2013 ESC guidelines on the management of stable coronary artery
... section 6.7.1 of the main text) may be difficult to distinguish from classical angina (see section 6.1 of the main text) as both are mainly exercise-related. Pure vasospastic angina, in contrast to classical and microvascular angina, is characterized by angina at rest with preserved effort tolerance ...
... section 6.7.1 of the main text) may be difficult to distinguish from classical angina (see section 6.1 of the main text) as both are mainly exercise-related. Pure vasospastic angina, in contrast to classical and microvascular angina, is characterized by angina at rest with preserved effort tolerance ...
Presentation (PowerPoint File) - IPAM
... Why does it matter? The recent recognition that up to 50% of patients admitted to hospitals with congestive heart failure have ‘normal systolic function’ as reflected by ejection fraction, has further emphasized the need to more fully understand the physiology of diastole. UCLA/IPAM 2/6/06 ...
... Why does it matter? The recent recognition that up to 50% of patients admitted to hospitals with congestive heart failure have ‘normal systolic function’ as reflected by ejection fraction, has further emphasized the need to more fully understand the physiology of diastole. UCLA/IPAM 2/6/06 ...
Pulsus paradoxus - European Respiratory Journal
... Inspiratory increase in lung volume Effects on right ventricular afterload The relationship between lung vessels resistance and lung volume is complex. From a series arrangement viewpoint, the pulmonary circulation may be divided into extra-alveolar vessels and intra-alveolar vessels [6]. Inspirator ...
... Inspiratory increase in lung volume Effects on right ventricular afterload The relationship between lung vessels resistance and lung volume is complex. From a series arrangement viewpoint, the pulmonary circulation may be divided into extra-alveolar vessels and intra-alveolar vessels [6]. Inspirator ...
Increased Susceptibility of the Heart to Ventricular Fibrillation During
... Calcium and potassium are known to affect cardiac function and the relationship between these ions and cardiac excitability has been emphasized.6"7 Our data do not point to any significant correlation between the plasma potassium concentration and ventricular fibrillation threshold during either res ...
... Calcium and potassium are known to affect cardiac function and the relationship between these ions and cardiac excitability has been emphasized.6"7 Our data do not point to any significant correlation between the plasma potassium concentration and ventricular fibrillation threshold during either res ...
coronary artery anomalies DR SANMATH
... (1) disabling symptoms and/or a high risk of sudden death (2) area stenosis more severe than 50% on IVUS (3) a large dependent myocardial territory (> 1/3rd of total) (4) reversible ischemia, as documented by a nuclear stress test. ...
... (1) disabling symptoms and/or a high risk of sudden death (2) area stenosis more severe than 50% on IVUS (3) a large dependent myocardial territory (> 1/3rd of total) (4) reversible ischemia, as documented by a nuclear stress test. ...
Heart to Heart: Inherited Cardiovascular
... for some conditions within existing services. In addition, while most services include an effective range of professional roles, they are often not working as a truly multidisciplinary team. The relative weight given to different areas of specialist expertise is variable and, in many services, genet ...
... for some conditions within existing services. In addition, while most services include an effective range of professional roles, they are often not working as a truly multidisciplinary team. The relative weight given to different areas of specialist expertise is variable and, in many services, genet ...
Applications of transesophageal echocardiography in treating
... valve activities, as well as whether the surwith diameter of left ventricular defect basal rounding tissues were entrapped, were then part 6.0-10.3 mm and diameter of right vencarefully examined. At this time, because the tricular surface shunt 2.5-7.3 mm. prolapsed aortic valve was pushed up by the ...
... valve activities, as well as whether the surwith diameter of left ventricular defect basal rounding tissues were entrapped, were then part 6.0-10.3 mm and diameter of right vencarefully examined. At this time, because the tricular surface shunt 2.5-7.3 mm. prolapsed aortic valve was pushed up by the ...
The Hand1 and Hand2 transcription factors regulate
... Generation of floxed Hand1 alleles To create a conditional Hand1-null allele, we flanked the first exon of the mouse Hand1 gene with loxP sites by homologous recombination in ES cells (Fig. 1A). Our targeting strategy introduced a neomycin resistance cassette into the 5′untranslated region of Hand1. ...
... Generation of floxed Hand1 alleles To create a conditional Hand1-null allele, we flanked the first exon of the mouse Hand1 gene with loxP sites by homologous recombination in ES cells (Fig. 1A). Our targeting strategy introduced a neomycin resistance cassette into the 5′untranslated region of Hand1. ...
Reproducibility of Echocardiographic Left Ventricular
... measurements, particularly of end-diastolic dimensions, is the simultaneous recording of QRS complexes with readily identifiable onset and peak of deflections. These criteria were found by Schieken et al.1 to result in high reproducibility of measurements of the left ventricle, left atrium, aortic r ...
... measurements, particularly of end-diastolic dimensions, is the simultaneous recording of QRS complexes with readily identifiable onset and peak of deflections. These criteria were found by Schieken et al.1 to result in high reproducibility of measurements of the left ventricle, left atrium, aortic r ...
Teaching Rounds in Cardiac Electrophysiology
... inexcitable and devoid of electrogram activity during prior EP study, appeared glistening white, compatible with complete fibrotic replacement (P. Tchou, MD, personal communication, July 2011). Histology may reveal myocardial fibrillar disarray, degeneration, and interstitial fibrosis. In 2 patients ...
... inexcitable and devoid of electrogram activity during prior EP study, appeared glistening white, compatible with complete fibrotic replacement (P. Tchou, MD, personal communication, July 2011). Histology may reveal myocardial fibrillar disarray, degeneration, and interstitial fibrosis. In 2 patients ...
Management of cardiogenic shock complicating acute myocardial
... without support or <2.0 to 2.2 l/min/m² with inotropic support) and adequate or elevated filling pressures (left ventricular end-diastolic pressure >18 mmHg or right ventricular end-diastolic pressure >10 to 15 mmHg).1 Hypoperfusion may be manifested clinically by cool extremities, decreased urinary ...
... without support or <2.0 to 2.2 l/min/m² with inotropic support) and adequate or elevated filling pressures (left ventricular end-diastolic pressure >18 mmHg or right ventricular end-diastolic pressure >10 to 15 mmHg).1 Hypoperfusion may be manifested clinically by cool extremities, decreased urinary ...
Disclaimer
... are caused by genetic mutations either in the ion channels themselves or, in some cases, other cellular processes that directly or indirectly affect the membrane potential so as to prolong repolarization (9,10). It is very important to identify affected individuals since therapies such as ßblockers ...
... are caused by genetic mutations either in the ion channels themselves or, in some cases, other cellular processes that directly or indirectly affect the membrane potential so as to prolong repolarization (9,10). It is very important to identify affected individuals since therapies such as ßblockers ...
Improving Acute and Long-term Myocardial Infarction Care
... Cardiovascular diseases are the number one cause of death and are projected to remain so for the next decades.(1) An estimated 17.5 million people died from cardiovascular diseases in 2005, representing 30% of all global deaths.(1) Of these deaths, 7.6 million were due to ischaemic heart disease. In ...
... Cardiovascular diseases are the number one cause of death and are projected to remain so for the next decades.(1) An estimated 17.5 million people died from cardiovascular diseases in 2005, representing 30% of all global deaths.(1) Of these deaths, 7.6 million were due to ischaemic heart disease. In ...
Acute coronary syndromes.
... cardiac markers, troponin T and troponin I, are extremely sensitive to myocardial injury and damage. Minimal damage can be detected, allowing identification of ‘micro-infarcts’ where there is an elevation in the troponin concentration without a significant rise in creatine kinase or other cardiac en ...
... cardiac markers, troponin T and troponin I, are extremely sensitive to myocardial injury and damage. Minimal damage can be detected, allowing identification of ‘micro-infarcts’ where there is an elevation in the troponin concentration without a significant rise in creatine kinase or other cardiac en ...
Annual Scientific Sessions
... The program will include several new components and we are looking forward to learn which one you like best. We are hoping that whatever your favorite aspect of the meeting will be, you will enjoy the atmosphere of an enthusiastic and dynamic field, gain new insights, and benefit from all the intera ...
... The program will include several new components and we are looking forward to learn which one you like best. We are hoping that whatever your favorite aspect of the meeting will be, you will enjoy the atmosphere of an enthusiastic and dynamic field, gain new insights, and benefit from all the intera ...
Endocardial Notch Signaling in Cardiac Development and Disease
... endocardium lining the outflow tract endocardial cushions (E and H), whereas Dll4 expression is reduced when compared with E9.5 (F and H), and endocardial N1ICD expression persists (G and H). I and L, At E12.5, Jag1 is strongly expressed in trabecular myocardium (I, arrowhead, L) and weakly in the c ...
... endocardium lining the outflow tract endocardial cushions (E and H), whereas Dll4 expression is reduced when compared with E9.5 (F and H), and endocardial N1ICD expression persists (G and H). I and L, At E12.5, Jag1 is strongly expressed in trabecular myocardium (I, arrowhead, L) and weakly in the c ...
Techniques for ventricular repolarization instability
... ECG time intervals will be described. In section III-B2 methods used to evaluate electrocardiographic T wave morphology changes, as a reflection of amplified heterogeneities in AP repolarization, will be presented. In addition to spatial heterogeneities, increased temporal repolarization heterogenei ...
... ECG time intervals will be described. In section III-B2 methods used to evaluate electrocardiographic T wave morphology changes, as a reflection of amplified heterogeneities in AP repolarization, will be presented. In addition to spatial heterogeneities, increased temporal repolarization heterogenei ...
The Architecture of the Right Ventricular Outflow Tract
... and softens connective tissue. At this stage, further fat and other connective-tissue structures ineluding valvular and endocardial tissues are easily removed mechanically. Then, to restore the tensile strength of the fibers, the heart is carried through increasing concentrations of ethyl alcohol, w ...
... and softens connective tissue. At this stage, further fat and other connective-tissue structures ineluding valvular and endocardial tissues are easily removed mechanically. Then, to restore the tensile strength of the fibers, the heart is carried through increasing concentrations of ethyl alcohol, w ...
Taser X26 Discharges in Swine: Ventricular
... movement. The manufacturer also states that, under a 400 ohm load, this device produces 90 microsecond pulses at 1200 V with a peak current of 3.5 A and 2.1 mA timeaveraged current. However, Webster11 and others10,12 assert that higher voltages and currents which exceed the human ventricular fibrill ...
... movement. The manufacturer also states that, under a 400 ohm load, this device produces 90 microsecond pulses at 1200 V with a peak current of 3.5 A and 2.1 mA timeaveraged current. However, Webster11 and others10,12 assert that higher voltages and currents which exceed the human ventricular fibrill ...
PDF Article - ScienceDirect
... simultaneously with bipolar intracardiac electrograms filtered between30 and 500 Hz on an Electronicsfor Medicine VR-16 recorder at a paper speed of 100 mm/s. The extrastimulus protocol is presented in Table 1. The initial stimulator settings were a pulse width of 2 ms, a stimulus intensity equal to ...
... simultaneously with bipolar intracardiac electrograms filtered between30 and 500 Hz on an Electronicsfor Medicine VR-16 recorder at a paper speed of 100 mm/s. The extrastimulus protocol is presented in Table 1. The initial stimulator settings were a pulse width of 2 ms, a stimulus intensity equal to ...
24. HIV-associated Pulmonary Hypertension
... of prostanoids stimulates a selective intrapulmonary effect. Repeated inhalation of iloprost has proved to be effective and safe in HIV-negative patients in a recent multi-centric, randomized placebo-controlled trial (Olschewski 2002). Iloprosttreated patients showed a significant improvement in exe ...
... of prostanoids stimulates a selective intrapulmonary effect. Repeated inhalation of iloprost has proved to be effective and safe in HIV-negative patients in a recent multi-centric, randomized placebo-controlled trial (Olschewski 2002). Iloprosttreated patients showed a significant improvement in exe ...
New Molecular Insights of Insulin in Diabetic Cardiomyopathy
... remodeling, LV hypertrophy (LVH), and the emergence of clinical indications of HF (Ozasa et al., 2008); however, whether LV systolic dysfunction ultimately develops is a matter of debate. Although some authors have suggested that there is an association between systolic dysfunction and long-standing ...
... remodeling, LV hypertrophy (LVH), and the emergence of clinical indications of HF (Ozasa et al., 2008); however, whether LV systolic dysfunction ultimately develops is a matter of debate. Although some authors have suggested that there is an association between systolic dysfunction and long-standing ...
Impact of Papillary Muscles Approximation on the Adequacy of Mitral
... class was noted in all three groups. Postoperative hemodynamic data in overall survivors showed a significant improvement of EF (from 19±7 to 32±9%) , LVEDVI (from 189±74 to 132±41 mL/m2), and LVDd (from 73±8 to 65±6 mm) (p<0.001 vs. preoperative EF, LVDd, and LVEDVI. Data from those with preoperati ...
... class was noted in all three groups. Postoperative hemodynamic data in overall survivors showed a significant improvement of EF (from 19±7 to 32±9%) , LVEDVI (from 189±74 to 132±41 mL/m2), and LVDd (from 73±8 to 65±6 mm) (p<0.001 vs. preoperative EF, LVDd, and LVEDVI. Data from those with preoperati ...
Myocardial contrast echocardiography is superior to - Heart
... stratification, there is therefore a need for a technique that accurately characterises myocardial perfusion. In response to this need, several different methods of reperfusion assessment have emerged, some new and others modifications of existing applications, but all have met with varying success. ...
... stratification, there is therefore a need for a technique that accurately characterises myocardial perfusion. In response to this need, several different methods of reperfusion assessment have emerged, some new and others modifications of existing applications, but all have met with varying success. ...
Guidelines for Deactivating Implantable cardioverter defibrillators
... end of life experience less distressing. It does not require a further procedure after death. Procedure for planned ICD deactivation (hospital setting, community or home). This is a simple non-invasive procedure and takes only a few minutes: 1. Discuss ICD deactivation with the patient (or next of k ...
... end of life experience less distressing. It does not require a further procedure after death. Procedure for planned ICD deactivation (hospital setting, community or home). This is a simple non-invasive procedure and takes only a few minutes: 1. Discuss ICD deactivation with the patient (or next of k ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.