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Cardiac Disease Evaluation and Management Among Kidney and
Cardiac Disease Evaluation and Management Among Kidney and

... asymptomatic patients only when at least 1 risk marker in present and the patient has poor (⬍4 METS) or unknown functional capacity (8). The ACC/AHA and ACCF guidelines were not written specifically for patients with end-stage organ failure, and the predictive value of the “absence of cardiac sympto ...
Stroke: Effective Strategies for Secondary Prevention
Stroke: Effective Strategies for Secondary Prevention

... hypertension (N = 1,400). Anti-hypertensive efficacy was similar with the calcium-channel blocking agent and the angiotensin receptor blocker (ARB) eprosartan. However, eprosartan protected against cerebrovascular and cardiovascular events, suggesting benefits above protection via blood pressure con ...
Assessment and classification of patients with - Heart
Assessment and classification of patients with - Heart

... 99th centile as the diagnostic threshold for acute myocardial infarction since 2007, with a rise or fall in cardiac troponin concentrations necessary to confirm the diagnosis1 Improvements in assay precision have identified differences in cardiac troponin concentrations between men and women, with the ...
Noninvasive single-beat determination of left ventricular end
Noninvasive single-beat determination of left ventricular end

... the broader application of this parameter to clinical heart failure diagnosis and management. Several approaches have been proposed for estimating Ees without loading interventions (14 –16), and these are generally referred to as single-beat methods (Ees(sb)). For example, based on similarities betw ...
ACC/AHA/ESC Practice Guidelines
ACC/AHA/ESC Practice Guidelines

... mobile ⫹44 07841322925, or e-mail [email protected]. Single copies of the executive summary and the full-text guidelines are also available by calling 800-253-4636 or writing the American College of Cardiology Foundation, Resource Center, at 9111 Old Georgetown Road, Bethesda, MD 2081 ...
The Efficacy of Administration of Intravenous Magnesium Sulfate for
The Efficacy of Administration of Intravenous Magnesium Sulfate for

... magnesium sulfate from 347 to 350 milliseconds (0.8%), when compared to baseline. Since lengthening the tachycardia cycle length will delay the atrioventricular node conduction, and thereby decrease the number of impulses going to the ventricles, this will cause a decrease in ventricular rate. These ...
Use of Pressure-volume Conductance Catheters in Real
Use of Pressure-volume Conductance Catheters in Real

... manipulation of an animal, and these data are compared to control animals without such interventions. These applications require delineation of steady state conditions before and after treatment or intervention, but neglect the time course of the transition. PV conductance catheters can be used as a ...
Late Systolic Murmurs and Non-Ejection - Heart
Late Systolic Murmurs and Non-Ejection - Heart

... a non-ejection click, or both, together with a "pathological" murmur (Table I). For purposes of this study, a " pathological" murmur is a diastolic murmur of mitral or aortic origin, an apical pansystolic murmur, or an aortic ejection murmur in young normotensive subjects (Barlow and Pocock, 1962). ...
Echocardiographic assessment of left ventricular diastolic function
Echocardiographic assessment of left ventricular diastolic function

... remains the cornerstone of diastolic evaluation. Several parameters can be derived from mitral inflow velocities, which are useful for this evaluation. These include early diastolic transmitral velocity (E), late diastolic transmitral velocity (A) recorded at the tips of mitral valve from an apical ...
ACC/AHA/ESC Practice Guidelines
ACC/AHA/ESC Practice Guidelines

... sinus node, then the sinus node can be overdriven and the ectopic focus will become the predominant pacemaker of the heart. The rapid firing rate may be incessant (ie, more than 50% of the day) or episodic. Triggered activity is a tachycardia mechanism associated with disturbances of recovery or rep ...
Standardized Definitions for Cardiovascular and Stroke
Standardized Definitions for Cardiovascular and Stroke

... In many studies, particularly those in which patients present acutely to hospitals which are not participating sites, it is not practical to stipulate the use of a single biomarker or assay, and the locally available results are to be used as the basis for adjudication. However, if possible, using t ...
Relative Contributions of the Atrial Systole
Relative Contributions of the Atrial Systole

... ventricular function was observed as a result of atrial pacing, sequential atrioventricular pacing, or atrial-His bundle pacing at an appropriate atrial systole-ventricular systole (As-Vs) interval. Ventricular function was depressed during ventricular pacing and during atrioventricular pacing with ...
Effect of Endurance Exercise on Autonomic Control of Heart Rate
Effect of Endurance Exercise on Autonomic Control of Heart Rate

... activity from high frequency power.[43] Low frequency heart rate fluctuations may also be related to baroreflex activity, temperature regulation and cardiovascular stresses such as haemorrhage and congestive heart failure.[21] The low frequency region includes a peak centred near 0.1Hz which is refe ...
Percutaneous Mitral Valve Replacement
Percutaneous Mitral Valve Replacement

... considered as a therapeutic option in the presence of severe continued symptoms unresponsive to medical therapy.2 Data from the Euro Heart Survey revealed that nearly 50% of patients with symptomatic severe MR are not referred for surgery.3 Older patients with additional comorbidities, MR of nonisch ...
ACC/AHA/ESC 2006 Guidelines for Management of
ACC/AHA/ESC 2006 Guidelines for Management of

... 353827, Fax ⫹44 (0)1865 353774, work mobile ⫹44 (0)7841 322925, or e-mail [email protected]. Single copies of the executive summary and the full-text guidelines are also available by calling 800-253-4636 or writing the American College of Cardiology Foundation, Resource Center, at 911 ...
ACC/AHA/ESC 2006 Guidelines for Management of Patients With
ACC/AHA/ESC 2006 Guidelines for Management of Patients With

... 353827, Fax ⫹44 (0)1865 353774, work mobile ⫹44 (0)7841 322925, or e-mail [email protected]. Single copies of the executive summary and the full-text guidelines are also available by calling 800-253-4636 or writing the American College of Cardiology Foundation, Resource Center, at 911 ...
AHA Scientific Statement
AHA Scientific Statement

... because of numerous catheter techniques, the increased numbers of persons and centers using these techniques, and the increased number of lesion types thought to be amenable to catheter therapy. In comparison with diagnostic cardiac catheterization, therapeutic catheter procedures require more time ...
ACC/AHA/ESC Practice Guideline
ACC/AHA/ESC Practice Guideline

... sinus node, then the sinus node can be overdriven and the ectopic focus will become the predominant pacemaker of the heart. The rapid firing rate may be incessant (ie, more than 50% of the day) or episodic. Triggered activity is a tachycardia mechanism associated with disturbances of recovery or rep ...
Standardized Definitions for Cardiovascular and Stroke
Standardized Definitions for Cardiovascular and Stroke

... In many studies, particularly those in which patients present acutely to hospitals which are not participating sites, it is not practical to stipulate the use of a single biomarker or assay, and the locally available results are to be used as the basis for adjudication. However, if possible, using t ...
Treatment and management of mitral regurgitation
Treatment and management of mitral regurgitation

Introduction to Pediatric ECGs
Introduction to Pediatric ECGs

... Seen in right precordial leads: V1, rV3  Common: occurs in 7% of kids  R and R’ both small and of short duration  S wave larger than R and R’  R’ is less than 10 mm (15 mm in infants)  Abnormal RSR’ may reflect RBBB or RVH (volume overload type) ...
Congenital Absence of Left Circumflex Coronary Artery
Congenital Absence of Left Circumflex Coronary Artery

... the anatomical course of coronary artery anomalies and their relationship to other cardiac and non-cardiac structures, because of the three-dimensional nature of the images it provides. This makes CT angiography an imaging modality of choice for the investigation of known or suspected coronary arter ...
Anomalous Left Coronary Artery from Pulmonary Artery
Anomalous Left Coronary Artery from Pulmonary Artery

... and increased oxygen saturation in the pulmonary artery at the time of catheterization (group A) appears to be immaterial, as all have survived. Mortality rates in patients with left-to-right shunts not large enough to be detected by oxygen studies (group B) indicate no significant difference in tho ...
The formulary has been developed to promote safe, evidence based
The formulary has been developed to promote safe, evidence based

... hypokalaemia is a problem; may take 2-3 days for full effect. Potassium supplements must not be given with potassium-sparing diuretics. Administration of a potassium-sparing diuretic to a patient receiving an ACE inhibitor or an angiotensin-II receptor antagonist can also cause severe hyperkalaemia. ...
Cardiac Pacing: Patient Management
Cardiac Pacing: Patient Management

... oesophagus just behind the left atrium to permit temporary atrial pacing. 6,7 The patient is to remain sedated for the duration of this type of pacing.7 This system may also be used in the diagnosis (electrophysiological study) and termination of arrhythmias including SVT.4 However, as this pacing o ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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