Ral Antic Director Thoracic Medicine Head of Sleep
... coronary syndrome (ACS) y Correlation between CAD, ACS & OSA well established – 65% admitted for MI ...
... coronary syndrome (ACS) y Correlation between CAD, ACS & OSA well established – 65% admitted for MI ...
Myocardial infarction with Q waves
... myocardium is a shift of pH in the acidic side (acidosis), which contributes to further reduction in electrical activity and myocardial contractility. ATP deficiency leads to the discovery of potassium channel cell K + ions out into the extracellular medium, thus reducing the transmembrane resting p ...
... myocardium is a shift of pH in the acidic side (acidosis), which contributes to further reduction in electrical activity and myocardial contractility. ATP deficiency leads to the discovery of potassium channel cell K + ions out into the extracellular medium, thus reducing the transmembrane resting p ...
animal models / simulations / manikin studies
... influence of using the Esmarch manoeuvre (bimanual jaw-thrust), a nasopharyngeal airway, an oropharyngeal airway, or the Jaw-Thrust-Device on airway physiology in 50 healthy adults with body mass index < 35 kg/m2, undergoing standard facemask ventilation for routine induction of anaesthesia. The ma ...
... influence of using the Esmarch manoeuvre (bimanual jaw-thrust), a nasopharyngeal airway, an oropharyngeal airway, or the Jaw-Thrust-Device on airway physiology in 50 healthy adults with body mass index < 35 kg/m2, undergoing standard facemask ventilation for routine induction of anaesthesia. The ma ...
A new electric method for non-invasive continuous monitoring of
... volume change, and ψ(τ ) is a measure of ventricular volume change (as will be shown in section Principle of Operation), at that particular instant τ during the cardiac cycle. Therefore, the graph of ψ(τ ) as function of time during one single specific heartbeat represents the in-vivo ventricular vo ...
... volume change, and ψ(τ ) is a measure of ventricular volume change (as will be shown in section Principle of Operation), at that particular instant τ during the cardiac cycle. Therefore, the graph of ψ(τ ) as function of time during one single specific heartbeat represents the in-vivo ventricular vo ...
Standard PDF - Wiley Online Library
... classification (i.e. identifying all the action potentials corresponding to the same IC neuron) was performed by template matching (template length: 5–6 ms, ∼30 samples) and validated by principal component analysis. Further manual validation was performed by visual inspection of the templates such ...
... classification (i.e. identifying all the action potentials corresponding to the same IC neuron) was performed by template matching (template length: 5–6 ms, ∼30 samples) and validated by principal component analysis. Further manual validation was performed by visual inspection of the templates such ...
(PIL) - (eMC)
... For all paediatric age groups (neonates to 18 years) an initial dose of 5 micrograms/kg/minute, adjusted according to clinical response to 2-20 micrograms/kg/minute is recommended. Occasionally, a dose as low as 0.5-1.0 micrograms/kg/minute will produce a response. There is reason to believe that th ...
... For all paediatric age groups (neonates to 18 years) an initial dose of 5 micrograms/kg/minute, adjusted according to clinical response to 2-20 micrograms/kg/minute is recommended. Occasionally, a dose as low as 0.5-1.0 micrograms/kg/minute will produce a response. There is reason to believe that th ...
Management of Stable Ischemic Heart Disease
... Weight Management. Recommendation 10: The organizations recommend assessing body mass index and/or waist circumference at every visit and consistently encouraging weight maintenance/reduction through an appropriate balance of lifestyle physical activity, structured exercise, caloric intake, and form ...
... Weight Management. Recommendation 10: The organizations recommend assessing body mass index and/or waist circumference at every visit and consistently encouraging weight maintenance/reduction through an appropriate balance of lifestyle physical activity, structured exercise, caloric intake, and form ...
Deciphering the Sinus Tachycardias
... positively coupled to adenyl cyclase. Activation of these receptors leads to an increase in cyclic adenosine monophosphate (cAMP) which directly triggers the opening of the inward sodium channels responsible for the “funny” current and indirectly stimulates opening of “L-type” calcium channels. The ...
... positively coupled to adenyl cyclase. Activation of these receptors leads to an increase in cyclic adenosine monophosphate (cAMP) which directly triggers the opening of the inward sodium channels responsible for the “funny” current and indirectly stimulates opening of “L-type” calcium channels. The ...
ECG TUTORIAL for Clinicians
... QT Interval (QTc 0.44s) Poor Man's Guide to the upper limit of QT: @ 70 bpm, QT 0.40s; for every 10 bpm increase above 70 bpm subtract 0.02s, and for every 10 bpm decrease below 70 bpm add 0.02s. For example: QT 0.38 @ 80 bpm QT 0.42 @ 60 bpm Frontal Plane QRS Axis: +90° to -30° (in the adult) ...
... QT Interval (QTc 0.44s) Poor Man's Guide to the upper limit of QT: @ 70 bpm, QT 0.40s; for every 10 bpm increase above 70 bpm subtract 0.02s, and for every 10 bpm decrease below 70 bpm add 0.02s. For example: QT 0.38 @ 80 bpm QT 0.42 @ 60 bpm Frontal Plane QRS Axis: +90° to -30° (in the adult) ...
are there deleterious cardiac effects of acute and chronic endurance
... relative to that individual’s maximal capacity. Higher relative workrates produce greater cardiac stress because they require a higher percentage of the individual’s maximal heart rate and generate more catecholamine spill over into the circulation. Increased catecholamine concentrations are arrhyth ...
... relative to that individual’s maximal capacity. Higher relative workrates produce greater cardiac stress because they require a higher percentage of the individual’s maximal heart rate and generate more catecholamine spill over into the circulation. Increased catecholamine concentrations are arrhyth ...
Guidelines for the Echocardiographic Assessment of the Right Heart
... American Society of Echocardiography (ASE). The current values are based on larger populations or pooled values from several studies, while several previous normal values were based on a single study. It is important for the interpreting physician to recognize that the values proposed are not indexe ...
... American Society of Echocardiography (ASE). The current values are based on larger populations or pooled values from several studies, while several previous normal values were based on a single study. It is important for the interpreting physician to recognize that the values proposed are not indexe ...
Inhibition of cyclooxygenase-2 improves cardiac - AJP
... prostanoids serve as intracrine, autocrine, and paracrine mediators, signaling changes within the immediate environment. Upregulation of COX in the heart could produce prostanoid products that would affect cell function. Previous studies examining the role of COX in the heart used nonselective COX i ...
... prostanoids serve as intracrine, autocrine, and paracrine mediators, signaling changes within the immediate environment. Upregulation of COX in the heart could produce prostanoid products that would affect cell function. Previous studies examining the role of COX in the heart used nonselective COX i ...
Guidelines ESC VD 2010 - Working Group for Echocardiography
... American Society of Echocardiography (ASE). The current values are based on larger populations or pooled values from several studies, while several previous normal values were based on a single study. It is important for the interpreting physician to recognize that the values proposed are not indexe ...
... American Society of Echocardiography (ASE). The current values are based on larger populations or pooled values from several studies, while several previous normal values were based on a single study. It is important for the interpreting physician to recognize that the values proposed are not indexe ...
Inability of Potassium Canrenoate to Convert Experimentally
... effectiveness of right vagal stimulation in producing sinoatrial arrest and the absence of a ventricular ectopic pacemaker. During the period of vagal stimulation, a single escape beat from the sinoatrial node was the only evidence ofautomaticity. B: Record obtained after the dog had received a toxi ...
... effectiveness of right vagal stimulation in producing sinoatrial arrest and the absence of a ventricular ectopic pacemaker. During the period of vagal stimulation, a single escape beat from the sinoatrial node was the only evidence ofautomaticity. B: Record obtained after the dog had received a toxi ...
Repolarization Phase at Various Sites of the Right Atrium
... location of the wave front at 10-msec intervals. In each figure about ten sites on the right atrial surface were selected for sampling. It can be noted that the spread of depolarization occurred in a similar manner in all eight instances illustrated. It was confirmed that the wave of excitation star ...
... location of the wave front at 10-msec intervals. In each figure about ten sites on the right atrial surface were selected for sampling. It can be noted that the spread of depolarization occurred in a similar manner in all eight instances illustrated. It was confirmed that the wave of excitation star ...
Decreased Expression of the Cardiac LIM Domain
... dilated and ischemic cardiomyopathy. MLP protein concentrations were significantly decreased in failing hearts, whereas MLP mRNA concentrations were unchanged compared with non-failing donor hearts. These results indicate that decreased MLP synthesis or enhanced MLP protein turnover, rather than a d ...
... dilated and ischemic cardiomyopathy. MLP protein concentrations were significantly decreased in failing hearts, whereas MLP mRNA concentrations were unchanged compared with non-failing donor hearts. These results indicate that decreased MLP synthesis or enhanced MLP protein turnover, rather than a d ...
Clinical significance of cardiac murmurs: Get the sound and rhythm
... commonly, horses still perform up to their expectations. Mitral regurgitation often progresses over time but progression is usually slow. Atrial fibrillation is a common sequel to mitral regurgitation. Cardiac failure is relatively rare, but if it occurs, it is often associated with severe mitral re ...
... commonly, horses still perform up to their expectations. Mitral regurgitation often progresses over time but progression is usually slow. Atrial fibrillation is a common sequel to mitral regurgitation. Cardiac failure is relatively rare, but if it occurs, it is often associated with severe mitral re ...
are there deleterious cardiac effects of acute and chronic endurance
... relative to that individual’s maximal capacity. Higher relative workrates produce greater cardiac stress because they require a higher percentage of the individual’s maximal heart rate and generate more catecholamine spill over into the circulation. Increased catecholamine concentrations are arrhyth ...
... relative to that individual’s maximal capacity. Higher relative workrates produce greater cardiac stress because they require a higher percentage of the individual’s maximal heart rate and generate more catecholamine spill over into the circulation. Increased catecholamine concentrations are arrhyth ...
Left Septal Atrial Tachycardias: Electrocardiographic
... procedural success was defined by the absence of tachycardia or ectopy 30 minutes after ablation including in response to isoproterenol infusion (up to 6 g/min) and burst atrial pacing. Follow-up was at 3, 6, and 12 months with clinical assessment and a 12-lead electrocardiogram. If patients experi ...
... procedural success was defined by the absence of tachycardia or ectopy 30 minutes after ablation including in response to isoproterenol infusion (up to 6 g/min) and burst atrial pacing. Follow-up was at 3, 6, and 12 months with clinical assessment and a 12-lead electrocardiogram. If patients experi ...
Dextrocardia with Situs Inversus, Atrio
... and situs inversus in 23% of the cases [4]. Another study reported dextrocardia to be associated with situs solitus in 64%, situs inversus in 27%, and situs ambiguous in 9% [2]. In our case report, the patient was incidentally found to have dextrocardia, situs inversus, concordant atrio-ventricular ...
... and situs inversus in 23% of the cases [4]. Another study reported dextrocardia to be associated with situs solitus in 64%, situs inversus in 27%, and situs ambiguous in 9% [2]. In our case report, the patient was incidentally found to have dextrocardia, situs inversus, concordant atrio-ventricular ...
Assessment of the course of the great cardiac vein in a
... side of the anterior interventricular branch of the left coronary artery, forming a closed triangle, whereas in our research the triangle most often (73%) appeared open in the right end, which is supported by the research carried out by Ortale (64%). Regarding the closed triangle, we were able to ob ...
... side of the anterior interventricular branch of the left coronary artery, forming a closed triangle, whereas in our research the triangle most often (73%) appeared open in the right end, which is supported by the research carried out by Ortale (64%). Regarding the closed triangle, we were able to ob ...
OSM enhances angiogenesis and improves ... infarction
... production, reducing cardiomyocytes fibrosis and apoptosis and improving cardiac function after ...
... production, reducing cardiomyocytes fibrosis and apoptosis and improving cardiac function after ...
Unusual RighttoLeft Shunt by SingleSided Bilateral Inferior Vena Cava
... vein and the absence of the hepatic portion of the IVC.9 Duplications of the IVC constitutes the major portion having a prevalence of 2–3%.10,11 The double IVC in the presented case is considered as a single sided, whereas from the most cases in the literature, the IVC duplication is double sided. W ...
... vein and the absence of the hepatic portion of the IVC.9 Duplications of the IVC constitutes the major portion having a prevalence of 2–3%.10,11 The double IVC in the presented case is considered as a single sided, whereas from the most cases in the literature, the IVC duplication is double sided. W ...
Cardiopulmonary exercise testing in patients with
... and (3) assessment of ventilatory efficiency (i.e., matching of pulmonary ventilation and perfusion).1 CPX is presently a well-accepted and widely utilized diagnostic test in patients with heart failure (HF) and for those individuals presenting with unexplained exertional dyspnea.2– 4 With respect t ...
... and (3) assessment of ventilatory efficiency (i.e., matching of pulmonary ventilation and perfusion).1 CPX is presently a well-accepted and widely utilized diagnostic test in patients with heart failure (HF) and for those individuals presenting with unexplained exertional dyspnea.2– 4 With respect t ...
Cardiac contractility modulation
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Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.