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AHA Scientific Statement
AHA Scientific Statement

... Nearly 80% of deaths in ACHD patients are associated with heart failure, sudden death, arrhythmias, and vascular complications.1 Hospital admissions occurred in 50% of ACHD patients over 5 years of follow-up in the CONCOR database12; 61% of admissions were for cardiovascular causes. In the United St ...
Warning Symptoms and Family History in Children and Young
Warning Symptoms and Family History in Children and Young

... Background: Children and young adults with undiagnosed cardiovascular disorders at risk for sudden death may have warning symptoms or significant family history that is detectable through screening. The objective of this study was to determine the prevalence of warning symptoms and family history in ...
Mitral Valve
Mitral Valve

... and right ventricular hypertrophy o Combination of decreased left ventricular volume and dysfunction results in diminished cardiac output o Atrial dilation with arrhythmias may occur if the MV obstruction is long standing  Mitral Valve Insufficiency o Presentation dependent on etiology, severity, a ...
Approach to infants and children with Cyanotic congenital heart
Approach to infants and children with Cyanotic congenital heart

... Recognizable cyanosis is due to a reduced Hb content of more than 4-6 gm/dl in capillary blood. It can occur also due to high (> 1.5 gm/dl) content of methemoglobin or very rarely high (>0.5 gm/dl) content of sulfhemoglobin. Recognizable cyanosis depends on hemoglobin value also. With a normal or hi ...
fibrillation
fibrillation

... ventricular response in atrial fibrillation is controversial. The classic electrophysiological mechanism used to explain atrioventricular transmission includes a conduction of atrial excitation through the atrioventricular node to the His-Purkinje system and the ventricular myocardium. In normal sin ...
Pacing Lead Perforation on the Right Side of the Heart
Pacing Lead Perforation on the Right Side of the Heart

Left ventricular diastolic collapse in regional left heart
Left ventricular diastolic collapse in regional left heart

... right ventricular diastolic collapse has been associated with a significant reduction in cardiac output without substantial changes in blood pressure . It has been hypothesized (19) that the left ventricle does not demonstrate this motion because of its greater thickness md its symmetric shape . How ...
NEW Bradycardia Booklet - April 2010.indd
NEW Bradycardia Booklet - April 2010.indd

... hear tbeat due to normal causes and commonly occurs in athletes or during a state of deep relaxation. This is perfectly normal and should not usually cause any difficulties. Sinus bradycardia can also occur in patients with hear t disease or in response to different medications. The severity of and ...
Hypertrophic Cardiomyopathy: A Review
Hypertrophic Cardiomyopathy: A Review

... ventricular hypertrophy). There are a number of treatment modalities for these patients, including pharmacotherapy to control symptoms, implantable cardiac defibrillators to manage malignant arrhythmias, and surgical myectomy and septal ablation to decrease the left ventricular outflow obstruction. ...
Ebstein™s anomaly - Swiss Medical Weekly
Ebstein™s anomaly - Swiss Medical Weekly

... hemodynamic variables, associated malformations and management options are essential. Management of EA patients is complex. Thus it is important that these patients are regularly seen by a cardiologist with expertise in congenital heart disease. Key words: Ebstein’s anomaly; tricuspid valve repair; ...
Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk
Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk

... vena cava, or an elevated systolic gradient through the tricuspid valve (.30 mmHg) in the absence of left ventricular or mitral valve disease [19, 20]. The sPESI was calculated as suggested by JIMÉNEZ et al. [4] and patients were classified into either a ‘‘low-risk’’ (0 points) or ‘‘high-risk’’ (o1 ...
The Apex Cardiogram in Left Ventricular Outflow Tract
The Apex Cardiogram in Left Ventricular Outflow Tract

... The former had a ventriculo-aortic gradient of 18 mm. Hg during exercise. In patients M.S., R.G., R.J., and M.P. the diagnosis had been suggested by clinical examination, since these patients presented many of the features characteristic of this condition.2 These four patients had a resting subvalvu ...
AHA Scientific Statement
AHA Scientific Statement

... Nearly 80% of deaths in ACHD patients are associated with heart failure, sudden death, arrhythmias, and vascular complications.1 Hospital admissions occurred in 50% of ACHD patients over 5 years of follow-up in the CONCOR database12; 61% of admissions were for cardiovascular causes. In the United St ...
Left Ventricular Hypertrophy Is Associated With Increased Infarct
Left Ventricular Hypertrophy Is Associated With Increased Infarct

... Methods and Results-—In this substudy of the DANAMI-3 trial, 764 patients underwent CMR. LVH was defined by CMR and considered present if LV mass exceeded 77 (men) and 67 g/m2 (women). One hundred seventy-eight patients (24%) had LVH. LVH was associated with a larger final infarct size (15% [interquar ...
Alterations in Left Ventricular Structure and Function in Young
Alterations in Left Ventricular Structure and Function in Young

... pregnant; and 8) were taking any vasoactive medications. All subjects signed an informed consent, which was approved by the Institutional Review Board at Washington University School of Medicine. Echocardiography. All subjects underwent a complete two-dimensional and Doppler echocardiographic examin ...
Supraventricular Tachycardia - UCSF Department of Anesthesia and
Supraventricular Tachycardia - UCSF Department of Anesthesia and

... procainamide, ibutilide, propafenone, or flecainide can be given intravenously if the patient’s blood pressure is stable.15 However, sequential trials with different antiarrhythmic agents should be undertaken only after careful consideration of their possible negative hypotensive, bradycardic, and p ...
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives

... kinase and catalase. By inhibiting endothelial nitric oxide synthase activity through AMP kinase [25] and catalase [26], peroxynitrite favours the generation of superoxide ions, thus inducing a vicious cycle leading to increasing local oxidative stress with deleterious consequences. In OSA, a reduct ...
The index of suspicion of RV infarction should be particularly high in
The index of suspicion of RV infarction should be particularly high in

... already described (Figure 2) clear demarcation between the levels is not absolute, and the practicalities of obtaining training in echocardiography provide challenges to the intensivist and their supervisor. Where echocardiography fellowships of appropriate focus and duration are not available, WINF ...
Understanding your child`s heart Pulmonary atresia with intact
Understanding your child`s heart Pulmonary atresia with intact

... septum are usually limited to some extent in their physical activities, but specific restrictions on exercise are usually not necessary. It is usually best to allow children with this condition to join in with their friends’ activities, including some sport at school, and for them to judge for thems ...
Dobutamine stress echo-induced apical ballooning (Takotsubo
Dobutamine stress echo-induced apical ballooning (Takotsubo

... Aims We report a case of dobutamine stress echocardiography (DSE) resulting in transient apical ballooning syndrome to highlight this rare condition as a potential complication of DSE. Background Takotsubo cardiomyopathy, or transient apical ballooning syndrome, is a recently described form of left ...
Slide Set  - Professional Heart Daily
Slide Set - Professional Heart Daily

... Level of Evidence B Data derived from a single grade A study, or one or more case-control studies, or studies using a reference standard applied by an unmasked evaluator Level of Evidence C Consensus opinion of experts ©2010 American Heart Association, Inc. All rights reserved. ...
Right Coronary Artery
Right Coronary Artery

Hybrid management of a large atrial septal defect and a patent
Hybrid management of a large atrial septal defect and a patent

... seconds in order to avoid compression of the posterior LA wall and make room for full deployment of the left atrial disk [Figure 3]. The waist of the device was exposed and the whole system was brought back toward the septum as a unit. The left disk approached the interatrial septum at a perfect ang ...
Understanding your child`s heart Pulmonary atresia with a
Understanding your child`s heart Pulmonary atresia with a

... not know how long children with this condition will live for. Even many years after apparently successful surgery new problems may arise, which require treatment. One of the most common late problems is the development of abnormal heart rhythms. These can usually be treated, but can be serious and i ...
Obtaining a High Quality ECG and Basic ECG
Obtaining a High Quality ECG and Basic ECG

... “rabbit ears” in V1. This is a frequent normal variant. ...
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Cardiac contractility modulation



Cardiac contractility modulation (CCM) is a treatment for patients with moderate to severe left ventricular systolic heart failure (NYHA class II–IV). The short- and long-term use of this therapy enhances both the strength of ventricular contraction and the heart’s pumping capacity. The CCM mechanism is based on stimulation of the cardiac muscle by non-excitatory electrical signals (NES). CCM treatment is delivered by a pacemaker-like device that applies the NES, adjusted to and synchronized with the electrical action in the cardiac cycle.In CCM therapy, electrical stimulation is applied to the cardiac muscle during the absolute refractory period. In this phase of the cardiac cycle, electrical signals cannot trigger new cardiac muscle contractions, hence this type of stimulation is known as a non-excitatory stimulation. However, the electrical CCM signals increase the influx of calcium ions into the cardiac muscle cells (cardiomyocytes). In contrast to other electrical stimulation treatments for heart failure, such as pacemaker therapy or implantable cardioverter defibrillators (ICD), CCM does not affect the cardiac rhythm directly. Rather, the aim is to enhance the heart’s natural contraction (the native cardiac contractility) sustainably over long periods of time. Furthermore, unlike most interventions that increase cardiac contractility, CCM is not associated with an unfavorable increase in oxygen demand by the heart (measured in terms of Myocardial Oxygen Consumption or MVO2). This may be explained by the beneficial effect CCM has in improving cardiac efficiency. A meta-analysis in 2014 and an overview of device-based treatment options in heart failure in 2013 concluded that CCM treatment is safe, that it is generally beneficial to patients and that CCM treatment increases the exercise tolerance (ET) and quality of life (QoL) of patients. Furthermore, preliminary long-term survival data shows that CCM is associated with lower long-term mortality in heart failure patients when compared with expected rates among similar patients not treated with CCM.
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