Immunotherapy in the battle against c
... therapies have failed to cure all cancer patients, immunotherapy might be a more clever strategy, since it specifically targets cancer cells aiming at their weakness. With approximately 25% of all deaths, cancer is the leading cause of mortality in Western countries. Since the early nineties the mor ...
... therapies have failed to cure all cancer patients, immunotherapy might be a more clever strategy, since it specifically targets cancer cells aiming at their weakness. With approximately 25% of all deaths, cancer is the leading cause of mortality in Western countries. Since the early nineties the mor ...
... disease kills between 1 and 2 million Africans and the economic losses due to malaria constitute a hindrance for economic development. In areas of stable malaria transmission the disease mainly affects children, because adults have acquired immunity which protects them against severe malaria syndrom ...
Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and
... removal of the cellular components was extracted by scraping at 90 °C in 1⫻ Laemmli sample buffer (60 mM Tris-HCl, pH 6.8, 2% SDS, 5% -mercaptoethanol, 5% glycerol). These fractions were designated as ECM as described previously (20). Cell Migration Assay—Cell migration was performed by trypsinizin ...
... removal of the cellular components was extracted by scraping at 90 °C in 1⫻ Laemmli sample buffer (60 mM Tris-HCl, pH 6.8, 2% SDS, 5% -mercaptoethanol, 5% glycerol). These fractions were designated as ECM as described previously (20). Cell Migration Assay—Cell migration was performed by trypsinizin ...
Seminar Winter Semester 2002/2003
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
... • Important to study what parts of a protein that binds to MHC molecules. • MHC I binds peptides with 8-10 aa • MHC II bind peptides with 12-25 aa • Potentials of peptide vaccines • Prediction of peptides is important!!!! ...
C UL1, H
... acquired during childhood by transmission through breast-feeding or contact with secretions. Upon infection, the virus persists in a life-long latent state, which is interrupted by periodical phases of reactivation, resulting in virus shedding and transmission to new hosts. Increased viral DNA and s ...
... acquired during childhood by transmission through breast-feeding or contact with secretions. Upon infection, the virus persists in a life-long latent state, which is interrupted by periodical phases of reactivation, resulting in virus shedding and transmission to new hosts. Increased viral DNA and s ...
Document
... The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD; Deutsche Börse:YP1B.DE). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification ...
... The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD; Deutsche Börse:YP1B.DE). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification ...
The ontogeny of the common carp (Cyprinus carpio L.) immune system
... approach because of its uncomplicated use, fast delivery, and less stressful entry route. ...
... approach because of its uncomplicated use, fast delivery, and less stressful entry route. ...
Vaccines and Autism
... Gamma-interferon, a pro-inflammatory cytokine from T-helper 1 CD4+ lymphocytes, exerts strong antiviral influences via multiple mechanisms, favors IgG production by B cells, and helps activate cytotoxic cells. Gamma-interferon is elevated in autistic children compared with matched controls in 2 stud ...
... Gamma-interferon, a pro-inflammatory cytokine from T-helper 1 CD4+ lymphocytes, exerts strong antiviral influences via multiple mechanisms, favors IgG production by B cells, and helps activate cytotoxic cells. Gamma-interferon is elevated in autistic children compared with matched controls in 2 stud ...
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral
... well-established model for human breast cancer research. Mice become infected by virus particles in mother’s milk (exogenous MMTV), and insertion of exogenous MMTV into somatic cell DNA sporadically leads to genetic damage and cancer. Alternatively, if exogenous MMTVs infect germline cells, the vira ...
... well-established model for human breast cancer research. Mice become infected by virus particles in mother’s milk (exogenous MMTV), and insertion of exogenous MMTV into somatic cell DNA sporadically leads to genetic damage and cancer. Alternatively, if exogenous MMTVs infect germline cells, the vira ...
The Lymphatic System
... When confronted with a toxin, the body's first reflex is to eliminate it, but because we have labelled such detoxification reactions as 'illness' and vigorously suppress them the body is then forced to accommodate the toxins. This leads to any number of different disease symptoms and the degenerativ ...
... When confronted with a toxin, the body's first reflex is to eliminate it, but because we have labelled such detoxification reactions as 'illness' and vigorously suppress them the body is then forced to accommodate the toxins. This leads to any number of different disease symptoms and the degenerativ ...
Combined action of anti-CD4 autoantibodies
... In sum, immunization of Wistar rats with HIV-1 gp120 induces chronic production of anti-CD4 autoantibodies and decreases CD4 lymphocytes in the blood. However, no correlation was found between antibodies to CD4 lymphocytes and the number of CD4 lymphocytes in the blood. Role of RF in the development ...
... In sum, immunization of Wistar rats with HIV-1 gp120 induces chronic production of anti-CD4 autoantibodies and decreases CD4 lymphocytes in the blood. However, no correlation was found between antibodies to CD4 lymphocytes and the number of CD4 lymphocytes in the blood. Role of RF in the development ...
Tetrahymena Contain Two Distinct and Unusual High Mobility Group
... macronucleus which governs the phenotype of the cell and a micronucleus which is a transcriptionally inactive germline nucleus (Gorovsky, 1973). If HMG-like proteins in Tetrahymena, like HMGs 14 and 17 in higher eukaryotes, are associated with transcriptionally active chromatin, one would expect to ...
... macronucleus which governs the phenotype of the cell and a micronucleus which is a transcriptionally inactive germline nucleus (Gorovsky, 1973). If HMG-like proteins in Tetrahymena, like HMGs 14 and 17 in higher eukaryotes, are associated with transcriptionally active chromatin, one would expect to ...
Hannah Akuffo Publications 1990 to 1999
... 35. Lavebratt C, Dalhammar G, Adamafio NA, Nykanen-Dejerud U, Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop ...
... 35. Lavebratt C, Dalhammar G, Adamafio NA, Nykanen-Dejerud U, Mingarini K, Ingemarsson K, Opoku N, Akuffo HO. A simple dot blot assay adaptable for field use in the diagnosis of onchocerciasis: preparation of an adult worm antigen fraction which enhances sensitivity and specificity. Trans R Soc Trop ...
Anthrax: Biology of Bacillus anthracis - ePrints@IISc
... ras-MAPKK pathway5 in athymic mice (mice lacking Tcell function due to absence of thymus since embryonic stage). Thus there is a potential for it being used as an anti-cancer drug in the near future. Recently, the crystal structure6 of the LF has been resolved at 2.2 Å. The molecule has dimensions o ...
... ras-MAPKK pathway5 in athymic mice (mice lacking Tcell function due to absence of thymus since embryonic stage). Thus there is a potential for it being used as an anti-cancer drug in the near future. Recently, the crystal structure6 of the LF has been resolved at 2.2 Å. The molecule has dimensions o ...
Testing the Effect of Changing Heat Shock Protein 90:
... Protein molecules are continuously synthesized and degraded in all living organisms. The concentration of individual cellular proteins is determined by a balance between the rates of synthesis and degradation, which in turn are controlled by a series of regulated biochemical mechanisms. The only way ...
... Protein molecules are continuously synthesized and degraded in all living organisms. The concentration of individual cellular proteins is determined by a balance between the rates of synthesis and degradation, which in turn are controlled by a series of regulated biochemical mechanisms. The only way ...
Fulltext PDF - Indian Academy of Sciences
... subunit of the galactose/N-acetyl-galactosamine inhibitable lectin; of six monoclonal antibodies raised against this molecule (Petri et al 1990b), only two reacted with E. histolytica and E. dispar while the other four reacted only with E. histolytica (Petri et al 1990a). These antibodies are the ba ...
... subunit of the galactose/N-acetyl-galactosamine inhibitable lectin; of six monoclonal antibodies raised against this molecule (Petri et al 1990b), only two reacted with E. histolytica and E. dispar while the other four reacted only with E. histolytica (Petri et al 1990a). These antibodies are the ba ...
Intestinal Dendritic Cells Specialize to Activate Transforming Growth
... and commensal bacteria that inhabit the gut.1 Regulatory processes must therefore prevent detrimental immune responses to these harmless antigens while still being able to mount protective responses against pathogens that enter the digestive tract. A breakdown in this tight regulation can lead to de ...
... and commensal bacteria that inhabit the gut.1 Regulatory processes must therefore prevent detrimental immune responses to these harmless antigens while still being able to mount protective responses against pathogens that enter the digestive tract. A breakdown in this tight regulation can lead to de ...
Immunity to Intracellular Salmonella Depends on Surface
... method [40] (for detailed description see Materials and Methods section). From these data, we selected additional antigens with a large range of abundances (Tab. 1). To determine potential cross-protection between different serovars, we cloned the corresponding genes from Salmonella enterica serovar ...
... method [40] (for detailed description see Materials and Methods section). From these data, we selected additional antigens with a large range of abundances (Tab. 1). To determine potential cross-protection between different serovars, we cloned the corresponding genes from Salmonella enterica serovar ...
Characteristics of Peptide
... each gene, and they are polygenic in that there are a number of different MHC genes. Class I MHC molecules consist of an a chain, in complex with b2microglobulin. Class II MHC molecules are composed of two noncovalently associated glycoproteins, the a and b chain, encoded by separate MHC genes. Both ...
... each gene, and they are polygenic in that there are a number of different MHC genes. Class I MHC molecules consist of an a chain, in complex with b2microglobulin. Class II MHC molecules are composed of two noncovalently associated glycoproteins, the a and b chain, encoded by separate MHC genes. Both ...
Amino acid utilisation and deamination of glutamine and asparagine
... study demonstrated that H. pylori grown in continuous culture in a defined medium containing glucose and amino acids utilised alanine, arginine, asparagine, aspartate, glutamine, glutamate, proline and serine. Specific asparaginase and glutaminase enzymes deaminated asparagine and glutamine respecti ...
... study demonstrated that H. pylori grown in continuous culture in a defined medium containing glucose and amino acids utilised alanine, arginine, asparagine, aspartate, glutamine, glutamate, proline and serine. Specific asparaginase and glutaminase enzymes deaminated asparagine and glutamine respecti ...
Pathophysiology and differential diagnosis of anaemia
... 160µM, 1.8mg/dL). Now that recombinant human Epo is commercially available, all pre-dialysis and dialysis patients benefit from Epo treatment. Anaemia with low Epo levels can also occur in the presence of neutralising antibodies to Epo (12). Such cases have been observed after repeated administratio ...
... 160µM, 1.8mg/dL). Now that recombinant human Epo is commercially available, all pre-dialysis and dialysis patients benefit from Epo treatment. Anaemia with low Epo levels can also occur in the presence of neutralising antibodies to Epo (12). Such cases have been observed after repeated administratio ...
Studies on the Mechanisms of Autophagy
... lumen as seen with lysosomal labeling but was limited to the area between the inner and outer membrane. Labeling of AVds was clearly evident with reaction product diffusing throughout the vacuole. It should be noted that at this time the inner membrane is no longer intact. The appearance of the reac ...
... lumen as seen with lysosomal labeling but was limited to the area between the inner and outer membrane. Labeling of AVds was clearly evident with reaction product diffusing throughout the vacuole. It should be noted that at this time the inner membrane is no longer intact. The appearance of the reac ...
REVIEWS - Advances in Clinical and Experimental Medicine
... able to replace organs in the human body like parts in a car. This is thanks to the recent achievement of a team from the Medical Research Council Center for Regenerative Medicine in Edinburgh, Scotland – the group of researchers tried to regenerate the thymus gland in mice. The thymus gland is an e ...
... able to replace organs in the human body like parts in a car. This is thanks to the recent achievement of a team from the Medical Research Council Center for Regenerative Medicine in Edinburgh, Scotland – the group of researchers tried to regenerate the thymus gland in mice. The thymus gland is an e ...
Full Text - Avicenna Journal of Dental Research
... pathologic outcomes. Several immune effectors function to minimize microbial interactions with host tissues (bacterial-epithelial contact). There is growing evidence from animal models indicating that certain bacteria can trigger immunopathology (18). The association between infection and autoimmune ...
... pathologic outcomes. Several immune effectors function to minimize microbial interactions with host tissues (bacterial-epithelial contact). There is growing evidence from animal models indicating that certain bacteria can trigger immunopathology (18). The association between infection and autoimmune ...
Dissociating Siv Env And Cd4: Consequenes For Virus And Host
... of the vaccine research field. Over a period of 28 years with 187 separate HIV vaccine trials (2), we have found that to develop a successful vaccine we must improve our understanding of pathogenesis along with correlates of protection and viral clearance, as well as identify immunogen(s) able to in ...
... of the vaccine research field. Over a period of 28 years with 187 separate HIV vaccine trials (2), we have found that to develop a successful vaccine we must improve our understanding of pathogenesis along with correlates of protection and viral clearance, as well as identify immunogen(s) able to in ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.