Novel Allergen Structures with Tandem Amino Acid Repeats
... animal danders, insects, and fungi induces IgE antibody responses in ;20% of the Western population. Immediate hypersensitivity reactions caused by IgE antibodies (Ab)1 occur in genetically predisposed individuals and may result in the development of allergic diseases such as rhinitis, asthma, and a ...
... animal danders, insects, and fungi induces IgE antibody responses in ;20% of the Western population. Immediate hypersensitivity reactions caused by IgE antibodies (Ab)1 occur in genetically predisposed individuals and may result in the development of allergic diseases such as rhinitis, asthma, and a ...
A Comparative Study - Carlos Ibanez Lab @ KI
... 1986), and a strong correlation exists between the reduction of cholinergic activity and the severity of the dementia (Perry et al., 1978; Wilcock et al., 1982). The known function of NGF in promoting the survival of basal forebrain cholinergic neurons has been used to argue that in SDAT a continuou ...
... 1986), and a strong correlation exists between the reduction of cholinergic activity and the severity of the dementia (Perry et al., 1978; Wilcock et al., 1982). The known function of NGF in promoting the survival of basal forebrain cholinergic neurons has been used to argue that in SDAT a continuou ...
Micro Chapter 12 [4-20
... preventing a full immune response to be mounted People who develop acute rheumatic fever have to take prophylactic antibiotics well into adulthood or for life to prevent another strep infection that would worsen the heart damage Group A strep has several stuff that look similar to host stuff to ...
... preventing a full immune response to be mounted People who develop acute rheumatic fever have to take prophylactic antibiotics well into adulthood or for life to prevent another strep infection that would worsen the heart damage Group A strep has several stuff that look similar to host stuff to ...
Immune Cognition, Micro-evolution,
... All living beings have the ability to present resistance to disease-causing agents, known as pathogens. These include viruses, bacteria, fungi, and parasites. The nature of this resistance varies from one species to the other, and is a function of the complexity of the organism. Mammals, in particul ...
... All living beings have the ability to present resistance to disease-causing agents, known as pathogens. These include viruses, bacteria, fungi, and parasites. The nature of this resistance varies from one species to the other, and is a function of the complexity of the organism. Mammals, in particul ...
abstract supplement - Society for Mucosal Immunology
... to wild-type mice, mice deficient in NLRP6 have an increased susceptibility to chemically-induced colitis which correlates with decreased levels of IL18 in the serum and colon explants in NLRP6-deficient mice during disease pointing to the possibility that NLRP6 forms an inflammasome. Notably, a pre ...
... to wild-type mice, mice deficient in NLRP6 have an increased susceptibility to chemically-induced colitis which correlates with decreased levels of IL18 in the serum and colon explants in NLRP6-deficient mice during disease pointing to the possibility that NLRP6 forms an inflammasome. Notably, a pre ...
Transcription factor Sp3 is silenced through - IMT
... this lysine lies within a motif (IKEE, amino acids 422±425 according to Kingsley and Winoto, 1992) that could act as a target for SUMO modi®cation (Melchior, 2000). SUMO-modi®ed proteins have an ~20 kDa higher apparent molecular weight compared with unmodi®ed proteins. However, previously we did not ...
... this lysine lies within a motif (IKEE, amino acids 422±425 according to Kingsley and Winoto, 1992) that could act as a target for SUMO modi®cation (Melchior, 2000). SUMO-modi®ed proteins have an ~20 kDa higher apparent molecular weight compared with unmodi®ed proteins. However, previously we did not ...
article in press
... cleavage and blastocyst rates when Cys was added to maturation medium. In contrast, the cleavage, morula and blastocyst rates were significantly different when 5 mM Ser was added to maturation media. There was also a significant difference in mean cell number per blastocyst, obtained from oocytes ma ...
... cleavage and blastocyst rates when Cys was added to maturation medium. In contrast, the cleavage, morula and blastocyst rates were significantly different when 5 mM Ser was added to maturation media. There was also a significant difference in mean cell number per blastocyst, obtained from oocytes ma ...
Biochemical, biophysical and interaction studies of the stress
... Designs and Patents Act 1988 (as amended) and regulations issued under it or, where appropriate, in accordance with licensing agreements which the University has from time to time. This page must form part of any such copies made. iii. The ownership of certain Copyright, patents, designs, trademarks ...
... Designs and Patents Act 1988 (as amended) and regulations issued under it or, where appropriate, in accordance with licensing agreements which the University has from time to time. This page must form part of any such copies made. iii. The ownership of certain Copyright, patents, designs, trademarks ...
Linköping University Post Print Induction of apoptosis in human neutrophils by
... representative of six separate experiments using PMNs from different donors. In Fig. 5C, the illustrated data represent apoptosis of the PMN population ± SD given as means of six separate experiments using PMNs from different donors. Significant differences between groups are indicated with *. ...
... representative of six separate experiments using PMNs from different donors. In Fig. 5C, the illustrated data represent apoptosis of the PMN population ± SD given as means of six separate experiments using PMNs from different donors. Significant differences between groups are indicated with *. ...
- Archives of Razi Institute
... Clindamycin is the drug of choice for treating clinical toxoplasmosis in cats. Because of its good intestinal absorption, oral and parenteral dosages are similar. Clindamycin dosages for treating toxoplasmosis are greater than those for treating anaerobic infections for which the drug is marketed. ...
... Clindamycin is the drug of choice for treating clinical toxoplasmosis in cats. Because of its good intestinal absorption, oral and parenteral dosages are similar. Clindamycin dosages for treating toxoplasmosis are greater than those for treating anaerobic infections for which the drug is marketed. ...
24. Lymphatic System
... fluid from the blood into the interstitial spaces around cells. This fluid is called interstitial fluid (not to be confused with extracellular fluid, a term that encompasses both interstitial fluid and plasma [see chapter 2]). Most of this fluid is reabsorbed at the venous end of the capillaries, b ...
... fluid from the blood into the interstitial spaces around cells. This fluid is called interstitial fluid (not to be confused with extracellular fluid, a term that encompasses both interstitial fluid and plasma [see chapter 2]). Most of this fluid is reabsorbed at the venous end of the capillaries, b ...
RabAvert - GSK Source
... Bite: Any penetration of the skin by teeth. Bites to highly innervated areas such as the face and hands carry the highest risk, but the site of the bite should not influence the decision to begin treatment. Recent epidemiologic data suggest that even the very limited injury inflicted by a bat bite ( ...
... Bite: Any penetration of the skin by teeth. Bites to highly innervated areas such as the face and hands carry the highest risk, but the site of the bite should not influence the decision to begin treatment. Recent epidemiologic data suggest that even the very limited injury inflicted by a bat bite ( ...
Micro Chapter 13 [4-20
... have symptoms because strep pneumonia is usually a nonharmful commensal microbiota Strep pneumonia love the respiratory tract When a host first meets strep pneumonia, the organism colonizes onto the nasopharynx Colonization then either results in clearance of the organism, asymptomatic persistence ( ...
... have symptoms because strep pneumonia is usually a nonharmful commensal microbiota Strep pneumonia love the respiratory tract When a host first meets strep pneumonia, the organism colonizes onto the nasopharynx Colonization then either results in clearance of the organism, asymptomatic persistence ( ...
Differential Host Immune Responses to Epidemic and Endemic
... in all age-groups. The aim of the study was to compare host immune responses to epidemic (T2218) and endemic strains of S. dysenteriae type 1. Shigellacidal activity of serum from rabbits immunized with epidemic or endemic strains, S. dysenteriae type 1-infected patients, and healthy adult controls ...
... in all age-groups. The aim of the study was to compare host immune responses to epidemic (T2218) and endemic strains of S. dysenteriae type 1. Shigellacidal activity of serum from rabbits immunized with epidemic or endemic strains, S. dysenteriae type 1-infected patients, and healthy adult controls ...
Our focus is on vaccines
... •Proliferation of CD8+ and CD4+ T cells •Increase in the proportion of CD8+ and CD4+ T cells producing the Th1 cytokines IFN-γ and TNF-α •Proliferation of CD19+CD138+ B cells •Proliferation of CD19+CD38+ B cells • Induces both T cell and B cell immune responses • Excellent potential to develop Proph ...
... •Proliferation of CD8+ and CD4+ T cells •Increase in the proportion of CD8+ and CD4+ T cells producing the Th1 cytokines IFN-γ and TNF-α •Proliferation of CD19+CD138+ B cells •Proliferation of CD19+CD38+ B cells • Induces both T cell and B cell immune responses • Excellent potential to develop Proph ...
Peer-Review Draft: Report on Carcinogens Monograph on Merkel Cell Polyomavirus
... definition for infectious diseases that emerge from complex interactions of multiple factors and may be caused by more than a single agent. An important consideration regarding multicausality is that most of the identified causes are neither necessary nor sufficient in the absence of other factors t ...
... definition for infectious diseases that emerge from complex interactions of multiple factors and may be caused by more than a single agent. An important consideration regarding multicausality is that most of the identified causes are neither necessary nor sufficient in the absence of other factors t ...
Pemphigoid diseases: Pathogenesis, diagnosis, and treatment
... cell subsets with immunoregulatory functions in BP patients has shown that while the number of circulating CD4 þ CD25 þ FOXP3 þ regulatory T cells, natural killer T cells, and natural killer cells are normal, gd T cells are reduced in BP patients [57,58]. Our knowledge about the functionally relevan ...
... cell subsets with immunoregulatory functions in BP patients has shown that while the number of circulating CD4 þ CD25 þ FOXP3 þ regulatory T cells, natural killer T cells, and natural killer cells are normal, gd T cells are reduced in BP patients [57,58]. Our knowledge about the functionally relevan ...
The diagnostic role of Saliva — A Review.
... misleading, since significant discrepancies between salivary and serum insulin levels were detected for several individuals (30). Additional studies are required to determine if salivary insulin levels should be used for the evaluation of serum insulin levels. Saliva also contains multiple component ...
... misleading, since significant discrepancies between salivary and serum insulin levels were detected for several individuals (30). Additional studies are required to determine if salivary insulin levels should be used for the evaluation of serum insulin levels. Saliva also contains multiple component ...
Collaborative Bioinspired Algorithms
... Use this idea to generate attribute strings that represent receptors Antibody production through a random concatenation from gene ...
... Use this idea to generate attribute strings that represent receptors Antibody production through a random concatenation from gene ...
Glycation by Ascorbic Acid Causes Loss of Activity of Ribulose
... (Hartman et al. 1987, Hartman and Lee 1989). Therefore, we examined whether glycation by AsA contributed towards the loss of Rubisco activity. In our results, glycated Rubisco of phase 1 decreased in activity linearly, and then the activity of Rubisco of phase 2 slowly decreased further (Fig. 6A). A ...
... (Hartman et al. 1987, Hartman and Lee 1989). Therefore, we examined whether glycation by AsA contributed towards the loss of Rubisco activity. In our results, glycated Rubisco of phase 1 decreased in activity linearly, and then the activity of Rubisco of phase 2 slowly decreased further (Fig. 6A). A ...
The Role of RNase L in Thymic Homeostasis and Humoral Responses
... pro-survival Bcl-2 protein; while the expression of the pro-apoptotic Bax protein was suppressed. Further investigation indicated that wild type thymocytes were prone to be arrested in the G1/S phase of the cell cycle by p27Kip1. In addition, PTPH1, a protein tyrosine phosphatase, and its substrate ...
... pro-survival Bcl-2 protein; while the expression of the pro-apoptotic Bax protein was suppressed. Further investigation indicated that wild type thymocytes were prone to be arrested in the G1/S phase of the cell cycle by p27Kip1. In addition, PTPH1, a protein tyrosine phosphatase, and its substrate ...
THE FORGOTTEN THYMUS
... • The Two Types of Immunity within the Immune System: "The type of immunity known as humoral immunity is due to a specialized group of plasma proteins called antibodies. Specific antibodies are formed against foreign materials called antigens. The humoral immune system is mobile. Antibodies are foun ...
... • The Two Types of Immunity within the Immune System: "The type of immunity known as humoral immunity is due to a specialized group of plasma proteins called antibodies. Specific antibodies are formed against foreign materials called antigens. The humoral immune system is mobile. Antibodies are foun ...
The Role of the Innate and Adaptive Immune Responses in
... reduction in the production of interferon γ, an 80% reduction in the number of CD4+ and CD8+ T cells, a significant increase in the severity of toxoplasma lesions in multiple organisms, and increased burdens of tachyzoites in the brain, lung, liver and spleen4. The innate immune system appears to pl ...
... reduction in the production of interferon γ, an 80% reduction in the number of CD4+ and CD8+ T cells, a significant increase in the severity of toxoplasma lesions in multiple organisms, and increased burdens of tachyzoites in the brain, lung, liver and spleen4. The innate immune system appears to pl ...
The human spleen after trauma Leemans, Rob
... approximately 8 times more than through all lymph nodes23. The lymphocytes enter the spleen through the arterial bloodstream and migrate to several splenic compartments. T-lymphocytes rapidly enter the central part of the periarteriolar lymphatic sheaths (PALS), while B-lymphocytes persist in more p ...
... approximately 8 times more than through all lymph nodes23. The lymphocytes enter the spleen through the arterial bloodstream and migrate to several splenic compartments. T-lymphocytes rapidly enter the central part of the periarteriolar lymphatic sheaths (PALS), while B-lymphocytes persist in more p ...
LMP1 signaling can replace CD40 signaling in B cells in vivo and
... Figure 1. Generation of a transgenic mouse line conditionally expressing CD40/LMP1. (A) Schematic representation of the chimeric protein CD40/LMP1. The N-terminal 215 amino acids (aa’s) of CD40 (receptor binding and transmembrane domain) were fused to the COOH-terminal 200 aa’s of LMP1 (cytoplasmic ...
... Figure 1. Generation of a transgenic mouse line conditionally expressing CD40/LMP1. (A) Schematic representation of the chimeric protein CD40/LMP1. The N-terminal 215 amino acids (aa’s) of CD40 (receptor binding and transmembrane domain) were fused to the COOH-terminal 200 aa’s of LMP1 (cytoplasmic ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.