Wickenden et al. EHA 2016 PB2040
... PROLIFERATING KI67 EXPRESSING B-CELLS ASSOCIATE WITH CD4+PD1+ T-CELLS IN MARGINAL ZONE LYMPHOMA K Wickenden1,*, N Nawaz1, E Lakidou1, A Wilson1, K Straatman2, S Wagner1, M Ahearne1 1Cancer Studies, 2Biochemistry, University of Leicester, Leicester, United Kingdom Background: Specific microbial antig ...
... PROLIFERATING KI67 EXPRESSING B-CELLS ASSOCIATE WITH CD4+PD1+ T-CELLS IN MARGINAL ZONE LYMPHOMA K Wickenden1,*, N Nawaz1, E Lakidou1, A Wilson1, K Straatman2, S Wagner1, M Ahearne1 1Cancer Studies, 2Biochemistry, University of Leicester, Leicester, United Kingdom Background: Specific microbial antig ...
Get PDF - Wiley Online Library
... The poly(A) tail is bound by the poly(A)-binding protein (PABP), which is necessary for efficient translation (for reviews, see Jacobson, 1996; Sachs et al., 1997). In yeast, eIF4G was found to associate with PABP (Tarun and Sachs, 1996). The PABP-binding site was mapped to an N-terminal region prox ...
... The poly(A) tail is bound by the poly(A)-binding protein (PABP), which is necessary for efficient translation (for reviews, see Jacobson, 1996; Sachs et al., 1997). In yeast, eIF4G was found to associate with PABP (Tarun and Sachs, 1996). The PABP-binding site was mapped to an N-terminal region prox ...
$doc.title
... Mortality rates can reach higher than 95%, depending on the form of the disease. This has a significant economic impact on the horse industry, particularly the lucrative sport of horse-racing. In addition, the financial stakes and horse-trading value in the more traditionally recreational sports of ...
... Mortality rates can reach higher than 95%, depending on the form of the disease. This has a significant economic impact on the horse industry, particularly the lucrative sport of horse-racing. In addition, the financial stakes and horse-trading value in the more traditionally recreational sports of ...
- Brain
... cord (Koritschoner and Schweinburg, 1925). In the 1930s, researchers attempted to reproduce the encephalitic complications associated with rabies vaccination by repetitive immunization of rhesus monkeys with CNS tissue (Rivers et al., 1933). Since then EAE was elicited in many different species, inc ...
... cord (Koritschoner and Schweinburg, 1925). In the 1930s, researchers attempted to reproduce the encephalitic complications associated with rabies vaccination by repetitive immunization of rhesus monkeys with CNS tissue (Rivers et al., 1933). Since then EAE was elicited in many different species, inc ...
Surface Protein-1 Carboxyl-Terminal Fragment of Merozoite
... following vaccination with a particular subunit preparation can be passively protected by adoptively transferred Abs. B10.BR mice are not protected following vaccination with GST-MSP119 (6). The reasons for this are not clear, but may relate to the titer of Ab induced by vaccination or to other fact ...
... following vaccination with a particular subunit preparation can be passively protected by adoptively transferred Abs. B10.BR mice are not protected following vaccination with GST-MSP119 (6). The reasons for this are not clear, but may relate to the titer of Ab induced by vaccination or to other fact ...
Lewis -Containing Oligosaccharide Attenuates Schistosome Egg
... responses to Lacto-n-fucopentaose III (LNFPIII) that contains Lewisx(Lex)-trisaccharide was assessed in PBMC from humans infected with Schistosoma mansoni. All patient groups with low, medium, and high egg counts in their feces responded to polyvalent LNFPIII-HSA (where HSA ⫽ human serum albumin) co ...
... responses to Lacto-n-fucopentaose III (LNFPIII) that contains Lewisx(Lex)-trisaccharide was assessed in PBMC from humans infected with Schistosoma mansoni. All patient groups with low, medium, and high egg counts in their feces responded to polyvalent LNFPIII-HSA (where HSA ⫽ human serum albumin) co ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
Helicobacter pylori vaccines and mechanisms of effective
... pathogen Helicobacter pylori has encountered several problems. Resolving these problems is impeded by our lack of understanding of the mechanisms by which the immune response influences bacterial colonization. Protective immunity requires CD4+ T cells, but the majority of helicobacters are located i ...
... pathogen Helicobacter pylori has encountered several problems. Resolving these problems is impeded by our lack of understanding of the mechanisms by which the immune response influences bacterial colonization. Protective immunity requires CD4+ T cells, but the majority of helicobacters are located i ...
T-Cell Subset Analysis of Lewis Lung Carcinoma
... page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. ...
... page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. ...
M261 MHC class I antigen presentation April 17, 2000
... The antigen-specific T-cell receptor (TCR) recognizes a complex of antigenic peptide and MHC. One consequence of this is that a T cell specific for peptide x and a particular MHC allele, MHCa (left panel), will not recognize the complex of peptide x with a different MHC allele, MHCb (center panel), ...
... The antigen-specific T-cell receptor (TCR) recognizes a complex of antigenic peptide and MHC. One consequence of this is that a T cell specific for peptide x and a particular MHC allele, MHCa (left panel), will not recognize the complex of peptide x with a different MHC allele, MHCb (center panel), ...
T cells - Amazon S3
... Antibodies: proteins (immunoglobulins) secreted by activated B cell (Figure 21-16) Structure of antibody molecules: an antibody molecule consists of two heavy and two light polypeptide chains; each molecule has two antigen-binding sites and two complement-binding sites (Figure 21-17) Mosby items and ...
... Antibodies: proteins (immunoglobulins) secreted by activated B cell (Figure 21-16) Structure of antibody molecules: an antibody molecule consists of two heavy and two light polypeptide chains; each molecule has two antigen-binding sites and two complement-binding sites (Figure 21-17) Mosby items and ...
Biological basis for the clinical use of interferon
... Variables affecting response to interferon The specific type of viral infection may influence the role of, and response to, interferon. Viruses that kill the cell before being released usually cause very acute infections and are not good targets for interferon. Viruses that mature on the cell surfac ...
... Variables affecting response to interferon The specific type of viral infection may influence the role of, and response to, interferon. Viruses that kill the cell before being released usually cause very acute infections and are not good targets for interferon. Viruses that mature on the cell surfac ...
HIV-1 Vpr-chloramphenicol acetyltransferase fusion proteins
... cell lysates (Figure 1b, upper left panel, lanes 2–8). The molecular weight of the different Vpr-CAT fusion proteins ranged between approximately 29 kDa and 35 kDa. Analysis of viral lysates indicates that Vpr-CAT fusion proteins R1-42CAT, R1-80CAT, R1-88CAT and R1488CAT are packaged into virions at ...
... cell lysates (Figure 1b, upper left panel, lanes 2–8). The molecular weight of the different Vpr-CAT fusion proteins ranged between approximately 29 kDa and 35 kDa. Analysis of viral lysates indicates that Vpr-CAT fusion proteins R1-42CAT, R1-80CAT, R1-88CAT and R1488CAT are packaged into virions at ...
ABSTRACT - Johns Hopkins University
... strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies have demonstrated a critical role for stromal elements in the development of cancer. Int ...
... strength of antigen activation (8). Galectin-3, therefore, is a ubiquitous protein that is involved in every step of the immune response. Galectin-3 and its role in the PDA tumor microenvironment Several studies have demonstrated a critical role for stromal elements in the development of cancer. Int ...
Immunomodulation of pathogen-host interactions
... In Experiment 2, we have described the removal of TLR agonist molecules, such endotoxin (TLR4), peptidoglycan (TLR-2/Nod2), lipopeptide (TLR-2) and bacterial DNA (TLR-9) from blood and plasma using affinity technology. We have tested the efficacy of removal by spiking the anticoagulated blood and pl ...
... In Experiment 2, we have described the removal of TLR agonist molecules, such endotoxin (TLR4), peptidoglycan (TLR-2/Nod2), lipopeptide (TLR-2) and bacterial DNA (TLR-9) from blood and plasma using affinity technology. We have tested the efficacy of removal by spiking the anticoagulated blood and pl ...
Bioassay-Validated Recombinant Cytokines
... in a dose-dependent manner. Endotoxin is less than 0.1 EU/µg (<0.01 ng/µg). Bottled carrier-free at 200 µg/mL for sizes 10–100 µg and at higher concentrations for sizes of 500 µg and higher. Bioactive Protein (Carrier-Free) ...
... in a dose-dependent manner. Endotoxin is less than 0.1 EU/µg (<0.01 ng/µg). Bottled carrier-free at 200 µg/mL for sizes 10–100 µg and at higher concentrations for sizes of 500 µg and higher. Bioactive Protein (Carrier-Free) ...
Full-Text PDF
... generation by conjugation of a drug-like core molecule to a surrounding randomized library peptide via the 10BASEd-T (Figure 1). As the model drug-like core molecule, commercially available 4-iodoacetamidosalicylic acid (Sal-IA) was used because it is one of the smallest pharmaceutical molecules pos ...
... generation by conjugation of a drug-like core molecule to a surrounding randomized library peptide via the 10BASEd-T (Figure 1). As the model drug-like core molecule, commercially available 4-iodoacetamidosalicylic acid (Sal-IA) was used because it is one of the smallest pharmaceutical molecules pos ...
Airway Inflammation and Bronchial Remodelling in - (BORA)
... 5% of workers exposed to diisocyanates develop asthma, which may persist indefinitely even in the absence of continued exposure [4]. Clinically, diisocyanate asthma displays similar manifestations to allergic asthma induced by high molecular weight allergens, suggesting common pathogenic processes, a ...
... 5% of workers exposed to diisocyanates develop asthma, which may persist indefinitely even in the absence of continued exposure [4]. Clinically, diisocyanate asthma displays similar manifestations to allergic asthma induced by high molecular weight allergens, suggesting common pathogenic processes, a ...
Expression of Dengue virus envelope glycoproteins using a
... Dengue virus (DENV) infection results in a spectrum of clinical manifestation ranging from asymptomatic to dengue fever (DF) which is characterized by flu-like-symptoms (headache, fever and severe eye pain), muscles pain, joint pain, abdominal pain, nausea and rash (6-8). Common laboratory abnormal ...
... Dengue virus (DENV) infection results in a spectrum of clinical manifestation ranging from asymptomatic to dengue fever (DF) which is characterized by flu-like-symptoms (headache, fever and severe eye pain), muscles pain, joint pain, abdominal pain, nausea and rash (6-8). Common laboratory abnormal ...
Proceedings Template - WORD
... saturation of APCs nor the arrival at the pathogen carrying capacity can reverse immune activation. In this section, we consider the evolution of the GDP response through the intermediate phase of the decision-making process. As the immune response develops, the populations of both mature Treg and m ...
... saturation of APCs nor the arrival at the pathogen carrying capacity can reverse immune activation. In this section, we consider the evolution of the GDP response through the intermediate phase of the decision-making process. As the immune response develops, the populations of both mature Treg and m ...
iiiiiiiiii - Cancer Research
... (1) The question under investigation when the observation (Table IV) which proved to be the source of this paper was made, was whether the sera of rats immunised against normal or malignant homologous cells were isohaemolytic. Table II shows the results in one of many experiments which invariably ag ...
... (1) The question under investigation when the observation (Table IV) which proved to be the source of this paper was made, was whether the sera of rats immunised against normal or malignant homologous cells were isohaemolytic. Table II shows the results in one of many experiments which invariably ag ...
9700/43 UNIVERSITY OF CAMBRIDGE INTERNATIONAL
... (a) Explain how, in the process of genetic fingerprinting, gel electrophoresis is able to distinguish between the VNTRs that occur at the same loci of different individuals. ...
... (a) Explain how, in the process of genetic fingerprinting, gel electrophoresis is able to distinguish between the VNTRs that occur at the same loci of different individuals. ...
Nerve activates contraction
... Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
... Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings ...
A dissection of T cell receptor signaling pathways
... The design of such supplements has been hindered by our limited mechanistic understanding of the effects of microgravity on T cell activation and function. The available data strongly implicates a defect in the ability of T cells to respond to antigenreceptor signals during exposure to microgravity ...
... The design of such supplements has been hindered by our limited mechanistic understanding of the effects of microgravity on T cell activation and function. The available data strongly implicates a defect in the ability of T cells to respond to antigenreceptor signals during exposure to microgravity ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.