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... Bacillus anthracis a Category A agent with the potential to be used in a large-scale bioterrorism attack. The current vaccine, known as Anthrax Vaccine Adsorbed (AVA), consists of a culture filtrate from an attenuated strain adsorbed to aluminum salts as an adjuvant. Although considered to be safe a ...
... Bacillus anthracis a Category A agent with the potential to be used in a large-scale bioterrorism attack. The current vaccine, known as Anthrax Vaccine Adsorbed (AVA), consists of a culture filtrate from an attenuated strain adsorbed to aluminum salts as an adjuvant. Although considered to be safe a ...
Mucosal vaccines: the promise and the challenge
... transmitted diseases. In the human intestine, 5–15% of mucosal plasma cells secrete IgG9, but IgG is susceptible to degradation by luminal intestinal and bacterial proteases. In large intestinal secretions, for example, IgG concentrations are generally 30- to 100-fold lower than those of sIgA26. Nev ...
... transmitted diseases. In the human intestine, 5–15% of mucosal plasma cells secrete IgG9, but IgG is susceptible to degradation by luminal intestinal and bacterial proteases. In large intestinal secretions, for example, IgG concentrations are generally 30- to 100-fold lower than those of sIgA26. Nev ...
Marine alga Sargassum horneri active component
... development [3-5]. Dysfunctions in autophagy are associated with severe diseases, such as heart disease, neurodegenerative disorders, and cancers [4,6,7]. There are three distinct types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroautophagy (hereafter referred ...
... development [3-5]. Dysfunctions in autophagy are associated with severe diseases, such as heart disease, neurodegenerative disorders, and cancers [4,6,7]. There are three distinct types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy. Macroautophagy (hereafter referred ...
The Role of Antibodies in Mouse Models of Rheumatoid Arthritis
... column, tail, and ear (Courtenay et al., 1980). Investigators generally examine the tarsal joints histologically, and we are not aware of a study documenting the degree of inflammation in proximal versus distal joints. Histologically, synovial hyperplasia is a relatively early finding, followed by i ...
... column, tail, and ear (Courtenay et al., 1980). Investigators generally examine the tarsal joints histologically, and we are not aware of a study documenting the degree of inflammation in proximal versus distal joints. Histologically, synovial hyperplasia is a relatively early finding, followed by i ...
Protective effect of the maternally derived porcine circovirus type 2
... PCV2. Antigen-specific DTH responses and lymphocyte proliferation indicate an anti-PCV2-specific adaptive cellular response. Furthermore, piglets that received maternal PCV2-specific memory T lymphocytes mount DTH reactions in response to intradermal injection of PCV2 antigen. The DTH response was P ...
... PCV2. Antigen-specific DTH responses and lymphocyte proliferation indicate an anti-PCV2-specific adaptive cellular response. Furthermore, piglets that received maternal PCV2-specific memory T lymphocytes mount DTH reactions in response to intradermal injection of PCV2 antigen. The DTH response was P ...
Poster: MenBioVax generates cross strain immunogenicity
... America, no broadly effective vaccine has been approved. This is due in part to the low immunogenicity of the serogroup B capsular polysaccharide. ...
... America, no broadly effective vaccine has been approved. This is due in part to the low immunogenicity of the serogroup B capsular polysaccharide. ...
Killed but metabolically active microbes: a new vaccine paradigm for
... we sought to derive vaccine platforms based on whole organisms that elicited strong cellular immunity, yet retained the safety profile of killed or subunit vaccines. Killed but metabolically active (KBMA) vaccines are based on bacterial nucleotide excision repair mutants, and are inactivated by phot ...
... we sought to derive vaccine platforms based on whole organisms that elicited strong cellular immunity, yet retained the safety profile of killed or subunit vaccines. Killed but metabolically active (KBMA) vaccines are based on bacterial nucleotide excision repair mutants, and are inactivated by phot ...
No Slide Title
... Reishi Spores The unseen microscopic oval spores come from the top of the mushroom at maturity (4–5 months of cultivation). The “Cracked Spore” technology softens and breaks open the shell of Reishi spores so that the potent active ingredients can be extracted. ...
... Reishi Spores The unseen microscopic oval spores come from the top of the mushroom at maturity (4–5 months of cultivation). The “Cracked Spore” technology softens and breaks open the shell of Reishi spores so that the potent active ingredients can be extracted. ...
Role and significance of the complement system in mucosal
... More than 90% of the detectable serum C3 and C4 have been shown, through allotype conversion following hepatic transplantation, to be produced by the liver.38 Most of the other body tissues are also able to synthesize all the components of the complement system, including milk macrophages. Evidence ...
... More than 90% of the detectable serum C3 and C4 have been shown, through allotype conversion following hepatic transplantation, to be produced by the liver.38 Most of the other body tissues are also able to synthesize all the components of the complement system, including milk macrophages. Evidence ...
The Role of Staphylococcus aureus Virulence Factors in Skin
... A number of S. aureus vaccines have reached clinical trials, all of which were composed of a single target antigen that was designed to induce neutralising and opsonising antibodies [4], and although these vaccines produced robust humoral immunity, and proved efficacious in pre-clinical models, they ...
... A number of S. aureus vaccines have reached clinical trials, all of which were composed of a single target antigen that was designed to induce neutralising and opsonising antibodies [4], and although these vaccines produced robust humoral immunity, and proved efficacious in pre-clinical models, they ...
Integrin-associated protein (CD47) and its ligands
... individual proteins to form a complex with new functions is a well-established principle of signal transduction. The binding of a ligand to its receptor results in the assembly of complexes of cytoplasmic molecules required to generate the cascades that transfer information from the extracellular mi ...
... individual proteins to form a complex with new functions is a well-established principle of signal transduction. The binding of a ligand to its receptor results in the assembly of complexes of cytoplasmic molecules required to generate the cascades that transfer information from the extracellular mi ...
Pathogenesis of 2009 Pandemic Influenza A Virus (H1N1) Infection
... The pathogenesis of pandemic H1N1 infection results from various processes involving the host immune system and their response to virus-induced changes. Understanding both virus and host response characteristics in severe and mild infection cases is important for the future development of therapeuti ...
... The pathogenesis of pandemic H1N1 infection results from various processes involving the host immune system and their response to virus-induced changes. Understanding both virus and host response characteristics in severe and mild infection cases is important for the future development of therapeuti ...
The MHC complex
... Function of non-conventional MHC molecules • Ligands of inhibitory (HLA-G) or activating (MIC) Natural Killer cell receptors • Presentation of non-conventional peptides to ?? Cells: In mice, the H-2M locus encodes a nonconventional MHC class I molecule that present peptides that have a formylated m ...
... Function of non-conventional MHC molecules • Ligands of inhibitory (HLA-G) or activating (MIC) Natural Killer cell receptors • Presentation of non-conventional peptides to ?? Cells: In mice, the H-2M locus encodes a nonconventional MHC class I molecule that present peptides that have a formylated m ...
R e v i s i ó n
... defence against bacterial infection since these mice exhibit increased mortality in a model of acute septic peritonitis in which it is known that host resistance rely on mast cells and complement (25). The mechanism for this regulation of resident mast cells numbers by αMβ2 is unknown. Thus, αMβ2 mi ...
... defence against bacterial infection since these mice exhibit increased mortality in a model of acute septic peritonitis in which it is known that host resistance rely on mast cells and complement (25). The mechanism for this regulation of resident mast cells numbers by αMβ2 is unknown. Thus, αMβ2 mi ...
Specific Control of Immunity by Regulatory CD8 T Cells
... the induction of CD8+CD75s+ Treg, DC2-induced CD8 Treg and CD8+CD45RChigh Tc1 Treg depends on antigen priming, the antigens recognized by these CD8 Treg remain unknown (25-27). In the early allo-suppression experiments, it was proposed that CD8+CD28- Treg recognize the MHC class I molecules on the a ...
... the induction of CD8+CD75s+ Treg, DC2-induced CD8 Treg and CD8+CD45RChigh Tc1 Treg depends on antigen priming, the antigens recognized by these CD8 Treg remain unknown (25-27). In the early allo-suppression experiments, it was proposed that CD8+CD28- Treg recognize the MHC class I molecules on the a ...
Capacitation-associated Changes in Protein
... ** Corresponding Author: Gen-lin Wang. Tel: +86-25-84395045, Fax: +86-25-8439-5314, E-mail: glwang@njau. edu.cn ...
... ** Corresponding Author: Gen-lin Wang. Tel: +86-25-84395045, Fax: +86-25-8439-5314, E-mail: glwang@njau. edu.cn ...
Linking immune defenses and life history at the
... These cells and proteins are constitutively present at low levels in the blood and provide rapid first-line defenses (Janeway and others 1999). Macrophages and granulocytes ingest pathogens, produce reactive oxygen species and produce cytokines that recruit additional white blood cells and help orga ...
... These cells and proteins are constitutively present at low levels in the blood and provide rapid first-line defenses (Janeway and others 1999). Macrophages and granulocytes ingest pathogens, produce reactive oxygen species and produce cytokines that recruit additional white blood cells and help orga ...
THE HLA SYSTEM
... sequences, characteristic for certain HLA antigens. These probes will then "type" for the presence of specific DNA sequences of HLA genes. CLINICAL RELEVANCE OF THE HLA SYSTEM Despite the temptation to think of them as "transplantation antigens", HLA antigens are not present on tissues simply to con ...
... sequences, characteristic for certain HLA antigens. These probes will then "type" for the presence of specific DNA sequences of HLA genes. CLINICAL RELEVANCE OF THE HLA SYSTEM Despite the temptation to think of them as "transplantation antigens", HLA antigens are not present on tissues simply to con ...
Lymphoid follicles in (very) severe COPD: beneficial or harmful? REVIEW
... confirmed by animal studies showing the necessity of both these cells for the induction of experimental emphysema by cigarette smoke (CS) [6, 7]. It later became clear that the specific immune system also plays a role; in particular CD8 positive T-lymphocytes were associated with smoking and subsequ ...
... confirmed by animal studies showing the necessity of both these cells for the induction of experimental emphysema by cigarette smoke (CS) [6, 7]. It later became clear that the specific immune system also plays a role; in particular CD8 positive T-lymphocytes were associated with smoking and subsequ ...
28-29_Per_tolerance_Regulatory T-cells_LA
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
... Stimulates production of IgA antibodies by inducing B-cells to switch to this isotype. (IgA is the major antibody isotype required for mucosal immunity.) Promotes tissue repair after local inflammatory reactions (stimulate collagen synthesis and angiogenesis). Membrane-tethered TGF-β can also ...
Novel approaches to the development of targeted therapeutic
... immunological pathways are dysregulated. Current therapies for SLE are based mainly on the use of nonspecific immunosuppressive drugs that cause serious side effects. There is, therefore, an unmet need for novel therapeutic means with improved efficacy and lower toxicity. Based on recent better unders ...
... immunological pathways are dysregulated. Current therapies for SLE are based mainly on the use of nonspecific immunosuppressive drugs that cause serious side effects. There is, therefore, an unmet need for novel therapeutic means with improved efficacy and lower toxicity. Based on recent better unders ...
O Seu Incrível Sistema Imune
... você querer aprender mais sobre o assunto. Tomoko Ishikawa generosamente ilustrou o livro. O livro inteiro foi criado através da dedicação e entusiasmo do Dr Yousuke Takahama, colaborando com membros do ...
... você querer aprender mais sobre o assunto. Tomoko Ishikawa generosamente ilustrou o livro. O livro inteiro foi criado através da dedicação e entusiasmo do Dr Yousuke Takahama, colaborando com membros do ...
New Zealand Colostrum
... antibody levels in the first milk produced after birth (colostrum) were much higher than were found in the milk produced after 72 hours. It was already known that these antibodies contained certain properties that enhanced protection. Prior to the development of sulphur drugs and antibiotics, colost ...
... antibody levels in the first milk produced after birth (colostrum) were much higher than were found in the milk produced after 72 hours. It was already known that these antibodies contained certain properties that enhanced protection. Prior to the development of sulphur drugs and antibiotics, colost ...
1 - Universitas Brawijaya
... together to form a “single” functional protein Functional proteins also might incorporate minerals or other nonprotein components ...
... together to form a “single” functional protein Functional proteins also might incorporate minerals or other nonprotein components ...
FIST/HIPK3: a Fas/FADD-interacting Serine/Threonine Kinase that
... 24). Another group of 6 clones contained identical (4 clones) or highly homologous sequences (2 clones) (Fig. 1 A). In the two-hybrid system, the protein fragments (we named the protein FIST for Fas-interacting Ser/Thr kinase) encoded by the insert of the various clones all strongly interacted with ...
... 24). Another group of 6 clones contained identical (4 clones) or highly homologous sequences (2 clones) (Fig. 1 A). In the two-hybrid system, the protein fragments (we named the protein FIST for Fas-interacting Ser/Thr kinase) encoded by the insert of the various clones all strongly interacted with ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.