Hypothesis review: are clathrin-mediated endocytosis and clathrin
... clathrin-interacting genes in psychotic disorders Genetic studies show that psychosis candidate genes either encode proteins of the clathrin interactome directly, or proteins that are closely functionally linked to clathrin-dependent processes (see Table 1). Particularly strong evidence implicates t ...
... clathrin-interacting genes in psychotic disorders Genetic studies show that psychosis candidate genes either encode proteins of the clathrin interactome directly, or proteins that are closely functionally linked to clathrin-dependent processes (see Table 1). Particularly strong evidence implicates t ...
Lipid-Protein Bio-Nanotubes with Open or Closed Ends
... closed ends with lipid caps. Because the main governing concepts for this self assembly are general(13, 14) we expect synthetic analogs to follow similar assembly pathways, so that synthetic versions mimicking the LPNs (e.g. replacing microtubules with rigid polyelectrolytes) may have applications i ...
... closed ends with lipid caps. Because the main governing concepts for this self assembly are general(13, 14) we expect synthetic analogs to follow similar assembly pathways, so that synthetic versions mimicking the LPNs (e.g. replacing microtubules with rigid polyelectrolytes) may have applications i ...
Delivery of a Secreted Soluble Protein to the Vacuole via a
... not to have plant vacuolar targeting information. When yeast invertase is equipped with a plant signal peptide, catalytically active protein is secreted in the apoplast (von Schaewen et al., 1990; Dickinson et al., 1991). We chose the transmembrane domain of yeast calnexin because we assumed that th ...
... not to have plant vacuolar targeting information. When yeast invertase is equipped with a plant signal peptide, catalytically active protein is secreted in the apoplast (von Schaewen et al., 1990; Dickinson et al., 1991). We chose the transmembrane domain of yeast calnexin because we assumed that th ...
isolation and characterization of membranes from the cells of maize
... cytoplasmic vesicles (Northcote, 1971, 1974). Some of the components of the system are joined by structural connexions and they all have a functional continuity in the cytoplasm of eukaryotic cells (Morr6 & Ovtracht, 1977). It is now generally believed that the endomembrane system is present in a dy ...
... cytoplasmic vesicles (Northcote, 1971, 1974). Some of the components of the system are joined by structural connexions and they all have a functional continuity in the cytoplasm of eukaryotic cells (Morr6 & Ovtracht, 1977). It is now generally believed that the endomembrane system is present in a dy ...
Functional Domains within Fusion Proteins: Prospectives for
... specific interactions mediated by N-terminal fusion peptides are required to form higher order oligomers necessary for membrane fusion (Kliger et al., 1997). Attempts to define the oligomeric state of the HIV-1 envelope glycoprotein have yielded conflicting results. Several reports indicated that th ...
... specific interactions mediated by N-terminal fusion peptides are required to form higher order oligomers necessary for membrane fusion (Kliger et al., 1997). Attempts to define the oligomeric state of the HIV-1 envelope glycoprotein have yielded conflicting results. Several reports indicated that th ...
Voltage-Gated Ion Channels and the Propagation of Action
... Action potentials move at speeds up to 100 meters per second. In humans, for instance, axons may be more than a meter long, yet it takes only a few milliseconds for an action potential to move along their length. Arrival of an action potential at an axon terminal leads to opening of voltagesensitive ...
... Action potentials move at speeds up to 100 meters per second. In humans, for instance, axons may be more than a meter long, yet it takes only a few milliseconds for an action potential to move along their length. Arrival of an action potential at an axon terminal leads to opening of voltagesensitive ...
Leukaemia Section t(4;17)(q12;q21) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... FIP homology domain and 403 carboxyl-terminal amino acids of RARA, including the DNA and ligand binding domains, with replacement of FIP1L1 amino acid 429 (Valine) and RARA amino acid 60 (Threonine) into an Alanine. Oncogenesis All known chimeric RARA fusion proteins provide additional homodimerizat ...
... FIP homology domain and 403 carboxyl-terminal amino acids of RARA, including the DNA and ligand binding domains, with replacement of FIP1L1 amino acid 429 (Valine) and RARA amino acid 60 (Threonine) into an Alanine. Oncogenesis All known chimeric RARA fusion proteins provide additional homodimerizat ...
ref. #27 of the TIBS article
... the microsomal in vitro system (Mothes et al., 1997), we also wanted to test the relation between MGD and n for a protein that does not use this pathway. Synaptobrevin is known to insert a hydrophobic C-terminal segment into the microsomal membrane by an as yet poorly understood mechanism that does ...
... the microsomal in vitro system (Mothes et al., 1997), we also wanted to test the relation between MGD and n for a protein that does not use this pathway. Synaptobrevin is known to insert a hydrophobic C-terminal segment into the microsomal membrane by an as yet poorly understood mechanism that does ...
PPT - Portland State University
... In a normal, healthy retinal rod outer segment 40% to 50% of the phospholipid acyl chains consist of docosahexaenoic acid (DHA, 22:6n-3). Diets that are deficient in n-3, or ω-3, fatty acids lead to the replacement of 22:6n-3 with 22:5n6. Dietary n-3 deficiency leads to a spectrum of developmental d ...
... In a normal, healthy retinal rod outer segment 40% to 50% of the phospholipid acyl chains consist of docosahexaenoic acid (DHA, 22:6n-3). Diets that are deficient in n-3, or ω-3, fatty acids lead to the replacement of 22:6n-3 with 22:5n6. Dietary n-3 deficiency leads to a spectrum of developmental d ...
ref. #29 of the TIBS article
... site. In contrast, Leu f Trp (but not Leu f Phe) substitutions placed further into the hydrophobic segment (positions 7 and 11) tend to pull the helix out of the membrane, toward the OST active site. We also note that Trp has a similar effect on the MGD as has Arg (and Lys, not shown) insofar as it ...
... site. In contrast, Leu f Trp (but not Leu f Phe) substitutions placed further into the hydrophobic segment (positions 7 and 11) tend to pull the helix out of the membrane, toward the OST active site. We also note that Trp has a similar effect on the MGD as has Arg (and Lys, not shown) insofar as it ...
Autophagy_Marc
... cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular components. During this process, targeted cytoplasmic constituent ...
... cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular components. During this process, targeted cytoplasmic constituent ...
α-Hemolysin pore formation into a supported
... The interaction of cell-free synthesized G-protein coupled receptors with a planar phospholipid bilayer was described qualitatively [4]. Integral membrane proteins were directly inserted into the lipidic bilayer of small unilamellar vesicles [5,6]. These works represent considerable technical advanc ...
... The interaction of cell-free synthesized G-protein coupled receptors with a planar phospholipid bilayer was described qualitatively [4]. Integral membrane proteins were directly inserted into the lipidic bilayer of small unilamellar vesicles [5,6]. These works represent considerable technical advanc ...
Mitofilin complexes: conserved organizers of mitochondrial
... water and shrinking of the mitochondrial matrix compartment. Electron microscopy images showed that, under these conditions, the inner boundary membrane was largely dissociated from the outer membrane, but specific membrane regions remained tightly tethered. These morphologically defined contact sit ...
... water and shrinking of the mitochondrial matrix compartment. Electron microscopy images showed that, under these conditions, the inner boundary membrane was largely dissociated from the outer membrane, but specific membrane regions remained tightly tethered. These morphologically defined contact sit ...
A New Subunit of Cytochrome b6f Complex Undergoes Reversible
... previously identified a nucleus-encoded polypeptide of 19-kDa apparent molecular mass that was absent from the thylakoid membranes of cytb6f mutants (21). To avoid its copurification with some ATP synthase subunits that display a similar apparent molecular mass, we recovered suV (PetO) from the ATP ...
... previously identified a nucleus-encoded polypeptide of 19-kDa apparent molecular mass that was absent from the thylakoid membranes of cytb6f mutants (21). To avoid its copurification with some ATP synthase subunits that display a similar apparent molecular mass, we recovered suV (PetO) from the ATP ...
Topology Prediction of Membrane Proteins
... all organisms. Cells are surrounded by membranes, usually a double layer of lipids, which separates them from the outside world. The membrane is a physical barrier that protects the cell from foreign molecules at the same time as it prevents leakage of internal components and substances. However, a ...
... all organisms. Cells are surrounded by membranes, usually a double layer of lipids, which separates them from the outside world. The membrane is a physical barrier that protects the cell from foreign molecules at the same time as it prevents leakage of internal components and substances. However, a ...
Transport of the precursor to neurospora ATPase
... on free cytoplasmic polysomes and released into the cytosol (3-5). They are then imported into the mitochondrion in a step which is, with most but not all proteins, dependent on an electrical potential across the inner mitochondrial membrane (6, 7). With the majority of precursor proteins, this tran ...
... on free cytoplasmic polysomes and released into the cytosol (3-5). They are then imported into the mitochondrion in a step which is, with most but not all proteins, dependent on an electrical potential across the inner mitochondrial membrane (6, 7). With the majority of precursor proteins, this tran ...
Building Blocks File
... • The cell membrane is composed of a …………………… bilayer • Cells are surrounded by …………..and have fluid inside them • The concentration of substances inside and outside the cell is usually the same/different (delete one) • To enter a cell, a substance may have to move AGAINST its ………………………………..gradient ...
... • The cell membrane is composed of a …………………… bilayer • Cells are surrounded by …………..and have fluid inside them • The concentration of substances inside and outside the cell is usually the same/different (delete one) • To enter a cell, a substance may have to move AGAINST its ………………………………..gradient ...
Chemiosmotic systems in bioenergetics
... problems: (i) it carries out the uphill transport of sugar from the medium to the cytoplasm and (ii) it initiates glycolysis by phosphorylating the sugar. The reversibility of chemiosmotic enzyme action allows two chemical processes, exergonic and endergonic, to be coupled to each other provided tha ...
... problems: (i) it carries out the uphill transport of sugar from the medium to the cytoplasm and (ii) it initiates glycolysis by phosphorylating the sugar. The reversibility of chemiosmotic enzyme action allows two chemical processes, exergonic and endergonic, to be coupled to each other provided tha ...
Lipids as hormones and second messengers
... [2 oo] that have been activated by the relevant agonist. Nearly all of the possible products of these cleavage reactions (i.e. phospholipid headgroups, lysophospholipids, DAGs, PA and fatty acids) have been implicated in signal transduction. For example, release of lysophospholipids and fatty acids ...
... [2 oo] that have been activated by the relevant agonist. Nearly all of the possible products of these cleavage reactions (i.e. phospholipid headgroups, lysophospholipids, DAGs, PA and fatty acids) have been implicated in signal transduction. For example, release of lysophospholipids and fatty acids ...
Keshara Senanayake Ms.Reep AP BIOLOGY STUDY GUIDE
... possible with intact cells for example in one of the cell fractionation resulting from centrifugation, biochemical test showed the presence of enzymes involved in cellular respiration (while EM showed large # of organelles called mitochondria) together these data help biologist (cytology + bioch ...
... possible with intact cells for example in one of the cell fractionation resulting from centrifugation, biochemical test showed the presence of enzymes involved in cellular respiration (while EM showed large # of organelles called mitochondria) together these data help biologist (cytology + bioch ...
cell biology and membrane biochemistry
... (phospholipids with one fatty acid attached to C-1of glycerol) i.e. all phospholipids with one tail. The micellar structure is favored when the hydrophilic area of the lipid molecule is greater than its hydrophobic area. However, with glycerophospholipids and sphingolipids with two fatty acyl chains ...
... (phospholipids with one fatty acid attached to C-1of glycerol) i.e. all phospholipids with one tail. The micellar structure is favored when the hydrophilic area of the lipid molecule is greater than its hydrophobic area. However, with glycerophospholipids and sphingolipids with two fatty acyl chains ...
SNARE (protein)
SNARE proteins (an acronym derived from ""SNAP (Soluble NSF Attachment Protein) REceptor"") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.