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Similarities between Severe Tinnitus and Chronic Pain
Similarities between Severe Tinnitus and Chronic Pain

... Figure 1 Hypotheses of how changes in the wide dynamic range (WDR) neurons in the spinal horn can lead to chronic pain . A, Normal innervation ofWDR neurons. Large circles : sensory transmission, small open circles with + signs: facilitatory interneurons, filled circles and - signs: inhibitory inter ...
1 - Libreria Universo
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... L-, M- and S-cone types normalized with respect to the white background (i.e. cone contrast). Stimulus chromaticity is given by the vector direction and contrast by vector length within the cone contrast space. Three cardinal stimuli (RG, BY and Ach) were determined within this space to isolate each ...
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No Slide Title

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Get PDF - IOS Press
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PDF - Department of Molecular Biology

... Endophilin mutations altering membrane tubulation activity produce corresponding defects in SV endocytosis in vivo, consistent with the membrane-bending model. These results also suggest that decreased and increased membrane-bending activity are both detrimental to SV endocytosis. Specificity of the ...
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Presynaptic Inhibition of Exteroceptive Afferents by Proprioceptive

... modified within the terminals of the sensory neurons themselves,by meansof presynaptic inhibition. Presynaptic inhibition alters the ability of an action potential to causetransmitter releaseand, in both vertebrates and invertebrates, may result from the activation of other sensory afferents in the ...
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Neuro Objectives 22 - U

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FREE Sample Here
FREE Sample Here

... A) Neural communication occurs every time an individual moves or has a thought. B) The synapse is the site where the pre-synaptic neuron communicates with the post-synaptic neuron. Incorrect. The neuron before the synapse is called pre-synaptic and the neuron after the synapse is called post-synapti ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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