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Longitudinal Strain Is a Marker of Microvascular Obstruction and
Longitudinal Strain Is a Marker of Microvascular Obstruction and

... Copyright: ß 2014 Bière et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: No current external fun ...
topography of cardiac ganglia in the adult human heart - East
topography of cardiac ganglia in the adult human heart - East

... tion procedures at Loyola University Medical Center. The Institutional Review Board at Loyola University approved the protocol for removal of heart tissue not directly used during heart transplantation procedures. Five complete hearts from autopsy cases, and atrial or ventricular tissue from ten add ...
ESC Guidelines on ST segment elevation acute myocardial
ESC Guidelines on ST segment elevation acute myocardial

... of assisting physicians in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk –benefit ratio of particular diagnostic or therapeutic means. Guidelines are not ...
ESC Guidelines for the management of acute myocardial infarction
ESC Guidelines for the management of acute myocardial infarction

Strain rate imaging: fundamental principles and progress so far
Strain rate imaging: fundamental principles and progress so far

... influence each other’s motion (an effect referred to in literature as ‘tethering’) [4] . Indeed, if one segment contracts the neighboring segments can be dragged along and therefore move without active contraction. As a result, the absolute value of the regional myocardial velocity does not necessar ...
Acute myocardial infarction in patients with ST segment elevation
Acute myocardial infarction in patients with ST segment elevation

... of assisting physicians in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk –benefit ratio of particular diagnostic or therapeutic means. Guidelines are not ...
The effect of connexin40 deficiency on ventricular conduction
The effect of connexin40 deficiency on ventricular conduction

... endocardium. (C) This pattern is similar at ED11.5, where a rich network of the pectinate muscles could be seen in both atrial appendages. White dots indicate the position of the PIR, devoid of Cx40, corresponding externally to forming interventricular groove. (A, B, C) Tissue autofluorescence in th ...
Sleep, dreams, and sudden death: the case for
Sleep, dreams, and sudden death: the case for

... [59] have shown that intracerebroventricular administration of subsystemic doses of I-propranolol but not d-proprano101significantly reduced the incidence of ventricular fibrillation during combined left anterior descending coronary artery occlusion and behavioral stress in the pig. Surprisingly, in ...
The Hypertrophic Cardiomyopathy Program
The Hypertrophic Cardiomyopathy Program

... Dr. Mathew Maurer, the medical director of The HCM Program at NewYork-Presbyterian Hospital/Columbia is now monitoring Joey’s progress and helping him to maintain his high fitness level. As a teenager, Joey played basketball and baseball, though most HCM patients refrain from competitive sports. He ...
Disease Management for Heart Failure
Disease Management for Heart Failure

... The “failing” heart keeps working, but it doesn’t work as efficiently as it should. People with heart failure cannot physically exert themselves because they become short of breath and fatigued. As blood flow out of the heart slows, blood returning to the heart through the veins often backs up, caus ...
Cardiac Computed Tomography (CT)
Cardiac Computed Tomography (CT)

... value over and above that of risk factors such as age, blood pressure, and cholesterol levels (and the widely used Framingham risk score, which combines these and other factors) in asymptomatic high-risk patients. However, there is no published evidence that coronary calcium screening lowers coronar ...
This gene encodes an alpha-1 subunit of a voltage
This gene encodes an alpha-1 subunit of a voltage

... Q-aTc: From the beginning of QRS complex to apex of T wave corrected for heart rate. Q-aTc interval is the more easily and precisely measured at elevated calcium levels and exhibited the strongest correlation over the range of calcium levels measured. The relation is linear and could be used to esti ...


... 75 retransplant recipients registered, only 25 are alive at any time between 5 days and 4 years from retransplantation (33%). Most have died within the first 3 months after retransplantation (40 out of 50 patients). The timing of retransplantation, a reflection of whether the primary graft failed ea ...
Learn ECG in a Day
Learn ECG in a Day

... moved to Netherlands in 1870. He received a medical degree from the University of Utrecht in 1885. After that he went on to become a professor at University of Leiden in 1886. Before Einthoven’s time, it was known that electrical currents were produced by the beating of the heart, but this phenome ...
Pacing System Malfunction: Evaluation and Troubleshooting
Pacing System Malfunction: Evaluation and Troubleshooting

Diastolic closure rate of normal mitral valve - Heart
Diastolic closure rate of normal mitral valve - Heart

Management of Acute Right Ventricular Failure in the
Management of Acute Right Ventricular Failure in the

... right heart failure and decreased survival in patients with pulmonary arterial hypertension (18). In pulmonary arterial hypertension, right atrial enlargement, pericardial effusion, low tricuspid annular plane systolic excursion, and septal displacement are poor prognostic indicators, but their use ...
Protection of Cardiac Cell-to-Cell Coupling Attenuate Myocardial
Protection of Cardiac Cell-to-Cell Coupling Attenuate Myocardial

... or attenuation of development of arrhythmogenic substrates in relation to Cx43 channels function to reduce a risk of arrhythmia occurrence (Sovari et al. 2013, Tribulova et al. 2015). Taking into consideration events involved in a development of malignant arrhythmias, such as oxidative/nitrosative s ...
Nervous System
Nervous System

... baroreceptors located in the carotid sinus and aortic arch causes reflex bradycardia and tachycardia, respectively. At the vascular level, stimulation of the arterial baroreceptors results in sympathetic inhibition and, in consequence, reflex vasodilation. In contrast, the deactivation of the arteri ...
Recommendations for Quantification Methods
Recommendations for Quantification Methods

... basal and midcavity minor-axis diameters and RV major-axis length can be measured at end-diastole (defined as the frame at which the TV closes), taking care not to foreshorten the right ventricle (Figure 12). Again, 2D measurements of the RV have correlated weakly with MRI measurements, especially i ...
Effect of adenosine on heart rate variability in
Effect of adenosine on heart rate variability in

... raises heart rate by decreasing parasympathetic and increasing cardiac sympathetic tone. These reflex effects may become clinically relevant during adenosine stress testing, or when endogenous adenosine is increased, such as during ischaemia, exercise or vasodepressor reactions, or in heart failure. ...
The effect of positive end-expiratory pressure on pulse pressure variation Original Research:
The effect of positive end-expiratory pressure on pulse pressure variation Original Research:

... Objectives: To determine the effect of different levels of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV). Design: An observational study. Setting: Operating theatres of a tertiary training hospital. Subjects: Ventilated patients who required intra-arterial blood pressure ...
Remodelling of gap junctions and connexin expression in diseased
Remodelling of gap junctions and connexin expression in diseased

... current flow that govern the regular rhythm of the healthy heart. As in most tissues and organs, multiple connexin types are expressed in the heart: connexin43 (Cx43), Cx40 and Cx45 are found in distinctive combinations and relative quantities in different, functionally-specialized subsets of cardiac ...
An ECG Primer
An ECG Primer

... The modified central lead is created by placing the positive electrode at the 4th intercostal space just to the right of the sternum and the negative electrode below the left clavicle near the shoulder. The ground electrode (red) electrode can be placed anywhere on the body (refer to Figure 4.3). Wh ...
ECGprimer
ECGprimer

... The modified central lead is created by placing the positive electrode at the 4th intercostal space just to the right of the sternum and the negative electrode below the left clavicle near the shoulder. The ground electrode (red) electrode can be placed anywhere on the body (refer to Figure 4.3). Wh ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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