Features of B lymphocyte development
... - Rearrangement & expression of Ig gene in a precise order - Selection & proliferation of pre-B cells via pre-Ag receptor 2. Selection of the mature B cell repertoire - Self Ag => Affect the strength of the BCR signal - Immature B cells => self Ag/high avidity => Receptor editing => Additional L cha ...
... - Rearrangement & expression of Ig gene in a precise order - Selection & proliferation of pre-B cells via pre-Ag receptor 2. Selection of the mature B cell repertoire - Self Ag => Affect the strength of the BCR signal - Immature B cells => self Ag/high avidity => Receptor editing => Additional L cha ...
course map example
... Discussions “Photosynthesis and Respiration Lesson Plan, Article Summary, Lab Enzymes, Photosynthesis and Respiration” ...
... Discussions “Photosynthesis and Respiration Lesson Plan, Article Summary, Lab Enzymes, Photosynthesis and Respiration” ...
Representing Biological Processes in Modular Action Language ALM
... original one. The interphase and the mitotic phase are conventionally described as sequences of sub-phases. Depending on the level of detail of the description, these sub-phases may be simple events or sequences of other sub-phases. For example, the more detailed mitotic phase is described as a sequ ...
... original one. The interphase and the mitotic phase are conventionally described as sequences of sub-phases. Depending on the level of detail of the description, these sub-phases may be simple events or sequences of other sub-phases. For example, the more detailed mitotic phase is described as a sequ ...
Reduction in DNA Binding Activity of the Transcription Factor Pax
... cell lineage, Pax-5 is expressed in progenitor, precursor, and mature B cells, but expression is down-regulated in plasma cells (9, 10). Pax-5 has been deleted in mice through targeted gene disruption and its absence in B cells from homozygous mutant mice results in a complete block in early B cell ...
... cell lineage, Pax-5 is expressed in progenitor, precursor, and mature B cells, but expression is down-regulated in plasma cells (9, 10). Pax-5 has been deleted in mice through targeted gene disruption and its absence in B cells from homozygous mutant mice results in a complete block in early B cell ...
CRISPR Applications: Mouse - Innovative Genomics Institute
... CRISPR editing in mice, remaining challenges Germline mouse models Simple design, easy manipulation, rapid and multiplex editing More reliable sgRNA design (particularly for desirable HDR editing) Complex genome editing still requires ESCs Precise genotyping in mouse embryos Somatic mouse models Ra ...
... CRISPR editing in mice, remaining challenges Germline mouse models Simple design, easy manipulation, rapid and multiplex editing More reliable sgRNA design (particularly for desirable HDR editing) Complex genome editing still requires ESCs Precise genotyping in mouse embryos Somatic mouse models Ra ...
Keratin Alterations during Embryonic Epidermal Differentiation: A
... Differentiation of the epidermis during embryonic rabbit development was found to be accompanied by dramatic changes in keratin proteins . Immunofluorescent labeling with keratin antiserum revealed that the undifferentiated epithelium of 12-d embryos was already committed to making keratin proteins ...
... Differentiation of the epidermis during embryonic rabbit development was found to be accompanied by dramatic changes in keratin proteins . Immunofluorescent labeling with keratin antiserum revealed that the undifferentiated epithelium of 12-d embryos was already committed to making keratin proteins ...
-Chain Gene Promoter ζ Antigen Receptor Elf
... factors at 252 (zEBS1) and 2135 (zEBS2). Mutation of these two sites results in a marked reduction of transcription from this promoter. Using electrophoretic mobility shift analysis, Elf-1 was demonstrated to be the Ets family member that binds to these sites. One site, zEBS1, matches the optimal El ...
... factors at 252 (zEBS1) and 2135 (zEBS2). Mutation of these two sites results in a marked reduction of transcription from this promoter. Using electrophoretic mobility shift analysis, Elf-1 was demonstrated to be the Ets family member that binds to these sites. One site, zEBS1, matches the optimal El ...
Gene Section PSCA (Prostate stem cell antigen) Atlas of Genetics and Cytogenetics
... PSCA homologues give some insight into possible functions. It has been previously shown that proteins in the Thy-1 family have been reported to function in T cell activation (Presky et al., 1990) and proliferation, stem cell survival, and cytokine and growth factor response (Rege et al., 2006), whil ...
... PSCA homologues give some insight into possible functions. It has been previously shown that proteins in the Thy-1 family have been reported to function in T cell activation (Presky et al., 1990) and proliferation, stem cell survival, and cytokine and growth factor response (Rege et al., 2006), whil ...
Role of E-cadherin and other cell adhesion molecules in survival
... in their molecular profile and growth factors requirements.60,61 Intriguingly, a current report described a mouse EpiSC-like cell type, termed FAB-SCs (i.e., fibroblast growth factor, Activin and BIO-derived stem cells),62 that share expression markers with EpiSCs but are unable to differentiate. Re ...
... in their molecular profile and growth factors requirements.60,61 Intriguingly, a current report described a mouse EpiSC-like cell type, termed FAB-SCs (i.e., fibroblast growth factor, Activin and BIO-derived stem cells),62 that share expression markers with EpiSCs but are unable to differentiate. Re ...
Genetic and Epigenetic Regulation in Age
... The most common DNA methylation form is the 5¶ methylcytosine. It occurs predominantly in the symmetric CG context. Approximately 70% to 80% of CG dinucleotides of the genome are normally methylated and are called CpG. In vertebrates, CpG dinucleotides tend to cluster together and form CpG islands. ...
... The most common DNA methylation form is the 5¶ methylcytosine. It occurs predominantly in the symmetric CG context. Approximately 70% to 80% of CG dinucleotides of the genome are normally methylated and are called CpG. In vertebrates, CpG dinucleotides tend to cluster together and form CpG islands. ...
WJG-23-1787
... KLHL31, FOXC1, UGT1A7 and MAGEA4 was most upregulated and of SLC22A14, HBG2, PCOLCE, A2M and KIAA1522 was most significantly downregulated in L02/HBx cells. These differentially expressed genes were diversely involved in DNA replication, cell cycle, cell proliferation, cell adhesion, cell-cell signa ...
... KLHL31, FOXC1, UGT1A7 and MAGEA4 was most upregulated and of SLC22A14, HBG2, PCOLCE, A2M and KIAA1522 was most significantly downregulated in L02/HBx cells. These differentially expressed genes were diversely involved in DNA replication, cell cycle, cell proliferation, cell adhesion, cell-cell signa ...
Fulltext PDF - Indian Academy of Sciences
... Heritable information in plants consists of genomic information in DNA sequence and epigenetic information superimposed on DNA sequence. The latter is in the form of cytosine methylation at CG, CHG and CHH elements (where H = A, T or C) and a variety of histone modifications in nucleosomes. The epial ...
... Heritable information in plants consists of genomic information in DNA sequence and epigenetic information superimposed on DNA sequence. The latter is in the form of cytosine methylation at CG, CHG and CHH elements (where H = A, T or C) and a variety of histone modifications in nucleosomes. The epial ...
Oral squamous cell carcinoma (OSCC) – molecular, viral and
... commonly found in human genetic material and perform the functions necessary to maintain the integrity of tissues and organs. Among other things, they control cell division and differentiation processes and also regulate their suicidal death (apoptosis). Mutated proto-oncogenes are over-expressed, a ...
... commonly found in human genetic material and perform the functions necessary to maintain the integrity of tissues and organs. Among other things, they control cell division and differentiation processes and also regulate their suicidal death (apoptosis). Mutated proto-oncogenes are over-expressed, a ...
Full Text
... We are interested in molecular mechanisms underlying notochord formation in chordate embryos (Satoh and Jeffery, 1995; Takahashi et al., 1999; Hotta et al., 2000; Suzuki and Satoh, 2000). The notochord of the ascidian tadpole larva is composed of 40 cells aligned longitudinally in a single row along ...
... We are interested in molecular mechanisms underlying notochord formation in chordate embryos (Satoh and Jeffery, 1995; Takahashi et al., 1999; Hotta et al., 2000; Suzuki and Satoh, 2000). The notochord of the ascidian tadpole larva is composed of 40 cells aligned longitudinally in a single row along ...
c-myc Driven by the Proto-Oncogene B Lymphocyte Commitment
... DNA (E-boxes) to regulate their target genes (16); of all of the Myc proteins, c-Myc is probably the best studied. In humans and mice, c-Myc deregulation is well established as a primary cause of some cancers. It is estimated that the c-myc proto-oncogene is activated in 20% of all human cancers (17 ...
... DNA (E-boxes) to regulate their target genes (16); of all of the Myc proteins, c-Myc is probably the best studied. In humans and mice, c-Myc deregulation is well established as a primary cause of some cancers. It is estimated that the c-myc proto-oncogene is activated in 20% of all human cancers (17 ...
Analysis of the histone H3 gene family in Arabidopsis and
... Plant Molecular Biology and Biotechnology laboratory, Australian Research Council Centre of Excellence for Integrative Legume Research, Institute of Land and Food Resources, The University of Melbourne, Parkville, Victoria 3010, Australia ...
... Plant Molecular Biology and Biotechnology laboratory, Australian Research Council Centre of Excellence for Integrative Legume Research, Institute of Land and Food Resources, The University of Melbourne, Parkville, Victoria 3010, Australia ...
SPECIAL ARTICLE The Continuum Model: An
... delayed entry into the S phase in the subsequent cycle [8, 91. The delay also occurred when cells were prevented from adhering to the substrate [9] or were exposed to caffeine [lo]. When the proliferating cells were deprived of serum [8] or exposed to caffeine [lo] during Gl phase, they were inhibit ...
... delayed entry into the S phase in the subsequent cycle [8, 91. The delay also occurred when cells were prevented from adhering to the substrate [9] or were exposed to caffeine [lo]. When the proliferating cells were deprived of serum [8] or exposed to caffeine [lo] during Gl phase, they were inhibit ...
University of Groningen The evolution of bacterial cell differentiation
... The dense aggregation of cells on a surface, as seen in bio"ilms, inevitably results in both environmental and cellular heterogeneity. For example, nutrient gradients can trigger cells to differentiate into various phenotypic states. Not only do cells adapt physiologically to the local environmental ...
... The dense aggregation of cells on a surface, as seen in bio"ilms, inevitably results in both environmental and cellular heterogeneity. For example, nutrient gradients can trigger cells to differentiate into various phenotypic states. Not only do cells adapt physiologically to the local environmental ...
Ascidian embryogenesis and the origins of the chordate body plan
... of transgcnic DNA and RNA into de\ eloping embryos. hlosaic incorporation is not ~1prohlcm in this system because of the small number of clca\~ges involved in the formation of adwnccd-stage embryos. ‘liansgenesis has been wed to characterize &rcgulatory I)NA elements that mediate tissue-specific and ...
... of transgcnic DNA and RNA into de\ eloping embryos. hlosaic incorporation is not ~1prohlcm in this system because of the small number of clca\~ges involved in the formation of adwnccd-stage embryos. ‘liansgenesis has been wed to characterize &rcgulatory I)NA elements that mediate tissue-specific and ...
Mbd3, a component of the NuRD co-repressor
... (Azuara et al., 2006; Boyer et al., 2006; Lee et al., 2006). Although the details of epigenetic modifications in pluripotent cells in vivo have been lacking owing to the scarcity of relevant tissue, a recent study has revealed that ICMs have more intense silencing marks than do ES cells, at in least ...
... (Azuara et al., 2006; Boyer et al., 2006; Lee et al., 2006). Although the details of epigenetic modifications in pluripotent cells in vivo have been lacking owing to the scarcity of relevant tissue, a recent study has revealed that ICMs have more intense silencing marks than do ES cells, at in least ...
Transcriptional Deregulation of Mutated BCL6 Alleles by Loss of
... diffuse large B cell lymphomas (DLBCL) and 5–14% of follicular lymphomas (FL), the BCL6 locus is altered by chromosomal translocations that deregulate its expression by a mechanism known as promoter substitution. In addition, the BCL6 5′ noncoding sequences are targeted by multiple somatic mutations ...
... diffuse large B cell lymphomas (DLBCL) and 5–14% of follicular lymphomas (FL), the BCL6 locus is altered by chromosomal translocations that deregulate its expression by a mechanism known as promoter substitution. In addition, the BCL6 5′ noncoding sequences are targeted by multiple somatic mutations ...
PDF
... (Azuara et al., 2006; Boyer et al., 2006; Lee et al., 2006). Although the details of epigenetic modifications in pluripotent cells in vivo have been lacking owing to the scarcity of relevant tissue, a recent study has revealed that ICMs have more intense silencing marks than do ES cells, at in least ...
... (Azuara et al., 2006; Boyer et al., 2006; Lee et al., 2006). Although the details of epigenetic modifications in pluripotent cells in vivo have been lacking owing to the scarcity of relevant tissue, a recent study has revealed that ICMs have more intense silencing marks than do ES cells, at in least ...
Gold nanoparticle-mediated gene delivery induces immunity genes
... promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findin ...
... promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findin ...
PPT Slide
... transfection for 24 hours, the CM was replaced with fresh media and then time-dependently collected as shown in the scheme. (B) HEK293T cells expressing WT or D148E variant APE1/Ref-1 were treated with 1 μM TSA for 1 hour. The CM was transferred into an empty plate and 0.5 mL of this CM was timedepe ...
... transfection for 24 hours, the CM was replaced with fresh media and then time-dependently collected as shown in the scheme. (B) HEK293T cells expressing WT or D148E variant APE1/Ref-1 were treated with 1 μM TSA for 1 hour. The CM was transferred into an empty plate and 0.5 mL of this CM was timedepe ...
Comparing The Effects of Small Molecules BIX
... molecules offer several advantages such as rapid, reversible and dose-dependent effects, structural diversity provided by synthetic chemistry and relative ease of handling and administration compared with genetic interventions (10). Moreover, by erasure of epigenetic marks (DNA methylation and histo ...
... molecules offer several advantages such as rapid, reversible and dose-dependent effects, structural diversity provided by synthetic chemistry and relative ease of handling and administration compared with genetic interventions (10). Moreover, by erasure of epigenetic marks (DNA methylation and histo ...