Program - Canadian Society of Transplantation
... Subclinical tacrolimus nephrotoxicity in protocol biopsies obtained more than 5 years after renal allograft transplantation Trana Hussaini Investigating the Association between Hypomagnesaemia and Calcineurin Inhibitor Induced Nephrotoxicity in Liver Transplant Recipients: A Case-Control Study Yasem ...
... Subclinical tacrolimus nephrotoxicity in protocol biopsies obtained more than 5 years after renal allograft transplantation Trana Hussaini Investigating the Association between Hypomagnesaemia and Calcineurin Inhibitor Induced Nephrotoxicity in Liver Transplant Recipients: A Case-Control Study Yasem ...
Structures Common to Different Glycans ...tials of Glycobiology
... Nacetyllactosamines to form the H antigen (Figure 13.5 and Figure 13.6) in epithelia lining the lumen of the gastrointestinal, respiratory, and reproductive tracts and in salivary glands. A or B blood group determinants are subsequently formed from type1, 2, 3, or 4 H determinants by glycosyltr ...
... Nacetyllactosamines to form the H antigen (Figure 13.5 and Figure 13.6) in epithelia lining the lumen of the gastrointestinal, respiratory, and reproductive tracts and in salivary glands. A or B blood group determinants are subsequently formed from type1, 2, 3, or 4 H determinants by glycosyltr ...
Technical Bulletin - Sigma
... (DMEM/High) (Catalog No. 51440) was supplemented with 8 mM concentrations of L-Glutamine Solution 200 mM (Catalog No. 59202) and stored at 2 to 8 C, 15 to 30 C and 37 C. Samples were taken daily from each condition and frozen for amino acid analysis. The level of remaining L-glutamine was measured a ...
... (DMEM/High) (Catalog No. 51440) was supplemented with 8 mM concentrations of L-Glutamine Solution 200 mM (Catalog No. 59202) and stored at 2 to 8 C, 15 to 30 C and 37 C. Samples were taken daily from each condition and frozen for amino acid analysis. The level of remaining L-glutamine was measured a ...
A Doctor`s Guide to a Healthy Immune System
... the body and not to those of the body itself. The ability to distinguish between what is “foreign” and what is “self” is a central aspect of the adaptive immune system. At times, the adaptive system fails to make this distinction and reacts destructively against the body’s own cells. The result may ...
... the body and not to those of the body itself. The ability to distinguish between what is “foreign” and what is “self” is a central aspect of the adaptive immune system. At times, the adaptive system fails to make this distinction and reacts destructively against the body’s own cells. The result may ...
Preclinical Imaging and its Importance in Drug Discovery and
... powerful cycle of informationgathering in drug development. Ensuring a smart choice of animal models, reporters and imaging modalities at the earliest preclinical time point can reduce time in each phase of development. Careful quantitative modelling and de-risking of each NME throughout development ...
... powerful cycle of informationgathering in drug development. Ensuring a smart choice of animal models, reporters and imaging modalities at the earliest preclinical time point can reduce time in each phase of development. Careful quantitative modelling and de-risking of each NME throughout development ...
Autoantibodies against Muscarinic Acetylcholine Receptor on
... factors causing the disorganization of glandular epithelial cells, which provoke local innate immune response and activate the toll-like receptor (TLR) pathway involving cell apoptosis [5]; the stimulation of the dendritic cells responsible for the production of INF, which, in turn, leads to the pro ...
... factors causing the disorganization of glandular epithelial cells, which provoke local innate immune response and activate the toll-like receptor (TLR) pathway involving cell apoptosis [5]; the stimulation of the dendritic cells responsible for the production of INF, which, in turn, leads to the pro ...
The integrity of a cholesterol-binding pocket in Niemann–Pick C2
... known mechanism of its action prompted a genetic structure– function study of its properties. To this end, we purified wild-type and mutant NPC2 proteins, starting from a culture medium into which cells had released NPC2. Previous studies of NPC2 used NPC2-conditioned media (7) or NPC2 purified from ...
... known mechanism of its action prompted a genetic structure– function study of its properties. To this end, we purified wild-type and mutant NPC2 proteins, starting from a culture medium into which cells had released NPC2. Previous studies of NPC2 used NPC2-conditioned media (7) or NPC2 purified from ...
Population dynamics of immune repertoires
... which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes from antigens. Strong antigenic recognition by mature lymphocytes generally triggers clonal expansion into effector and memory cells. These strong signals are usually ...
... which we describe now. The general idea behind this class of models is that one important signal for which lymphocytes compete comes from antigens. Strong antigenic recognition by mature lymphocytes generally triggers clonal expansion into effector and memory cells. These strong signals are usually ...
Proteolytic Degradation of Hemoglobin in the Intestine of the Human
... gene knockout (Plasmodium) and gene silencing (Schistosoma) technologies have resolved some of these issues. For example, hemoglobinase knockout and double-knockout P. falciparum have been used to show that Hb degradation is partially redundant and relies on dual protease families with overlapping f ...
... gene knockout (Plasmodium) and gene silencing (Schistosoma) technologies have resolved some of these issues. For example, hemoglobinase knockout and double-knockout P. falciparum have been used to show that Hb degradation is partially redundant and relies on dual protease families with overlapping f ...
Antigen Presentation to T Lymphocytes
... Vertebrate adaptive immune cells possess two types of antigen receptors: the immunoglobulins that serve as antigen receptors on B cells, and the T-cell receptors. While immunoglobulins can recognize native antigens, T cells recognize only antigens that are displayed by MHC complexes on cell surfaces ...
... Vertebrate adaptive immune cells possess two types of antigen receptors: the immunoglobulins that serve as antigen receptors on B cells, and the T-cell receptors. While immunoglobulins can recognize native antigens, T cells recognize only antigens that are displayed by MHC complexes on cell surfaces ...
Licentiate thesis from the Department of Immunology, Wenner-Gren Institute,
... parasites and some viruses and are found in the outer cell membrane. However, the TLRs that are specialized in recognition of intracellular bacteria and viruses, such as TLR3, TLR7, TLR8, and TLR9 are located intracellularly. The motifs that they recognize are not necessarily unique to viruses. In f ...
... parasites and some viruses and are found in the outer cell membrane. However, the TLRs that are specialized in recognition of intracellular bacteria and viruses, such as TLR3, TLR7, TLR8, and TLR9 are located intracellularly. The motifs that they recognize are not necessarily unique to viruses. In f ...
The Most Cunning Parasite From an Immunological Perspective
... a fully formed gut, although they do not feed. They move actively in the water, resembling a free-living nematode, and can live for a few days in water, until a copepod recognizes the movement as food. The fifth step shows how the larvae are expelled from the foot and the copepods consume them. The ...
... a fully formed gut, although they do not feed. They move actively in the water, resembling a free-living nematode, and can live for a few days in water, until a copepod recognizes the movement as food. The fifth step shows how the larvae are expelled from the foot and the copepods consume them. The ...
full text pdf
... area, are extensively vascularised, and contain APCs such as dendritic cells and alveolar macrophages [22]. Pulmonary vaccines are administered to the alveoli using an aerosol [12]. Bronchus-associated lymphoid tissue (BALT) is present in the lungs, and is able to generate not only a systemic immune ...
... area, are extensively vascularised, and contain APCs such as dendritic cells and alveolar macrophages [22]. Pulmonary vaccines are administered to the alveoli using an aerosol [12]. Bronchus-associated lymphoid tissue (BALT) is present in the lungs, and is able to generate not only a systemic immune ...
Structural organization of the components of the cell wall from
... both yeast and mycelial forms. Fraction B was composed almost exclusively of glucan with trace amounts of mannan and chitin. Again no significant difference was observed between yeast and mycelium. Fraction C was made of a higher proportion of glucans, but the relative proportions of mannan and chit ...
... both yeast and mycelial forms. Fraction B was composed almost exclusively of glucan with trace amounts of mannan and chitin. Again no significant difference was observed between yeast and mycelium. Fraction C was made of a higher proportion of glucans, but the relative proportions of mannan and chit ...
The Department of Electrical and Computer Engineering
... secondary antibodies for signal amplification. HRP catalyzes H2O2 and generates electrons for amperometric based measurement. (A) conventional single HRP labeled secondary antibody (B) multiple HRP and secondary antibody on carbon nanotube for signal amplification (Yu et al., ...
... secondary antibodies for signal amplification. HRP catalyzes H2O2 and generates electrons for amperometric based measurement. (A) conventional single HRP labeled secondary antibody (B) multiple HRP and secondary antibody on carbon nanotube for signal amplification (Yu et al., ...
The Immune System - Wiley-VCH
... All living things – animals, plants and even bacteria – can act as hosts for infectious organisms and thus have evolved mechanisms to defend themselves against infection. Infection can be by other living things, non-living things (viruses) and possibly even molecules (prions). Since it is so crucial ...
... All living things – animals, plants and even bacteria – can act as hosts for infectious organisms and thus have evolved mechanisms to defend themselves against infection. Infection can be by other living things, non-living things (viruses) and possibly even molecules (prions). Since it is so crucial ...
... of Krebs buffer containing 20 mmol/L HEPES, 5 mmol/L D-glucose, 0.3 mmol/L NH4Cl, 5 µL of 20 U/mL insulin, and 0, 0.5 or 2 L-leucine plus L-[1-14C]- or L-[U-14C]-labeled leucine, and other amino acids at physiological concentrations found in plasma (36). Values, expressed as nmol/106 cells per 2h un ...
Effects of signaling on subcellular localization of MITF
... melanocytes and then to the surrounding keratinocytes. The association between these cell types also plays an important role in photoprotection of the skin cells (Cichorek et al., ...
... melanocytes and then to the surrounding keratinocytes. The association between these cell types also plays an important role in photoprotection of the skin cells (Cichorek et al., ...
Harnessing Local Immunity for an Effective Universal Swine
... responses. In adults with extensive and partially cross-reactive pre-existing influenza immunity, LAIV boosting of secretory IgA reactive with HA and non-HA antigenic targets expressed by circulating influenza strains, may be an important additional mechanism of vaccine-induced immunity [42]. FluMis ...
... responses. In adults with extensive and partially cross-reactive pre-existing influenza immunity, LAIV boosting of secretory IgA reactive with HA and non-HA antigenic targets expressed by circulating influenza strains, may be an important additional mechanism of vaccine-induced immunity [42]. FluMis ...
European Journal of Biochemistry
... of the rate of inactivation of phage K3 by complexes of protein d and lipopolysaccharide are very similar to those observed for whole cells. With lipopolysaccharide isolated from cells grown at 37 "C inflection points are observed at 20 "C and 28 "C. With lipopolysaccharide from cells grown at 12 "C ...
... of the rate of inactivation of phage K3 by complexes of protein d and lipopolysaccharide are very similar to those observed for whole cells. With lipopolysaccharide isolated from cells grown at 37 "C inflection points are observed at 20 "C and 28 "C. With lipopolysaccharide from cells grown at 12 "C ...
manualE6901
... affect the cleavage reaction and should be taken into consideration (see Tables 1A and 1B). These tables are only a guide, since the folding of the entire fusion protein, not just a single amino acid, affects cleavage. It is difficult to accurately predict the expression of a target protein-intein f ...
... affect the cleavage reaction and should be taken into consideration (see Tables 1A and 1B). These tables are only a guide, since the folding of the entire fusion protein, not just a single amino acid, affects cleavage. It is difficult to accurately predict the expression of a target protein-intein f ...
basic immunology
... me off the ground [and I’m hardly small]; my serum DAMPs went up significantly at that point. Prominent DAMPs are the heat shock proteins [hsp60 for instance], hyaluronan, precipitated uric acid, and heparin. Others include the nuclear protein high-mobility group protein B1 [HMGB1], which can be see ...
... me off the ground [and I’m hardly small]; my serum DAMPs went up significantly at that point. Prominent DAMPs are the heat shock proteins [hsp60 for instance], hyaluronan, precipitated uric acid, and heparin. Others include the nuclear protein high-mobility group protein B1 [HMGB1], which can be see ...
Thesis of Rownok_12376001
... Amena Akhter, Md. Shahidul Islam, Md. Arifur Rahman, Mrs. Rehana and other members of the immunology Laboratory who have contributed in various ways during this work. Getting through my dissertation required more than academic support, and I have many, many people to thank for listening to and, at t ...
... Amena Akhter, Md. Shahidul Islam, Md. Arifur Rahman, Mrs. Rehana and other members of the immunology Laboratory who have contributed in various ways during this work. Getting through my dissertation required more than academic support, and I have many, many people to thank for listening to and, at t ...
Preventing Infection at Mucosal Surfaces
... In every mucosal tissue, a layer of epithelial cells joined by tight junctions separates the outside environment from the inside of the body. The epithelial layer provides a formidable barrier that prevents commensal and pathogenic organisms from gaining access to the internal issues. Adding to this ...
... In every mucosal tissue, a layer of epithelial cells joined by tight junctions separates the outside environment from the inside of the body. The epithelial layer provides a formidable barrier that prevents commensal and pathogenic organisms from gaining access to the internal issues. Adding to this ...
20070622084130718_2 - Trees for Life Journal
... disease may affect various ethnic groups such as the people of the Hispanic and Middle East descent, it affects those of African descent, the more. The most clinical manifestations are largely due to hemolytic processes leading to severe anemia and vasoocclusive crises resulting in pain and organ da ...
... disease may affect various ethnic groups such as the people of the Hispanic and Middle East descent, it affects those of African descent, the more. The most clinical manifestations are largely due to hemolytic processes leading to severe anemia and vasoocclusive crises resulting in pain and organ da ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.