A dissection of T cell receptor signaling pathways
... The design of such supplements has been hindered by our limited mechanistic understanding of the effects of microgravity on T cell activation and function. The available data strongly implicates a defect in the ability of T cells to respond to antigenreceptor signals during exposure to microgravity ...
... The design of such supplements has been hindered by our limited mechanistic understanding of the effects of microgravity on T cell activation and function. The available data strongly implicates a defect in the ability of T cells to respond to antigenreceptor signals during exposure to microgravity ...
determining the innate and adaptive immune responses to vesicular
... The goal of this research project is to determine the response of dendritic cells and T cells to vesicular stomatitis virus (VSV) vectors that express flagellin. VSV is currently in clinical trials as a recombinant vaccine vector against heterologous antigens (1). Incorporating flagellin gene into t ...
... The goal of this research project is to determine the response of dendritic cells and T cells to vesicular stomatitis virus (VSV) vectors that express flagellin. VSV is currently in clinical trials as a recombinant vaccine vector against heterologous antigens (1). Incorporating flagellin gene into t ...
Immunotolerance against a foreign antigen transgenically
... founders were identified by a standard polymerase chain reaction (PCR) assay using HEL primers. Phenotypic changes in eyes of the Tg mice were examined using conventional histologic methods. All procedures with mice were carried out in compliance with the ARVO Statement for the Use of Animals in Oph ...
... founders were identified by a standard polymerase chain reaction (PCR) assay using HEL primers. Phenotypic changes in eyes of the Tg mice were examined using conventional histologic methods. All procedures with mice were carried out in compliance with the ARVO Statement for the Use of Animals in Oph ...
Matching Questions - Sinoe Medical Association
... D) One antigen may have many different antigenic determinants and may therefore cause the formation of more than one antibody. Answer: D ...
... D) One antigen may have many different antigenic determinants and may therefore cause the formation of more than one antibody. Answer: D ...
Lymphatic System - El Camino College
... absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd lumbar vertebrae. Right thoracic duct is not present in all humans. Lymphoid Cells Lymphoid Cells ...
... absent, the lymphatic trunks directly open into veins of the neck. Thoracic Duct – collects lymph from rest of the body. It arises inferiorly as an extended sac – Cisterna Chyli, in front of 1st and 2nd lumbar vertebrae. Right thoracic duct is not present in all humans. Lymphoid Cells Lymphoid Cells ...
Mapping of murine Thl and Th2 helper T
... spleen mononuclear cells (MNC) of BALB/c mice (H-2d haplotype) immunised with the fimbrial protein antigen and adjuvant GM-53 in Freund's incomplete adjuvant (FIA). Sixtyseven sequential overlapping 10-mer peptides covering the complete 337 amino-acids (AA) protein of P . gingivalis fimbrilin were s ...
... spleen mononuclear cells (MNC) of BALB/c mice (H-2d haplotype) immunised with the fimbrial protein antigen and adjuvant GM-53 in Freund's incomplete adjuvant (FIA). Sixtyseven sequential overlapping 10-mer peptides covering the complete 337 amino-acids (AA) protein of P . gingivalis fimbrilin were s ...
Molecular and phenotypic studies of human antigen - edoc
... the serum and cellular level whereby discordances between both were detected, suggesting different restrictions for the humoral and B cellular layer. The unexpected simultaneous presence of low and highly mutated circulating KLH-specific (KLHspec) plasmablasts (PB) 2-3 weeks after vaccination sugges ...
... the serum and cellular level whereby discordances between both were detected, suggesting different restrictions for the humoral and B cellular layer. The unexpected simultaneous presence of low and highly mutated circulating KLH-specific (KLHspec) plasmablasts (PB) 2-3 weeks after vaccination sugges ...
Seroprevalence of Mycoplasma pneumoniae in HIV
... 1997). Numerous authors have described serology as the standard laboratory method for the diagnosis of M. pneumoniae infections (Sillis, 1990). Therefore, our study used serology to look for the seroprevalence of M. pneumoniae infections among HIV-infected subjects. This study was aimed primarily at ...
... 1997). Numerous authors have described serology as the standard laboratory method for the diagnosis of M. pneumoniae infections (Sillis, 1990). Therefore, our study used serology to look for the seroprevalence of M. pneumoniae infections among HIV-infected subjects. This study was aimed primarily at ...
17_MHC antigen processing and presentation(EN)GPv2.32
... Pathogens try to evade the immune response by disabling the MHC I expression of the host cells NK cells possess various inhibitory NK cell receptors which recognise different MHC class I molecules. Decreased or missing MHC I molecule expression on the target cells results NK cell activation. • Abse ...
... Pathogens try to evade the immune response by disabling the MHC I expression of the host cells NK cells possess various inhibitory NK cell receptors which recognise different MHC class I molecules. Decreased or missing MHC I molecule expression on the target cells results NK cell activation. • Abse ...
Resveratrol attenuates L-DOPA-induced hydrogen
... similar to mature DA neurons in vivo; therefore, SKNSH cells serve as an appropriate model of the dopaminergic neuron and is suitable for the study of L-DOPA-induced toxicity and furthermore, antioxidant protection. RESV’s cellular mechanism of antioxidant activity is not yet clearly defined [7]. In ...
... similar to mature DA neurons in vivo; therefore, SKNSH cells serve as an appropriate model of the dopaminergic neuron and is suitable for the study of L-DOPA-induced toxicity and furthermore, antioxidant protection. RESV’s cellular mechanism of antioxidant activity is not yet clearly defined [7]. In ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Phagocytes such as neutrophils and macrophages protect the host by killing the fungi or inhibiting growth. The mechanisms used involve oxidative means where reactive oxygen species produced by respiratory burst damage fungi by lipid peroxidation and nucleic acid breaks [50, 51, 52]. Non- oxidative m ...
... Phagocytes such as neutrophils and macrophages protect the host by killing the fungi or inhibiting growth. The mechanisms used involve oxidative means where reactive oxygen species produced by respiratory burst damage fungi by lipid peroxidation and nucleic acid breaks [50, 51, 52]. Non- oxidative m ...
ACUTE ANTERIOR UVEITIS AND HLA-B27: INFECTIOUS BACKGROUND, SYSTEMIC INFLAMMATION,
... (TNF)-α production in response to bacterial lipopolysaccharide (LPS) was studied using whole blood culture assay. The levels of TNF-α in culture supernatants and soluble interleukin-2 receptor (sIL-2R) in serum were determined by chemiluminescent immunoassay (Immulite). The monocyte surface express ...
... (TNF)-α production in response to bacterial lipopolysaccharide (LPS) was studied using whole blood culture assay. The levels of TNF-α in culture supernatants and soluble interleukin-2 receptor (sIL-2R) in serum were determined by chemiluminescent immunoassay (Immulite). The monocyte surface express ...
Innate immunity and new adjuvants
... emulsions. The mechanisms by which these adjuvants work are not well understood, but many of them form a ‘depot’ at the site of injection, where the antigen is slowly released and stimulates infiltrating cells of the immune system. Furthermore, these are often poorly defined, crude substances that h ...
... emulsions. The mechanisms by which these adjuvants work are not well understood, but many of them form a ‘depot’ at the site of injection, where the antigen is slowly released and stimulates infiltrating cells of the immune system. Furthermore, these are often poorly defined, crude substances that h ...
Artificial Immune Systems: An Emerging Technology
... Biochemical barriers Phagocyte Innate immune response Lymphocytes Adaptive immune response ...
... Biochemical barriers Phagocyte Innate immune response Lymphocytes Adaptive immune response ...
Metabolic reaction network approach for CHO
... then, several advances have been made within different applications and fields like the development of new vaccines and drugs [3]. Animal cell culture consists in the growth and proliferation of cells outside the tissue using a mixture of different components. The mixture is called medium and its co ...
... then, several advances have been made within different applications and fields like the development of new vaccines and drugs [3]. Animal cell culture consists in the growth and proliferation of cells outside the tissue using a mixture of different components. The mixture is called medium and its co ...
Immunoglobulin and T cell receptor genes: IMGT® and
... and 285 for 3D structures) were precisely defined (60). They are written in capital letters (no plural) to be recognizable without creating new terms. Standardized labels assigned to the description of sequences are found in the “FT” (feature) lines of the IMGT/LIGM-DB files (9). Querying these labe ...
... and 285 for 3D structures) were precisely defined (60). They are written in capital letters (no plural) to be recognizable without creating new terms. Standardized labels assigned to the description of sequences are found in the “FT” (feature) lines of the IMGT/LIGM-DB files (9). Querying these labe ...
Characterization of extracellular and surface bound adherence
... metallo-protease domain cleaves in turn mec1, which allows the transcription of mecA (Fig. 1) [6, 9]. Several different forms have been described, with variation in size and genetic structure [6, 9]. Most MRSA strains are resistant to all known antibiotics, apart from glycopeptides (e.g. Vancomycin) ...
... metallo-protease domain cleaves in turn mec1, which allows the transcription of mecA (Fig. 1) [6, 9]. Several different forms have been described, with variation in size and genetic structure [6, 9]. Most MRSA strains are resistant to all known antibiotics, apart from glycopeptides (e.g. Vancomycin) ...
Systemic lupus erythematosus and myasthenia gravis
... sion in the clinical course, and by the presence of anti‑nuclear antibodies.6 Moreover, it is as sumed that both diseases are provoked by genet ic, environmental, hormonal, and immunological factors.8,23‑30 There are more abundant published data on SLA than on MG. Common causative fac tors inclu ...
... sion in the clinical course, and by the presence of anti‑nuclear antibodies.6 Moreover, it is as sumed that both diseases are provoked by genet ic, environmental, hormonal, and immunological factors.8,23‑30 There are more abundant published data on SLA than on MG. Common causative fac tors inclu ...
A first attempt to elucidate the amino acid sequence of some lichen
... to form a new biological entity different from its individual components. Recognition mechanisms used by lichens are based on the production and secretion of fungal lectins as signalling molecules (Kardish et al., 1991), which therefore develop arginase enzymatic activity (Molina et al., 1993). Wher ...
... to form a new biological entity different from its individual components. Recognition mechanisms used by lichens are based on the production and secretion of fungal lectins as signalling molecules (Kardish et al., 1991), which therefore develop arginase enzymatic activity (Molina et al., 1993). Wher ...
Immunoblot assay for determining the incidence allergens specific
... This study clearly suggests that pollen constitute the most important group of sensitizing allergens in patients with allergic rhinitis in this region with as many as 68.3% of all positive cases sensitized to at least one pollen. In this study IgE - mediated sensitization to fungal allergen was rare ...
... This study clearly suggests that pollen constitute the most important group of sensitizing allergens in patients with allergic rhinitis in this region with as many as 68.3% of all positive cases sensitized to at least one pollen. In this study IgE - mediated sensitization to fungal allergen was rare ...
What is the T-cell receptor (TCR)? (abridged
... The αβ version of the TCR was described on the previous page. The αβ type is more common, however another TCR type called γδ can also exist. This type of receptor is made up of gamma (γ) and delta (δ) proteins. These are also composed of subunits, but are different from αβ. The type of TCR that is f ...
... The αβ version of the TCR was described on the previous page. The αβ type is more common, however another TCR type called γδ can also exist. This type of receptor is made up of gamma (γ) and delta (δ) proteins. These are also composed of subunits, but are different from αβ. The type of TCR that is f ...
Negative regulation of SEK1 signaling by serum and
... ally identified as the product of a gene whose transcription was controlled by serum and glucocorticoids in rat mammary tumor cells (Webster et al, 1993a). SGK1 is implicated in a variety of cellular activities including the regulation of ion channel conductance, cell volume, and cell survival (Brune ...
... ally identified as the product of a gene whose transcription was controlled by serum and glucocorticoids in rat mammary tumor cells (Webster et al, 1993a). SGK1 is implicated in a variety of cellular activities including the regulation of ion channel conductance, cell volume, and cell survival (Brune ...
Cardiovasc. Res. 81197-205 (2009) - digital
... support to this notion was provided by the observation that systemic treatment with different ...
... support to this notion was provided by the observation that systemic treatment with different ...
Immune System Computation and the Immunological Homunculus
... existence as well as to sporadic episodes of clinical illness due to infection or injury. The immune system acts as a maintenance system; defense is only one aspect of maintenance (9). Actually, Eli Metchnikoff experimented with immune maintenance a century ago, but the discovery of antibodies to in ...
... existence as well as to sporadic episodes of clinical illness due to infection or injury. The immune system acts as a maintenance system; defense is only one aspect of maintenance (9). Actually, Eli Metchnikoff experimented with immune maintenance a century ago, but the discovery of antibodies to in ...
by MICHAEL WING-YIN WU
... death. RNAi therapeutics was employed as a novel way to silence the anti-apoptotic protein by using Mcl-1 mRNA sequence-specific siRNAs in vitro. In our hands, passive non-targeted delivery of RNAi therapy into melanoma tumours has been shown to be neither effective, nor selective in vitro and in vi ...
... death. RNAi therapeutics was employed as a novel way to silence the anti-apoptotic protein by using Mcl-1 mRNA sequence-specific siRNAs in vitro. In our hands, passive non-targeted delivery of RNAi therapy into melanoma tumours has been shown to be neither effective, nor selective in vitro and in vi ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.