Assembling the Presynaptic Active Zone: A Characterization of an
... al., 1995), we next examined the temporal and spatial appearance of Piccolo in differentiating neurons by double-label immunofluorescent microscopy. Antibodies against MAP2 were used to mark dendrites at different stages of neuronal differentiation (Goslin and Banker, 1991). In stage 2 neurons, when ...
... al., 1995), we next examined the temporal and spatial appearance of Piccolo in differentiating neurons by double-label immunofluorescent microscopy. Antibodies against MAP2 were used to mark dendrites at different stages of neuronal differentiation (Goslin and Banker, 1991). In stage 2 neurons, when ...
Transport Between the Endoplasmic Reticulum and Golgi Apparatus
... those that function in vesicle direction, such as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) in the process. The membrane becomes deformed during the polymerization of the coat, resulting in the formation of a nascent vesicle. Small proteins with GTPase activity ...
... those that function in vesicle direction, such as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) in the process. The membrane becomes deformed during the polymerization of the coat, resulting in the formation of a nascent vesicle. Small proteins with GTPase activity ...
ref. #28 of the TIBS article
... lumenal end of the TMH and the glycosylation acceptor Asn needed to get half-maximal glycosylation. Calibration: the phage M13 coat protein We have shown that the N-terminal TMH from the H-subunit of the photosynthetic reaction center can be used as a reference helix against which the membrane posit ...
... lumenal end of the TMH and the glycosylation acceptor Asn needed to get half-maximal glycosylation. Calibration: the phage M13 coat protein We have shown that the N-terminal TMH from the H-subunit of the photosynthetic reaction center can be used as a reference helix against which the membrane posit ...
Structure and function of basement membranes
... Our current research program originated from the hypothesis that basement membranes are spatially and temporally unique. This may seem obvious today, but 10 years ago it was still jusl a hypothesis. At that time, the structural aspects of extracellular matrices and basement membranes were emphasized ...
... Our current research program originated from the hypothesis that basement membranes are spatially and temporally unique. This may seem obvious today, but 10 years ago it was still jusl a hypothesis. At that time, the structural aspects of extracellular matrices and basement membranes were emphasized ...
Two-step and one-step secretion mechanisms in Gram
... The T2SS (type II secretion system) spans both the membranes but require the Sec or Tat pathway for transporting substrates across the inner membrane [4]. The T3SS (type III secretion system) or injectisome forms large supramolecular structures spanning both membranes and is structurally and evoluti ...
... The T2SS (type II secretion system) spans both the membranes but require the Sec or Tat pathway for transporting substrates across the inner membrane [4]. The T3SS (type III secretion system) or injectisome forms large supramolecular structures spanning both membranes and is structurally and evoluti ...
The Role of Neurotrophins in Neurotransmitter Release
... actions at presynaptic terminals. Here, using BDNF as a prototypical example, the authors provide an update of recent evidence demonstrating that NTs enhance quantal neurotransmitter release at synapses through presynaptic mechanisms. The authors further propose that a potential target for NT action ...
... actions at presynaptic terminals. Here, using BDNF as a prototypical example, the authors provide an update of recent evidence demonstrating that NTs enhance quantal neurotransmitter release at synapses through presynaptic mechanisms. The authors further propose that a potential target for NT action ...
Role of the spindle pole body of yeast in mediating assembly of the
... 1999). Many coiled-coil proteins are also crucially important for the organization of various aspects of the cytoskeleton. For example, motor proteins, which exhibit large stalks formed by coiled-coil domains, provide motile functions essential for the organization of the microtubules in concert wit ...
... 1999). Many coiled-coil proteins are also crucially important for the organization of various aspects of the cytoskeleton. For example, motor proteins, which exhibit large stalks formed by coiled-coil domains, provide motile functions essential for the organization of the microtubules in concert wit ...
on the effect of motor nerve degeneration on the fine
... (for a summary of such experiments, see Csillik, 1967). For the electron-histochemical localization of end-plate esterases, various substrates and experimental parameters were employed in various muscles, so that a clear-cut comparison of these studies is extremely difficult. In 1959, Lehrer & Ornst ...
... (for a summary of such experiments, see Csillik, 1967). For the electron-histochemical localization of end-plate esterases, various substrates and experimental parameters were employed in various muscles, so that a clear-cut comparison of these studies is extremely difficult. In 1959, Lehrer & Ornst ...
Chapter 10
... pathways are used in yeast. The first step in the cotranslational pathway is the association of the ribosome-mRNA complex with the ER. Ribosomes are targeted for binding to the ER membrane by the amino-acid sequence of the polypeptide chain being synthesized, rather than by intrinsic properties of t ...
... pathways are used in yeast. The first step in the cotranslational pathway is the association of the ribosome-mRNA complex with the ER. Ribosomes are targeted for binding to the ER membrane by the amino-acid sequence of the polypeptide chain being synthesized, rather than by intrinsic properties of t ...
Exocytosis and cell polarity in plants exocyst and recycling domains
... c. 70 nm (Ketelaar et al., 2008). Chara has two classes of exocytotic vesicle – 200 nm light and 180 nm dark (Limbach et al., 2008). Even budding yeast has two types of 100 nm secretory vesicle – those containing the Bgl2 glucantransferase and plasma membrane proteins and those carrying periplasmic ...
... c. 70 nm (Ketelaar et al., 2008). Chara has two classes of exocytotic vesicle – 200 nm light and 180 nm dark (Limbach et al., 2008). Even budding yeast has two types of 100 nm secretory vesicle – those containing the Bgl2 glucantransferase and plasma membrane proteins and those carrying periplasmic ...
Studies of focal adhesion assembly
... The ability of integrins to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. In a high-resolution structure, we showed that the integrin β tail forms an extended β-strand that interacts with β-strands C and D of the 21st imm ...
... The ability of integrins to transmit biochemical signals and mechanical force across cell membranes depends on interactions with the actin cytoskeleton. In a high-resolution structure, we showed that the integrin β tail forms an extended β-strand that interacts with β-strands C and D of the 21st imm ...
Deletion of the Chloroplast-Localized Thylakoid Formation1 Gene
... membrane and are perhaps transported to thylakoids via a membrane vesicle transit system (Zak et al., 2001). Such vesicle-transfer mechanisms are utilized in many aspects of membrane and protein transfer in biological systems, enabling cargo to move both within and to the outside of the cell (Bock e ...
... membrane and are perhaps transported to thylakoids via a membrane vesicle transit system (Zak et al., 2001). Such vesicle-transfer mechanisms are utilized in many aspects of membrane and protein transfer in biological systems, enabling cargo to move both within and to the outside of the cell (Bock e ...
The resting membrane potential - Lectures For UG-5
... Graded potentials are produced in response to stimulus (here neurotransmitter released from other neurons) • Axons are specialized to deliver information by generation of action potentials Axon hillock is the portion of the axon where action potentials are triggered or initiated by the graded potent ...
... Graded potentials are produced in response to stimulus (here neurotransmitter released from other neurons) • Axons are specialized to deliver information by generation of action potentials Axon hillock is the portion of the axon where action potentials are triggered or initiated by the graded potent ...
Membrane lipids and gill Na+/K+-ATPase in eel
... Furthermore, many membrane-associated proteins are influenced by the chemical and/or physical properties of the membrane (Deuticke and Haest, 1987; Vemuri and Philipson, 1989). Na+/K+-ATPase is among the integral membrane proteins that appear to be particularly sensitive to variation in membrane phy ...
... Furthermore, many membrane-associated proteins are influenced by the chemical and/or physical properties of the membrane (Deuticke and Haest, 1987; Vemuri and Philipson, 1989). Na+/K+-ATPase is among the integral membrane proteins that appear to be particularly sensitive to variation in membrane phy ...
research article Numerical study of the electroporation pulse shape
... As can be seen in Figure 2A for the bipolar pulses, the pulse switch from positive to negative takes place very fast. During the switch time, the pore creation rate and, therefore, membrane conductivity decrease. But due to very short time of switching related to pulse duration, these changes are ne ...
... As can be seen in Figure 2A for the bipolar pulses, the pulse switch from positive to negative takes place very fast. During the switch time, the pore creation rate and, therefore, membrane conductivity decrease. But due to very short time of switching related to pulse duration, these changes are ne ...
Golgi complex
... The Golgi complex distributes substances to other parts of the cell. membrane bound structure. The Golgi complex transports nutrients and waste by breaking of part of itself in bubbles .which transports the nutrients and waste to other parts of the cell, and out side of the cell with the bubble even ...
... The Golgi complex distributes substances to other parts of the cell. membrane bound structure. The Golgi complex transports nutrients and waste by breaking of part of itself in bubbles .which transports the nutrients and waste to other parts of the cell, and out side of the cell with the bubble even ...
Forespore membrane assembly in yeast
... and development of the FSM How does the FSM extend and encapsulate each daughter nucleus? There are at least two different regions in the FSM: the SPB attachment site and the leading edge. Once the prespore is completed, the FSM is released from the SPB. The mechanism by which the FSM is anchored to ...
... and development of the FSM How does the FSM extend and encapsulate each daughter nucleus? There are at least two different regions in the FSM: the SPB attachment site and the leading edge. Once the prespore is completed, the FSM is released from the SPB. The mechanism by which the FSM is anchored to ...
Document
... • Peripheral proteins are associated with just one face of the bilayer and are held by noncovalent interactions with the hydrophobic lipid tails or the hydrophilic head groups. • Integral proteins extend completely through the membrane and are anchored by hydrophobic regions that extend through the ...
... • Peripheral proteins are associated with just one face of the bilayer and are held by noncovalent interactions with the hydrophobic lipid tails or the hydrophilic head groups. • Integral proteins extend completely through the membrane and are anchored by hydrophobic regions that extend through the ...
Proteomics of Plasma Membranes from Poplar Trees Reveals
... Proteomics of Plasma Membranes from Poplar Trees Reveals Tissue Distribution of Transporters, Receptors, and Proteins in Cell ...
... Proteomics of Plasma Membranes from Poplar Trees Reveals Tissue Distribution of Transporters, Receptors, and Proteins in Cell ...
unravelling the therapeutic potential of transmembrane peptides
... involved in native interactions. Therefore, other strategies have been proposed to create a plethora of non‐natural TM peptides, which can differently modulate TM protein activity. Directed evolution can select TM‐helix binders by creating libraries of virus proteins variants diff ...
... involved in native interactions. Therefore, other strategies have been proposed to create a plethora of non‐natural TM peptides, which can differently modulate TM protein activity. Directed evolution can select TM‐helix binders by creating libraries of virus proteins variants diff ...
ppt - Chair of Computational Biology
... for this unusual secondary structure. Two features of the PPII helix make it a useful recognition motif: First, in this structure both the side chains and the backbone carbonyls point out from the helical axis into solution at regular intervals (Fig. 1B). The lack of intramolecular hydrogen bonds in ...
... for this unusual secondary structure. Two features of the PPII helix make it a useful recognition motif: First, in this structure both the side chains and the backbone carbonyls point out from the helical axis into solution at regular intervals (Fig. 1B). The lack of intramolecular hydrogen bonds in ...
REVIEWS
... transiently recruited to specific locations in plasma (and other) membranes, where they exert their functions (such as lipid modification or activation of small GTPases) or become effectively co-localized with partners in a signal-transduction pathway2,3. Some cellular compartments are ‘marked’ by t ...
... transiently recruited to specific locations in plasma (and other) membranes, where they exert their functions (such as lipid modification or activation of small GTPases) or become effectively co-localized with partners in a signal-transduction pathway2,3. Some cellular compartments are ‘marked’ by t ...
Proteins: Fundamental Chemical Properties
... quantitatively and qualitatively, which accounts for the origin of their name derived from the Greek word prôtos, meaning ‘first rank of importance’. Quantitatively, proteins are the most abundant class of biomolecules since they represent over 50% of the dry weight of cells, far more than other imp ...
... quantitatively and qualitatively, which accounts for the origin of their name derived from the Greek word prôtos, meaning ‘first rank of importance’. Quantitatively, proteins are the most abundant class of biomolecules since they represent over 50% of the dry weight of cells, far more than other imp ...
SNARE (protein)
SNARE proteins (an acronym derived from ""SNAP (Soluble NSF Attachment Protein) REceptor"") are a large protein superfamily consisting of more than 60 members in yeast and mammalian cells. The primary role of SNARE proteins is to mediate vesicle fusion, that is, the fusion of vesicles with their target membrane bound compartments (such as a lysosome). The best studied SNAREs are those that mediate docking of synaptic vesicles with the presynaptic membrane in neurons. These SNAREs are the targets of the bacterial neurotoxins responsible for botulism and tetanus.