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Dobutamine stress echo-induced apical ballooning (Takotsubo
Dobutamine stress echo-induced apical ballooning (Takotsubo

... Aims We report a case of dobutamine stress echocardiography (DSE) resulting in transient apical ballooning syndrome to highlight this rare condition as a potential complication of DSE. Background Takotsubo cardiomyopathy, or transient apical ballooning syndrome, is a recently described form of left ...
PDF - Heart Rhythm Society
PDF - Heart Rhythm Society

... Chair, Appropriate Use Criteria Task Force ...
Heart valve closure timing intervals in response to left ventricular
Heart valve closure timing intervals in response to left ventricular

Hyperoxia causes oxygen free radical
Hyperoxia causes oxygen free radical

... during extracorporeal membrane oxygenation or for 2–5 h during a cardiac operation (1, 35). The original rationale for the use of hyperoxia was to ensure adequate oxygen delivery, assuming that higher levels of oxygen could only benefit the patient receiving critical care (6, 41). The potentially de ...
Heart WaLL, cHambers, and VaLVes
Heart WaLL, cHambers, and VaLVes

... Of all organs, the heart has a unique ability—automaticity. The heart can contract by itself, independent of any signals or stimulation from the body. The heart contracts in response to an electrical current conveyed by a conduction system (Fig. 19-8). Specialized cells in the sinoatrial (SA) node n ...
Final heart development
Final heart development

... the roof of the common atrium shows gradual resorption forming an opening called ostium secondum. • Another septum descends on the right side of the septum primum called septum secundum. • It forms an incomplete partition between the two atria. • Consequently a valvular oval foramen forms, (foramen ...
1-position of the aorta - Heart
1-position of the aorta - Heart

... posterior margin. Both aortic and pulmonary valves were related to the defect, the pulmonary valve exactly overriding the septum (Fig. 4). Heart 2 had a dysplastic tricuspid valve, right ventricle, and aorta. The ventricular septal defect occupied the posterior septum and was subpulstretched superio ...
Cardiac Screening before Participation in Sports
Cardiac Screening before Participation in Sports

... and the loss of decades of life have a lasting impact on friends, peers, and both the lay and medical communities. Deaths are usually attributable to hereditary or congenital abnormalities affecting the cardiac structure or the electrical system of the heart. These conditions are often associated wi ...
New insights in the assessment of right ventricular function
New insights in the assessment of right ventricular function

... with different extent of contribution to the overall systolic function. In PH, RV becomes one dyssynchronous compartment which itself may have perpetual effect on overall cardiac dysfunction. In addition, critical aortic stenosis results in RV configuration changes with the inflow tract, rather than ...
Usefulness of the 12-lead electrocardiogram in the follow
Usefulness of the 12-lead electrocardiogram in the follow

... Figure 4. Diagram showing the usual direction of the mean frontal plane axis during apical right ventricular (RV) pacing, RV septal/outflow tract pacing, monochamber left ventricular (LV) pacing from a posterior or posterolateral coronary vein, biventricular (BIV) pacing with LV from a posterior or ...
Perventricular device closure of congenital muscular ventricular
Perventricular device closure of congenital muscular ventricular

... National Health Vigilance Agency. It is made of a self-expanding Nitinol wire mesh woven into two discs connected by a 7-mm long cylindrical waist. Reinforced layers of polyester patches are sewn into the internal part of the Nitinol wire mesh to increase its occlusion rates. The device is malleable ...
BRS Physiology Cases and Problems 2nd Edition
BRS Physiology Cases and Problems 2nd Edition

... 9. Superimpose a new pressure-volume loop to illustrate the effect of an increase in left ventricular end-diastolic volume (i.e., increased preload). What is the effect on stroke volume? 10. Superimpose a new pressure-volume loop to illustrate the effect of an increase in contractility. What is the ...
HRS/ACC/AHA Expert Consensus Statement on
HRS/ACC/AHA Expert Consensus Statement on

... guideline on a specific clinical subject. Recommendations are not given a Class recommendation; instead, phrases ...
Normal electrocardiographic findings: recognising physiological
Normal electrocardiographic findings: recognising physiological

Dear High School, Sudden Cardiac Arrest
Dear High School, Sudden Cardiac Arrest

... Costa County alone from May 2009 - February 2010, there were 9 sudden cardiac arrests experienced by children and youth, which resulted in 4 deaths and 5 saved lives. The youngest victim was 10; the oldest was 17. In each of these cases, there was a direct correlation between bystander use of cardio ...
Therapeutic effect of MG132 on diabetic cardiomyopathy is
Therapeutic effect of MG132 on diabetic cardiomyopathy is

... From clinical setting, there is an urgent need for an efficient approach that can provide a ...
PDF
PDF

... during isoproterenol infusion and washout. Data are reported (averaged over 30s) when a steady-state response was achieved at each dose, and 2 min after dosing discontinuation. Finally, the possible confounding effects of exercise-mediated heart rate changes were evaluated in another subset of dogs ...
A molecular and genetic outline of cardiac - UvA-DARE
A molecular and genetic outline of cardiac - UvA-DARE

... caudal or venous pole to the cranial or arterial pole.2 The addition of cells to both poles will  cause the tube to elongate. The primary myocardial cells that make up the heart tube at this  stage will subsequently start to proliferate and differentiate at localized regions to give rise  to the car ...
Download(302)
Download(302)

... • Etiology: Recent theories suggest that it is due to multiple re-entrant wavelets conducted between the R & L atria. Either way, impulses are formed in a totally unpredictable fashion. The AV node allows some of the impulses to pass through at variable intervals (so rhythm is irregularly irregular) ...
MINISTRY OF HEALTH OF THE REPUBLIC OF UZBEKISTAN
MINISTRY OF HEALTH OF THE REPUBLIC OF UZBEKISTAN

... continuously recidivous forms of diseases. At the first attack of rheumatism, its sharp current with involvement in process of joints of the patient can specify not only day, but also hour of the beginning of a disease. In the last 15-20 years the clinical picture of rheumatism significantly changed ...
Document
Document

... clinical studies Following ESC06, DAT duration in DES clinical studies has been extended more and more. In some cases it’s been extended beyond 3years (much longer than the suggested DAT duration in product IFUs) Latest available DES ...
HEART IN NORMAL MAN output of the heart per unit of time. This
HEART IN NORMAL MAN output of the heart per unit of time. This

... There is a general agreement of opinion that digitalis increases the output of the heart per unit of time. This opinion is based in large part upon pharmacological experiments upon animals. Although in some of these experiments, as Cohn (1915) has pointed out, the dose was greater than that administ ...
Improvement of left ventricular contractile function by
Improvement of left ventricular contractile function by

... function in patients with coronary artery disease, we studied 25 patients, 52 ± 2 years old (mean + SE), who completed a 12 month program of endurance exercise training and 14 additional patients with comparable maximal exercise capacities and ejection fractions who did not exercise. The training pr ...
Intramyocardial Analysis of Regional Systolic and Diastolic Function
Intramyocardial Analysis of Regional Systolic and Diastolic Function

... Background: Preliminary experimental data have shown a nonuniform distribution of myocardial velocities (MVs) across the myocardial wall in normal conditions. However, after ischemic damage to the myocardium, a different pattern of reduction in the myocardial layers has been reported. The aim of thi ...
Thermodynamic analysis questions claims of improved cardiac
Thermodynamic analysis questions claims of improved cardiac

... There is sufficient creatine phosphate in the myocytes to provide ATP via the Lohmann reaction to power the ionic pumps and cross-bridges for only a few contractions. Thereafter, if performance is to continue, ATP must be supplied by the mitochondria, via oxidative phosphorylation of metabolic subst ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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