedure for planned ICD deactivation (hospital setting, community or home). This is a simple non-invasive procedure and takes only a few minutes: 1. Discuss ICD deactivation with the patient (or next of k ...
All About Your Heart Failure Device
All About Your Heart Failure Device

... need a device suddenly, before they ever realized they had heart problems. This can be a confusing time, but let us look at a few facts you may not have known about heart failure devices.  Heart failure devices are actually similar in technology to pacemakers (which have been around for more than 5 ...
PACES/HRS Expert Consensus Statement on the Recognition and
PACES/HRS Expert Consensus Statement on the Recognition and

... higher than in age-matched controls.18,19 Fortunately, the absolute incidence of these devastating events remains relatively low, at approximately 0.1% per year. A tabular representation of approximate expected risks for atrial arrhythmia, ventricular arrhythmia, AV block, and ventricular dyssynchro ...
Effects of Allicin on Hypertension and Cardiac Function in Chronic
Effects of Allicin on Hypertension and Cardiac Function in Chronic

... overload. With time, abnormalities in both structure and function are observed and occur even at the earliest stages of CKD without a manifest CVD [6]. A fundamental response of cardiomyocyte and left ventricular wall to intrinsic and biochemical stress in CKD is hypertrophy, which at first stages m ...
PACES/HRS Expert Consensus Statement on the Recognition and
PACES/HRS Expert Consensus Statement on the Recognition and

... higher than in age-matched controls.18,19 Fortunately, the absolute incidence of these devastating events remains relatively low, at approximately 0.1% per year. A tabular representation of approximate expected risks for atrial arrhythmia, ventricular arrhythmia, AV block, and ventricular dyssynchro ...
Pulmonary Hypertension Advances in Hypertension and
Pulmonary Hypertension Advances in Hypertension and

... “Ten years ago physicians treating pulmonary hypertension would have been amazed at today’s options for managing a disease that had a dismal prognosis. Progress has been swift, and we stand at the threshold of a new era in treatment. As our treatment options for pulmonary hypertension have expanded ...
Inhibition of nitric oxide synthase slows heart rate recovery from
Inhibition of nitric oxide synthase slows heart rate recovery from

... node (SAN) (17), and atrioventricular node cells (16), but NO does not affect the regulation of IKA Ch by ACh (17). In addition, low concentrations of NO donors can increase If in single rabbit SAN cells and the beating rate of atria isolated from guinea pigs. This effect is virtually abolished by a ...
Transcatheter Heart Valve Procedures
Transcatheter Heart Valve Procedures

... A Hayes report concluded that there is sufficient evidence to support the use of TAVR in patients with severe aortic stenosis who are deemed by a heart team to be at high or greater surgical risk. The overall quality of the evidence is moderate. Most studies showed no difference in mortality rates b ...
PDF Article
PDF Article

... Histological assessment. Myocyte diameters were measured separately in the inner, middle and outer thirds of the left ventricular free wall. Two investigators (M.A., T.I.), who were unaware of the treatment protocol, independently reviewed the sections and randomly selected a total of 100 myocardial ...
Accepted Manuscript
Accepted Manuscript

... the quality and availability of expertise in the area where care is provided. When these guidelines are used as the basis for regulatory or payer decisions, the goal should be improvement in quality of care. The Task Force recognizes that situations arise in which additional data are needed to infor ...
Effect of Baseline and Changes in Systolic Blood Pressure Over
Effect of Baseline and Changes in Systolic Blood Pressure Over

ACC/AHA/ESC 2006 guidelines for management of patients with
ACC/AHA/ESC 2006 guidelines for management of patients with

... The content of these European Society of Cardiology (ESC) Guidelines has been published for personal and educational use only. No commercial use is authorized. No part of the ESC Guidelines may be translated or reproduced in any form without written permission from the ESC. Permission can be obtaine ...
Pectus excavatum
Pectus excavatum

... pseudonyms describing the same deformity of gations blame their abnormal findings on the dewhich the aetiology remains unknown and open to formity of the chest wall, but we believe that a speculation. Brodkin (1953) and Chin (1957) blame negative pressure behind the sternum is the main the xiphoid o ...
Association between collagen cross
Association between collagen cross

... DCM [11], studies from our group demonstrated the beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in this furazolidone-induced DCM rat model [12]. Recent clinical study demonstrated that myocardial fibrosis (detected by late gadolinium enhancement cardiovas ...
BENEFICIAL ROLE OF MELATONIN IN THE COMPLETE RECOVERY FROM ISOPROTERENOL-
BENEFICIAL ROLE OF MELATONIN IN THE COMPLETE RECOVERY FROM ISOPROTERENOL-

... levels indicating improvement in cardiac function. Conclusion: The present study shows that continuation of melatonin treatment post-ISO is capable of completely ameliorating the ISO-induced ischemic injury pointing toward melatonin’s efficacy as a cardioprotective agent. Keywords: Antioxidant, isop ...
Right Ventricular Dilatation on Bedside Echocardiography
Right Ventricular Dilatation on Bedside Echocardiography

... In this study, right ventricular dilatation was assessed by qualitative visual comparison in an A4C view. The right ventricle was considered dilated if its size was equal to or greater than the size of the left ventricle. Other studies have reported higher sensitivities in using echocardiography to ...
PDF - 1.9 MB
PDF - 1.9 MB

... and Rv the resistance to venous flow. Q is the mean flow rate, Pa the arterial transmural pressure, Pv the venous transmural pressure, and Pf the right atrial or “filling” pressure. Typical values for each of the components for an adult human are as follows: ...
dbl dobutamine hydrochloride injection
dbl dobutamine hydrochloride injection

... who were given dobutamine hydrochloride at doses that increased both heart rate and myocardial contractility, there were electrocardiographic signs of increased ischaemia. Recent studies in animals suggest that functional deterioration and possible enlargement of experimental myocardial lesions duri ...
Modification of ventricular repolarization in silent long QT
Modification of ventricular repolarization in silent long QT

... the outward currents, particularly the IKs or IKr potassium currents and/or enhancement of the inward currents (INa) during phases 2 and 3 of the action potential (Ackerman and Clapham 1997). The different APD lengths between layers of cells or areas of the heart is named dispersion of repolarizatio ...
Arrhythmias - Cardiac Associates
Arrhythmias - Cardiac Associates

... with the heart or any of its valves. More information will be needed before it can be labeled a problem. The next step is to schedule one or more routine non-invasive tests designed to identify heart problems with a minimum of risk, inconvenience and discomfort to the patient. When the problem is pa ...
Cardiac Disease Evaluation and Management Among Kidney and
Cardiac Disease Evaluation and Management Among Kidney and

... asymptomatic patients only when at least 1 risk marker in present and the patient has poor (⬍4 METS) or unknown functional capacity (8). The ACC/AHA and ACCF guidelines were not written specifically for patients with end-stage organ failure, and the predictive value of the “absence of cardiac sympto ...
YOU CAN LIVE WITH IT! - Cardiovascular Consultants
YOU CAN LIVE WITH IT! - Cardiovascular Consultants

... with the heart or any of its valves. More information will be needed before it can be labeled a problem. The next step is to schedule one or more routine non-invasive tests designed to identify heart problems with a minimum of risk, inconvenience and discomfort to the patient. When the problem is pa ...
The Treatment of Atrial Fibrillation - Michigan Medicine
The Treatment of Atrial Fibrillation - Michigan Medicine

... energy. In most patients, the ablation procedure can be performed safely without interrupting treatment with warfarin (Coumadin). However, in some patients it is safer to stop taking warfarin (Coumadin) a few days before the ablation procedure. In these patients, an injectable form of heparin (Lovon ...
Surgical removal of a large mobile left ventricular thrombus via left
Surgical removal of a large mobile left ventricular thrombus via left

... Left ventricular (LV) thrombus is a life-threatening complication of severe LV dysfunction. Ventriculotomy has been a commonly performed procedure for LV thrombus; however, it often further decrease LV function after surgery. We present an alternative approach to thrombectomy in order to minimize th ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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