The Ostrich (Struthio camelus) egg
... (groupe U - 1 1 6 ) . T h e excellent technical assist a n c e of Mrs. M. BERGER (purification of the e n z y m e a n d analyses) a n d of Mr. L v QUAN LE ( a u t o m a t e d E d m a n d e g r a d a t i o n ) is gratefully a c k n o w l e d g e d by the authors. T h e latter express also their t h a ...
... (groupe U - 1 1 6 ) . T h e excellent technical assist a n c e of Mrs. M. BERGER (purification of the e n z y m e a n d analyses) a n d of Mr. L v QUAN LE ( a u t o m a t e d E d m a n d e g r a d a t i o n ) is gratefully a c k n o w l e d g e d by the authors. T h e latter express also their t h a ...
Construction of a new peptide insertion site in the top
... The non-structural proteins are thought to be involved in various facets of viral morphogenesis, including virus assembly and release from infected cells. NS1 , encoded by genome segment M5, is synthesised in large quantities and polymerises into NS1 tubules in AHSV-infected cells (Huismans, 1979; U ...
... The non-structural proteins are thought to be involved in various facets of viral morphogenesis, including virus assembly and release from infected cells. NS1 , encoded by genome segment M5, is synthesised in large quantities and polymerises into NS1 tubules in AHSV-infected cells (Huismans, 1979; U ...
Amino Acid Transporters and Release of Hydrophobic Amino Acids
... pCSR13, pCSR23, pCSS4, pCSVM4, pCSVM5, or pCSVM6 with helper and methylation plasmid pRL623 was effected by the conjugative plasmid pRL443, carried in E. coli ED8654, and performed as described previously [39]. Exconjugants were selected for their resistance to Sm and Sp, or to Nm; for the generatio ...
... pCSR13, pCSR23, pCSS4, pCSVM4, pCSVM5, or pCSVM6 with helper and methylation plasmid pRL623 was effected by the conjugative plasmid pRL443, carried in E. coli ED8654, and performed as described previously [39]. Exconjugants were selected for their resistance to Sm and Sp, or to Nm; for the generatio ...
Drug-Induced Hematologic Disorders
... Although drug-induced hematologic disorders are less common than other types of adverse reactions, they are associated with significant morbidity and mortality. An epidemiologic study conducted in the United States estimated that 4,490 deaths in 1984 were attributable to blood dyscrasias from all ca ...
... Although drug-induced hematologic disorders are less common than other types of adverse reactions, they are associated with significant morbidity and mortality. An epidemiologic study conducted in the United States estimated that 4,490 deaths in 1984 were attributable to blood dyscrasias from all ca ...
Software Modeling of the Complement System and its role in
... thesis and having been of invaluable assistance in my endeavors. He has given me constant support and guidance through out. I would like to thank Dr. Karen Newell and Dr. Maria Augusteijn for agreeing to be my thesis committee members. Dr. Karen Newell was especially helpful in giving me a good insi ...
... thesis and having been of invaluable assistance in my endeavors. He has given me constant support and guidance through out. I would like to thank Dr. Karen Newell and Dr. Maria Augusteijn for agreeing to be my thesis committee members. Dr. Karen Newell was especially helpful in giving me a good insi ...
Formation of Monoterpenes in Antirrhinum majus
... apex, inflorescences, young buds, and flowers at different developmental stages as well as fertilized and unfertilized carpels. This search revealed three different GGPPS-like contigs. Of these, we determined experimentally that one was not expressed in petals (data not shown), and a second sequence ...
... apex, inflorescences, young buds, and flowers at different developmental stages as well as fertilized and unfertilized carpels. This search revealed three different GGPPS-like contigs. Of these, we determined experimentally that one was not expressed in petals (data not shown), and a second sequence ...
Complement-targeted therapeutics
... of complement that triggers inflammation and cell lysis. Many inflammatory, autoimmune, neurodegenerative and infectious diseases have been shown to be associated with excessive complement activity (Fig. 3). Complement involvement is usually complex and may include both an inappropriate initiation o ...
... of complement that triggers inflammation and cell lysis. Many inflammatory, autoimmune, neurodegenerative and infectious diseases have been shown to be associated with excessive complement activity (Fig. 3). Complement involvement is usually complex and may include both an inappropriate initiation o ...
Advanced Tests
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
sir frank macfarlane burnet
... Nobel Prize for this work. Fenner and Billingham were very unlucky not to have shared the award because Nobel Prizes can be split into two or three awards, but not four. The Danish medical scientist Niels K. Jerne published a paper on natural selection in cell production. Burnet recognised a basic f ...
... Nobel Prize for this work. Fenner and Billingham were very unlucky not to have shared the award because Nobel Prizes can be split into two or three awards, but not four. The Danish medical scientist Niels K. Jerne published a paper on natural selection in cell production. Burnet recognised a basic f ...
How do red blood cells know when to die?
... boosting the population of RBCs [7,8]. Conversely, if oxygen levels rise above physiological needs (e.g. in acclimation to higher partial pressure of oxygen after descent to sea level from high altitudes), fibroblasts lower the production of Epo and the population of RBCs shrinks to a new equilibriu ...
... boosting the population of RBCs [7,8]. Conversely, if oxygen levels rise above physiological needs (e.g. in acclimation to higher partial pressure of oxygen after descent to sea level from high altitudes), fibroblasts lower the production of Epo and the population of RBCs shrinks to a new equilibriu ...
How do red blood cells know when to die?
... boosting the population of RBCs [7,8]. Conversely, if oxygen levels rise above physiological needs (e.g. in acclimation to higher partial pressure of oxygen after descent to sea level from high altitudes), fibroblasts lower the production of Epo and the population of RBCs shrinks to a new equilibriu ...
... boosting the population of RBCs [7,8]. Conversely, if oxygen levels rise above physiological needs (e.g. in acclimation to higher partial pressure of oxygen after descent to sea level from high altitudes), fibroblasts lower the production of Epo and the population of RBCs shrinks to a new equilibriu ...
11111 Hhllill II III 11111 /III 11111 lihA IFU III III /MUll 110 III
... molecules, i.e. the T cells recognise a combination of virus antigen plus self HLA. There are probably about 120 different HLA class I molecules, and each individual human has a limited selection, and so will respond only to certain epitopes. Following the example of p24-20, which can be recognised ...
... molecules, i.e. the T cells recognise a combination of virus antigen plus self HLA. There are probably about 120 different HLA class I molecules, and each individual human has a limited selection, and so will respond only to certain epitopes. Following the example of p24-20, which can be recognised ...
Dangerous Byproducts of Alcohol Breakdown
... In Vivo Formation of Adducts During Alcohol Consumption The fact that it is possible to create adducts through chemical reactions in test tubes (i.e., in vitro) does not prove that adduct formation actually occurs in the liver (i.e., in vivo) and contributes to the development of alcoholic liver di ...
... In Vivo Formation of Adducts During Alcohol Consumption The fact that it is possible to create adducts through chemical reactions in test tubes (i.e., in vitro) does not prove that adduct formation actually occurs in the liver (i.e., in vivo) and contributes to the development of alcoholic liver di ...
Construction of a recombinant human GM
... 1 . 2 . 5 Cytotoxicity of rhGM-CSF/MCAF in vitro . well of 96-well culture plates. Serially diluted samples were then added. After the plates were incubated at 37°C in a humidified atmosphere containing 5 % C Q in air for 66 h, the cytotoxicity was determined by the MTT incorporation assayL6]. After ...
... 1 . 2 . 5 Cytotoxicity of rhGM-CSF/MCAF in vitro . well of 96-well culture plates. Serially diluted samples were then added. After the plates were incubated at 37°C in a humidified atmosphere containing 5 % C Q in air for 66 h, the cytotoxicity was determined by the MTT incorporation assayL6]. After ...
Neuropathy in a mouse model of CD8+ T cell
... mice, disease was inhibited and did not occur in mice injected early with antiB7.2 monoclonal antibody (mAb) [21]. ...
... mice, disease was inhibited and did not occur in mice injected early with antiB7.2 monoclonal antibody (mAb) [21]. ...
Pinto, A. K., A. M. Jamieson, D. H. Raulet, and A. B. Hill. 2007. The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40. J. Viro 81:12564-12571 .
... 123 days postinfection. The phenomenon of m152/gp40’s disproportionate impact on CTL lysis, which we wanted to address in these experiments, was described by using in vitro CTL lines. To confirm that NKG2D expression was maintained upon culture, we generated short-term polyclonal CTL lines specific ...
... 123 days postinfection. The phenomenon of m152/gp40’s disproportionate impact on CTL lysis, which we wanted to address in these experiments, was described by using in vitro CTL lines. To confirm that NKG2D expression was maintained upon culture, we generated short-term polyclonal CTL lines specific ...
study of the human humoral immune response against rotavirus
... in some low-income countries in Africa and Asia [6], where 85% of worldwide mortality occurs [7]. This drawback and the difficulty, given by the cost, to include RV vaccines in the national immunization programs of the poorest countries make it necessary to improve them or to develop new RV vaccines ...
... in some low-income countries in Africa and Asia [6], where 85% of worldwide mortality occurs [7]. This drawback and the difficulty, given by the cost, to include RV vaccines in the national immunization programs of the poorest countries make it necessary to improve them or to develop new RV vaccines ...
The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the
... We investigated T and B cell subsets as well as CMV status in a 66-year-old Swedish population-based sample with a CD4/CD8 ratio less/greater than 1. The present study demonstrates that individuals with an inverted CD4/CD8 ratio reveal an immune profile consisting of high CD8 and low CD4 and CD19 pe ...
... We investigated T and B cell subsets as well as CMV status in a 66-year-old Swedish population-based sample with a CD4/CD8 ratio less/greater than 1. The present study demonstrates that individuals with an inverted CD4/CD8 ratio reveal an immune profile consisting of high CD8 and low CD4 and CD19 pe ...
PDF - The Journal of Experimental Medicine
... and cell lines (Kaplan et al., 1998; Dunn et al., 2005). Its relevance to humans treated with anti–PD-1 therapy has been highlighted by the description of patients who developed acquired resistance to the therapy through new truncating mutations in JAK1 or JAK2 (Zaretsky et al., 2016). These were pa ...
... and cell lines (Kaplan et al., 1998; Dunn et al., 2005). Its relevance to humans treated with anti–PD-1 therapy has been highlighted by the description of patients who developed acquired resistance to the therapy through new truncating mutations in JAK1 or JAK2 (Zaretsky et al., 2016). These were pa ...
Sinusoid-lining cells are novel myeloid- endothelial innate cells that form splenic
... CPS4, which bypass the TI pathway by preferentially stimulating follicular B cells through the TD pathway. However, also conjugated vaccines present major limitations. Firstly, conjugated vaccines have higher costs of preparation, which limits their widespread use in developing countries. Secondly, ...
... CPS4, which bypass the TI pathway by preferentially stimulating follicular B cells through the TD pathway. However, also conjugated vaccines present major limitations. Firstly, conjugated vaccines have higher costs of preparation, which limits their widespread use in developing countries. Secondly, ...
Medical Veterinary Entomology
... recognized by the host’s immune system. The recruitment of immune reactive cells increases gradually from the nasal to sinus cavities in infected hosts. Mast cells, eosinophils, macrophages and lymphocytes are always more numerous in infected than non-infected animals. Humoral (antibody) systemic re ...
... recognized by the host’s immune system. The recruitment of immune reactive cells increases gradually from the nasal to sinus cavities in infected hosts. Mast cells, eosinophils, macrophages and lymphocytes are always more numerous in infected than non-infected animals. Humoral (antibody) systemic re ...
Purification of Arrestin from Bovine Retinas
... species. Arrestin contains a relatively high proportion of nonpolar amino acids (55%) that are assembled in a /3-sheet conformation (7, 8). However, very little is known about the biochemical/biophysical and structural properties of the protein. Arrestin is also of interest because of its ability to ...
... species. Arrestin contains a relatively high proportion of nonpolar amino acids (55%) that are assembled in a /3-sheet conformation (7, 8). However, very little is known about the biochemical/biophysical and structural properties of the protein. Arrestin is also of interest because of its ability to ...
The immune response to yellow fever vaccination in aged individuals
... infection in humans. Involving complex individual systemic immune properties, such investigations have been very challenging particularly with the given restrictions of experimental infections in humans. In our study, we explored age-related changes in human immunity during experimental, primary imm ...
... infection in humans. Involving complex individual systemic immune properties, such investigations have been very challenging particularly with the given restrictions of experimental infections in humans. In our study, we explored age-related changes in human immunity during experimental, primary imm ...
The role of lymph node sinus macrophages in host defense
... shown to directly target B cells to enhance humoral immune responses upon subsequent antigen challenge.46 These off-target effects should be taken into account when interpreting experimental results that make use of bisphosphonate-based preparations to study macrophage function. An alternative appro ...
... shown to directly target B cells to enhance humoral immune responses upon subsequent antigen challenge.46 These off-target effects should be taken into account when interpreting experimental results that make use of bisphosphonate-based preparations to study macrophage function. An alternative appro ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.