1 - Tistory
... I do not believe the court in General Tire was seeking to address factual circumstances like those said to arise in this case. In principle the common general knowledge of a skilled person must be capable of including contradictory ideas on a topic, always assuming that information reaches the stand ...
... I do not believe the court in General Tire was seeking to address factual circumstances like those said to arise in this case. In principle the common general knowledge of a skilled person must be capable of including contradictory ideas on a topic, always assuming that information reaches the stand ...
Licentiate thesis from the Department of Immunology,
... susceptibility to malaria observed between two sympatric ethnic tribes, the Fulani and the Dogon, living in Mali. The genotypes were correlated to both ethnicity and malariometric indexes. A statistically significant inter-ethnic difference in the allele frequency and genotype inheritance pattern fo ...
... susceptibility to malaria observed between two sympatric ethnic tribes, the Fulani and the Dogon, living in Mali. The genotypes were correlated to both ethnicity and malariometric indexes. A statistically significant inter-ethnic difference in the allele frequency and genotype inheritance pattern fo ...
clever-1 as an immune suppressive molecule
... system to protect the host against an infection and to protect self-molecules in different pathophysiological conditions. Pregnancy is one of the conditions where the maternal immune system remains resistant against microbes and yet attains tolerance to protect the fetus, whose genetic material diff ...
... system to protect the host against an infection and to protect self-molecules in different pathophysiological conditions. Pregnancy is one of the conditions where the maternal immune system remains resistant against microbes and yet attains tolerance to protect the fetus, whose genetic material diff ...
Development of Small Designer Aldolase Enzymes: Catalytic Activity
... been developed. Peptide phage libraries were created by appending six randomized amino acid residues to the C-terminus or to the N-terminus of an 18-mer R-helix peptide containing lysine residues. Reactionbased selection with 1,3-diketones was performed to trap the amino groups of reactive lysine re ...
... been developed. Peptide phage libraries were created by appending six randomized amino acid residues to the C-terminus or to the N-terminus of an 18-mer R-helix peptide containing lysine residues. Reactionbased selection with 1,3-diketones was performed to trap the amino groups of reactive lysine re ...
Modulation of AAV vector dosing and avoidance of capsid immune
... • Gene therapy in pediatric patients may require vector readministration • Vector re-dosing may be necessary to achieve full therapeutic efficacy ...
... • Gene therapy in pediatric patients may require vector readministration • Vector re-dosing may be necessary to achieve full therapeutic efficacy ...
ABSTRACT
... alert the cell that the material being ingested is foreign. Toll-like receptors are membrane associated receptors present on phagocytes and other cells that lead to activation of the innate immune system. Toll was first discovered as a gene having a role in dorsal-ventral polarity in Drosophila mela ...
... alert the cell that the material being ingested is foreign. Toll-like receptors are membrane associated receptors present on phagocytes and other cells that lead to activation of the innate immune system. Toll was first discovered as a gene having a role in dorsal-ventral polarity in Drosophila mela ...
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... Follicular dendritic cells (FDCs) are unique immune cells that contribute to the regulation of humoral immune responses. These cells are located in the B-cell follicles of secondary lymphoid tissues where they trap and retain antigens (Ags) in the form of highly immunogenic immune complexes (ICs) co ...
... Follicular dendritic cells (FDCs) are unique immune cells that contribute to the regulation of humoral immune responses. These cells are located in the B-cell follicles of secondary lymphoid tissues where they trap and retain antigens (Ags) in the form of highly immunogenic immune complexes (ICs) co ...
Part III, Endotoxin Test Concerns of Biologics
... demonstrated that low levels of contaminants including LPS that they have termed IIMRIs or “innate immune response modulating impurities” can, either alone or synergistically to greater effect, stimulate the immune system against therapeutic proteins at a level that may be well below the level consi ...
... demonstrated that low levels of contaminants including LPS that they have termed IIMRIs or “innate immune response modulating impurities” can, either alone or synergistically to greater effect, stimulate the immune system against therapeutic proteins at a level that may be well below the level consi ...
B cells - Cloudfront.net
... T Cells are lymphocytes that go through the thymus gland before migrating to the lymph nodes and spleen Pre–T cells develop into thymocytes while in the thymus Thymocytes stream into the blood and are carried to the T-dependent zones in the spleen and the lymph nodes Mosby items and derived items © ...
... T Cells are lymphocytes that go through the thymus gland before migrating to the lymph nodes and spleen Pre–T cells develop into thymocytes while in the thymus Thymocytes stream into the blood and are carried to the T-dependent zones in the spleen and the lymph nodes Mosby items and derived items © ...
GenScript TissueDirect Multiplex PCR System Protocol
... I. INTRODUCTION GenScript’s Mouse Laminin ELISA Kit is based on standard sandwich enzyme-linked immune-sorbent assay technology. A polyclonal antibody specific for mouse laminin is precoated onto each 96-well plate. Standards and samples are added to the wells and any laminin present is bound by the ...
... I. INTRODUCTION GenScript’s Mouse Laminin ELISA Kit is based on standard sandwich enzyme-linked immune-sorbent assay technology. A polyclonal antibody specific for mouse laminin is precoated onto each 96-well plate. Standards and samples are added to the wells and any laminin present is bound by the ...
Expression of CD1d in human scalp skin and hair follicles: hair cycle
... cycle. Several studies have shown that keratinocyte proliferation and differentiation are induced by lipids. N-Acylated forms of sphingolipids, such as ceramides, have been shown to promote keratinocyte differentiation, and sphingosine and sphingosylphosphorylcholine promote keratinocyte proliferati ...
... cycle. Several studies have shown that keratinocyte proliferation and differentiation are induced by lipids. N-Acylated forms of sphingolipids, such as ceramides, have been shown to promote keratinocyte differentiation, and sphingosine and sphingosylphosphorylcholine promote keratinocyte proliferati ...
Cellular-mediated and humoral immunity in children with autism
... Cellular-mediated and humoral immunity in children with autism Background: Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the ...
... Cellular-mediated and humoral immunity in children with autism Background: Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impaired social interaction and communication, often accompanied by repetitive and stereotyped behavior. The condition manifests within the ...
Phage therapy: awakening a sleeping giant
... advances in sequencing technologies and genetic engineering have allowed for the design of phages with more predictable and domesticated therapeutic properties. For instance, recombinant phages can be created to have hybrid tail fibers from related phages to broaden bacterial host ranges [26,27]. Mor ...
... advances in sequencing technologies and genetic engineering have allowed for the design of phages with more predictable and domesticated therapeutic properties. For instance, recombinant phages can be created to have hybrid tail fibers from related phages to broaden bacterial host ranges [26,27]. Mor ...
Serum Dioxin and Immunologic Response in Veterans of Operation
... murine monoclonal antibodies. Antibodies to the following antigens were used: T-cell antigens (CD3, CD4, CD5, and CD8), B-cell antigens (CD20), NKcell antigens (CD 16 and CD56), and activation antigen (CD25). CD25 antigen expression was measured on total CD3+ cells. Row cytometric analyses were perf ...
... murine monoclonal antibodies. Antibodies to the following antigens were used: T-cell antigens (CD3, CD4, CD5, and CD8), B-cell antigens (CD20), NKcell antigens (CD 16 and CD56), and activation antigen (CD25). CD25 antigen expression was measured on total CD3+ cells. Row cytometric analyses were perf ...
Molecular and functional characterization of the immunoreceptors CD300d and CD300f
... evolution, the innate immune system appeared before the adaptive immune system 3 and the same innate immunity molecular modules are found in plants and animals, meaning that it arose before the split into these two kingdoms 4. Innate immunity operates through the intertwined action of several cell t ...
... evolution, the innate immune system appeared before the adaptive immune system 3 and the same innate immunity molecular modules are found in plants and animals, meaning that it arose before the split into these two kingdoms 4. Innate immunity operates through the intertwined action of several cell t ...
Combining Human and Rat Sequences in Her
... (Fig. 1A; Supplementary Fig. S1). The chimeric E2-NeuTM protein is a transmembrane Her-2-neu fusion protein with a truncated ICD. Neu-E2TM is the reverse product with neu at the NH2 terminus and Her-2 at the COOH terminus (36). The third chimeric vaccine pE2-Neu500TM was modified from pE2-NeuTM to r ...
... (Fig. 1A; Supplementary Fig. S1). The chimeric E2-NeuTM protein is a transmembrane Her-2-neu fusion protein with a truncated ICD. Neu-E2TM is the reverse product with neu at the NH2 terminus and Her-2 at the COOH terminus (36). The third chimeric vaccine pE2-Neu500TM was modified from pE2-NeuTM to r ...
Virology Journal
... Background: The bacterial pathogen Edwardsiella ictaluri is a primary cause of mortality in channel catfish raised commercially in aquaculture farms. Additional treatment and diagnostic regimes are needed for this enteric pathogen, motivating the discovery and characterization of bacteriophages spec ...
... Background: The bacterial pathogen Edwardsiella ictaluri is a primary cause of mortality in channel catfish raised commercially in aquaculture farms. Additional treatment and diagnostic regimes are needed for this enteric pathogen, motivating the discovery and characterization of bacteriophages spec ...
Excludes Superantigen-Like Recognition Complementarity
... main-chain atoms of amino acids in peptides or proteins (19, 20). These coordination complexes are rather stable and, therefore, a noncovalent interaction of Ni21 ions with MHC-embedded peptides was suggested as a hapten-like epitope for Ni-reactive T cells (21, 22). However, the definitive structur ...
... main-chain atoms of amino acids in peptides or proteins (19, 20). These coordination complexes are rather stable and, therefore, a noncovalent interaction of Ni21 ions with MHC-embedded peptides was suggested as a hapten-like epitope for Ni-reactive T cells (21, 22). However, the definitive structur ...
... conserved microbial components, which are usually crucial for microbial survival, known as pathogen-associated molecular patterns (PAMPs). The scavenger receptors (SRs) are members of the PRRs family, present on macrophages, DCs and certain epithelial cells. SRs not only recognize different microbia ...
44. Mapping of neutralising sites on FMDV type Asia 1
... The antigenic profile of MAR-mutants, determined by ELISA (figure 2) lead to the definition of 4 distinct neutralizing sites; sites were denominated I, II, IV, V to maintain a common denomination in relation with analogous sites previously described in other FMDV types; substantially the 4 sites are ...
... The antigenic profile of MAR-mutants, determined by ELISA (figure 2) lead to the definition of 4 distinct neutralizing sites; sites were denominated I, II, IV, V to maintain a common denomination in relation with analogous sites previously described in other FMDV types; substantially the 4 sites are ...
Production of exopolysaccharide from mycelial culture of Grifola
... and antitumor agents for clinical use [13–15]. Apart from these applications, polysaccharides have been used as a substance that enhances the skins natural ability to heal and protect itself against infection [2]. Recently, several polysaccharides have been used as alternative ingredients for enhan ...
... and antitumor agents for clinical use [13–15]. Apart from these applications, polysaccharides have been used as a substance that enhances the skins natural ability to heal and protect itself against infection [2]. Recently, several polysaccharides have been used as alternative ingredients for enhan ...
An Approach to the Patient Refractory to Platelets Transfusion
... This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient has antibodies This approach was described in 29 HLA-alloimmunized patients refractory to transfusion with ran ...
... This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient has antibodies This approach was described in 29 HLA-alloimmunized patients refractory to transfusion with ran ...
A Nonpolymorphic Major Histocompatibility Complex Class Ib
... in Mammal~n Gdk Sin~ Qa-2 molecules are expressed in vivo as a heterogeneous mixture of products of several related genes in relatively low quantities (28), we have developed a genetically engineered cell line producing high levels of a single Qa-2 product, SQ7 b. Full-size eDNA encoding SQ7b (20) w ...
... in Mammal~n Gdk Sin~ Qa-2 molecules are expressed in vivo as a heterogeneous mixture of products of several related genes in relatively low quantities (28), we have developed a genetically engineered cell line producing high levels of a single Qa-2 product, SQ7 b. Full-size eDNA encoding SQ7b (20) w ...
Immune complex formation in IgA nephropathy
... News & Views Why patients with IgAN have excess amounts of poorly galactosylated IgA1 Oglycoforms in their serum remains unknown. A number of explanations have been put forward, including an enzymatic defect in IgA1 O-glycosylation that is at least in part inherited.6 One alternative explanation is ...
... News & Views Why patients with IgAN have excess amounts of poorly galactosylated IgA1 Oglycoforms in their serum remains unknown. A number of explanations have been put forward, including an enzymatic defect in IgA1 O-glycosylation that is at least in part inherited.6 One alternative explanation is ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.