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How to Use Imaging - Circulation: Cardiovascular Imaging
How to Use Imaging - Circulation: Cardiovascular Imaging

... totally resolved in the literature: even recently, some authors, on the basis of inexact definitions, have assumed that an intramural course is not an essential feature of malignant anomalous origin or that it varies in the general group (eg, it sometimes includes passing through an intraseptal, or ...
Emergency Management of Pacemaker Failure
Emergency Management of Pacemaker Failure

... Another troublesome complication is twitching of the diaphragm. This is uncommon, but when present it is usually a sign of trouble; such as perforation of the heart or malposition of the epicardial electrodes. Occasionally, a transvenous electrode may have pulled back into the atrium where it would ...
Outcomes of Patients With Prior Coronary Artery Bypass Grafting
Outcomes of Patients With Prior Coronary Artery Bypass Grafting

... prior CABG are shown in Figure 4. MACE at 30 days and 1 year were not significantly different after randomization to bivalirudin compared with heparin plus a GPI. Discussion The main results of the present analysis are as follows. 1) Prior CABG is common in patients admitted for ACS. 2) Patients wit ...
Right Ventricular Volume Determinations in 18 Patients
Right Ventricular Volume Determinations in 18 Patients

... numerous morphologic factors in these patients. However, reconstitution of right ventricular-pulmonary artery continuity and a nonobstructive tricuspid valve are probably two of the more important factors. ...
Cardiac MRI: Part 1, Cardiovascular Shunts
Cardiac MRI: Part 1, Cardiovascular Shunts

... typically acquired using oximetry or cardiac catheterization, both of which have limitations. Because there is an inverse exponential relationship between pulmonary blood flow (Qp) and PVR, pulmonary flow (Qp) measured with phase-contrast MRI can potentially be used to indirectly estimate the PVR [7 ...
IntraAortic Balloon Pump (IABP): Indication For and Beyond
IntraAortic Balloon Pump (IABP): Indication For and Beyond

... y Severe decompensated MR y Progressive right and/or left heart failure despite  medical therapy (bridge to other treatment) ...
Focal atrial tachycardia
Focal atrial tachycardia

... Microreentry. In isolated human atrial myocardium with nonuniform anisotropic proprieties, Spach et al. 23 were able to induce stable reentrant ATs in areas as small as 1.6 mm2. In the intact human heart these tachycardias may arise due to an increase in the fibrous connective tissue between cardiac ...
Fully automated tracking of cardiac structures using radiopaque
Fully automated tracking of cardiac structures using radiopaque

... conditions such as e.g. myocardial infarction or cardiomyopathy, geometry, dynamics and function of the heart muscle and valves may alter significantly. To date, many of these alterations are still incompletely understood. One explanation may be that clinically available imaging modalities (such as ...
Atsuyoshi Takao
Atsuyoshi Takao

... the syndrome,4 and microdeletion of this region was confirmed in 1991 and 1992.5,6 Conotruncal anomaly face syndrome had first been reported in 1976.7 In the early 1970s, Atsuyoshi Takao had begun to recognize a characteristic facial appearance, with a flat nasal bridge, a small mouth, a nasal voic ...
Indications by Appropriate Use Ratings
Indications by Appropriate Use Ratings

... Syncope in Patients With Nonischemic Structural Heart Disease Unexplained Syncope in a Patient With Left Ventricular Hypertrophy Without Criteria for Hypertrophic Cardiomyopathy ...
in Man by High-Frequency Components
in Man by High-Frequency Components

... W. J. TOLLESON, M.D., AND J. R. THOMAS, M.D. ...
Dual atrioventricular nodal non-re
Dual atrioventricular nodal non-re

... eliminates dual conduction.68 Cryoablation is possible, but has only been reported in one patient.24 In this case, a second procedure using radiofrequency ablation was necessary due to recurrent DAVNNT. Recurrence of reduced symptoms has only been reported in three patients treated with modulation/a ...
Metformin Actavis 500 mg film
Metformin Actavis 500 mg film

... All patients should continue their diet with a regular distribution of carbohydrate intake during the day. Overweight patients should continue their energy-restricted diet. The usual laboratory tests for diabetes monitoring should be performed regularly. Metformin alone does not cause hypoglycaemia, ...
Metformin Actavis 850 mg film
Metformin Actavis 850 mg film

... All patients should continue their diet with a regular distribution of carbohydrate intake during the day. Overweight patients should continue their energy-restricted diet. The usual laboratory tests for diabetes monitoring should be performed regularly. Metformin alone does not cause hypoglycaemia, ...
Pericarditis in Bovines- A Review - Open Access Journals
Pericarditis in Bovines- A Review - Open Access Journals

... International Journal of Advanced Veterinary Science and Technology ...
The Three-Dimensional Arrangement of the Myocytes Aggregated
The Three-Dimensional Arrangement of the Myocytes Aggregated

... been shown, using anatomical dissections (Pettigrew, 1864), and confirmed histologically (Streeter et al., 1969), that the long axes of the tangentially oriented myocytes are also inclined at angles relative to the equatorial plane, with these so-called helical angles varying according to the depth ...
Determining a discernable pattern in intensive care unit and
Determining a discernable pattern in intensive care unit and

... patients, though, agreement on common risk factors or high-risk patient profiles has not been achieved (Lai et al., 2012; Metnitz et al., 2003; & Rosenberg et al., 2001). Studies have proclaimed that a significant number of readmission cases were potentially preventable and that specific treatments ...
Function and mechanics of the left ventricle: from
Function and mechanics of the left ventricle: from

... Rather than assessing the rapid velocity blood pool as with conventional Doppler, uses filters to remove these signals to concentrate solely on the lower velocity myocardial motion. Velocities in the myocardial wall are much lower than that of the blood pool and are typically less than 15 cm/s. Tiss ...
NIH Public Access - IUPUI ScholarWorks
NIH Public Access - IUPUI ScholarWorks

... canine hearts. The same effects are observed with low amplitude electrical stimulation of the left stellate ganglion.32 Zhou et al33 performed a study of the mechanisms of nerve sprouting using a canine model of myocardial infarction. The results show a persistent elevation of NGF levels in aorta an ...
Transcatheter Heart Valve Procedures
Transcatheter Heart Valve Procedures

... The mitral valve directs blood flow from the left atrium into the left ventricle. Mitral regurgitation (MR) occurs when the mitral valve does not close properly, allowing blood to flow backwards from the ventricle to the atrium. MR is sometimes referred to as mitral incompetence or mitral insufficie ...
Science | Discovery | Innovation
Science | Discovery | Innovation

... “Honoring Our Past. Shaping Our Future.” As we explore the latest advances in science, discovery, and innovation, we will look back at the groundbreaking events that made such advances possible and how what we know today will improve patient care tomorrow. We are excited about our 34th Annual Scient ...
ALLHAT Publications - University of Texas School of Public Health
ALLHAT Publications - University of Texas School of Public Health

... Maitland-van der Zee AH, Boerwinkle E, Arnett DK, Davis BR, Leiendecker-Foster C, Miller MB, Klungel OH, Ford CE, Eckfeldt JH. Absence of an interaction between the angiotensin converting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patie ...
Approach to Dextrocardia in Adults: Review
Approach to Dextrocardia in Adults: Review

... ventricle. Growth of the conus also helps to form the infundibulum, separating the inflow and outflow regions of the right ventricle. With proper conal development, the pulmonary trunk twists around the ascending aorta as the now-anterior proximal right pulmonary artery arises from the anterior vent ...
Cardiac Murmurs
Cardiac Murmurs

... area is reduced from 3 to 4 cm2 to 1.5 to 2 cm2. However, an additional reduction in t he valve area from half its normal size to a quarter of it’s normal size produces severe obstruction to flow and progressive pressure overload on the left ventricle. ...
Intrinsic cardiac ganglia and acetylcholine are important in the
Intrinsic cardiac ganglia and acetylcholine are important in the

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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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