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Functional Synaptic Contacts by Intranuclear
Functional Synaptic Contacts by Intranuclear

... branches, and we could not follow them over long distances (⬍50 3B). These data suggest that the increase in the short depolarizing ␮m). However, the delicate nature of these collaterals made them potentials is, indeed, a result of excitation of neurons that synapparticularly difficult to find (and, ...
Cortical remodelling induced by activity of ventral tegmental
Cortical remodelling induced by activity of ventral tegmental

... Representations of sensory stimuli in the cerebral cortex can undergo progressive remodelling according to the behavioural importance of the stimuli1,2. The cortex receives widespread projections from dopamine neurons in the ventral tegmental area (VTA)3±5, which are activated by new stimuli or unpr ...
Theroleofdendritesinauditory coincidence detection
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... Coincidence-detector neurons in the auditory brainstem of mammals and birds use interaural time differences to localize sounds1,2. Each neuron receives many narrow-band inputs from both ears and compares the time of arrival of the inputs with an accuracy of 10–100 ms (refs 3–6). Neurons that receive ...
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Electrophysiological Identification of Tonic and Phasic Neurons in
Electrophysiological Identification of Tonic and Phasic Neurons in

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Chapter 3
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... extract mechanisms of disease, and to develop and screen targeted therapies for acute and chronic diseases. Interrogation of these systems performed at the single- and multi-cell level enables relevant extracellular cell-scale change and control. Micro- and nanofluidic technologies, developed over t ...
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Human olfaction: from genomic variation to phenotypic diversity

... an accurate ‘odor image’ in the brain. Widespread phenotypic diversity in human olfaction is, in part, attributable to prevalent genetic variation in OR genes, owing to copy number variation, deletion alleles and deleterious single nucleotide polymorphisms. The development of new genomic tools, incl ...
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Unit 08 Notes

... move the actin filaments closer together. 2. ___ Calcium ions attach to the troponin causing the tropomyosin to move and expose the myosin cross bridge binding sites 3. ___ Acetylcholine is released from the axon of the motor neuron into the synaptic cleft of the sarcolemma triggering a muscle impul ...
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The Brain and Behaviour
The Brain and Behaviour

... The temporal lobe is located in the lower, central, area of the brain, above and around the top of each ear. The temporal lobe in each hemisphere is primarily involved with auditory perception, but also plays an important role in memory, in aspects of visual perception such as our ability to recogni ...
Computational themes of peripheral processing
Computational themes of peripheral processing

... The way adaptation changes the onset response curve of the sensory periphery determines which and how much information about a given stimulus is available at more central stages. In most cases, these changes can be described as either subtractive or divisive (Fig. 2c; Hildebrandt et al. 2011). While ...
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Stimulus (physiology)



In physiology, a stimulus (plural stimuli) is a detectable change in the internal or external environment. The ability of an organism or organ to respond to external stimuli is called sensitivity. When a stimulus is applied to a sensory receptor, it normally elicits or influences a reflex via stimulus transduction. These sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanorceptors. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.
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